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11 results on '"Emiliano Barbieri"'

1. Comparison of isatuximab-pomalidomide-dexamethasone versus elotuzumab-pomalidomidedexamethasone in relapsed/refractory multiple myeloma patients: a target trial emulation using real-world data

Author

Enrica Antonia Martino, Annalisa Pitino, Massimo Offidani, Roberta Della Pepa, Alessandro Gozzetti, Velia Bongarzoni, Antonio Maroccia, Valeria Amico, Paola Stefanoni, Elena Zamagni, Sofia Terlizzi, Daniele Derudas, Salvatore Palmieri, Rosario Bianco, Concetta Conticello, Marino Brunori, Angela Rago, Flavia Lotti, Raffaele Fontana, Nicola Sgherza, Elena Rossi, Anna Maria Cafro, Massimiliano Arangio Febbo, Angela Maria Quinto, Claudio Cerchione, Gloria Margiotta Casaluci, Annalisa Citro, Catello Califano, Renato Zambello, Silvia Mangiacavalli, Carmine Liberatore, Gabriele Buda, Claudio De Magistris, Angela Amendola, Ernesto Vigna, Antonella Bruzzese, Emiliano Barbieri, Micol Quaresima, Daniela Roccotelli, Francesca Farina, Jacopo Micozzi, Iolanda Donatella Vincelli, Giuseppe Tarantini, Elisabetta Antonioli, Sara Aquino, Alessandro Maggi, Alessandra Lombardo, Giuseppe Bertuglia, Anna Furlan, Anna Mele, Ombretta Annibali, Emilia Cotzia, Pietro Benvenuti, Lorenzo De Paoli, Gregorio Barilà, Sonia Morè, Valerio De Stefano, Francesco Di Raimondo, Maria Teresa Petrucci, Niccolò Bolli, Pellegrino Musto, Antonino Neri, Fortunato Morabito, Giovanni Tripepi, and Massimo Gentile

Subjects
Diseases of the blood and blood-forming organs, RC633-647.5
Abstract

Not available.

Published
2025
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2. Isatuximab, pomalidomide, and dexamethasone as salvage therapy for patients with multiple myeloma: the Italian, multicenter, retrospective clinical experience with 270 cases outside of controlled clinical trials

Author

Enrica Antonia Martino, Daniele Derudas, Elena Rossi, Sofia Terlizzi, Giovanni Reddiconto, Paola Stefanoni, Jacopo Micozzi, Silvia Mangiacavalli, Elena Zamagni, Massimo Offidani, Anna Furlan, Gabriele Buda, Flavia Lotti, Carmine Liberatore, Antonio Lazzaro, Roberta Della Pepa, Giuseppe Bertuglia, Emiliano Barbieri, Concetta Conticello, Claudio De Magistris, Lorenzo De Paoli, Velia Bongarzoni, Anna Maria Cafro, Anna Mele, Pietro Benvenuti, Claudio Cerchione, Cirino Botta, Elisabetta Antonioli, Nicola Sgherza, Sara Aquino, Giuseppe Mele, Gregorio Barilà, Salvatore Palmieri, Ombretta Annibali, Rosario Bianco, Massimiliano Arangio Febbo, Gloria Margiotta Casaluci, Angela Rago, Raffaele Fontana, Francesca Farina, Ernesto Vigna, Antonella Bruzzese, Katia Mancuso, Davide Nappi, Sonia Morè, Elena Rivolti, Catello Califano, Angela Amendola, Daniela Roccotelli, Alessandra Lombardo, Annalisa Citro, Giuseppina Uccello, Renato Zambello, Alessandro Maggi, Santo Neri, Michele Monachesi, Alessandro Gozzetti, Vittorio Montefusco, Marino Brunori, Emilia Cotzia, Giuseppe Pietrantuono, Angela Maria Quinto, Valeria Amico, Nicola Di Renzo, Marta Coscia, Monica Galli, Valerio De Stefano, Maria Teresa Petrucci, Antonino Neri, Francesco Di Raimondo, Fortunato Morabito, Pellegrino Musto, and Massimo Gentile

Subjects
Diseases of the blood and blood-forming organs, RC633-647.5
Abstract

Not available.

Published
2024
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3. Clinical features and metabolic complications for non-alcoholic fatty liver disease (NAFLD) in youth with obesity

Author

Emiliano Barbieri, Nicola Santoro, and Giuseppina Rosaria Umano

Subjects
NAFLD, type 2 diabetes, youth, insulin resistance, genetics, Diseases of the endocrine glands. Clinical endocrinology, RC648-665
Abstract

Pediatric obesity has become in the last forty years the most common metabolic disease in children and adolescents affecting about 25% of the pediatric population in the western world. As obesity worsens, a whole-body insulin resistance (IR) occurs. This phenomenon is more pronounced during adolescence, when youth experience a high degree of insulin resistance due the production of growth hormone. As IR progresses, the blunted control of insulin on adipose tissue lipolysis causes an increased flux of fatty acids with FFA deposition in ectopic tissues and organs such as the liver, leading to the development of NAFLD. In this brief review, we will discuss the clinical implications of IR and NAFLD in the context of pediatric obesity. We will review the pathogenesis and the link between these two entities, the major pathophysiologic underpinnings, including the role of genetics and metagenomics, how these two entities lead to the development of type 2 diabetes, and which are the therapeutic options for NAFLD in youth.

Published
2023
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4. Investigating the association between physicians self-efficacy regarding communication skills and risk of 'burnout'

Author

Andrea Messerotti, Federico Banchelli, Silvia Ferrari, Emiliano Barbieri, Francesca Bettelli, Elena Bandieri, Davide Giusti, Hillary Catellani, Eleonora Borelli, Elisabetta Colaci, Valeria Pioli, Monica Morselli, Fabio Forghieri, Gian Maria Galeazzi, Roberto Marasca, Sarah Bigi, Roberto D’Amico, Peter Martin, Fabio Efficace, Mario Luppi, and Leonardo Potenza

Subjects
Breaking serious news, Attitudes, Burnout, Communication skills, Computer applications to medicine. Medical informatics, R858-859.7
Abstract

Abstract Background Breaking bad news (BBN) may be associated with increasing risk of burnout in practising physicians. However, there is little research on the association between the way bad news is broken and burnout. We investigated the association between physicians’ self-efficacy regarding communication to patients and risk of burnout. Methods We performed a cross-sectional study by proposing an ad-hoc survey exploring attitudes and practice regarding BBN and the Maslach Burnout Inventory - Human Service Survey to 379 physicians from two University Hospitals in Italy. Associations were assessed by multivariable logistic regression models. Results Two-hundred twenty-six (60%) physicians returned the questionnaires. 76% of physicians acquired communication skills by observing mentors or colleagues, 64% considered BBN as discussing a poor prognosis, 56% reported discussing prognosis as the most difficult task, 38 and 37% did not plan a BBN encounter and considered it stressful. The overall burnout rate was 59%. Considering BBN a stressful task was independently associated with high risk of burnout (OR 3.01; p = 0.013). Planning the encounter (OR = 0.43, p = 0.037), mastering communication skills (OR = 0.19, p = 0.034) and the self-evaluation as good or very good at BBN (OR 0.32; 0.15 to 0.71; p = 0.0) were associated with low risk of burnout. Conclusions Our findings suggest that some physicians’ BBN attitudes and knowledge of conceptual frameworks may influence the risk of burnout and support the notion that increasing knowledge about communication skills may protect clinicians from burnout. Further research is needed in this area.

Published
2020
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6. Feasibility of autologous peripheral blood stem cell mobilization and harvest in adult patients with FLT3-mutated acute myeloid leukemia receiving chemotherapy combined with midostaurin: a single-center experience

Author

Stefano Cordella, Angelica Parisotto, Francesca Bettelli, Monica Morselli, Emiliano Barbieri, Stefano Pozzi, Anna Aquilino, Gianluca Repaci, Angela Cuoghi, Paola Bresciani, Andrea Messerotti, Corrado Colasante, Andrea Gilioli, Valeria Pioli, Davide Giusti, Elisabetta Colaci, Luca Cassanelli, Giovanni Ceccherelli, Mirco Bevini, Roberta Malavolti, Donatella Venturelli, Ambra Paolini, Silvia Martinelli, Rossana Maffei, Giovanni Riva, Vincenzo Nasillo, Tommaso Trenti, Patrizia Comoli, Enrico Tagliafico, Rossella Manfredini, Patrizia Barozzi, Leonardo Potenza, Roberto Marasca, Mario Luppi, and Fabio Forghieri

Subjects
Hematology, General Medicine
Published
2022
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7. Effects of the BTN162b2 mRNA COVID-19 vaccine in humoral and cellular immunity in patients with chronic lymphocytic leukemia

Author

Stefania Fiorcari, Claudio Giacinto Atene, Rossana Maffei, Nicolò Mesini, Giulia Debbia, Corrado Colasante, Stefano Pozzi, Emiliano Barbieri, Monica Maccaferri, Giovanna Leonardi, Leonardo Potenza, Mario Luppi, and Roberto Marasca

Subjects
Cancer Research, Oncology, chronic lymphocytic leukemia, COVID-19, immunity, vaccine, Hematology, General Medicine
Abstract

Chronic lymphocytic leukemia (CLL), the most common leukemia in the western countries, is characterized by immunosuppression due to disease itself and cytotoxic treatments. Since the beginning of COVID-19 pandemic, patients with CLL appear to be a vulnerable population. In addition, phase III mRNA vaccine trials did not provide information about the efficacy in immunocomprised population. In CLL, the antibody-mediated response to SARS-CoV-2 vaccine is impaired. The goal of this study was to evaluate the effects of SARS-CoV-2 vaccination on humoral immune response and on cellular immunity in CLL patients. Humoral immune response to BNT162b2 messenger RNA COVID-19 vaccine was evaluated in 44 CLL patients comprising 20 treatment-naïve, 14 under treatment with ibrutinib and 10 in follow-up after completion of therapy. A positive serological response to SARS-CoV-2 vaccination with IgG titers higher than 13 UA/ml was detected in 54.6% of CLL patients with a higher response in patients who obtained remission after treatment. Reduced antibody response was detected in patients under ibrutinib treatment. T-cell response to overlapping pool of peptides representing the spike region was assessed in paired CLL samples collected before and after 1 month from the second dose of COVID-19 vaccine in treatment-naïve and ibrutinib-treated CLL patients using cytokine secretion assay. Both CD3+ CD4+ and CD3+ CD8+ T cells are able to mount a cellular response to spike peptides with secretion of IFNγ and TNFα before and after vaccination in both treatment naïve and ibrutinib-treated patients and this cellular immune response is independent by COVID-19 vaccination. Collectively, T cell response to spike peptides appeared more blunted in CLL patients under treatment with ibrutinib compared to untreated ones. Our study supports the need for optimization of vaccination strategy to achieve an adequate immune response keeping strict preventive measures by CLL patients against COVID-19.

Published
2023

8. Adverse outcome associated with daratumumab-based treatments in relapsed/refractory multiple myeloma patients with amplification of chromosome arm 1q21: a single-center retrospective experience

Author

Emiliano Barbieri, Monica Maccaferri, Giovanna Leonardi, Francesca Giacobbi, Giorgia Corradini, Ivana Lagreca, Patrizia Barozzi, Leonardo Potenza, Roberto Marasca, and Mario Luppi

Subjects
Antineoplastic Combined Chemotherapy Protocols, Humans, Hematology, General Medicine, Multiple Myeloma, Neoplasms, Plasma Cell, Chromosomes, Retrospective Studies
Published
2022

10. Diagnosis and management of intralabyrinthine schwannoma: case series and review of the literature

Author

Antonella Miriam, Di Lullo, Aldo, Paolucci, Sergio, Motta, Elena, Cantone, Emiliano, Barbieri, Domenico, Cicala, Roberta, Grassi, Federico, Bruno, Alessandra, Splendiani, Fabio, Tortora, Michele, Cavaliere, Luca, Brunese, Di Lullo, A. M., Paolucci, A., Motta, S., Cantone, E., Barbieri, E., Cicala, D., Grassi, R., Bruno, F., Splendiani, A., Tortora, F., Cavaliere, M., and Brunese, L.

Subjects
Diagnosis, Differential, Schwannoma, Differential Diagnosis, Labyrinth, Magnetic Resonance Imaging, Humans, Neuroma, Acoustic, Review, Differential Diagnosi, Neurilemmoma
Abstract

Summary. Intralabyrinthine schwannoma (ILS) is a rare benign tumor affecting cochlear and vestibular nerves, whose symptoms are generally unspecific and frequently responsible for a late diagnosis. Radiological examinations, with particular reference to magnetic resonance imaging (MRI), represent the only diagnostic technique to identify ILS. On computed tomography ILS can only be indirectly suspected by the presence of surrounding bone remodeling, whereas MRI provides direct visualization of the neoplasm as a filling defect within the labyrinth with vivid contrast enhancement. At the same time, MRI is also helpful in defining ILS anatomical extension into adjacent structures and in planning therapeutic management. Here we report three representative cases of ILS with new pictorial imaging features to improve ILS early detection and optimize subsequent therapeutic management. (www.actabiomedica.it).

Published
2020

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