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1. Vitamin E treatment in insulin-deficient diabetic rats reduces cardiac arrhythmias and mortality during severe hypoglycemia

Author

Candace M. Reno-Bernstein, Milan Oxspring, Justin Bayles, Emily Yiqing Huang, Ivana Holiday, and Simon J. Fisher

Subjects
Blood Glucose, Rats, Sprague-Dawley, Diabetes Mellitus, Type 1, Physiology, Physiology (medical), Endocrinology, Diabetes and Metabolism, Animals, Insulin, Vitamin E, Arrhythmias, Cardiac, Hypoglycemia, Rats, Diabetes Mellitus, Experimental
Abstract

In people with type 1 diabetes, hypoglycemia can induce cardiac arrhythmias. In rodent experiments, severe hypoglycemia can induce fatal cardiac arrhythmias, especially so in diabetic models. Increased oxidative stress associated with insulin-deficient diabetes was hypothesized to increase susceptibility to severe hypoglycemia-induced fatal cardiac arrhythmias. To test this hypothesis, Sprague-Dawley rats were made insulin deficient with streptozotocin and randomized into two groups

Published
2022

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