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Lichen planus is a chronic autoimmune multi-factorial inflammatory condition of the mucocutaneous skin that mainly interests the skin and oral mucosa. Oral Lichen Planus (OLP) affects 0.5 to 1% of the world's population and all human races equally. The factors that act as triggers of autoimmune processes and determine the appearance of OLP are represented by genetic predisposition, skin injuries, viral infections, contact allergies, and medications. OLP affects the oral mucosa and occurs frequently on the inside of the cheeks and less often on the edges of the tongue, gums, or lips. The condition is manifested by the appearance of painful erosions and mouth ulcers, accompanied by erythema and gingival scaling, and sometimes localized inflammation of the gums, near the amalgam fillings. There are 132 genes currently involved in the etiopathogenesis of OLP, but only a few appear to play a major role. These genes have been termed "leader genes". Thus, based on bioinformatics studies, the main genes involved in the pathogenesis of OPL are JUN, EGFR, FOS, IL2, and ITGB4. Although genetic status, immune system background, and infectious diseases are considered to be the most important incriminating and determining factors, the etiopathogenesis of OLP remains poorly known. Further genetic research is needed in order to achieve the generalizability of the findings and to strengthen the obtaining results.

Vitamins are essential for the proper functioning of the body, and Folic Acid, also known as Vitamin B9, has many benefits for the body. Folic Acid contributes to the normal development of the fetus, preventing the risk of fetal birth defects, mainly represented by neural tube defects and orofacial clefts. At the same time, Folic Acid deficiency can cause serious health problems. That is why it is necessary to know the roles of Folic Acid in the body, the symptoms of Folic Acid deficiency, but also what foods are rich in Folic Acid and how to supplement the body's need for Folic Acid.