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Whether visual short-term memory can be lost over an unfilled delay, in line with time-dependent forgetting, is controversial and prior work has yielded mixed results. The present study explored ti...

Despite attempts at active maintenance in the focus of attention, the fragile nature of the visual nonverbal memory trace may be revealed when the retention interval between target memoranda and probed recall on a trial is extended. In contrast, a passively maintained or unattended visual memory trace may be revealed as persisting proactive interference extending across quite extended intervals between trials in a recent probes task. The present study, comprising five experiments, used this task to explore the persistence of such a passive visual memory trace over time. Participants viewed some target visual items (for example, abstract colored patterns) followed by a variable retention interval and a probe item. The task was to report whether the probe matched one of the targets or not. A decaying active memory trace was indicated by poorer performance as the memory retention interval was extended on a trial. However, when the probe was a member of the target set from the preceding trial, task performance was poorer than a comparison novel probe, demonstrating proactive interference. Manipulations of the intertrial interval revealed that the temporal persistence of the passive memory trace of an old target was impressive, and proactive interference was largely resilient to a simple ‘cued forgetting’ manipulation. These data support the proposed two-process memory conception (active–passive memory) contrasting fragile active memory traces decaying over a few seconds with robust passive traces extending to tens of seconds.

e23507 Background: Ewing sarcoma (EwS) is an aggressive sarcoma with few treatment options for patients with relapsed disease. CDK4 is a known genomic vulnerability in EwS, but an unappealing monotherapy target given propensity for innate resistance. In laboratory studies to identify targets synergistic with CDK4 inhibition, IGF-1R scored highly. We present the results of a phase 2 study combining palbociclib (CDK4/6 inhibitor) with ganitumab (IGF-1R monoclonal antibody) for patients with relapsed or refractory EwS. Methods: This was a prospective open-label, non-randomized, single-center, phase 2 study (NCT04129151) for patients with relapsed EwS and RECIST measurable disease. Patients with relapsed EwS ≥12 years and a documented fusion consistent with EwS were eligible. Patients initially received Palbociclib 125 mg on days 1-21 and ganitumab 18 mg/kg on days 1 and 15 of a 28-day cycle. The primary endpoints were objective response (complete or partial) per RECIST and toxicity by CTCAE. Secondary endpoints included progression-free survival (PFS) and overall survival (OS). A one-stage design required ≥4 responders out of 15 to evaluate an alternative hypothesis of 40% response rate against a null of 10%. Results: Ten evaluable patients enrolled between 5/2019-8/2021. The study closed 12/2021 due to lack of ganitumab drug supply. The median age at enrollment was 25.7 years (range 12.3-40.1; Table). The median duration of therapy was 2.5 months (range = 0.9-10.8). There were no complete or partial responders. Three of 10 patients had stable disease for > 4 cycles and 2 had stable disease at completion of planned therapy or study closure. 6-month PFS was 30±14.5%. Two patients had cycle 1 hematologic DLTs triggering the pre-defined toxicity rule; the palbociclib dose was subsequently reduced to 100 mg daily for 21 days. Among the remaining 8 patients, two had cycle 1 hematologic DLTs at the 100 mg dose. 80% of patients had grade 3/4 AEs; the most commons AEs were neutropenia (n = 8), white blood cell decreased (n = 7), and thrombocytopenia (n = 5). Total IGF-1 testing demonstrated intrapatient elevations in serum levels after a single cycle of therapy. Analysis of serial ctDNA samples is ongoing. Conclusions: Four responders out of 15 were required to reject the null hypothesis of a 10% response rate. With 0/10 responders, we concluded that this combination lacked adequate therapeutic activity for further study. The combination was tolerable at a palbociclib dose of 100 mg, with primarily hematologic toxicity in patients with relapsed EwS. Clinical trial information: NCT04129151. [Table: see text]

Diderot’s Letter on the Blind (1749) is widely held to have inaugurated a new, rational and humane approach to visual impairment, which, so it has further been argued, helped to shape the way that the blind were represented by eighteenth-century French artists. By contrast, this essay contends that such images are heavily indebted to iconographic convention and other established tropes of blindness, as well as to the professional and personal concerns of the artists. Most of these works depict a blind beggar from the Hopital des Quinze-Vingts, which was located in the heart of Paris; a quintessentially Parisian figure, the ‘quinze-vingt’ embodied the city’s street life. Such insights as the artists offer into blindness as a condition can be attributed as much to the familiarity of this figure as to the enlightened ideas of philosophers such as Diderot. Nor did works of art challenge the outsider status of the blind man, since it was in his isolation and vulnerability that the significance and appeal of this figure very largely lay. Works discussed include etchings by Abraham Bosse and Sebastien Le Clerc, a drawing by (and print after) Edme Bouchardon, paintings by Jean-Simeon Chardin and Jean-Baptiste Greuze and Jacques-Louis David’s Belisarius.

Background: Employability, employment destinations and utilisation of knowledge–skill domains of new graduate health information managers (HIMs) have not been explored. Objectives: To capture the timing from course completion to employment and employment locations of a 5-year cohort of health information management graduates of La Trobe University, Australia, in 2017–2018; identify professional knowledge and skills used by the graduates in executing their roles; and map these to four domains of the health information management curriculum. Method: A mixed-methods descriptive study utilising a survey investigated early career pathways of new graduates of health information management courses from 2012 to 2016. Demographic data included age, year of graduation, lead time from course completion to employment, position title, number of positions held post-graduation and knowledge–skills used in the workplace. Results: Eighty percent ( n = 167) of graduates working in Australia with known contact details responded to the survey. Of these, 96.4% ( n = 161) worked in at least one “health information management-related” position since graduation. Forty-five percent ( n = 72) of graduates obtained a position before course completion, and over 94% ( n = 150) were employed in the profession within 6 months of completion. Sixty percent ( n = 97) of graduates had worked in two or more positions from 2012 to 2016. The large majority of new graduate HIMs (82.4%) were employed in the public healthcare sector in “health information management” (44%), or “health classification” (28.1%) roles. Most graduates (61%) had utilised at least three or four domains of professional knowledge–skills in the workplace. Whereas 16% ( n = 26) of graduates used, solely, their health classification knowledge–skill set, almost 74% ( n = 117) undertook some health classification-related activities. Only 16% ( n = 26) of graduates were over 40 years of age, and there were no statistically significant differences between Bachelor and Master (Combined Degree Programs) graduates and Graduate-entry Master degree graduates in terms of lead time to employment, number of positions held, type of employing agency and professional knowledge–skills utilised in the workplace. Conclusion: Graduate HIMs have very high employability, demonstrate job mobility consistent with the national trends, are largely represented in the public sector but have presence throughout the healthcare system and utilise most or all of the specialised domains of professional knowledge and skills studied at university.

11515 Background: Dedifferentiated liposarcoma (DDL) is characterized by ring chromosomes of chromosone12, which includes amplification of MDM2 and CDK4. Exposure to CDK4 inhibitors in Rb+ leiomyosarcoma (LMS) cell lines leads to decreased cell proliferation, and increased senescence, and G0/G1-phase arrest. When combined, ribociclib a CDK4 inhibitor and everolimus, an mTOR inhibitor show synergistic growth inhibition in multiple tumor models. We hypothesized that this combination could lead to increased disease control in patients with DDL. Methods: This study enrolled patients (pts) into one of two cohorts: DDL or Rb+ LMS. LMS pts were required to have 1 prior line of therapy; DDL pts required no prior therapy. There were no limits to prior therapies in either group. Measurable disease by RECIST 1.1 was also required. Ribociclib was given at 300 mg daily for 21/28 days and everolimus was given continuously at 2.5 mg daily in 28 day cycles. The primary endpoint was progression free rate at 16 weeks. A Simon two-stage design was utilized and if at least 8 out of 24 pts were progression free at 16 weeks, the treatment was declared promising for the cohort. Here in we present data on the DDL cohort. Results: To date, 21 DDS pts, median age of 63 (range 40-79), of which 43% (n = 9) female were treated. Median prior lines of therapy was 1 (range 0-6). Of 19 pts with complete data, 8 (42%) met the primary endpoint of non-progression at 16 weeks. Confirmed partial response was seen in 2 pts (10%). Median PFS was 16 weeks, and stable disease occurring as best response in 11 (55%) pts. Grade 3-4 toxicities were uncommon except for lymphopenia (24%) and neutropenia (33%); no episode of neutropenic fever were observed. There was one death on study secondary to myocardial infarction, considered possibly related to therapy. Results of optional tissue biopsies pre and on therapy obtained to assess pharmacodynamic changes in PTEN, pAKT, CDK4, Rb and pS6 will be presented. Conclusions: The combination of ribociclib and everolimus demonstrates activity in DDL with prolonged stable disease (>16 weeks) meeting the primary protocol endpoint. Notably partial responses were also observed. The combination was well tolerated with acceptable side effects. Updated outcomes will be presented. Clinical trial information: NCT03114527.

BACKGROUND: Allergies are among the most common chronic conditions. In addition to physical and social impacts, a number of studies have consistently linked allergies to poor psychological outcomes, including depression and anxiety. OBJECTIVES: The aim of the present systematic literature review was to analyze the existing literature about the relationship between allergies and fatal and nonfatal suicidal behaviors. METHODS: Data sources include articles retrieved from Scopus, PubMed, ProQuest, and Web of Knowledge. Search terms: "suicid* and (allerg* or hay fever or atop* or eczema or aeroallergen*)" in English-language peer-reviewed journals between 1990 and 2014. ELIGIBILITY CRITERIA: Original research articles that provide empiric evidence about the potential link between allergies and suicidal behaviors. RESULTS: The initial search identified a total of 769 articles with 17 original research articles that present empiric evidence. Nine articles analyzed the relationship between allergies and fatal suicidal behavior, and nine analyzed nonfatal suicidal behaviors (one article included both). There currently is little research into the relationship between allergies and suicidal behavior. LIMITATIONS: The review was restricted to English-language articles published within the chosen time period; other limitations included the small number of articles that involve suicide mortality, and the fact that the majority of articles originated from the United States and Scandinavia. CONCLUSIONS: Analysis of the results indicates a link between allergies and suicidality, particularly suicide mortality; however, results for nonfatal suicidal behaviors are mixed. It is important that further research by using more rigorous study designs be carried out to lend strength to these findings. Language: en

This article argues identifying as lesbian, gay, bisexual, transgender, intersex, queer and/or questioning (LGBTIQ) in rural spaces can produce specific types of policing experiences. While some literature examines the experiences of LGBTIQ people with police, very little has focused on how rurality explicitly shapes these experiences. This is significant considering research highlights how rurality can be connected to pronounced experiences of homophobia and trans-phobia. The article highlights examples from three research projects that explored: LGBTIQ young people's interactions with police; LGBTI people's interactions with police liaison services; and LGBTIQ-identifying police officers. The examples demonstrate the need for further research to examine how policing “happens” with rural LGBTIQ people to ensure more accountable policing policies and practice, and to highlight the complexities of localized, rural policing contexts that can both support and marginalize LGBTIQ people.

Asthma is a highly prevalent chronic condition worldwide, and is particularly common in younger people compared to other chronic conditions. Asthma can result in a number of symptoms that are detrimental to the quality of life of sufferers. The aim of the present systematic literature review was to analyse the existing literature on the relationship between asthma and fatal and nonfatal suicidal behaviours.Articles were retrieved from Scopus, PubMed, ProQuest and Web of Knowledge. We searched for the terms (suicid* OR self-harm) AND (asthma* OR “bronchial hyperreactivity”) published in English-language peer-reviewed journals between 1990 and December 2014. Original research papers providing empirical evidence about the potential link between asthma and suicidal behaviours were included.The initial search identified 746 articles. Specific limiting criteria reduced the number of articles to the 19 articles that were finally included in the systematic review.The review found a potential link between asthma and suicide mortality, ideation and attempts across the age groups. Limitations of the review include the restriction to English-language papers published within the chosen time period, the limited number of papers involving suicide mortality, and the fact that the majority of papers originated from the USA.

During the eighteenth century, so it is conventionally argued, the family portrait underwent a decisive transformation. Hitherto stiff and formal, such pictures took on a new informality and intimacy in response to the rise of a new set of domestic ideals. In the case of French family portraiture, this narrative has continued to be rehearsed in a largely uncritical way. What has not been adequately grasped to date is the way that such pictures functioned to legitimate the sitters and, more particularly, the male head of the family in the eyes of an external beholder. Although sometimes commissioned by a royal or noble family in response to a dynastic crisis, they most often functioned to consolidate the social ascent of wealthy commoners. The changes that the family portrait underwent during this period are bound up with the shift of political authority away from the absolute monarch towards the public sphere.

Automatic summarization of reader comments in on-line news is a challenging but clearly useful task. Work to date has produced extractive summaries using well-known techniques from other areas of NLP. But do users really want these, and do they support users in realistic tasks? We specify an alternative summary type for reader comments, based on the notions of issues and viewpoints, and demonstrate our user interface to present it. An evaluation to assess how well summarization systems support users in time-limited tasks (identifying issues and characterizing opinions) gives good results for this prototype.

The anniversary of the loss of a loved one is known to induce negative emotions, which for some can be significant. The present study examined the incidence of suicide around the time of such anniversaries using data from the Queensland Suicide Register for the years 1998 to 2008. There were statistically significant increases in suicide events immediately after the loss of a loved one and around the anniversary of the loss. Limitations of the study are noted.

We present a supervised approach to automat- ically labelling topic clusters of reader com- ments to online news. We use a feature set that includes both features capturing proper- ties local to the cluster and features that cap- ture aspects from the news article and from comments outside the cluster. We evaluate the approach in an automatic and a manual, task-based setting. Both evaluations show the approach to outperform a baseline method, which uses tf*idf to select comment-internal terms for use as topic labels. We illustrate how cluster labels can be used to generate cluster summaries and present two alternative sum- mary formats: a pie chart summary and an ab- stractive summary.

Existing approaches to summarizing multi-party argumentative conversations in reader comment are extractive and fail to capture the argumentative nature of these conversations. Work on argument mining proposes schemes for identifying argument elements and relations in text but has not yet addressed how summaries might be generated from a global analysis of a conversation based on these schemes. In this paper we: (1) propose an issue-centred scheme for analysing and graphically representing argument in reader comment discussion in on-line news, and (2) show how summaries capturing the argumentative nature of reader comment can be generated from our graphical representation.

This paper investigates graph-based approaches to labeled topic clustering of reader comments in online news. For graph-based clustering we propose a linear regression model of similarity between the graph nodes (comments) based on similarity features and weights trained using automatically derived training data. To label the clusters our graph-based approach makes use of DBPedia to abstract topics extracted from the clusters. We evaluate the clustering approach against gold standard data created by human annotators and compare its results against LDA – currently reported as the best method for the news comment clustering task. Evaluation of cluster labelling is set up as a retrieval task, where human annotators are asked to identify the best cluster given a cluster label. Our clustering approach significantly outperforms the LDA baseline and our evaluation of abstract cluster labels shows that graph-based approaches are a promising method of creating labeled clusters of news comments, although we still find cases where the automatically generated abstractive labels are insufficient to allow humans to correctly associate a label with its cluster.

Researchers are beginning to explore how to generate summaries of extended argumentative conversations in social media, such as those found in reader comments in on-line news. To date, however, there has been little discussion of what these summaries should be like and a lack of humanauthored exemplars, quite likely because writing summaries of this kind of interchange is so difficult. In this paper we propose one type of reader comment summary – the conversation overview summary – that aims to capture the key argumentative content of a reader comment conversation. We describe a method we have developed to support humans in authoring conversation overview summaries and present a publicly available corpus – the first of its kind – of news articles plus comment sets, each multiply annotated, according to our method, with conversation overview summaries.

Glycerol (propane-1,2,3-triol) has been an object of interest in recent years as a byproduct in the production of biodiesel, a parental molecule for syngas production, and a representative compound of the tar components derived from the carbohydrate fraction of biomass. Kinetic models describing the thermal degradation of glycerol toward lighter hydrocarbons and noncondensable gases are considered beneficial to an effective implementation of processes for its valorization. The aim of this work is to analyze and discuss the primary propagation reactions of glycerol, together with the ones of acetol (1-hydroxypropan-2-one) and 3-hydroxypropanal (the primary products of glycerol). This kinetic model is then evaluated in comparison with three independent sets of experimental measurements. The first one refers to pyrolysis experiments at intermediate temperatures, while syngas is obtained from glycerol pyrolysis at higher temperatures in the second one. The model is also tested against experiments on combustio...

Objectives/Hypothesis: The objective of this study was to analyze the patterns of failure and to determine clinical and pathologic factors predictive of recurrence and survival of patients treated for squamous cell carcinoma of the buccal mucosa at Princess Margaret Hospital. Study Design: Retrospective chart review. Methods: A retrospective chart review of patients treated for buccal carcinoma between 1994 and 2004 was performed. Seventy patients with newly diagnosed and previously untreated squamous cell carcinoma of the buccal mucosa were included. Demographic, clinical, and pathological parameters were identified and correlated with outcomes. Results: The patient cohort consisted of 33 males and 37 females. Most patients presented with early-stage local disease (T1-T2). Surgery was the primary treatment in 61 patients. Twenty-three patients were treated with postoperative radiotherapy. Median follow-up was 3.3 years. The 5-year local, regional, and overall control rates were 57.5%, 83.5%, and 50%, respectively. The 5-year overall survival rate was 69%. The 5-year disease-specific and recurrence-free survival rates were 76.4% and 46%, respectively. The only significant predictors of survival were the nodal status and extranodal extension. Conclusions: Carcinoma of the buccal mucosa is an aggressive disease, characterized by a high rate of locoregional failure. Transoral wide excision is an adequate treatment for early-stage lesions; however, a combined approach and an elective neck dissection should be considered in advanced lesions.

BACKGROUND AND OBJECTIVE Results of interventional trials in renovascular hypertension have been disappointing, and medical therapy is the current recommended gold standard. However, the comparative long-term benefits of different antihypertensive drug classes in atherosclerotic renal artery stenosis are not known. We aim to assess the effect of different antihypertensive drug classes on outcomes in renovascular hypertension DESIGN, SETTING, PARTICIPANTS, AND MEASUREMENTS: Using Tayside Health Informatics Centre database, anonymized data over a 6-year period was analyzed. Biochemistry, prescribing data, morbidity, mortality, and demographic data were accessed via hospital medical records and electronic data stored in the Tayside Health Informatics Centre Safe Haven. General Registrar's Office data were used to identify patients who died from cardiovascular disease. Independent predictors of survival in each group were analyzed using Kaplan-Meier survival curves and Cox proportional hazard models, adjusted for a range of covariates, using time-updated drug analysis. Blood pressure data were obtained from primary and secondary care clinic blood pressure records for each patient. Adjustments for mean systolic blood pressure over the follow-up period and baseline blood pressure were made. RESULTS A total of 579 patients with atherosclerotic renal artery stenosis were identified. In the unilateral renal artery stenosis cohort, calcium channel blockers but not ACE inhibitors/ARBs were associated with a significant reduction in all-cause (HR = 0.45, CI = 0.31, 0.65; P =

The aim of this work is to analyze the optimal operating conditions for fast biomass pyrolysis. The operating conditions required to maximize the yield of liquid products are investigated and discussed on the basis of a comprehensive mathematical model of wood/biomass devolatilization. Crucial issues are the fast and complete heating of biomass particles to reduce char formation and the rapid cooling of released products to reduce the role of secondary gas-phase pyrolysis reactions. Chemical kinetics as well as heat- and mass-transfer phenomena play an important role in this process; thus, a comprehensive kinetic model is applied. The proposed model, when compared to the majority of other devolatilization models, attempts to characterize pyrolysis reactions with a lumped stoichiometry using a limited number of equivalent components to describe not only gaseous products but also tar species. Model predictions are compared to experimental measurements not only with further validation in mind but also princi...

During the artist's lifetime, A Child Playing with a Dog was one of Jean-Baptiste Greuze's most admired and best-known works. The painting represents the physical, instinctual nature of the child in a manner unprecedented in French art. The image of childhood that it offers has close parallels in the scientific and medical discourse of the later eighteenth century. Like many contemporary commentators, Greuze evokes not simply the innocence of children but also their vulnerability, above all, that of little girls. He thereby implicates the viewer in the child's fate, both for good and ill.

Background. This cross-sectional study sought to determine patient quality of life and function after prosthetic rehabilitation for maxillary and palate defects following cancer resection. Methods. Sixty-nine patients were identified, 42 participated in the study (61%). The Obturator Functioning Scale (OFS) and 4 general quality of life measures (Mental Health Inventory (MHI), Impact of Events Scale (IES), Illness Intrusiveness Rat- ings Scale (IIRS), and Centre for Epidemiologic Studies Depres- sion Scale (CES-D)) were correlated with clinical parameters. Results. Leakage when swallowing foods was the most fre- quently reported problem with the obturator (29%). Positive correlation was noted between the OFS and both the IES sub- scales (p < .01) and CES-D (p < .001). Difficulty with speech and eating was associated with increased avoidance of social situations. The surgical approach had a significant effect on the OFS, IES, and MHI subscales (p < .01). Conclusion. These results support the findings that good ob- turator function is associated with a better quality of life. V