40 results on '"Elsaman, Ahmed"'
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2. Rheumatoid arthritis study of the Egyptian College of Rheumatology (ECR): nationwide presentation and worldwide stance
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Gheita, Tamer A., Raafat, Hala A., El-Bakry, Samah A., Elsaman, Ahmed, El-Saadany, Hanan M., Hammam, Nevin, El-Gazzar, Iman I., Samy, Nermeen, Elsaid, Nora Y., Al-Adle, Suzan S., Tharwat, Samar, Ibrahim, Amira M., Fawzy, Samar M., Eesa, Nahla N., Shereef, Rawhya El, Ismail, Faten, Elazeem, Mervat I Abd, Abdelaleem, Enas A., El-Bahnasawy, Amany, Selim, Zahraa I., Gamal, Nada M., Nassr, Maha, Nasef, Samah I., Moshrif, Abdel Hafeez, Elwan, Shereen, Abdel-Fattah, Yousra H., Amer, Marwa A., Mosad, Doaa, Mohamed, Eman F., El-Essawi, Dina F., Taha, Hanan, Salem, Mohamed N., Fawzy, Rasha M., Ibrahim, Maha E., Khalifa, Asmaa, Abaza, Nouran M., Abdalla, Ahmed M., El-Najjar, Amany R., Azab, Noha A., Fathi, Hanan M., El-Hadidi, Khaled, and El-Hadidi, Tahsin
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- 2023
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3. Damage in rheumatic diseases: Contemporary international standpoint and scores emerging from clinical, radiological and machine learning
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Tharwat, Samar, El-Gazzar, Iman I., El Shereef, Rawhya, Ismail, Faten, Ali, Fatma, Taha, Hanan, Elsaman, Ahmed, El-Bahnasawy, Amany, Hisham, Yousra, Amer, Marwa, El Najjar, Amany, Fathi, Hanan M., Eesa, Nahla, Mohammed, Reem H., Khalil, Noha M., Shahaat, Nouran M., Hammam, Nevin, and Fawzy, Samar
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- 2024
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4. Unsupervised cluster analysis of clinical and ultrasound features reveals unique gout subtypes: Results from the Egyptian College of Rheumatology (ECR)
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Hammam, Nevin, Tharwat, Samar, M Elsaman, Ahmed, Bakhiet, Ali, Mahmoud, Mohamed Bakrey, Ismail, Faten, El Saadany, Hanan, R ElShereef, Rawhya, F Mohamed, Eman, I Abd Elazeem, Mervat, Eid, Ayman, Ali, Fatma, Hamdy, Mona, El Mallah, Reem, Ha Mohammed, Reem, M Gamal, Rania, Fawzy, Samar, Senara, Soha, Hammam, Osman, M Fathi, Hanan, Aboul Fotouh, Adham, and A Gheita, Tamer
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- 2023
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5. Continuous Wave Transscleral Cyclophotocoagulation and Endoscopic Cyclophotocoagulation in Childhood Glaucoma: A Meta-Analysis.
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Elhusseiny, Abdelrahman M., Hassan, Amr K., Elsaman, Ahmed S., Azhari, Jamal O., Veen, Deborah K. Vander, Abdelnaem, Salah, Pakravan, Mohammad, Chang, Ta C., Khodeiry, Mohamed M., Khouri, Albert S., Sayed, Mohamed S., Lee, Richard K., and Sallam, Ahmed B.
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- 2024
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6. Congenital deficiency reveals critical role of ISG15 in skin homeostasis
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Malik, Muhammad Nasir Hayat, Waqas, Syed Fakhar-ul-Hassnain, Zeitvogel, Jana, Cheng, Jingyuan, Geffers, Robert, Gouda, Zeinab Abu-Elbaha, Elsaman, Ahmed Mahrous, Radwan, Ahmed R., Schefzyk, Matthias, Braubach, Peter, Auber, Bernd, Olmer, Ruth, Musken, Mathias, Roesner, Lennart M., Gerold, Gisa, Schuchardt, Sven, Merkert, Sylvia, Martin, Ulrich, Meissner, Felix, Werfel, Thomas, and Pessler, Frank
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Interferon -- Health aspects -- Genetic aspects -- Case studies ,Genetic disorders -- Complications and side effects -- Case studies -- Diagnosis ,Immunity -- Genetic aspects -- Health aspects -- Case studies ,Skin -- Ulcers ,Pediatric research ,Health care industry - Abstract
Ulcerating skin lesions are manifestations of human ISG15 deficiency, a type I interferonopathy. However, chronic inflammation may not be their exclusive cause. We describe two siblings with recurrent skin ulcers that healed with scar formation upon corticosteroid treatment. Both had a homozygous nonsense mutation in the ISG15 gene, leading to unstable ISG15 protein lacking the functional domain. We characterized [ISG15.sup.-/-] dermal fibroblasts, HaCaT keratinocytes, and human induced pluripotent stem cell-derived vascular endothelial cells. ISG15-deficient cells exhibited the expected hyperinflammatory phenotype, but also dysregulated expression of molecules critical for connective tissue and epidermis integrity, including reduced collagens and adhesion molecules, but increased matrix metalloproteinases. [ISG15.sup.-/-] fibroblasts exhibited elevated ROS levels and reduced ROS scavenger expression. As opposed to hyperinflammation, defective collagen and integrin synthesis was not rescued by conjugation-deficient ISG15. Cell migration was retarded in [ISG15.sup.-/-] fibroblasts and HaCaT keratinocytes, but normalized under ruxolitinib treatment. Desmosome density was reduced in an [ISG15.sup.-/-] 3D epidermis model. Additionally, there were loose architecture and reduced collagen and desmoglein expression, which could be reversed by treatment with ruxolitinib/doxycycline/TGF-[beta]1. These results reveal critical roles of ISG15 in maintaining cell migration and epidermis and connective tissue homeostasis, whereby the latter likely requires its conjugation to yet unidentified targets., Introduction Monogenic type I interferonopathies are a heterogeneous group of autoinflammatory and autoimmune disorders characterized by persistently elevated levels of type I interferons (IFN-I) (1-3). The underlying molecular mechanisms are [...]
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- 2022
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7. Ankle Evaluation in Active Rheumatoid Arthritis by Ultrasound: A Cross-Sectional Study
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Elsaman, Ahmed M., Mostafa, Ehab Saad, and Radwan, Ahmed R.
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- 2017
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8. Metabolic Syndrome in Behçets Disease Patients: Keep an Eye on the Eye
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Gheita, Tamer A., primary, ElAdle, Suzan S., additional, Latif, Eiman Abdel, additional, Abdel-Fattah, Yousra H., additional, Shebini, Emad El, additional, El-Gazzar, Iman I., additional, El-Saadany, Hanan M., additional, Samy, Nermeen, additional, El-Mallah, Reem, additional, Salem, Mohamed N., additional, Eesa, Nahla, additional, Shereef, Rawhya El, additional, El Khalifa, Marwa, additional, Tharwat, Samar, additional, Nasef, Samah I., additional, Ibrahim, Maha Emad, additional, Khalil, Noha M., additional, Abdalla, Ahmed M., additional, Abd Elazeem, Mervat I., additional, Noor, Rasha Abdel, additional, Sallam, Rehab, additional, El-Bahnasawy, Amany, additional, Shanawany, Amira El, additional, Senara, Soha, additional, Fathi, Hanan M., additional, Bakry, Samah A. El, additional, Elsaman, Ahmed, additional, Najjar, Amany El, additional, Ragab, Usama, additional, Talaat, Esraa A., additional, Hammam, Nevin, additional, El-Hindawy, Aya K., additional, and Ismail, Faten, additional
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- 2023
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9. Sonographic Findings in Gouty Arthritis: Diagnostic Value and Association with Disease Duration
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Elsaman, Ahmed M., Muhammad, Eman M.S., and Pessler, Frank
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- 2016
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10. Idiopathic Carpal Tunnel Syndrome: Evaluation of the Depth of the Carpal Tunnel by Ultrasonography
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Elsaman, Ahmed Mohammed Mahrous Yousif, Thabit, Mohamed Nasreldin, Radwan, Ahmed Roshdy Al-Agamy, and Ohrndorf, Sarah
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- 2015
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11. The mounting importance of knee sonographic signs in 425 gouty arthritis patients: A multi-centre study
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Elsaman, Ahmed, primary, El Shereef, Rawhya R, additional, El Saadany, Hanan, additional, Mohamed, Eman F, additional, Ismail, Faten, additional, I Abd Elazeem, Mervat, additional, Eid, Ayman, additional, Hamdy, Mona, additional, Ali, Fatma, additional, El Mallah, Reem, additional, HA Mohammed, Reem, additional, Tharwat, Samar, additional, Senara, Soha, additional, Fawzy, Samar, additional, Gamal, Rania M, additional, Ibrahim, Hamdy M, additional, Fawzy, Rasha, additional, Amer, Marwa A, additional, El-Najjar, Amany, additional, Abaza, Nouran M, additional, Hammam, Nevin, additional, Aboul Fotouh, Adham, additional, and Mosaad, Doaa, additional
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- 2022
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12. The Emerging Era of Interventional Imaging in Rheumatology: An Overview During the Coronavirus Disease-2019 (COVID-19) Pandemic
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Fottouh,Adham Aboul, Hamdy,Mona, Ali,Fatma, Mohamed,Eman F, Allam,Abdallah, Hassan,Waleed A, Elsaman,Ahmed, El-Najjar,Amany, Amer,Marwa A, Mosad,Doaa, Tharwat,Samar, El-Bakry,Samah A, Saleh,Hanan, Zaghloul,Ahmed, Mahmoud,Mostafa, Mohammed,Reem HA, El-Saadany,Hanan, Fathi,Hanan M, Hammam,Nevin, Raafat,Hala A, Moharram,Ashraf N, and Gheita,Tamer A
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Research and Reviews [Open Access Rheumatology] - Abstract
Adham Aboul Fotouh,1 Mona Hamdy,2 Fatma Ali,2 Eman F Mohamed,3 Abdallah Allam,4 Waleed A Hassan,5 Ahmed Elsaman,6 Amany El-Najjar,7 Marwa A Amer,8 Doaa Mosad,9 Samar Tharwat,10 Samah A El Bakry,11 Hanan Saleh,12 Ahmed Zaghloul,13 Mostafa Mahmoud,14 Reem HA Mohammed,15 Hanan El-Saadany,4 Hanan M Fathi,16 Nevin Hammam,17 Hala A Raafat,15 Ashraf N Moharram,14 Tamer A Gheita15 On behalf of the Egyptian College of Rheumatology (ECR) Musculoskeletal Ultrasound Study Group1Cairo University Hospital, Cairo, Egypt; 2Rheumatology Department, Faculty of Medicine, Minia University, Minia, Egypt; 3Internal Medicine Department, Rheumatology Unit, Faculty of Medicine, AlAzhar Girls, Cairo, Egypt; 4Rheumatology Department, Faculty of Medicine, Tanta University, Tanta, Egypt; 5Rheumatology Department, Faculty of Medicine, Benha University, Banha, Egypt; 6Rheumatology Department, Faculty of Medicine, Sohag University, Sohag, Egypt; 7Rheumatology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt; 8Rheumatology Department, Faculty of Medicine, Alexandria University, Alexandria, Egypt; 9Rheumatology Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt; 10Internal Medicine Department, Rheumatology Unit, Faculty of Medicine, Mansoura University, Mansoura, Egypt; 11Internal Medicine Department, Rheumatology Unit, Faculty of Medicine, Ain Shams University, Cairo, Egypt; 12Rheumatology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt; 13Interventional Pain Management and Anesthesia, Faculty of Medicine, Cairo University, Cairo, Egypt; 14Orthopedic and Microsurgery, Faculty of Medicine, Cairo University, Cairo, Egypt; 15Rheumatology and Clinical Immunology Department, Faculty of Medicine, Cairo University, Cairo, Egypt; 16Rheumatology Department, Faculty of Medicine, Fayoum University, Fayoum, Egypt; 17Rheumatology Department, Faculty of Medicine, Assiut University, Assiut, EgyptCorrespondence: Tamer A Gheita, Rheumatology and Clinical Immunology Department, Faculty of Medicine, Cairo University, Cairo, Egypt, Tel +20 1004567975, Email gheitamer@hotmail.comAbstract: Imaging has long been taking its place in the diagnosis, monitor, and prognosis of rheumatic diseases. It plays a vital role in the appraisal of treatment. Key progress in the clinical practice of rheumatology is the innovation of advanced imaging modalities; such as musculoskeletal ultrasound (MSUS), computerized tomography (CT) and magnetic resonance imaging (MRI). These modalities introduced a promising noninvasive method for visualizing bone and soft tissues to enable an improved diagnosis. The use of MSUS in rheumatology is considered a landmark in the evolution of the specialty and its ease of use and many applications in rheumatic diseases make it a forerunner instrument in the practice. The use of MSUS among rheumatologists must parallel the development rate of the excellence revealed in the specialty. Moreover, innovative interventional imaging in rheumatology (III-R) is gaining fame and key roles in the near future for a comprehensive management of rheumatic diseases with precision. This review article throws light on the emergence of these robust innovations that may reshape the guidelines and practice in rheumatology, in particular, efforts to enhance best practice during the coronavirus disease 2019 (COVID-19) pandemic are endorsed.Keywords: interventional imaging, musculoskeletal ultrasound, rheumatology, COVID-19 pandemic
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- 2022
13. Construct validity and response to therapy of the U9 ultrasonographic scale for assessment of disease activity in rheumatoid arthritis
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Mortada, Mohamed, primary, Aly, Hany, additional, Elmallah, Reem, additional, Radwan, Ahmed, additional, and Elsaman, Ahmed, additional
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- 2021
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14. Adult systemic lupus erythematosus in Egypt: The nation-wide spectrum of 3661 patients and world-wide standpoint
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Gheita, Tamer A, primary, Noor, Rasha Abdel, additional, Abualfadl, Esam, additional, Abousehly, Osama S, additional, El-Gazzar, Iman I, additional, El Shereef, Rawhya R, additional, Senara, Soha, additional, Abdalla, Ahmed M, additional, Khalil, Noha M, additional, ElSaman, Ahmed M, additional, Tharwat, Samar, additional, Nasef, Samah I, additional, Mohamed, Eman F, additional, Noshy, Nermeen, additional, El-Essawi, Dina F, additional, Moshrif, Abdel Hafeez, additional, Fawzy, Rasha M, additional, El-Najjar, Amany R, additional, Hammam, Nevin, additional, Ismail, Faten, additional, ElKhalifa, Marwa, additional, Samy, Nermeen, additional, Hassan, Eman, additional, Abaza, Nouran M, additional, ElShebini, Emad, additional, Fathi, Hanan M, additional, Salem, Mohamed N, additional, Abdel-Fattah, Yousra H, additional, Saad, Ehab, additional, Abd Elazim, Mervat I, additional, Eesa, Nahla N, additional, El-Bahnasawy, Amany S, additional, El-Hammady, Dina H, additional, El-Shanawany, Amira T, additional, Ibrahim, Soha E, additional, Said, Emtethal A, additional, El-Saadany, Hanan M, additional, Selim, Zahraa I, additional, Fawzy, Samar M, additional, and Raafat, Hala A, additional
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- 2021
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15. Misdiagnosis and Mistreatment of Post-Kala-Azar Dermal Leishmaniasis
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Ahmed Mohamed El Hassan, Eltahir Awad Gasim Khalil, Waleed Mohamed Elamin, Lamyaa Ahmed Mohamed El Hassan, Mogtaba Elsaman Ahmed, and Ahmed Mudawi Musa
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Medicine - Abstract
Post-kala-azar dermal leishmaniasis (PKDL) is a known complication of visceral leishmaniasis (VL) caused by L. donovani. It is rare in VL caused by L. infantum and L. chagasi. In Sudan, it occurs with a frequency of 58% among successfully treated VL patients. In the majority of cases, PKDL can be diagnosed on the basis of clinical appearance, distribution of the lesions, and past history of treated VL. The ideal diagnostic method is to demonstrate the parasite in smears, by culture or PCR. Diagnosis is particularly difficult in patients who develop PKDL in the absence of previous history of visceral leishmaniasis. We describe a case of cutaneous leishmaniasis misdiagnosed as PKDL and 3 cases of PKDL who were either misdiagnosed or mistreated as other dermatoses. This caused exacerbation of their disease leading to high parasite loads in the lesions and dissemination to internal organs in one of the patients, who was also diabetic. The latter patient had L. major infection. A fourth patient with papulonodular lesions on the face and arms of 17-year duration and who was misdiagnosed as having PKDL is also described. He turned out to have cutaneous leishmaniasis due to L. major. Fortunately, he was not treated with steroids. He was cured with intravenous sodium stibogluconate.
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- 2013
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16. The Emerging Era of Interventional Imaging in Rheumatology: An Overview During the Coronavirus Disease-2019 (COVID-19) Pandemic.
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Fotouh, Adham Aboul, Hamdy, Mona, Ali, Fatma, Mohamed, Eman F, Allam, Abdallah, Hassan, Waleed A, Elsaman, Ahmed, El-Najjar, Amany, Amer, Marwa A, Mosad, Doaa, Tharwat, Samar, El Bakry, Samah A, Saleh, Hanan, Zaghloul, Ahmed, Mahmoud, Mostafa, Mohammed, Reem HA, El-Saadany, Hanan, Fathi, Hanan M, Hammam, Nevin, and Raafat, Hala A
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RHEUMATOLOGY ,COVID-19 ,MAGNETIC resonance imaging ,PROGNOSIS ,RHEUMATISM ,CORONAVIRUS diseases - Abstract
Imaging has long been taking its place in the diagnosis, monitor, and prognosis of rheumatic diseases. It plays a vital role in the appraisal of treatment. Key progress in the clinical practice of rheumatology is the innovation of advanced imaging modalities; such as musculoskeletal ultrasound (MSUS), computerized tomography (CT) and magnetic resonance imaging (MRI). These modalities introduced a promising noninvasive method for visualizing bone and soft tissues to enable an improved diagnosis. The use of MSUS in rheumatology is considered a landmark in the evolution of the specialty and its ease of use and many applications in rheumatic diseases make it a forerunner instrument in the practice. The use of MSUS among rheumatologists must parallel the development rate of the excellence revealed in the specialty. Moreover, innovative interventional imaging in rheumatology (III-R) is gaining fame and key roles in the near future for a comprehensive management of rheumatic diseases with precision. This review article throws light on the emergence of these robust innovations that may reshape the guidelines and practice in rheumatology, in particular, efforts to enhance best practice during the coronavirus disease 2019 (COVID-19) pandemic are endorsed. [ABSTRACT FROM AUTHOR]
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- 2022
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17. Therapeutic Potential of Digital Nerve Block in Rheumatoid Arthritis Patients
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Elsaman, Ahmed M., primary, Hamed, Ahmed, additional, and Radwan, Ahmed R., additional
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- 2021
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18. Therapeutic potentials of bilateral sacroiliac joint (SIJ) injection in lumbar disc prolapse: a prospective study
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Elsaman, Ahmed and Radwan, Ahmed
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ddc: 610 ,610 Medical sciences ,Medicine - Abstract
Introduction: Low back pain prevalence ranges from 15-30% at a certain point of lifetime to 60-80 % in whole lifetime. It is one of the commonest health problems, and considered as the second cause of pain. Disc herniation/prolapse is a major source of low back pain. SIJ dysfunctions [for full text, please go to the a.m. URL], Deutscher Rheumatologiekongress 2020, 48. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 34. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh)
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- 2020
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19. Ankle Joint in Active Rheumatoid Arthritis
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Mohammed, Doaa, primary, Mahmoud, Zeinab, additional, and elsaman, ahmed, additional
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- 2020
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20. Development of an Arabic version of the Behçet's Disease Current Activity Form (Ar-BDCAF): cross-cultural adaptation and validation initiative in Egypt.
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Gheita, Tamer A., Fathi, Hanan M., Eesa, Nahla N., El-Shebini, Emad, Tharwat, Samar, Hammam, Nevin, Fawzy, Rasha M., El-Shereef, Rawhya R., Abd El-Samea, Mona H., Abdel Noor, Rasha A., Salem, Mohamed N., on behalf of the Egyptian College of Rheumatology Study Group, Moshrif, Abdel Hafeez, Elsaman, Ahmed, El-Najjar, Amany R., Al Shanawany, Amira, Elessawi, Dina, Saad, Ehab, Abd El-Latif, Eiman M., and Mohamed, Eman F.
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BEHCET'S disease ,ARABIC language ,PHYSICIANS ,SILK Road ,INFORMATION technology - Abstract
Background: Behçet's disease (BD), commonly seen in the Silk road countries, is a variable vessel vasculitis with no specific investigation that reflects disease activity. The Behçet's Disease Current Activity Form (BDCAF) is the most famous and acceptable clinical activity score. Purpose: To develop a cross-cultural adaptation of the BDCAF to the Arabic language (Ar-BDCAF)—Egyptian dialect—across the country and to consider preliminary evaluation of its reliability in assessment of BD activity. Patients and methods: The score was translated to Arabic language and revised by 3 rheumatology consultants. Reliability of Ar-BDCAF was tested among 88 BD patients from 9 Egyptian main city centers. Patients were questioned by two specialists at 30 min interval to evaluate inter-observer rating and twice by the same physician within 24 h to assess the intra-observer rating. Results: Patients were 64 males and 24 females (2.7:1) with a mean age of 35 ± 10.3 years. The average time required by the consultant to fill in the form was 5.1 ± 2.2 min (1.5–15 min). The mean Ar-BDCAF scores were 9.81 ± 6.22 (0–25) and 9.53 ± 6.13 (0–28) with an intra-observer concordance (p = 0.28) and was 9.95 ± 6.47 (0–29) for the inter-observer rating (p = 0.89 and p = 0.66, respectively). Conclusion: The Ar-BDCAF is a measurable, easy to calculate, and reliable index for assessing disease activity in Egyptian BD. The Ar-BDCAF score can be used in daily clinical practice to assess BD activity and its use can be extended to other Arab countries for possible regional validation and adaptations. Key Points • The Arabic version of the BDCAF can be extended to other Arab countries for development of a Pan-Arab score. • This is the first study to provide a reliable and valid Arabic version of the BDCAF-Egyptian dialect for measuring current disease activity in BD patients. [ABSTRACT FROM AUTHOR]
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- 2021
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21. Rheumatology university faculty opinion on coronavirus disease-19 (COVID-19) vaccines: the vaXurvey study from Egypt.
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Hammam, Nevin, Tharwat, Samar, Shereef, Rawhya R. El, Elsaman, Ahmed M., Khalil, Noha M., Fathi, Hanan M., Salem, Mohamed N., El-Saadany, Hanan M., Samy, Nermeen, El-Bahnasawy, Amany S., Abdel-Fattah, Yousra H., Amer, Marwa A., ElShebini, Emad, El-Shanawany, Amira T., El-Hammady, Dina H., Noor, Rasha Abdel, ElKhalifa, Marwa, Ismail, Faten, Fawzy, Rasha M., and El-Najjar, Amany R.
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COLLEGE teacher attitudes ,TEACHER attitudes ,COVID-19 ,UNIVERSITY faculty ,VACCINE hesitancy - Abstract
Objectives: The aim of the present work was to explore the perspectives of Egyptian Rheumatology staff members as regards the coronavirus disease-19 (COVID-19) vaccine. Methods: The survey is composed of 25 questions. Some questions were adapted from the global rheumatology alliance COVID-19 survey for patients. Results: 187 rheumatology staff members across Egypt from 18 universities and authorizations actively participated with a valid response. The mean time needed to complete the survey was 17.7 ± 13 min. Participants were 159 (85%) females (F:M 5.7:1). One-third agreed that they will be vaccinated once available, 24.6% have already received at least one dose, 29.4% are unsure while 16% will not take it. Furthermore, 70.1% agreed that they will recommend it to the rheumatic diseases (RD) patients once available, 24.1% are not sure while 5.9% will not recommend it. RD priority to be vaccinated against COVID-19 in descending order include SLE (82.9%), RA (55.1%), vasculitis (51.3%), systemic sclerosis (39.6%), MCTD (31.6%), Behcet's disease (28.3%). The most common drugs to be avoided before vaccination included biologics (71.7%), DMARDs (44.4%), biosimilars (26.7%), IVIg (17.1%) and NSAIDs (9.1%). Conclusions: The results of the study and specifically the low rate of acceptability are alarming to Egyptian health authorities and should stir further interventions to reduce the levels of vaccine hesitancy. As rheumatic disease patients in Egypt were not systematically provided with the vaccine till present, making the vaccine available could as well enhance vaccine acceptance. Further studies to investigate any possible side effects, on a large scale of RD patients are warranted. [ABSTRACT FROM AUTHOR]
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- 2021
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22. Development and validation of a Behçet's Disease Damage Index for adults with BD: An Explicit, Composite and Rated (ECR) tool.
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Gheita, Tamer A., Hammam, Nevin, Fawzy, Samar M., Abd El‐Latif, Eiman, El‐Gazzar, Iman I., Samy, Nermeen, El‐Hammady, Dina H., Abdel Noor, Rasha, El‐Shebini, Emad, El‐Najjar, Amany R., Eesa, Nahla N., Salem, Mohamed N., Ibrahim, Soha E., El‐Essawi, Dina F., Elsaman, Ahmed M., Senara, Soha, Fathi, Hanan M., Sallam, Rehab A., El Shereef, Rawhya R., and Abd Elazeem, Mervat I.
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BEHCET'S disease ,ADULTS ,TEST validity ,MUCOCUTANEOUS lymph node syndrome - Abstract
Background: Behçet's disease (BD) is a chronic multisystem variable vessel vasculitis. Disease damage is irreversible and permanent. Validated tools evaluating damage are limited. Enhancements in the clinical treatment of vasculitis will take place from the development of refined and exclusive indices for individual vasculitic syndromes including BD and attempting their international validation. Objectives: This aim was to develop and validate a simple BD Damage Index (BDI). Methods: This was a nationwide study including 1252 BD patients. The work consisted of 3 stages. Stage 1: items generation for score content. Stage 2: items selection for the draft score was performed by an expert rheumatologist. Stage 3: the content validity of the draft score was assessed and BDI, Vasculitis Damage Index (VDI), Antineutrophil cytoplasmic antibody‐associated Vasculitis Index of Damage (AVID) and Combined Damage Assessment Index (CDAI) were calculated and compared. Results: The mean age of the BD patients was 36.1 ± 9.9 years. Stages 1 and 2 resulted in a BDI instrument containing 73 items with a maximum score of 100. Stage 3, the VDI, CDAI, AVID, and BDI were 2.9 ± 2.2, 3.1 ± 2.3, 3.1 ± 2.3 and 5.1 ± 2.9, respectively. High correlations (r =.9) between comparable damage scores assured acceptable concurrent validity. Conclusion: The proposed BDI represents a new robust and potentially useful tool when dealing with BD chronic status. [ABSTRACT FROM AUTHOR]
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- 2021
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23. Hand Assessment in Type2 Diabetes Mellitus: New Insight by Ultrasound
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Elsaman, Ahmed, Shaban, Salma, Radwan, Ahmed, Abu-Alfadl, Esam, and Ohrndorf, Sarah
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ddc: 610 ,610 Medical sciences ,Medicine - Abstract
Background: Diabetes mellitus (DM) is a chronic metabolic disease with high morbidity and mortality. Over than 7.8 million in Egypt suffer from DM in 2015 (1). Most of DM morbidity and mortality is related to micro and macro vascular complications. However, it is also associated with musculoskeletal[for full text, please go to the a.m. URL], 45. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 31. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh), 27. Jahrestagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR)
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- 2017
24. Carpal tunnel syndrome in rheumatoid arthritis patients: evaluation of the depth by ultrasonography
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Elsaman, Ahmed, Hamed, Ahmed, Borai, Ahmed, and Radwan, Ahmed
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ddc: 610 ,610 Medical sciences ,Medicine ,nervous system diseases - Abstract
Background: Ultrasound (US) is one of the most widely used tools for diagnosis and evaluation of carpal tunnel syndrome (CTS). US achievement is comparable to the gold standard electrophysiological studies. Depth of the carpal tunnel is a promising, relatively new sonographic parameter used for assessment[for full text, please go to the a.m. URL], 45. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 31. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh), 27. Jahrestagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR)
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- 2017
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25. Amyloid arthropathy associated with multiple myeloma: polyarthritis without synovial infiltration of CD20+ or CD38+ cells
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Pessler, Frank, Ogdie, Alexis R, Mayer, Christian T, Kretzschmar, Warren W, Dai, Lie, Elsaman, Ahmed M, Einhorn, Eugene, Krenn, Veit, and Schumacher, H Ralph
- Subjects
Male ,B cells ,Membrane Glycoproteins ,Arthritis ,Plasma Cells ,Amyloidosis ,Middle Aged ,Antigens, CD20 ,ADP-ribosyl Cyclase 1 ,multiple myeloma ,Fatal Outcome ,hemic and lymphatic diseases ,Synovial Fluid ,Humans ,Original Article ,synovitis ,Aged - Abstract
Objectives To describe histological, immunohistochemical and ultrastructural features of synovial biopsies of amyloid arthropathy associated with multiple myeloma (MM). Methods Synovial biopsies from affected joints of two patients with MM and amyloid arthropathy were examined with light and electron microscopy, and immunohistochemically for expression of CD3, CD8, CD20, CD38, CD68, Ki-67 and vWF. Results were compared to values from osteoarthritis (OA, n = 26), rheumatoid arthritis (RA, n = 24) and normal (n = 15) synovial membranes. Results There was no or only mild lining hyperplasia. Vascular density was not elevated, and there were few Ki-67+ proliferating cells in the stroma. The Krenn synovitis score classified one specimen as “low-grade” and one as “high-grade” synovitis. CD68+ and CD3+ cells were the predominant mononuclear inflammatory cells, whereas CD20+ and CD38+ cells were absent from both synovial membrane and synovial fluid sediment. Electron microscopy demonstrated amyloid phagocytosis by synovial macrophages. In hierarchical clustering the two amyloid arthropathy specimens were more closely related to OA than to RA or normal synovium. Conclusions This first detailed immunohistological analysis of MM-associated amyloid arthropathy suggests that it is a chronic synovitis that evolves despite the loss of humoral immunity seen in advanced MM. Instead, amyloid phagocytosis by synovial macrophages likely triggers and perpetuates local disease.
- Published
- 2013
26. Low dose spironolactone: treatment for osteoarthritis related effusion: A prospective sonographic and clinically based study
- Author
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Elsaman, Ahmed, Radwan, Ahmed, Mohammed, Walaa, and Ohrndorf, Sarah
- Subjects
musculoskeletal diseases ,ddc: 610 ,610 Medical sciences ,Medicine - Abstract
Introduction: Osteoarthritis (OA) is a group of mechanical disorders leading to joint components degradation, including articular cartilage and subchondral bone. Symptoms include joint pain, tenderness, stiffness, and effusion. A variety of causes are known of which hereditary, developmental, metabolic,[for full text, please go to the a.m. URL], 43. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh); 29. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh); 25. wissenschaftliche Jahrestagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR)
- Published
- 2015
27. Dr. Elsaman, et al reply
- Author
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ELSAMAN, AHMED, primary, RADWAN, AHMED, additional, MOHAMMED, WALAA, additional, and OHRNDORF, SARAH, additional
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- 2016
- Full Text
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28. Behçet's disease in Egypt: a multicenter nationwide study on 1526 adult patients and review of the literature.
- Author
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Gheita, Tamer A., El-Latif, Eiman Abd, El-Gazzar, Iman I., Samy, Nermeen, Hammam, Nevin, Abdel Noor, Rasha A., El-Shebeiny, Emad, El-Najjar, Amany R., Eesa, Nahla N., Salem, Mohamed N., Ibrahim, Soha E., El-Essawi, Dina F., Elsaman, Ahmed M., Fathi, Hanan M., Sallam, Rehab A., El-Shereef, Rawhya R., Abd-Elazeem, Mervat I., Said, Emtethal A., Khalil, Noha M., and Shahin, Dina
- Subjects
BEHCET'S disease ,LITERATURE reviews ,VENOUS thrombosis ,AGE of onset ,DISEASE duration ,BODY mass index - Abstract
Objectives: The present work was conducted to estimate the prevalence of adult Behçet's disease (BD) in adult Egyptian and to study the clinical pattern and influence of age at-onset and sex on disease phenotype. Also, we investigated the spectrum of presentation and frequencies along the north-to-south gradient of the country. Patients and method: The population-based, multicenter, cross-sectional study included 1526 adult BD patients from 26 specialized Egyptian rheumatology centers. Demographic, clinical, and therapeutic data are assessed for all patients. Results: The mean age of patients was 35.7 ± 9.84 years, disease duration 6.58 ± 5.25 years, and age at onset 29.37 ± 8.6 years; 91 were juvenile-onset (JoBD). There were 1102 males and 424 females (M:F 2.6:1). Regarding co-morbidities, 19.92% were diabetic, and 26.05% were hypertensive. The mean body mass index was 27.57 ± 5.24 (43.1% overweight; 25.9% obese). The mean BD current activity form was 4.48 ± 4.28. Regarding the medications use, systemic steroid and colchicine were the most common drugs used (947 (90.2%) and 611 (82.7%), respectively). The overall estimated prevalence of BD in Egypt was 3.6/100,000 population being highest in the two main cities: Alexandria (15.27) and Cairo (8.72). Pathergy test was positive in 43.4%. 90.2% were receiving systemic steroids and 8.3%, biologics. Disease characteristics were comparable between JoBD and adult-onset BD cases. Central nervous system (CNS), deep venous thrombosis (DVT), and gastrointestinal (GIT) involvement were significantly higher in males (p = 0.01, p = 0.001, and p = 0.001 respectively) while joint affection (p = 0.001) and disease activity (p = 0.011) were increased in females. Conclusions: This study provides current prevalence of BD in Egypt; 3.6/100,000 with no remarkable north-to-south gradient. The sex influences the disease phenotype with the CNS, DVT, and GIT involvement are higher in males, while the joint affection and disease activity were increased in females. Key Points: • The prevalence and phenotype of Behçet's disease across Egypt is presented in a multicenter nationwide study. • The potential influence of the age at onset and sex on disease phenotype is highlightened. • A review of the literature worldwide is presented allowing comparisons with studies from other nations. [ABSTRACT FROM AUTHOR]
- Published
- 2019
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29. Features of gouty arthritis by high frequency ultrasonography
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Elsaman, Ahmed, Salah, Eman, and Pessler, Frank
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Gout ,ddc: 610 ,Microtophi ,Arthritis ,610 Medical sciences ,Medicine ,Ultrasonography - Abstract
Background: To evaluate the sonographic features of gouty arthritis in patients living in Sohag city in Upper Egypt and correlate them with disease duration. Methods: A study was conducted on 60 patients, aged ≥40 years, attending the outpatient clinic of Rheumatology and Rehabilitation in[for full text, please go to the a.m. URL], 42. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh); 28. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh); 24. wissenschaftliche Jahrestagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR)
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- 2014
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30. Low-dose Spironolactone: Treatment for Osteoarthritis-related Knee Effusion. A Prospective Clinical and Sonographic-based Study
- Author
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Elsaman, Ahmed M., primary, Radwan, Ahmed R., additional, Mohammed, Walaa I., additional, and Ohrndorf, Sarah, additional
- Published
- 2016
- Full Text
- View/download PDF
31. Misdiagnosis and mistreatment of post-kala-azar dermal leishmaniasis
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Eltahir A G Khalil, Lamyaa A.M. El Hassan, Ahmed Eleojo Musa, Waleed Mohamed Elamin, Ahmed M. El Hassan, and Mogtaba Elsaman Ahmed
- Subjects
medicine.medical_specialty ,Pathology ,Exacerbation ,Sodium stibogluconate ,030231 tropical medicine ,lcsh:Medicine ,Case Report ,Disease ,03 medical and health sciences ,0302 clinical medicine ,Cutaneous leishmaniasis ,parasitic diseases ,medicine ,030304 developmental biology ,Post-kala-azar dermal leishmaniasis ,0303 health sciences ,business.industry ,lcsh:R ,Leishmaniasis ,General Medicine ,medicine.disease ,Dermatology ,3. Good health ,Visceral leishmaniasis ,Complication ,business ,medicine.drug - Abstract
Post-kala-azar dermal leishmaniasis (PKDL) is a known complication of visceral leishmaniasis (VL) caused byL. donovani. It is rare in VL caused byL. infantumandL. chagasi. In Sudan, it occurs with a frequency of 58% among successfully treated VL patients. In the majority of cases, PKDL can be diagnosed on the basis of clinical appearance, distribution of the lesions, and past history of treated VL. The ideal diagnostic method is to demonstrate the parasite in smears, by culture or PCR. Diagnosis is particularly difficult in patients who develop PKDL in the absence of previous history of visceral leishmaniasis. We describe a case of cutaneous leishmaniasis misdiagnosed as PKDL and 3 cases of PKDL who were either misdiagnosed or mistreated as other dermatoses. This caused exacerbation of their disease leading to high parasite loads in the lesions and dissemination to internal organs in one of the patients, who was also diabetic. The latter patient hadL. majorinfection. A fourth patient with papulonodular lesions on the face and arms of 17-year duration and who was misdiagnosed as having PKDL is also described. He turned out to have cutaneous leishmaniasis due toL. major. Fortunately, he was not treated with steroids. He was cured with intravenous sodium stibogluconate.
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- 2012
32. An easy synthesis of nanostructured magnetite-loaded functionalized carbon spheres and cobalt ferrite
- Author
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Hassan, Ali M., primary, Nassar, Amr M., additional, Ibrahim, Nabila M., additional, Elsaman, Ahmed M., additional, and Rashad, Mohamed M., additional
- Published
- 2013
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33. Amyloid arthropathy associated with multiple myeloma: A systematic analysis of 101 reported cases
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Elsaman, Ahmed M., primary, Radwan, Ahmed R., additional, Akmatov, Manas K., additional, Della Beffa, Cristina, additional, Walker, Alisha, additional, Mayer, Christian T., additional, Dai, Lie, additional, Nativ, Simona, additional, Rygg, Marite, additional, Atsali, Erato, additional, Saijo, Kaoru, additional, Ogdie, Alexis R., additional, Srinivasulu, Nagaraj, additional, Fathi, Nihal, additional, Schumacher, H. Ralph, additional, and Pessler, Frank, additional
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- 2013
- Full Text
- View/download PDF
34. Amyloid arthropathy associated with multiple myeloma: polyarthritis without synovial infiltration of CD20+ or CD38+ cells.
- Author
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Pessler, Frank, Ogdie, Alexis R., Mayer, Christian T., Kretzschmar, Warren W., Dai, Lie, Elsaman, Ahmed M., Einhorn, Eugene, Krenn, Veit, and Schumacher, H. Ralph
- Subjects
AMYLOID ,JOINT diseases ,MULTIPLE myeloma ,OSTEOARTHRITIS ,RHEUMATOID arthritis ,SYNOVITIS - Abstract
Objectives: To describe histological, immunohistochemical and ultrastructural features of synovial biopsies of amyloid arthropathy associated with multiple myeloma (MM). Methods: Synovial biopsies from affected joints of two patients with MM and amyloid arthropathy were examined with light and electron microscopy, and immunohistochemically for expression of CD3, CD8, CD20, CD38, CD68, Ki-67 and vWF. Results were compared to values from osteoarthritis (OA, n = 26), rheumatoid arthritis (RA, n = 24) and normal ( n = 15) synovial membranes. Results: There was no or only mild lining hyperplasia. Vascular density was not elevated, and there were few Ki-67+ proliferating cells in the stroma. The Krenn synovitis score classified one specimen as 'low-grade' and one as 'high-grade' synovitis. CD68+ and CD3+ cells were the predominant mononuclear inflammatory cells, whereas CD20+ and CD38+ cells were absent from both synovial membrane and synovial fluid sediment. Electron microscopy demonstrated amyloid phagocytosis by synovial macrophages. In hierarchical clustering the two amyloid arthropathy specimens were more closely related to OA than to RA or normal synovium. Conclusions: This first detailed immunohistological analysis of MM-associated amyloid arthropathy suggests that it is a chronic synovitis that evolves despite the loss of humoral immunity seen in advanced MM. Instead, amyloid phagocytosis by synovial macrophages likely triggers and perpetuates local disease. [ABSTRACT FROM AUTHOR]
- Published
- 2014
- Full Text
- View/download PDF
35. Correction to: Behçet's disease in Egypt: a multicenter nationwide study on 1526 adult patients and review of the literature.
- Author
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Gheita, Tamer A., El-Latif, Eiman Abd, El-Gazzar, Iman I., Samy, Nermeen, Hammam, Nevin, Abdel Noor, Rasha A., El-Shebeiny, Emad, El-Najjar, Amany R., Eesa, Nahla N., Salem, Mohamed N., Ibrahim, Soha E., El-Essawi, Dina F., Elsaman, Ahmed M., Fathi, Hanan M., Sallam, Rehab A., El-Shereef, Rawhya R., Abd-Elazeem, Mervat I., Said, Emtethal A., Khalil, Noha M., and Shahin, Dina
- Subjects
BEHCET'S disease ,LITERATURE reviews - Abstract
The author wishes to correct the record and clarify that in the original version of this article in the Discussion section under "Prevalence over the country governorates" inadvertently presented incorrect data cited in the reference [30]. [ABSTRACT FROM AUTHOR]
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- 2019
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36. Development of Machine Learning Models (Artificial Neural Networks) for Prediction of Vision Threatening Behcet's Disease
- Author
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Hammam, Nevin, Abd El-Latif, Eiman, El-Gazzar, Iman I., Samy, Nermeen, Noor, Rasha A. Abdel, El-Shebeiny, Emad, El-Najjar, Amany R., Eesa, Nahla N., Salem, Mohamed N., Ibrahim, Soha E., El-Essawi, Dina F., Elsaman, Ahmed M., Fathi, Hanan M., Sallam, Rehab A., El-Shereef, Rawhya R., Abd-Elazeem, Mervat I., Said, Emtethal A., Khalil, Noha M., Shahin, Dina, El-Saadany, Hanan M., Elkhalifa, Marwa S., Nasef, Samah I., Abdalla, Ahmed M., Noshy, Nermeen, Fawzy, Rasha M., Saad, Ehab, Moshrif, Abdel-Hafeez, El-Shanawany, Amira T., Abdel-Fattah, Yousra H., Khali, Hossam M., and Gheita, Tamer A.
37. Reduction of Knee Pain by Effusion Reduction.
- Author
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ROTHSCHILD, BRUCE, ELSAMAN, AHMED, RADWAN, AHMED, MOHAMMED, WALAA, and OHRNDORF, SARAH
- Published
- 2016
- Full Text
- View/download PDF
38. Metabolic Syndrome in Behçets Disease Patients: Keep an Eye on the Eye.
- Author
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ElAdle SS, Latif EA, Abdel-Fattah YH, Shebini EE, El-Gazzar II, El-Saadany HM, Samy N, El-Mallah R, Salem MN, Eesa N, Shereef RE, El Khalifa M, Tharwat S, Nasef SI, Ibrahim ME, Khalil NM, Abdalla AM, Abd Elazeem MI, Noor RA, Sallam R, El-Bahnasawy A, Shanawany AE, Senara S, Fathi HM, Bakry SAE, Elsaman A, Najjar AE, Ragab U, Talaat EA, Hammam N, El-Hindawy AK, Gheita TA, and Ismail F
- Subjects
- Adult, Humans, Middle Aged, Obesity, Severity of Illness Index, Behcet Syndrome complications, Behcet Syndrome epidemiology, Metabolic Syndrome epidemiology, Arthritis
- Abstract
Background: Metabolic syndrome (MetS) is characterized by insulin resistance, high blood pressure/ sugar, dyslipidemia, and obesity. Whether MetS and its components affect the development of Behçet's Disease (BD) remains unclear., Aims: The aim was to determine the frequency of MetS among BD patients and to study its relationship with disease characteristics., Methods: The study included 1028 adult BD patients recruited from 18 specialized rheumatology centers. 51 healthy matched control were considered. Behçet Disease Current Activity Form (BDCAF) and the BD damage index (BDI) were estimated. Adult Treatment Panel-III criteria were used to define MetS., Results: The mean age of patients was 36.8 ± 10.1 years, M:F 2.7:1 and disease duration 7.01 ± 5.2 years. Their mean BDCAF was 5.1 ± 4.6 and BDI 5.5 ± 2.8. MetS was present in 22.8% of patients and in 5.9% of control (3.9 fold higher-risk). Patients with MetS had a significantly increased age at onset (31.8 ± 9.2 vs. 29 ± 8.5 years) and higher frequency of genital ulcers (96.2% vs. 79.7%), skin involvement (73.1% vs. 50.4%), arthritis (48.3% vs. 29.1%) (p<0.0001) and CNS manifestations (18.8% vs. 13%) (p=0.042) compared to those without it. Eye involvement was significantly increased in those with MetS (82.1% vs. 74.2%) (p=0.003) with increased frequency of posterior uveitis (67.1% vs. 43.5%), retinal vessel occlusion (35.9% vs. 21.3%), retinal vasculitis (41.9% vs. 26.4%) (p<0.0001) and vitritis (37.2% vs. 24%) (p=0.001). BDCAF was significantly lower (3.9 ± 4.3 vs. 5.6 ± 4.6) and BDI higher (7.4 ± 2.7vs5 ± 2.6) (p<0.0001)., Conclusion: BD patients with MetS are predisposed to mucocutaneous, musculoskeletal, neuropsychiatric and ocular manifestations with consequently increased damage. The involvement of the deeper structures of the eye should alarm rheumatologists to keep in mind that all patients should have an eye examination, especially those with MetS., (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.)
- Published
- 2023
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39. The Emerging Era of Interventional Imaging in Rheumatology: An Overview During the Coronavirus Disease-2019 (COVID-19) Pandemic.
- Author
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Fotouh AA, Hamdy M, Ali F, Mohamed EF, Allam A, Hassan WA, Elsaman A, El-Najjar A, Amer MA, Mosad D, Tharwat S, El Bakry SA, Saleh H, Zaghloul A, Mahmoud M, Mohammed RHA, El-Saadany H, Fathi HM, Hammam N, Raafat HA, Moharram AN, and Gheita TA
- Abstract
Imaging has long been taking its place in the diagnosis, monitor, and prognosis of rheumatic diseases. It plays a vital role in the appraisal of treatment. Key progress in the clinical practice of rheumatology is the innovation of advanced imaging modalities; such as musculoskeletal ultrasound (MSUS), computerized tomography (CT) and magnetic resonance imaging (MRI). These modalities introduced a promising noninvasive method for visualizing bone and soft tissues to enable an improved diagnosis. The use of MSUS in rheumatology is considered a landmark in the evolution of the specialty and its ease of use and many applications in rheumatic diseases make it a forerunner instrument in the practice. The use of MSUS among rheumatologists must parallel the development rate of the excellence revealed in the specialty. Moreover, innovative interventional imaging in rheumatology (III-R) is gaining fame and key roles in the near future for a comprehensive management of rheumatic diseases with precision. This review article throws light on the emergence of these robust innovations that may reshape the guidelines and practice in rheumatology, in particular, efforts to enhance best practice during the coronavirus disease 2019 (COVID-19) pandemic are endorsed., Competing Interests: The authors report no conflicts of interest for this work., (© 2022 Fotouh et al.)
- Published
- 2022
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40. Systemic lupus erythematosus children in Egypt: Homeland spectrum amid the global situation.
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Eesa NN, Abdel Nabi H, Owaidy RE, Khalifa I, Radwan AR, NourEl-Din AM, Amer MA, ElShereef RR, Hassan E, Ismail F, El-Gazzar II, Khalil NM, Moshrif AH, Abualfadl E, Tharwat S, Fathi HM, Abd Elazeem MI, El-Shebini E, Samy N, Noshy N, El-Bahnasawy AS, Abdalla AM, Abousehly OS, Mohamed EF, Nasef SI, Elsaman AM, ElKhalifa M, Salem MN, Abaza NM, Fathy HM, Abdel Salam N, El-Saadany HM, El-Najjar AR, El-Hammady DH, Hammam N, Mohammed RH, and Gheita TA
- Subjects
- Adolescent, Child, Cohort Studies, Egypt epidemiology, Female, Humans, Male, Severity of Illness Index, Lupus Erythematosus, Systemic epidemiology, Lupus Nephritis
- Abstract
Objectives: This study aims to present the manifestations of juvenile systemic lupus erythematosus (JSLE) across Egypt, to focus on age at onset and gender-driven influence on disease characteristics, and to compare findings to other countries., Methods: The study included 404 Egyptian children with systemic lupus erythematosus (SLE) presenting to one of the specialized rheumatology centers corresponding to 13 major governorates. Juvenile cases age was ≤ 16°years at the time of recruitment. The SLE Disease Activity Index (SLEDAI) and damage index (DI) were assessed., Results: The mean age was 13.2 ± 2.4°years; 355 females and 49 males (7.2:1), and the disease duration was 2.3 ± 1.6 years, while age at disease onset was 11.1 ± 2.5°years. Their SLEDAI was 13.5 ± 12.3, and DI, 0.36 ± 0.78. The overall estimated prevalence of childhood-SLE patients in the recruited cohort in Egypt was 1/100,000 population (0.24/100000 males and 1.8/100000 females). 7.4% developed pre-pubertal SLE (≤ 7 years); 73.3%, peri-pubertal; and 19.3% during early adolescence. The differences according to age group were equal for gender and clinical manifestations except skin lesions present in 59.3% of pre-pubertal onset, 74.6% of peri-pubertal, and 84.2% of adolescents ( p = 0.029), and renal involvement in 73.8% of peripubertal, 62.1% of pre-pubertal and 58.9% of adolescents ( p = 0.03). Laboratory investigations, SLEDAI, and DI were similar among age categories. Lupus nephritis was more common in Egypt compared to JSLE from other countries., Conclusion: Our large multicenter study identified that female gender influenced disease characteristics with more frequent skin involvement. Skin lesions were significantly higher in adolescents, while renal involvement in peri-pubertal children.
- Published
- 2021
- Full Text
- View/download PDF
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