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This article is a systematic review of summer reading programs from 2012 to 2021 and provides a synthesis of 16 articles on summer programs in children from prekindergarten through Grade 8 together with several individual and environmental characteristics (e.g., socioeconomic status, the language of learning, reading and/or behavioral disabilities). Compared to a control group, most studies have shown improvements, or at least no loss, in reading and writing skills and social behaviors. This is the reason why the programs are designed to incorporate a holistic approach to child development and are increasingly used in preparation for the next grade. Furthermore, this article highlights the heterogeneity of the intervention programs in terms of duration (2 weeks to 8 weeks), parental involvement (involved or not in literacy development) and type of intervention (at home vs. at center/school). Finally, the effectiveness of the programs is considered and the characteristics of and tips for successful programs are indicated.

DMRT1 is the testis-determining factor in several species of vertebrates, but its involvement in mammalian testes differentiation, whereSRYis the sex-determining gene, remains ambiguous. So far, DMRT1 loss of function has been described in two mammalian species and induces different phenotypes: disorders of sex development (XY DSD) in men and male infertility in mice. We thus abolished the DMRT1 expression by CRISPR/Cas9 in a third species of mammal, the rabbit. First, we observed that gonads from XYDMRT1-/-rabbit fetuses differentiated like ovaries, highlighting that DMRT1 is involved in testis determination. In addition to SRY, DMRT1 is required in the supporting cells to increase the expression of theSOX9gene, which heads the testicular genetic cascade. Second, we highlighted another function of DMRT1 in the germline since XX and XYDMRT1-/-ovaries did not undergo meiosis and folliculogenesis. XXDMRT1-/-adult females were sterile, showing that DMRT1 is also crucial for female fertility. To conclude, these phenotypes indicate an evolutionary continuum between non-mammalian vertebrates such as birds and non-rodent mammals. Furthermore, our data support the potential involvement ofDMRT1mutations in different human pathologies, such as XY DSD and male and female infertility.

Estrogens are steroid hormones produced by the aromatization of androgens by the aromatase enzyme, encoded by theCYP19A1gene. Although generally referred to as “female sex hormones”, estrogen is also produced in the adult testes of many mammals, including humans. To better understand the function of estrogens in the male, we used the rabbit model which is an important biomedical model. First, the expression ofCYP19A1was localized, demonstrating that testicular estrogens are produced by meiotic germ cells inside the seminiferous tubules. Next, the cells expressing ESR1 and ESR2 were identified, showing that estrogens could exert their function on post-meiotic germ cells in the tubules and play a role during sperm maturation, since ESR1 and ESR2 were detected in thecaudaepididymis. Then, CRISPR/Cas9CYP19A1−/−genetically modified rabbits were analyzed.CYP19A1−/−males showed decreased fertility with lower sperm count associated with hypo-spermatogenesis and lower spermatid number. Germ/sperm cell DNA methylation was unchanged, while sperm parameters were affected asCYP19A1−/−males exhibited reduced sperm motility associated with increased flagellar defects. In conclusion, testicular estrogens could be involved in the spermatocyte-spermatid transition in the testis, and in the acquisition of sperm motility in the epididymis.

The purpose of the present paper is to provide the norms of widely used tests of vocabulary, reading, and spelling skills for a French population of young adults. Data were collected from 18- to 26-year-old university students during individual sessions. We assessed 771 participants with the Mill Hill part B vocabulary test, 410 with the LexTale-Fr test, 1231 with the Alouette-R test, and 361 with the Pollueur word/pseudoword dictation and text dictation. Stepwise regression analyses showed the need to stratify the reference population according to the level of education and gender for some tests. The Alouette-R and Mill Hill scores increased with educational level. Moreover, for the tests whose performance differed according to gender, women generally performed better than men. The present normative data concerning vocabulary, reading, and spelling skills should provide useful tools for researchers and practitioners alike to rate young individuals within their reference population.

Two large samples were assessed twice in Grade 1: the control group (Cont; N = 2302), which received no specific interventions, and the experimental group (Exp; N = 484), which received interventio...

Estrogens are steroid hormones produced by the aromatization of androgens by the aromatase enzyme, encoded by the CYP19A1 gene. Although generally referred to as “female sex hormones”, estrogen is also produced in the adult testes of many mammals, including humans. To better understand the function of estrogens in the male, we used the rabbit model which is an important biomedical model. First, the expression of CYP19A1 transcripts was localized mainly in meiotic germ cells. Thus, testicular estrogen appears to be produced inside the seminiferous tubules. Next, the cells expressing ESR1 and ESR2 were identified, showing that estrogens could exert their function on post-meiotic germ cells in the tubules and play a role during sperm maturation, since ESR1 and ESR2 were detected in the cauda epididymis. Then, CRISPR/Cas9 CYP19A1−/− genetically modified rabbits were analyzed. CYP19A1−/− males showed decreased fertility with lower sperm count associated with hypo-spermatogenesis and lower spermatid number. Germ/sperm cell DNA methylation was unchanged, while sperm parameters were affected as CYP19A1−/− males exhibited reduced sperm motility associated with increased flagellar defects. In conclusion, testicular estrogens could be involved in the spermatocyte–spermatid transition in the testis, and in the acquisition of sperm motility in the epididymis.

This study investigates whether deletion neighbourhood frequency influences the processing of French written words, and whether it might also be influenced by individual differences in skilled adult readers. For this purpose, words with at least 1 higher-frequency deletion neighbour (e.g., pliage [folding]/plage [beach]) and others with no higher-frequency neighbour (e.g., morose [gloomy]) were presented in lexical decision (Experiment 1), progressive demasking (Experiment 2), and naming (Experiment 3) tasks. For each experiment, the participants' lexical skills were assessed by spelling, reading, and vocabulary tests. In Experiments 1-3, participants responded more slowly to words with at least 1 higher-frequency deletion neighbour than they did to words with no such neighbour. We also found evidence that the inhibitory effect of deletion neighbourhood frequency was sensitive to lexical skills in the naming task. These findings are discussed in terms of lexical competition underlying visual word recognition according to individual differences. (PsycInfo Database Record (c) 2020 APA, all rights reserved).

Despite extensive knowledge of the genetic structure of sea bass (Dicentrarchus labrax) populations, no studies have investigated genetic structure within early life stages, or compared such structure between such stages and (sub)adults. Using nine newly developed microsatellite loci, we investigated patterns of genetic variation and relatedness among juveniles that settled in two NW Mediterranean nursery grounds in close geographical proximity. There was no evidence for differentiation among samples at settlement (θ = −0.0010), and no significant genetic relatedness. Nevertheless, significant departures from Hardy-Weinberg equilibrium were detected in each sample, which could not be attributed exclusively to the presence of null alleles and to Wahlund effect. These results are compared with and discussed in relation to the genetic structure of adults described in the same area 10 years ago.