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84 results on '"Eloise Mastrangelo"'

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1. Acid-sensing ion channel 3 is a new potential therapeutic target for the control of glioblastoma cancer stem cells growth

2. Stabilization of the retromer complex: Analysis of novel binding sites of bis-1,3-phenyl guanylhydrazone 2a to the VPS29/VPS35 interface

3. A novel hotspot of gelsolin instability triggers an alternative mechanism of amyloid aggregation

4. Structure-based identification of a new IAP-targeting compound that induces cancer cell death inducing NF-κB pathway

5. Retromer stabilization results in neuroprotection in a model of Amyotrophic Lateral Sclerosis

6. New Class of Benzodiazepinone Derivatives as Pro-Death Agents Targeting BIR Domains in Cancer Cells

7. Targeting the BIR Domains of Inhibitor of Apoptosis (IAP) Proteins in Cancer Treatment

8. Virucidal Activity of the Pyridobenzothiazolone Derivative HeE1-17Y against Enveloped RNA Viruses

9. Comprehensive response to Usutu virus following first isolation in blood donors in the Friuli Venezia Giulia region of Italy: Development of recombinant NS1-based serology and sensitivity to antiviral drugs.

10. Discovery of a Novel Class of Norovirus Inhibitors with High Barrier of Resistance

11. Modulation of Guanylate Cyclase Activating Protein 1 (GCAP1) Dimeric Assembly by Ca2+ or Mg2+: Hints to Understand Protein Activity

12. Liposomal Systems as Nanocarriers for the Antiviral Agent Ivermectin

13. Structural bases of norovirus RNA dependent RNA polymerase inhibition by novel suramin-related compounds.

14. Structural insight into inhibitor of apoptosis proteins recognition by a potent divalent smac-mimetic.

15. Structure-based identification of a new IAP-targeting compound that induces cancer cell death inducing NF-κB pathway

16. Computational and Experimental Characterization of NF023, A Candidate Anticancer Compound Inhibiting cIAP2/TRAF2 Assembly

17. A novel hotspot of gelsolin instability triggers an alternative mechanism of amyloid aggregation

18. Discovery of a Novel Class of Norovirus Inhibitors with High Barrier of Resistance

19. Functionalized 2,1-benzothiazine 2,2-dioxides as new inhibitors of Dengue NS5 RNA-dependent RNA polymerase

20. Nanobody interaction unveils structure, dynamics and proteotoxicity of the Finnish-type amyloidogenic gelsolin variant

21. Structural and functional characterization of TgpA, a critical protein for the viability of Pseudomonas aeruginosa

22. Structure‐activity relationship of NF023 derivatives binding to XIAP‐BIR1

23. Ligand Binding in Allosteric Flavoproteins: Part 2. Quantitative Analysis of the Redox-Dependent Interaction of the Apoptosis-Inducing Factor (AIF) with Its Protein Partner

24. Ligand Binding in Allosteric Flavoproteins: Part 2. Quantitative Analysis of the Redox-Dependent Interaction of the Apoptosis-Inducing Factor (AIF) with Its Protein Partner

25. Combined in silico and in vitro approaches identified the antipsychotic drug lurasidone and the antiviral drug elbasvir as SARS-CoV2 and HCoV-OC43 inhibitors

26. Synthesis and Characterization of Novel Mono- And Bis-Guanyl Hydrazones as Potent and Selective ASIC1 Inhibitors Able to Reduce Brain Ischemic Insult

27. Combined in silico docking and in vitro antiviral testing for drug repurposing identified lurasidone and elbasvir as SARS-CoV-2 and HCoV-OC43 inhibitors

28. Discovery of Zika Virus NS2B/NS3 Inhibitors That Prevent Mice from Life-Threatening Infection and Brain Damage

29. Comparative specificity and sensitivity of NS1-based serological assays for the detection of Flavivirus immune response

30. Role and inhibition of GLI1 protein in cancer

31. Gelsolin pathogenic Gly167Arg mutation promotes domain-swap dimerization of the protein

32. High-resolution crystal structure of gelsolin domain 2 in complex with the physiological calcium ion

33. Evaluation of sofosbuvir activity and resistance profile against West Nile virus in vitro

34. An alternative non-proteolytic mechanism may underlie AGel amyloidosis

35. The structure of N184K amyloidogenic variant of gelsolin highlights the role of the H-bond network for protein stability and aggregation properties

36. Broad spectrum anti-flavivirus pyridobenzothiazolones leading to less infective virions

38. Targeting flavivirus RNA dependent RNA polymerase through a pyridobenzothiazole inhibitor

39. Liposomal Systems as Nanocarriers for the Antiviral Agent Ivermectin

40. Modulation of guanylate cyclase activating protein 1 (GCAP1) dimeric assembly by Ca2+ or Mg2+: Hints to understand protein activity

41. Targeting the BIR Domains of Inhibitor of Apoptosis (IAP) Proteins in Cancer Treatment

42. Structure-based design and molecular profiling of Smac-mimetics selective for cellular IAPs

43. NF023 binding to XIAP-BIR1: Searching drugs for regulation of the NF-κB pathway

44. Identification of a Small Molecule That Compromises the Structural Integrity of Viroplasms and Rotavirus Double-Layered Particles

45. Structural bases of the altered catalytic properties of a pathogenic variant of apoptosis inducing factor

46. PPNDS inhibits murine Norovirus RNA-dependent RNA-polymerase mimicking two RNA stacking bases

47. Naphthalene-sulfonate inhibitors of human norovirus RNA-dependent RNA-polymerase

48. One hundred years of X-ray diffraction, 50 years of structural biology

49. Structure and functionality in flavivirus NS-proteins: perspectives for drug design

50. Ivermectin is a potent inhibitor of flavivirus replication specifically targeting NS3 helicase activity: new prospects for an old drug

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