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Abstract Background Emotional stimuli used as targets of working memory (WM) tasks can moderate age-related differences in WM performance, showing that aging is associated with reductions in negativity bias. This phenomenon is referred to as the positivity effect. However, there is little research on whether emotional distractors have a similar moderating effect. Moreover, the underlying neural mechanism of this effect has not been studied. In this study, we examined the behavioral and neurophysiological basis for age differences in resistance to emotional distractors within WM. Methods Older adults (n = 30, ages 60–74) and young adults (n = 35, ages 19–26) performed a 2-back task in which a digit was superimposed on a face with a happy, angry, or neutral expression as a distractor. Event-related potential (ERP) was simultaneously recorded to assess P2, N2, and later positive potential (LPP) amplitudes. Results Older adults were less accurate and slower than young adults on the WM task. Moreover, the results demonstrated a significant interaction between age and emotional valence on response accuracy, young adults' performance was worse when the distractor was neutral or positive than when it was negative, but there was no effect of the emotional valence of distractors on older adults’ WM performance. ERP analyses revealed greater P2 amplitude in older adults than young adults, regardless of the emotional valence of distractors. However, older adults and young adults did not differ on N2 or LPP amplitude, and negative distractors elicited greater N2 than positive distractors in both age groups. Conclusions The behavioral findings provided evidence of age-related reductions in negativity bias. Thus, the behavioral measures indicated a positivity effect in WM. However, the ERP results did not show this same interaction. These discrepant results raise questions about whether and to what extent older and young adults differ in controlling the effect of emotional distractors in WM.

Background: Emotional stimuli used as targets of working memory (WM) tasks can moderate age-related differences in WM performance, showing that aging is associated with reductions in negativity bias. This phenomenon is referred to as the positivity effect. However, there is little research on whether emotional distractors have a similar moderating effect. Moreover, the underlying neural mechanism of this effect has not been studied. In this study, we examined the behavioral and neurophysiological basis for age differences in resistance to emotional distractors within WM. Methods: Older adults (n = 30, ages 60–74) and young adults (n = 35, ages 19–26) performed a 2-back task in which a digit was superimposed on a face with a happy, angry, or neutral expression as a distractor. Event-related potential (ERP) was simultaneously recorded to assess P2, N2, and later positive potential (LPP) amplitudes. Results: Older adults were less accurate and slower than young adults on the WM task. Moreover, the results demonstrated a significant interaction between age and emotional valence on response accuracy, young adults' performance was worse when the distractor was neutral or positive than when it was negative, but there was no effect of the emotional valence of distractors on older adults’ WM performance. ERP analyses revealed greater P2 amplitude in older adults than young adults, regardless of the emotional valence of distractors. However, older adults and young adults did not differ on N2 or LPP amplitude, and negative distractors elicited greater N2 than positive distractors in both age groups. Conclusions: The behavioral findings provided evidence of age-related reductions in negativity bias. Thus, the behavioral measures indicated a positivity effect in WM. However, the ERP results did not show this same interaction. These discrepant results raise questions about whether and to what extent older and young adults differ in controlling the effect of emotional distractors in WM. [ABSTRACT FROM AUTHOR]

Objective: The neural correlates underlying the effects of emotional distraction during working memory (WM) tasks in patients with schizophrenia have yet to be clearly identified. Thus, the present study employed functional magnetic resonance imaging (fMRI) to investigate the effects of emotional distraction involving fear during WM maintenance in patients with schizophrenia. Methods: This study included 17 patients with schizophrenia who were diagnosed based on Diagnostic and Statistical Manual of Mental Disorders fourth edition, text revision (DSM-IV-TR) criteria and 17 matched healthy controls. Event-related fMRI data were acquired while the participants performed a delayed-response WM task that included neutral and fearful distractors. Results: Patients with schizophrenia may have tried to maintain WM function during the presentation of task-irrelevant fearful distractors that induced interruption and required attention. Compared to healthy controls, the schizophrenia patients exhibited significantly increased activity in the dorsolateral prefrontal cortex, medial prefrontal cortex, superior temporal gyrus, middle temporal gyrus, insula, hippocampus, caudate nucleus, and postcentral gyrus in a delayed-response WM task when presented with fearful relative to neutral distractors. In addition to its series of increased brain activations, prefrontal areas exhibited interconnections with more caudal brain regions, including temporal areas and the hippocampus and insula. Conclusion: The present study identified specific brain areas associated with the interaction between emotional regulation and cognitive functioning during fearful distractors presented while patients with schizophrenia performed a WM maintenance task. These findings further the current understanding of the neural correlates underlying the effects of emotional distraction on cognitive functioning in patients with schizophrenia. [ABSTRACT FROM AUTHOR]

Few studies have assessed the neural mechanisms of the effects of emotion on cognition in generalized anxiety disorder (GAD) patients. In this functional MRI (fMRI), we investigated the effects of emotional interference on working memory (WM) maintenance in GAD patients. Fifteen patients with GAD participated in this study. Event-related fMRI data were obtained while the participants performed a WM task (face recognition) with neutral and anxiety-provoking distracters. The GAD patients showed impaired performance in WM task during emotional distracters and showed greater activation on brain regions such as DLPFC, VLPFC, amygdala, hippocampus which are responsible for the active maintenance of goal relevant information in WM and emotional processing. Although our results are not conclusive, our finding cautiously suggests the cognitive-affective interaction in GAD patients which shown interfering effect of emotional distracters on WM maintenance.