1. Functional status decline in older patients with breast and colorectal cancer after cancer treatment: a prospective cohort study
- Author
-
Roel J.W. van Kampen, Marjan van den Akker, Els Lambooij, Franchette W P J van den Berkmortel, Laura Deckx, Arnée van Vuuren, Judith de Vos-Geelen, Doris van Abbema, Vivianne C. G. Tjan-Heijnen, Maaike de Boer, Frank Buntinx, Kenniscentrum ACHIEVE, RS: CAPHRI - R5 - Optimising Patient Care, RS: GROW - R3 - Innovative Cancer Diagnostics & Therapy, Promovendi ODB, RS: CAPHRI - R6 - Promoting Health & Personalised Care, Family Medicine, Interne Geneeskunde, and MUMC+: MA Medische Oncologie (9)
- Subjects
Male ,Activities of daily living ,Colorectal cancer ,NETHERLANDS ,FATIGUE ,Breast cancer ,Elderly ,ADJUVANT CHEMOTHERAPY ,0302 clinical medicine ,Quality of life ,QUALITY-OF-LIFE ,Medicine ,Longitudinal Studies ,Prospective Studies ,030212 general & internal medicine ,Prospective cohort study ,Aged, 80 and over ,SURVIVORS ,OUTCOMES ,Age Factors ,Middle Aged ,Oncology ,030220 oncology & carcinogenesis ,INSTRUMENTAL ACTIVITIES ,Female ,Colorectal Neoplasms ,CLINICAL-TRIALS ,medicine.medical_specialty ,Antineoplastic Agents ,Breast Neoplasms ,03 medical and health sciences ,AGE ,Internal medicine ,Older patients ,Instrumental activities of daily living ,Humans ,Chemotherapy ,Cognitive Dysfunction ,Progression-free survival ,Geriatric Assessment ,Aged ,Psychiatric Status Rating Scales ,business.industry ,Case-control study ,Cancer ,Functional status ,medicine.disease ,Case-Control Studies ,Physical therapy ,POINTS ,Geriatrics and Gerontology ,business ,human activities - Abstract
OBJECTIVES: The aim of the present study was to disentangle the impact of age and that of cancer diagnosis and treatment on functional status (FS) decline in older patients with cancer. MATERIALS AND METHODS: Patients with breast and colorectal cancer aged 50-69years and aged ≥70years who had undergone surgery, and older patients without cancer aged ≥70years were included. FS was assessed at baseline and after 12months follow-up, using the Katz index for activities of daily living (ADL) and the Lawton scale for instrumental activities of daily living (IADL). FS decline was defined as ≥1 point decrease on the ADL or IADL scale from baseline to 12months follow-up. RESULTS: In total, 179 older patients with cancer (≥ 70years), 341 younger patients with cancer (50-69years) and 317 older patients without cancer (≥ 70years) were included. FS decline was found in 43.6%, 24.6% and 28.1% of the groups, respectively. FS decline was significantly worse in older compared to younger patients with cancer receiving no chemotherapy (44.5% versus 17.6%, p
- Published
- 2017