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Se ofrece un marco epistemológico al evaluar la cientificidad de las imágenes exocoriónicas de Llorente-Bousquets y cols., entendidas como representaciones esquemáticas de un sistema de caracteres morfológicos. Las imágenes se evalúan en la intersección de dos unidades de análisis: estilos y virtudes epistémicas. Se analizan según: i) tres estilos: quirografía, fotografía y microscopía electrónica de barrido (MEB); ii) cuatro virtudes: Fidelidad con la Naturaleza (TtN), Objetividad Mecánica (MO), Objetividad Estructural (SO) y Juicio Entrenado (TJ). Se ubican dos subestilos de quirografía: descriptivo-realista y ‘esquema letrado’. Se interpreta al esquema como characteristica universalis, conceptografía o representación directa de conceptos morfológicos, de los que aporta conocimiento a priori.Se analiza y evalúa la cientificidad del proceso productivo de imágenes a través del modelo de virtudes epistémicas y se propone unaversión extendida del mismo (D&G+).

Patients admitted for acute coronary syndrome (ACS) usually have high cardiovascular risk scores with low levels of high-density lipoprotein cholesterol (HDL-C) and high low-density lipoprotein cholesterol (LDL-C) levels. Here, we investigated the role of lipoprotein functionality as well as particle number and size in patients with a first-onset ACS with on-target LDL-C levels. Ninety-seven patients with chest pain and first-onset ACS with LDL-C levels of 100 ± 4 mg/dL and non-HDL-C levels of 128 ± 4.0 mg/dL were included in the study. Patients were categorized as ACS and non-ACS after all diagnostic tests were performed (electrocardiogram, echocardiogram, troponin levels and angiography) on admission. HDL-C and LDL-C functionality and particle number/size by nuclear magnetic resonance (NMR) were blindly investigated. A group of matched healthy volunteers (n = 31) was included as a reference for these novel laboratory variables. LDL susceptibility to oxidation was higher and HDL-antioxidant capacity lower in the ACS patients than in the non-ACS individuals. ACS patients had lower HDL-C and Apolipoprotein A-I levels than non-ACS patients despite the same prevalence of classical cardiovascular risk factors. Cholesterol efflux potential was impaired only in the ACS patients. ACS-STEMI (Acute Coronary Syndrome—ST-segment-elevation myocardial infarction) patients, had a larger HDL particle diameter than non-ACS individuals (8.4 ± 0.02 vs. 8.3 ± 0.02 and, ANOVA test, p = 0.004). In conclusion, patients admitted for chest pain with a first-onset ACS and on-target lipid levels had impaired lipoprotein functionality and NMR measured larger HDL particles. This study shows the relevance of HDL functionality rather than HDL-C concentration in ACS patients.

Background There are nonestablished protocols in use for first-line allergy screening based on IgE testing. These protocols attempt to address an unmet need for sustainability of clinical laboratories, at a time when demand is increasing. Objective To present a novel protocol for first-line allergy screening and to evaluate the implementation benefits for patients, the health care system, and payers. Methods We carried out an observational retrospective study analyzing 4359 interventions on primary care testing requests. Interventions included overriding redundant serum IgE (sIgE) testing for allergen mixes, extracts included in mixes, low-prevalence extracts, and milk and egg molecular components without previous positive results when exposed to extracts. We also added prevalent allergen testing. Results The strategy saved 683 tests from being performed unnecessarily. Test volume decline was primarily driven by the cancelation of 2186 egg and milk components tests; 561 tests were added for mixes, together with 942 allergen extracts tests. Discussion The results of this study show how the allergy laboratory plays a key role in actively managing demand for sIgE testing, leading to optimized diagnosis.

The use of gamma glutamyl transpeptidase (GGT) levels as screening test for liver function is controversial. The GGT main utility is in cases in which alkaline phosphatase (ALP) is elevated. We aimed to investigate the request over time for alanine amino transferase (ALT), ALP and GGT, study the effect of a new demand management (DM) intervention for optimal GGT measurement in primary care. Our descriptive study was conducted from January 2010 to December 2020. The intervention was established in November 2019 and consisted of the laboratory information system would automatically remove GGT, if the test had been ordered simultaneously with ALP and there was no prior pathological result on record. We counted the absolute number of measured ALT, ALP and GGT, and calculated the ratios for each of the three markers related to creatinine, and GGT related to ALT in a monthly basis. The number of measured GGT increased slightly and progressively along the study until October 2019, when a decrease was observed. The ALT and ALP request from primary care also increased slightly along years. However, the GGT/ALT ratio never reached the 0.2 goal. Out of the 57,614 GGT requested in primary care patients, 38,167 (66.2%) were not measured. 7633.4€ were saved in reagent. The DM intervention to reduce the measurement of GGT when requested redundantly with ALP in primary care was successful, and the results have been maintained over time as observed by monitoring the GGT/CREA and GGT/ALT indicator results.

A woman aged 63 years presented at the gynecological oncology outpatient clinic with the following medical history: smoking history (smoking index of 10); systemic arterial hypertension diagnosed 6 years ago; menarche at 16 years; menopause at 52 years; 4 pregnancies, 4 deliveries; beginning of active sexual life at 18 years; 3 sexual partners; and no early cancer detection method in her life. Her performance status per ECOG criteria was 1. The patient presented with transvaginal bleeding with 5 months of evolution. Upon physical exploration, a 5 x 5 cm tumor in the cervix was detected, with the following characteristics: exophytic, friable, bleeding, with invasion to the lower third of the vagina, affection to the cul-de-sac and parametria, and bilaterally fixed to the pelvic wall. A biopsy of the cervix showed moderately differentiated invasive squamous cell carcinoma.

Las relaciones interpersonales constituyen un papel crítico en una empresa debido a la interacción con personas que conservan puntos de vista, ideas, percepciones o formación diferentes, las mismas que pueden afectar para bien o mal en el desempeño laboral, por ende, permitir o distraer el logro de los objetivos organizacionales. En ese contexto la investigación tiene como objetivos: analizar cómo son las relaciones interpersonales de los colaboradores de los hoteles del departamento de Puno y determinar el desempeño laboral de los colaboradores de los hoteles del departamento de Puno. Los métodos enmarcan una investigación de enfoque cuantitativo, de alcance exploratorio-descriptivo y diseño no experimental. La población está conformada por 40 hoteles categorizados en tres estrellas, de la misma se ha obtenido una muestra de 16 hoteles, que albergan 84 colaboradores a ser encuestados. La técnica de recolección de datos fue la encuesta y el instrumento el cuestionario para la variable relaciones interpersonales, que contiene 15 preguntas medidas a una escala de Likert y para la variable desempeño laboral se aplicó la evaluación por el método de escala gráfica. El proceso de datos se ha dado a través de la hoja de cálculo Excel y el paquete estadístico SPSS. Mediante este se calculó las frecuencias y porcentajes de cada variable y sus dimensiones. Los resultados permiten concluir que las relaciones interpersonales en los hoteles del departamento de Puno según escala del instrumento utilizado son buenas, así el desempeño laboral de los colaboradores de los hoteles del departamento de Puno es bueno según la escala grafica.

Objective To illustrate the changes in stat laboratory procedures over a 10 year period. Materials and Methods We implemented 5 different interventions: reporting total bilirubin through the icteric index, replacing total proteins for albumin, reporting albumin-adjusted calcium in hyper- or hypocalcemia, using lipase as a first marker and amylase-selected scenario, and measuring magnesium in hypocalcemia, hypokalemia, or high lipase values. Results Only 9.9% of total bilirubin that was requested was measured, which resulted in savings of $22,492.83. There were 30,036 albumin tests measured, and $15,625.18 was saved replacing total protein. There was $41,374.38 spent to measure lipase and amylase; the difference in costs from the lipase establishment was $16,929.62. Finally, $382.30 was spent for magnesium: 717 magnesium levels were measured given hypocalcemia or hypokalemia (42.8% hypomagnesemia), and 123 tests were added because of high lipase (35% hypomagnesemia). Overall, $53,374.15 was saved. Conclusion Progressive changes in stat laboratory procedures resulted in more efficient resources expenditures.

Resumen: El objetivo del presente estudio es analizar el comportamiento del consumidor respecto a la influencia de facilidad y rapidez en la obtención de información virtual para la elaboración de trabajos académicos en la Universidad Nacional del Altiplano (Perú). El enfoque es cuantitativo y el tipo de investigación es descriptiva, explicativa y de diseño no experimental. La muestra de estudio se obtuvo proporcionalmente de cada escuela profesional. Se utiliza la técnica de encuesta escala de Likert en 5 categorías: muy deficiente, deficiente, regular, bueno y excelente. Los resultados muestran que solo en 17 % influyen los criterios de selección de información virtual, análisis crítico y reflexión de los temas en la elaboración de los trabajos académicos. Se concluye que los estudiantes adquirieron los conocimientos de buena conducta en investigación formativa, por lo que en sus trabajos académicos muestran un uso correcto de las fuentes utilizadas.

Objectives We aimed to share a new laboratory model based on laboratory knowledge, meaningful use of information technology, and partnership with clinicians, to lead the appropriate use of laboratory testing and clinical decision making in the diagnosis of as-yet-undiagnosed disease. More specifically, we evaluate the role of eight different opportunistic interventions to diagnose certain asymptomatic disorders, by means of the automatic registration of appropriate laboratory testing according to different scenarios. Methods This is a retrospective longitudinal study to evaluate the impact of laboratory interventions on the diagnosis of different diseases and on patient care, including data from January 2012 to September 2020. Results Overall, the above strategies have so far identified 2063 patients with clinically relevant as-yet-undiagnosed disorders who would have otherwise remained occult, such as for instance, primary hyperparathyroidism, diabetes, and hypomagnesemia. Conclusions We are facing a new laboratory model, a leading laboratory rather than a passive traditional laboratory, not just to intervene in clinical decision-making, but to make the clinical decision, through the identification of patients with occult disease.

Los enfrentamientos entre las empresas privadas y las poblaciones locales se dan permanentemente en el Perú en los procesos de extracción energética por alteraciones en aspectos socioeconómicos, ambientales y culturales de los pueblos. El objetivo fue analizar los conflictos socioambientales entre la empresa constructora Odebrecht y las Comunidades Campesinas de la Provincia de Canas - Cusco involucradas en el proyecto Mejoras a la Seguridad Energética del País y Desarrollo del Gasoducto Sur Peruano. La población informante fue 320 de 8 Comunidades Campesinas y representantes de la empresa, el diseño es etnográfico y método cualitativo. Los resultados muestran oposición categórica de los pobladores a la construcción del proyecto, debido a la disconformidad con el accionar errado de la empresa en los procesos de diálogo, interrelación y comunicación. Se concluye que los proyectos de impacto ambiental sin una línea de base social, cultural, económica y medio ambiental establecida generan enfrentamientos complejos de solucionar.

espanolEn las lineas que vienen, como macro objetivo, se intentara examinar la violencia politica y las pretensiones de revolucion por los actores de la Nacion Aymara (NAM), al encontrarse con un profundo impacto causado por los grupos sediciosos y el Estado peruano en el contexto de la decada oscura de los anos ´80 y ´90 del siglo pasado que, todavia queda como secuela en la memoria colectiva de las victimas. Considerando el enfoque cualitativo, la entrevista en profundidad y el analisis de discurso como orientacion hermeneutica fundamental, se examinan las percepciones de los 12 actores que en el entramado de la violencia fueron dirigentes. Los resultados evidencian que, la violacion de los Derechos Humanos (DH) bajo la represion, persecucion y las desapariciones selectivas en detrimento de la poblacion Aymara, ha generado tensiones, miedo, paranoia y el deseo de revolucion contra los grupos insurgentes y el mismo Estado que en su momento fue complice del genocidio hacia el corazon de los habitantes de la NAM. En conclusion, solo la apertura de los canales democraticos vinculantes entre el gobierno y los aymaras, podra redefinir nuevos espacios de dialogos transdisciplinares custodiados por la verdad y la justicia imperativa. EnglishIn the lines that come, as a target macro, attempts will be made to examine the political violence and claims of revolution by the actors of the Aymara Nation (NAM) as it encounters a profound impact caused by the seditious groups and the Peruvian state in the context of the dark decade of the 80s and 90s of the last century that remains a sequel to the collective memory of the victims. Considering the qualitative approach, in-depth interview and discourse analysis as a fundamental hermeneutic orientation, the perceptions of the 12 actors who were leaders in the fabric of violence are examined. The results show that the violation of Human Rights (HR) under repression, persecution and selective disappearances to the detriment of the Aymara population, creates tensions, fear, paranoia and the desire of revolution against insurgent groups and the same State that was once complicit in the genocide to the heart of the inhabitants of the NAM. In conclusion, only the opening of binding democratic channels between government and Aymara can redefine new spaces for transdisciplinary dialogues guarded by truth and imperative justice.

Introduction To test the efficacy of two interventions to promote the measurement of serum vitamin B12 (s- vitamin B12) in patients with long-term proton pump inhibitor (PPI) use and to decrease inadequate s-vitamin B12 measurement by implementing a minimum retest interval. Material and Methods The Laboratory Information System (LIS) automatically registered s-vitamin B12 when not ordered by General Practitioners to all requests patients with long term (>3years) PPI treatment, and with no s-vitamin B12 testing in the previous year. Through the second intervention, the LIS reported the previous s-vitamin B12 result through an explanatory comment in the report, when the test had been requested in the previous three months. We calculated the new diagnoses of vitamin deficiency (s-vitamin B12 Results The strategy added 548 s-vitamin B12 and identified 47 new cases of vitamin B12 deficit. The number of added s-vitamin B12 needed to identify a new case by means of the intervention was 12. The total intervention reagent cost was 1446€, with a cost of 30.7€ per new case. The second intervention avoided unnecessary measurement of 611 tests, with 1613€ savings. Conclusions Through the two automated interventions we improved the diagnosis of vitamin B12 deficiency, and decreased inadequate redundant s-vitamin B12 measurement, cutting unnecessary laboratory costs.

Background and Objectives: The work was aimed to determine the chronological sequence of events triggered by a fructose-rich diet (FRD) (10% w/v in the drinking water) in normal rats. Material and Methods: Serum parameters, liver and islet markers of metabolism, inflammation and oxidative stress were determined weekly for 21 days. Results: At the end of the first week, rats fed with a FRD showed an early increase in circulating triglycerides, fat liver deposit, and enzymatic activity of liver glucokinase and glucose-6-phosphate dehydrogenase (G6P-DH). After two weeks of such a diet, liver glucose-6-phosphatase (G6Pase) activity and liver oxidative stress markers were significantly increased. Liver sterol regulatory element-binding protein 1c (SREBP1c) mRNA also increased in the second week while their target genes fatty acid synthase (FAS) and glycerol-3-phosphate dehydrogenase (GPAT) enhanced their expression at the third week. Liver and pancreatic inflammation markers also enhanced their gene expression in the last week of treatment. Whereas both control and FRD rats remained normoglycemic throughout the entire period of treatment, blood insulin levels were significantly higher in FRD animals at the third week, thereby evidencing an insulin-resistant state (higher HOMA-IR, HOMA-B and HIS indexes). Pancreatic islets isolated from rats fed with a FRD for 3 weeks also increased glucose-induced insulin secretion (8.3 and 16.7 mM). Conclusions: FRD induces asynchronous changes involving early hypertriglyceridemia together with intrahepatic lipid deposit and metabolic disturbances from week one, followed by enhanced liver oxidative stress, liver and pancreas inflammation, pancreatic β-cell dysfunction, and peripheral insulin-resistance registered at the third week. Knowledge of time-course adaptation mechanisms involved in our rat model could be helpful in developing appropriate strategies to prevent the progression from prediabetes to Type 2 diabetes (T2D) triggered by unhealthy diets.

Bioactive compounds and nutritional characterization in three genotypes of mashua tubers (

Prompt identification of the clinical status and severity of COVID-19 can be a challenge in the emergency department (ED), as the clinical severity of the disease is variable, real-time reverse-transcription PCR (RT-PCR) results may not be immediately available, and imaging findings appear approximately 10 days after the onset of symptoms. There is currently no set of simple, readily available and fast battery of tests that can be used in the ED as prognostic factors. The purpose was to study laboratory test results in patients with COVID-19 at hospital emergency admission and to evaluate the results in non-survivors and their potential prognostic value. A profile of laboratory markers was agreed with the ED providers based on the International Federation of Clinical Chemistry and Laboratory Medicine recommendation of its usefulness, which was made in 218 patients with COVID-19. Non-survivors were significantly older, and the percentage of patients with pathological values of creatinine, albumin, lactate dehydrogenase (LDH), C reactive protein, prothrombin time, D-dimer, and arterial blood gas, PaO2/FIO2 and satO2/FIO2 indices were significantly higher among the patients with COVID-19 who died than those who survived. Patients who died also presented higher neutrophil counts. Among all studied tests, albumin and LDH were independent prognostic factors for death. The results of the study show pathology in nine laboratory markers in patients with COVID-19 admitted in the ED, valuable findings to take into consideration for its prompt identification when there is no immediate availability of RT-PCR results.

Resumen El articulo trata sobre el consumo de cine en plena etapa de desarrollo de la industria cinematográfica nacional e internacional, orientado hacia un público consumidor activo que pueda garantizar su permanencia en el mercado. El objetivo de la investigación fue determinar el nivel de consumo de cine peruano en los estudiantes de la Facultad de Ciencias Sociales de la Universidad Nacional del Altiplano – Puno, 2018-I. El estudio corresponde a una metodología cuantitativa, ya que se utilizó la recolección de datos por medio de la encuesta, para realizar un análisis estadístico descriptivo, con el fin de interpretar los resultados obtenidos y establecer pautas para mejorar o fortalecer la producción de películas peruanas. El resultado de la investigación evidencia que el 78.9% tienen un consumo de cine peruano de nivel medio, lo que equivale al grupo mayoritario. Por lo tanto, la investigación ha permitido llegar a la siguiente conclusión: el nivel de consumo de cine peruano de los estudiantes es medio. Resumo O artigo trata do consumo de filmes em plena fase de desenvolvimento da indústria cinematográfica nacional e internacional, orientada para um público consumidor ativo que possa garantir sua permanência no mercado. O objetivo da pesquisa foi determinar o nível de consumo do cinema peruano nos alunos da Faculdade de Ciências Sociais da Universidade Nacional do Altiplano - Puno, 2018-I. O estudo corresponde a uma metodologia quantitativa, uma vez que a coleta de dados foi utilizada através da pesquisa, para realizar uma análise estatística descritiva, a fim de interpretar os resultados obtidos e estabelecer diretrizes para melhorar ou fortalecer a produção de filmes peruanos. O resultado da pesquisa mostra que 78,9% possuem um consumo de filmes peruanos de médio porte, o que equivale ao grupo majoritário. Portanto, a pesquisa levou à seguinte conclusão: o nível de consumo de filmes peruanos dos estudantes é médio. Abstract The paper deals with the consumption of films in full stage of development of the national and international film industry, oriented towards an active consumer audience that can guarantee its permanence in the market. The objective of the research was to determine the level of consumption of Peruvian cinema among the students of the Faculty of Social Sciences of the National University of Altiplano - Puno, 2018-I. The study corresponds to a quantitative methodology, since data collection was used through the survey, to perform a descriptive statistical analysis, in order to interpret the results obtained and establish guidelines to improve or strengthen the production of Peruvian films. The result of the investigation shows that 78.9% of students have a medium level Peruvian film consumption, which is equivalent to the majority group. Therefore, the research has led to the following conclusion: the level of Peruvian film consumption of students is medium.

Background Vitamin B12 deficiency is common worldwide and is also linked to several diseases including autoimmune atrophic gastritis (AAG). The presence of anti-parietal cell antibodies (APCA) and/or intrinsic factor blocking antibodies (IFBA) is indicative of AAG that may develop into pernicious anemia. Both conditions are known to be associated with an increased risk of gastric carcinoma. The aim of this study was to estimate the frequency of individuals positive for APCA and IFBA antibodies in primary care patients with severe vitamin B12 deficiency. Methods An observational study was designed and 5468 consecutive patients from primary care with a request for vitamin B12 status were included and add-on testing for APCA and IFBA that were automatically registered if severe vitamin B12 deficiency was identified ( Results Seventy-seven patients with severe vitamin B12 deficiency were identified and out of these 44 (57%) presented with antibodies to APCA and 11 (14%) to IFBA, 25 (32.5%) had anemia, and 25 (32.5%) had macrocytosis. The majority of APCA and/or IFBA positive patients were found in the age group >70 years. Both anemia and macrocytosis were more common among APCA positive patients but the association was not statistically significant, neither was the correlation between IFBA status and anemia and/or macrocytosis. Among the patients with anemia, 10 (39%) had macrocytosis, although the rate of macrocytosis among patients with or without anemia did not differ significantly. Conclusions The automated analysis strategy of measuring antibodies to APCA and IFBA in patients with severe vitamin B12 deficiency, efficiently detected positivity in more than 60% the patients. The result point to the presence of a high rate of otherwise undetected AAG and the potential clinical utility of APCA and IFBA as markers in primary care.

Introduction The aim was to present two automated laboratory strategies designed to detect new cases of type 2 diabetes and prediabetes and improve their monitoring. Methods To improve diabetes diagnosis, we automatically registered the glycated hemoglobin (HbA1c) levels of every primary care patient between 25 and 46 years old in case of abnormal lipid testing when an HbA1c test had not been requested in the current order or during the previous year and when fasting glucose was > 100 mg/dl. We counted the number of detected cases of diabetes and prediabetes and calculated the cost per identified patient. To improve diabetes monitoring, the levels of HbA1c, total cholesterol, high- and low-density lipoprotein cholesterol and triglycerides and the spot urinary albumin-to-creatinine ratios (ACRs) were automatically registered in patients with diabetes when not ordered according to guidelines. We calculated the total economic costs according to the total number of additional registered tests and reagent cost. Results Of 103,425 requests, 224 (0.22%) met the inclusion criteria. Seventeen (7.6%) patients were identified as having new cases of diabetes and 149 (66.5%) of prediabetes, at a cost of €15.2 and €2.3, respectively, per case detected. From 13,874 requests in patients with diabetes, 91 HbA1c and 708 lipid tests and 862 ACRs were automatically registered to comply with guidelines, resulting in expenses of €1948.90. Conclusions Making use of laboratory technology, it is possible to detect new cases of type 2 diabetes and prediabetes and to improve disease monitoring.

Objective To improve clinical laboratory contribution to the treatment of primary care patients with anorexia through automated computerized strategies. Methods We recorded the number of laboratory requests due to anorexia; the demographic data, laboratory values, and presence of pathological values for the applicable patients. In a prospective study, the laboratory information management system (LIMS) automatically added thyroid-stimulating hormone (TSH) and/or ferritin testing when it was not requested by general practitioners for all primary care patients with anorexia who were younger than 16 years. Results A total of 3562 patients underwent laboratory testing due to anorexia, of whom 47% were younger than 16 years. The tests in which the results most frequently were abnormal were hemoglobin, ferritin, and TSH. TSH results were abnormal in 20% of patients younger than 16 years. Through the intervention, we detected 3 low ferritin values and 7 cases of pathological TSH levels. Conclusions The LIMS required TSH and ferritin testing in young patients even when not requested, potentially avoiding the adverse effects of iron deficiency and thyroid disorders on neurological development and cognition in those patients.

The research deals with the typology of students according to the satisfaction in their professional training of the University Andina Nestor Caceres Velasquez and University of San Carlos. The methodology used was transversal and descriptive, for the data collection the Likert scale was used and it was applied to a representative sample of 150 students from the fifth semester to tenth. The results obtained show a partial satisfaction that leads towards an indifferent attitude towards the students in front of their institution where they are formed; likewise, there are students with characteristics of apostolic, mercenary and hostage clients in small numbers. Concluding that the satisfaction in their professional training of students is partial and therefore they become indifferent clients from Chiesa's point of view, who do not show fidelity with their center of studies.

La sociedad moderna aspira que los seres humanos tengan las mismas oportunidades, sin importar el sexo, la raza y la clase social, en temas como salud, educación, alimentación y participación en la política en beneficio del bien común de los habitantes de un pueblo o de un país, contrariamente al pensamiento de las sociedades tradicionales autocráticas y machistas, donde marginaban y maltrataban a las personas de raza diferente a la suya y esclavizaban a las mujeres en trabajos domésticos y deberes de pareja, sin derecho a protestas contra los maltratos de sus parejas u otros parecidos que atentaban la salud mental y física de las mujeres.

With the increasing adoption of electromobility, it has become crucial to balance the consumer demand and offer from electric vehicle charging points. To improve end-users’ electromobility experience and access to related services, the NeMO project developed a Hyper-Network of tools and services. As a service, this paper describes the artificial neural network (ANN) models that are built to predict the occupancy statuses of electric vehicle charging points in Barcelona. The models are designed to do both short- and long-term predictions of the next 2 h and next week, respectively, considering the different power levels. We propose to combine similar charging points by behavior with no geolocational information to reduce the computational cost by considering the high number of charging stations in the future.

RESUMEN Los conocimientos ancestrales respecto a la medicina tradicional son importantes debido a que tuvieron presencia en la lucha contra diversas enfermedades, cuando no había hospitales ni profesionales de salud. Sin embargo, en la actualidad están siendo subestimados y dejados de lado por la ciencia. Muchos pobladores altoandinos y de otros lugares sufren de la inflamación de la próstata, que antes se curaba con el isaño. El objetivo de este artículo es sistematizar los saberes de la práctica del tratamiento de la prostatitis a través del isaño cultivado (para consumo) y pajarillu (isaño silvestre) en las comunidades campesinas de las provincias de Yunguyo, Chucuito, El Collao y Puno de la región de Puno - Perú. El enfoque de esta investigación es cualitativo, método etnográfico y fenomenológico. La población de estudio fueron adultos mayores que saben sobre la prevención y curación de los problemas de próstata con isaño. Se utilizó la técnica de la entrevista semiestructurada para obtener la información de cam po. El resultado sugiere que el isaño silvestre o pajarillu es el tubérculo que cumple el papel curativo de la próstata y no el isaño cultivado, que solo cumple el papel de prevención. Se concluyó que muchas personas con enfermedades de la próstata fueron sanadas por curanderos a base de isaño silvestre.

To identify new transcriptomic alterations in pancreatic islets associated with metabolic dysfunctions in people with prediabetes (PD)/type 2 diabetes (T2D).We collected information from public data repositories T2D related microarray datasets from pancreatic islets. We identified Differential Expressed Genes (DEGs) in non-diabetic (ND) vs people with T2D in each study. To identify relevant DEGs in T2D, we selected those that varied consistently in the different studies for further meta-analysis and functional enrichment analysis. DEGs were also evaluated at the PD stage.A total of seven microarray datasets were collected and analysed to find the DEGs in each study and meta-analysis was performed with 245 ND and 96 T2D cases. We identified 55 transcriptional alterations potentially associated with specific metabolic dysfunctions in T2D. Meta-analysis showed that 87% of transcripts identified as DEGs (48 out of 55) were confirmed as having statistically significant up- or down-modulation in T2D compared to ND. Notably, nine of these DEGs have not been previously reported as dysregulated in pancreatic islets from people with T2D. Consistently, the most significantly enriched pathways were related to the metabolism and/or development/maintenance of β-cells. Eighteen of the 48 selected DEGs (38%) showed an altered expression in islets from people with PD.These results provide new evidence to interpret the pathogenesis of T2D and the transition from PD to T2D. Further studies are necessary to validate its potential use for the development/implementation of efficient new strategies for the prevention, diagnosis/prognosis and treatment of T2D.

Objectives Malnutrition is an unfavorable prognostic factor associated with an increase in mortality, hospital stays, readmissions and resources consumption. The aim was to screen primary care patients for risk of malnutrition by using the control nutritional (CONUT) score, calculated through total lymphocytes count, serum albumin and total cholesterol, when the three markers were requested, and to compare results between primary care centers (PCC). Methods The clinical laboratory located in a 370-bed suburban University Community Hospital serves the Health Department inhabitants (2,34,551), attended in nine PCC. The laboratory information system (LIS) automatically calculated the CONUT score in every primary care patient over 18 years old, when all three laboratory markers were ordered by the General Practitioner. For all primary care patients, we collected demographic data, CONUT index and PCC. We classified results by PCC, and compared them. Results The clinical laboratory received 74,743 requests from primary care. The CONUT score was calculated in 7,155 (12.28%) patients. Nine hundred seventy-six (13.6%) were at risk of malnutrition according to the CONUT score, mainly male (p Conclusions It is possible to use CONUT score as a front-line population-wide laboratory marker to screen for the risk for malnutrition in primary care patients that was lower in one PCC.

Background Risk of malnutrition can be evaluated through Controlling Nutritional (CONUT) Score based on total peripheral lymphocytes, serum albumin, and total cholesterol. Our aim was to automatically calculate CONUT in primary care when involved markers were requested and compare its performance with albumin to identify patients at risk of malnutrition. CONUT was evaluated according to patient age, and calculated the potential expenses to calculate CONUT, when serum markers were no requested, and measured. Methods We calculated CONUT when the three laboratory markers were requested, compared CONUT and albumin, considering risk of malnutrition CONUT ≥ 2, and albumin

To test the efficacy of two interventions to promote the measurement of serum vitamin BThe Laboratory Information System (LIS) automatically registered s-vitamin BThe strategy added 548 s-vitamin BThrough the two automated interventions we improved the diagnosis of vitamin B

Islet Neogenesis Associated Protein pentadecapeptide (INGAP-PP) increases β-cell mass and function in experimental animals. A short clinical trial also yielded promising results. However, HTD4010, a new peptide derived from INGAP-PP, was developed in order to optimize its specific effects by minimizing its side effects. To study and compare the tertiary structure, stability dynamics, and plasma stability of HTD4010, an INGAP-PP analogue. Both peptides were pre-incubated in human, rat and mouse plasma at 37 °C, and their presence was identified and quantified by high performance liquid chromatography at different time-points. GROMACS 2019 package and the Gromos 54A7 force field were used to evaluate overall correlated motion of the peptide molecule during molecular dynamics simulation by essential dynamics. HTD4010 exhibited significantly larger plasma stability than INGAP-PP, and its structural stability was almost 3.36-fold higher than INGAP-PP. These results suggest that HTD4010 may facilitate longer tissue interaction, thereby developing higher potential biological effects. If so, HTD4010 may become a promising therapeutic agent to treat people with diabetes. Communicated by Ramaswamy H. Sarma.