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1,415 results on '"Elnahas A"'

1. Assessment of guidelines for bariatric and metabolic surgery: a systematic review and evaluation using appraisal of guidelines for research and evaluation II (AGREE II)

Author

Lee, Yung, Hircock, Caroline, Dang, Jerry, Jung, James, Zevin, Boris, Elnahas, Ahmad, Khamar, Jigish, Vergis, Ashley, Tahir, Umair, Hardy, Krista, Samarasinghe, Yasith, Gill, Richdeep, Gu, Jeffrey, McKechnie, Tyler, Pescarus, Radu, Biertho, Laurent, Lam, Elaine, Neville, Amy, Ellsmere, James, Karmali, Shahzeer, Jackson, Timothy, Okrainec, Allan, Doumouras, Aristithes, Kroh, Matthew, and Hong, Dennis

Published
2024
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3. Abdominal Fat Necrosis in a Female Dromedary Camel: Clinical, Hematobiochemical, Sonographic and Pathologic Findings

Author

Mohamed Tharwat, Mohie Haridy, Hazem Elmoghazy, Ayman Elnahas, and Abdulrahman Alkheraif

Subjects
camels, fat necrosis, diagnostic imaging, pathology, ultrasound, Zoology, QL1-991
Abstract

Background: Abdominal fat necrosis is mostly an incidental finding during rectal examination manifested by the presence of hard necrotic masses of different sizes. Differential diagnosis includes gastrointestinal neoplasia, abdominal abscessation and mummified fetuses. This report describes the clinical, hematological, biochemical, sonographic, and pathologic findings in a female Arabian camel (Camelus dromedaries) with abdominal fat necrosis. Case Description: A 7-year-old female dromedary camel was presented for examination because of weakness and progressive weight loss since months ago. Anthelmintics, analgesics, broad-spectrum antimicrobials, anti-inflammatories and stomachics were administered, but did not result in significant improvement. Preliminary examination of the case revealed emaciation with a body condition score of 2.5 (scale 1 to 5). The cardiopulmonary, digestive, and urinary systems were evaluated transcutaneously by sonography in the recumbent position. Multiple echogenic masses - located within the intestinal loops were observed alongside few hypoechogenic masses. A hyperechogenic peritoneal effusion and enlarged mesenteric lymph nodes were also detected. Decreased hematocrit value, normocytic normochromic anemia, neutrophilic leukocytosis, hypoalbuminemia, hhyperglobulinemia, hyperglycemia, hyponatremia, and hyperkalemia were detected. A free-hand, ultrasound-guided biopsy was examined histopathologically and revealed multiple abdominal fat necrosis, severe fibrosis and pancreatitis. Conclusion: It is concluded that, transabdominal ultrasonography in camels was valuable for suspicious of abdominal mesenteric masses and helpful in sampling of a representative biopsy specimen However, histological examination of the biopsy remains the final diagnostic method. [Open Vet J 2024; 14(7.000): 1726-1732]

Published
2024
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4. Distinct and shared genetic architectures of gestational diabetes mellitus and type 2 diabetes

Author

Elliott, Amanda, Walters, Raymond K., Pirinen, Matti, Kurki, Mitja, Junna, Nella, Goldstein, Jacqueline I., Reeve, Mary Pat, Siirtola, Harri, Lemmelä, Susanna M., Turley, Patrick, Lahtela, Elisa, Mehtonen, Juha, Reis, Kadri, Elnahas, Abdelrahman G., Reigo, Anu, Palta, Priit, Esko, Tõnu, Mägi, Reedik, Palotie, Aarno, Daly, Mark J., and Widén, Elisabeth

Published
2024
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10. What are the current anti-COVID-19 drugs? From traditional to smart molecular mechanisms

Author

Sawsan Aboul-Fotouh, Ahmed Nageh Mahmoud, Esraa M. Elnahas, Mohamed Z. Habib, and Sahar M. Abdelraouf

Subjects
COVID-19, SARS-CoV-2, Pharmacotherapy, Infectious and parasitic diseases, RC109-216
Abstract

Abstract Background Coronavirus disease 19 (COVID-19) is the disease caused by SARS-CoV-2, a highly infectious member of the coronavirus family, which emerged in December 2019 in “Wuhan, China”. It induces respiratory illness ranging from mild symptoms to severe disease. It was declared a “pandemic” by the World Health Organization (WHO) in March 2020. Since then, a vast number of clinical and experimental studies have been conducted to identify effective approaches for its prevention and treatment. Main body The pathophysiology of COVID-19 represents an unprecedented challenge; it triggers a strong immune response, which may be exacerbated by “a cytokine storm syndrome”. It also induces thrombogenesis and may trigger multi-organ injury. Therefore, different drug classes have been proposed for its treatment and prevention, such as antivirals, anti-SARS-CoV-2 antibody agents (monoclonal antibodies, convalescent plasma, and immunoglobulins), anti-inflammatory drugs, immunomodulators, and anticoagulant drugs. To the best of our knowledge, this review is the first to present, discuss, and summarize the current knowledge about the different drug classes used for the treatment of COVID-19, with special emphasis on their targets, mechanisms of action, and important adverse effects and drug interactions. Additionally, we spotlight the latest “October 2023” important guidelines (NIH, IDSA, and NICE) and FDA approval or authorization regarding the use of these agents in the management of COVID-19. Conclusion Despite the wide array of therapeutic strategies introduced for the treatment of COVID-19, one of the most prominent therapeutic challenges is SARS-CoV-2 mutations and emerging new variants and subvariants. Currently, the anti-COVID-19 drug pipeline is continuously affording novel treatments to face this growing challenge.

Published
2023
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11. The utility of self-expanding metal stents in benign biliary strictures- a retrospective case series

Author

Katlin Mallette, Jeffrey Hawel, Ahmad Elnahas, Nawar A. Alkhamesi, Christopher M. Schlachta, and Ephraim S. Tang

Subjects
Biliary stricture, Self expanding metal stents, Liver transplant, Plastic stent, Diseases of the digestive system. Gastroenterology, RC799-869
Abstract

Abstract Background Benign biliary strictures can have a significant negative impact on patient quality of life. There are several modalities which can be utilized with the goal of stricture resolution. These techniques include balloon dilatation, placement of multiple plastic stents and more recently, the use of metal stents. The aim of this study was to evaluate the local success of self-expanding metal stents in successfully resolving benign biliary strictures. Methods This was a single institution, retrospective case series. Patients included in our study were patients who underwent endoscopic retrograde cholangiopancreatography with placement of self expanding metal stents for benign biliary strictures at our institution between 2016–2022. Patients were excluded for the following: malignant stricture, and inability to successfully place metal stent. Data was evaluated using two-sided t-test with 95% confidence interval. Results A total of 31 patients underwent placement of 43 self-expanding metal stents and met inclusion criteria. Mean age of patients was 59 ± 10 years, and were largely male (74.2% vs. 25.8%). Most strictures were anastomotic stricture post liver transplant (87.1%), while the remainder were secondary to chronic pancreatitis (12.9%). Complications of stent placement included cholangitis (18.6%), pancreatitis (2.3%), stent migration (20.9%), and inability to retrieve stent (4.7%). There was successful stricture resolution in 73.5% of patients with anastomotic stricture and 33.3% of patients with stricture secondary to pancreatitis. Resolution was more likely if stent duration was > / = 180 days (73.3% vs. 44.4%, p / = 365 days (75% vs. 60.9%, p = 0.64). Conclusions This study demonstrates that self expanding metal stents are a safe and effective treatment for benign biliary strictures, with outcomes comparable to plastic stents with fewer interventions. This study indicates that the optimal duration to allow for stricture resolution is 180–365 days.

Published
2023
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12. Exploring Ventilator-Associated Pneumonia: Microbial Clues and Biomarker Insights from a Retrospective Study

Author

Ahmed M. Gouda, Ashraf E. Sileem, Hanan M. Elnahas, Ahmed E. Tawfik, Refaat A. Eid, Ayed A. Shati, Saleh M. Al-Qahtani, Samy A. Dawood, Mohammed A. Alshehri, Mohamed Eissa, Mohamed A. Soltan, Ahmed E. Noreldin, Amir Helmy Elwishahy, and Essamedin M. Negm

Subjects
ventilator-associated pneumonia (VAP), broncho alveolar lavage (BAL), Sequential Organ Failure Assessment (SOFA), Acute Physiology and Chronic Health Evaluation II (APACHE II) scores, Medicine (General), R5-920
Abstract

Background and Objectives: Ventilator-associated pneumonia (VAP) is a common complication in critically ill patients receiving mechanical ventilation. The incidence rates of VAP vary, and it poses significant challenges due to microbial resistance and the potential for adverse outcomes. This study aims to explore the microbial profile of VAP and evaluate the utility of biomarkers and illness severity scores in predicting survival. Materials and Methods: A retrospective cohort study was conducted involving 130 patients diagnosed with VAP. Microbial analysis of bronchoalveolar lavage (BAL) fluid, as well as measurements of C-reactive protein (CRP) and procalcitonin (PCT) levels, were performed. Sequential Organ Failure Assessment (SOFA) and Acute Physiology and Chronic Health Evaluation II (APACHE II) scores were calculated to assess illness severity. Statistical analyses were conducted to determine correlations and associations. Results: The study revealed that Klebsiella pneumoniae (K. pneumoniae) (50.7%) and Pseudomonas aeruginosa (P. aeruginosa) (27.69%) were the most identified microorganisms in VAP cases. SOFA (p-value < 0.0001) and APACHE II (p-value < 0.0001) scores were effective in assessing the severity of illness and predicting mortality in VAP patients. Additionally, our investigation highlighted the prognostic potential of CRP levels (odds ratio [OR]: 0.980, 95% confidence interval [CI] 0.968 to 0.992, p = 0.001). Elevated levels of CRP were associated with reduced survival probabilities in VAP patients. Conclusion: This study highlights the microbial profile of VAP and the importance of biomarkers and illness severity scores in predicting survival. Conclusions: The findings emphasize the need for appropriate management strategies to combat microbial resistance and improve outcomes in VAP patients.

Published
2024
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14. Global incidence, prevalence, years lived with disability (YLDs), disability-adjusted life-years (DALYs), and healthy life expectancy (HALE) for 371 diseases and injuries in 204 countries and territories and 811 subnational locations, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021

Author

Ferrari, Alize J, Santomauro, Damian Francesco, Aali, Amirali, Abate, Yohannes Habtegiorgis, Abbafati, Cristiana, Abbastabar, Hedayat, Abd ElHafeez, Samar, Abdelmasseh, Michael, Abd-Elsalam, Sherief, Abdollahi, Arash, Abdullahi, Auwal, Abegaz, Kedir Hussein, Abeldaño Zuñiga, Roberto Ariel, Aboagye, Richard Gyan, Abolhassani, Hassan, Abreu, Lucas Guimarães, Abualruz, Hasan, Abu-Gharbieh, Eman, Abu-Rmeileh, Niveen ME, Ackerman, Ilana N, Addo, Isaac Yeboah, Addolorato, Giovanni, Adebiyi, Akindele Olupelumi, Adepoju, Abiola Victor, Adewuyi, Habeeb Omoponle, Afyouni, Shadi, Afzal, Saira, Afzal, Sina, Agodi, Antonella, Ahmad, Aqeel, Ahmad, Danish, Ahmad, Firdos, Ahmad, Shahzaib, Ahmed, Ali, Ahmed, Luai A, Ahmed, Muktar Beshir, Ajami, Marjan, Akinosoglou, Karolina, Akkaif, Mohammed Ahmed, Al Hasan, Syed Mahfuz, Alalalmeh, Samer O, Al-Aly, Ziyad, Albashtawy, Mohammed, Aldridge, Robert W, Alemu, Meseret Desalegn, Alemu, Yihun Mulugeta, Alene, Kefyalew Addis, Al-Gheethi, Adel Ali Saeed, Alharrasi, Maryam, Alhassan, Robert Kaba, Ali, Mohammed Usman, Ali, Rafat, Ali, Syed Shujait Shujait, Alif, Sheikh Mohammad, Aljunid, Syed Mohamed, Al-Marwani, Sabah, Almazan, Joseph Uy, Alomari, Mahmoud A, Al-Omari, Basem, Altaany, Zaid, Alvis-Guzman, Nelson, Alvis-Zakzuk, Nelson J, Alwafi, Hassan, Al-Wardat, Mohammad Sami, Al-Worafi, Yaser Mohammed, Aly, Safwat, Alzoubi, Karem H, Amare, Azmeraw T, Amegbor, Prince M, Ameyaw, Edward Kwabena, Amin, Tarek Tawfik, Amindarolzarbi, Alireza, Amiri, Sohrab, Amugsi, Dickson A, Ancuceanu, Robert, Anderlini, Deanna, Anderson, David B, Andrade, Pedro Prata, Andrei, Catalina Liliana, Ansari, Hossein, Antony, Catherine M, Anwar, Saleha, Anwar, Sumadi Lukman, Anwer, Razique, Anyanwu, Philip Emeka, Arab, Juan Pablo, Arabloo, Jalal, Arafat, Mosab, Araki, Daniel T, Aravkin, Aleksandr Y, Arkew, Mesay, Armocida, Benedetta, Arndt, Michael Benjamin, Arooj, Mahwish, Artamonov, Anton A, Aruleba, Raphael Taiwo, Arumugam, Ashokan, Ashbaugh, Charlie, Ashemo, Mubarek Yesse, Ashraf, Muhammad, Asika, Marvellous O, Askari, Elaheh, Astell-Burt, Thomas, Athari, Seyyed Shamsadin, Atorkey, Prince, Atout, Maha Moh'd Wahbi, Atreya, Alok, Aujayeb, Avinash, Ausloos, Marcel, Avan, Abolfazl, Awotidebe, Adedapo Wasiu, Awuviry-Newton, Kofi, Ayala Quintanilla, Beatriz Paulina, Ayuso-Mateos, Jose L, Azadnajafabad, Sina, Azevedo, Rui M S, Babu, Abraham Samuel, Badar, Muhammad, Badiye, Ashish D, Baghdadi, Soroush, Bagheri, Nasser, Bah, Sulaiman, Bai, Ruhai, Baker, Jennifer L, Bakkannavar, Shankar M, Bako, Abdulaziz T, Balakrishnan, Senthilkumar, Bam, Kiran, Banik, Palash Chandra, Barchitta, Martina, Bardhan, Mainak, Bardideh, Erfan, Barker-Collo, Suzanne Lyn, Barqawi, Hiba Jawdat, Barrow, Amadou, Barteit, Sandra, Barua, Lingkan, Bashiri Aliabadi, Somaye, Basiru, Afisu, Basu, Sanjay, Basu, Saurav, Bathini, Prapthi Persis, Batra, Kavita, Baune, Bernhard T, Bayileyegn, Nebiyou Simegnew, Behnam, Babak, Behnoush, Amir Hossein, Beiranvand, Maryam, Bejarano Ramirez, Diana Fernanda, Bell, Michelle L, Bello, Olorunjuwon Omolaja, Beloukas, Apostolos, Bensenor, Isabela M, Berezvai, Zombor, Bernabe, Eduardo, Bernstein, Robert S, Bettencourt, Paulo J G, Bhagavathula, Akshaya Srikanth, Bhala, Neeraj, Bhandari, Dinesh, Bhargava, Ashish, Bhaskar, Sonu, Bhat, Vivek, Bhatti, Gurjit Kaur, Bhatti, Jasvinder Singh, Bhatti, Manpreet S, Bhatti, Rajbir, Bhutta, Zulfiqar A, Bikbov, Boris, Bishai, Jessica Devin, Bisignano, Catherine, Bitra, Veera R, Bjørge, Tone, Bodolica, Virginia, Bodunrin, Aadam Olalekan, Bogale, Eyob Ketema, Bonakdar Hashemi, Milad, Bonny, Aime, Bora Basara, Berrak, Borhany, Hamed, Boxe, Christopher, Brady, Oliver J, Bragazzi, Nicola Luigi, Braithwaite, Dejana, Brant, Luisa C, Brauer, Michael, Breitner, Susanne, Brenner, Hermann, Brown, Julie, Brugha, Traolach, Bulamu, Norma B, Buonsenso, Danilo, Burkart, Katrin, Burns, Richard A, Busse, Reinhard, Bustanji, Yasser, Butt, Zahid A, Byun, Justin, Caetano dos Santos, Florentino Luciano, Calina, Daniela, Cámera, Luis Alberto, Campos-Nonato, Ismael R, Cao, Chao, Capodici, Angelo, Carr, Sinclair, Carreras, Giulia, Carugno, Andrea, Carvalho, Márcia, Castaldelli-Maia, Joao Mauricio, Castañeda-Orjuela, Carlos A, Castelpietra, Giulio, Catapano, Alberico L, Cattaruzza, Maria Sofia, Caye, Arthur, Cegolon, Luca, Cembranel, Francieli, Cenderadewi, Muthia, Cerin, Ester, Chakraborty, Promit Ananyo, Chan, Jeffrey Shi Kai, Chan, Raymond N C, Chandika, Rama Mohan, Chandrasekar, Eeshwar K, Charalampous, Periklis, Chattu, Vijay Kumar, Chatzimavridou-Grigoriadou, Victoria, Chen, Angela W, Chen, An-Tian, Chen, Catherine S, Chen, Haowei, Chen, Nathalie M, Cheng, Esther T W, Chimed-Ochir, Odgerel, Chimoriya, Ritesh, Ching, Patrick R, Cho, William C S, Choi, Sungchul, Chong, Bryan, Chong, Yuen Yu, Choudhari, Sonali Gajanan, Chowdhury, Rajiv, Christensen, Steffan Wittrup McPhee, Chu, Dinh-Toi, Chukwu, Isaac Sunday, Chung, Eric, Chung, Eunice, Chutiyami, Muhammad, Claassens, Mareli M, Cogen, Rebecca M, Columbus, Alyssa, Conde, Joao, Cortesi, Paolo Angelo, Cousin, Ewerton, Criqui, Michael H, Cruz-Martins, Natália, Dadras, Omid, Dai, Siyu, Dai, Xiaochen, Dai, Zhaoli, Dalaba, Maxwell Ayindenaba, Damiani, Giovanni, Das, Jai K, Das, Saswati, Dashti, Mohsen, Dávila-Cervantes, Claudio Alberto, Davletov, Kairat, De Leo, Diego, Debele, Aklilu Tamire, Debopadhaya, Shayom, DeCleene, Nicole K, Deeba, Farah, Degenhardt, Louisa, Del Bo', Cristian, Delgado-Enciso, Ivan, Demetriades, Andreas K, Denova-Gutiérrez, Edgar, Dervenis, Nikolaos, Desai, Hardik Dineshbhai, Desai, Rupak, Deuba, Keshab, Dhama, Kuldeep, Dharmaratne, Samath Dhamminda, Dhingra, Sameer, Dias da Silva, Diana, Diaz, Daniel, Diaz, Luis Antonio, Diaz, Michael J, Dima, Adriana, Ding, Delaney D, Dirac, M Ashworth, Do, Thao Huynh Phuong, do Prado, Camila Bruneli, Dohare, Sushil, Dominguez, Regina-Mae Villanueva, Dong, Wanyue, Dongarwar, Deepa, D'Oria, Mario, Dorsey, E Ray, Doshmangir, Leila, Dowou, Robert Kokou, Driscoll, Tim Robert, Dsouza, Haneil Larson, Dsouza, Viola, Dube, John, Dumith, Samuel C, Duncan, Bruce B, Duraes, Andre Rodrigues, Duraisamy, Senbagam, Durojaiye, Oyewole Christopher, Dzianach, Paulina Agnieszka, Dziedzic, Arkadiusz Marian, Eboreime, Ejemai, Ebrahimi, Alireza, Edinur, Hisham Atan, Edvardsson, David, Eikemo, Terje Andreas, Eini, Ebrahim, Ekholuenetale, Michael, Ekundayo, Temitope Cyrus, El Sayed, Iman, El Tantawi, Maha, Elbarazi, Iffat, Elemam, Noha Mousaad, ElGohary, Ghada Metwally Tawfik, Elhadi, Muhammed, Elmeligy, Omar Abdelsadek Abdou, ELNahas, Gihan, Elshaer, Mohammed, Elsohaby, Ibrahim, Engelbert Bain, Luchuo, Erkhembayar, Ryenchindorj, Eshrati, Babak, Estep, Kara, Fabin, Natalia, Fagbamigbe, Adeniyi Francis, Falzone, Luca, Fareed, Mohammad, Farinha, Carla Sofia e Sá, Faris, MoezAlIslam Ezzat Mahmoud, Faro, Andre, Farrokhi, Pegah, Fatehizadeh, Ali, Fauk, Nelsensius Klau, Feigin, Valery L, Feng, Xiaoqi, Fereshtehnejad, Seyed-Mohammad, Feroze, Abdullah Hamid, Ferreira, Nuno, Ferreira, Paulo H, Fischer, Florian, Flavel, Joanne, Flood, David, Flor, Luisa S, Foigt, Nataliya A, Folayan, Morenike Oluwatoyin, Force, Lisa M, Fortuna, Daniela, Foschi, Matteo, Franklin, Richard Charles, Freitas, Alberto, Fukumoto, Takeshi, Furtado, João M, Gaal, Peter Andras, Gadanya, Muktar A, Gaidhane, Abhay Motiramji, Gaihre, Santosh, Galali, Yaseen, Ganbat, Mandukhai, Gandhi, Aravind P, Ganesan, Balasankar, Ganie, Mohd Ashraf, Ganiyani, Mohammad Arfat, Gardner, William M, Gebi, Tilaye Gebru, Gebregergis, Miglas W, Gebrehiwot, Mesfin, Gebremariam, Tesfay B B, Gebremeskel, Teferi Gebru, Gela, Yibeltal Yismaw, Georgescu, Simona Roxana, Getachew Obsa, Abera, Gething, Peter W, Getie, Molla, Ghadiri, Keyghobad, Ghadirian, Fataneh, Ghailan, Khalid Yaser, Ghajar, Alireza, Ghasemi, MohammadReza, Ghasempour Dabaghi, Ghazal, Ghasemzadeh, Afsaneh, Ghazy, Ramy Mohamed, Gholamrezanezhad, Ali, Ghorbani, Mahsa, Ghotbi, Elena, Gibson, Ruth Margaret, Gill, Tiffany K, Ginindza, Themba G, Girmay, Alem, Glasbey, James C, Göbölös, Laszlo, Godinho, Myron Anthony, Goharinezhad, Salime, Goldust, Mohamad, Golechha, Mahaveer, Goleij, Pouya, Gona, Philimon N, Gorini, Giuseppe, Goulart, Alessandra C, Grada, Ayman, Grivna, Michal, Guan, Shi-Yang, Guarducci, Giovanni, Gubari, Mohammed Ibrahim Mohialdeen, Gudeta, Mesay Dechasa, Guha, Avirup, Guicciardi, Stefano, Gulati, Snigdha, Gulisashvili, David, Gunawardane, Damitha Asanga, Guo, Cui, Gupta, Anish Kumar, Gupta, Bhawna, Gupta, Ishita, Gupta, Mohak, Gupta, Rajeev, Gupta, Veer Bala, Gupta, Vijai Kumar, Gupta, Vivek Kumar, Gutiérrez, Reyna Alma, Habibzadeh, Farrokh, Habibzadeh, Parham, Haddadi, Rasool, Hadi, Najah R, Haep, Nils, Hafezi-Nejad, Nima, Hafiz, Abdul, Hagins, Hailey, Halboub, Esam S, Halimi, Aram, Haller, Sebastian, Halwani, Rabih, Hamilton, Erin B, Hankey, Graeme J, Hannan, Md Abdul, Haque, Md Nuruzzaman, Harapan, Harapan, Haro, Josep Maria, Hartvigsen, Jan, Hasaballah, Ahmed I, Hasan, Ikramul, Hasanian, Mohammad, Hasnain, Md Saquib, Hassan, Amr, Haubold, Johannes, Havmoeller, Rasmus J, Hay, Simon I, Hayat, Khezar, Hebert, Jeffrey J, Hegazi, Omar E, Heidari, Golnaz, Helfer, Bartosz, Hemmati, Mehdi, Hendrie, Delia, Henson, Claire A, Hezam, Kamal, Hiraike, Yuta, Hoan, Nguyen Quoc, Holla, Ramesh, Hon, Julia, Hossain, Md Mahbub, Hosseinzadeh, Hassan, Hosseinzadeh, Mehdi, Hostiuc, Mihaela, Hostiuc, Sorin, Hsu, Johnathan M, Huang, Junjie, Hugo, Fernando N, Hushmandi, Kiavash, Hussain, Javid, Hussein, Nawfal R, Huynh, Chantal K, Huynh, Hong-Han, Hwang, Bing-Fang, Iannucci, Vincent C, Ihler, Audrey L, Ikiroma, Adalia I, Ikuta, Kevin S, Ilesanmi, Olayinka Stephen, Ilic, Irena M, Ilic, Milena D, Imam, Mohammad Tarique, Immurana, Mustapha, Irham, Lalu Muhammad, Islam, Md Rabiul, Islam, Sheikh Mohammed Shariful, Islami, Farhad, Ismail, Faisal, Ismail, Nahlah Elkudssiah, Isola, Gaetano, Iwagami, Masao, Iwu, Chidozie C D, Iyer, Mahalaxmi, Jaafari, Jalil, Jacobsen, Kathryn H, Jadidi-Niaragh, Farhad, Jafarinia, Morteza, Jaggi, Khushleen, Jahankhani, Kasra, Jahanmehr, Nader, Jahrami, Haitham, Jain, Akhil, Jain, Nityanand, Jairoun, Ammar Abdulrahman, Jaiswal, Abhishek, Jakovljevic, Mihajlo, Jatau, Abubakar Ibrahim, Javadov, Sabzali, Javaheri, Tahereh, Jayapal, Sathish Kumar, Jayaram, Shubha, Jee, Sun Ha, Jeganathan, Jayakumar, Jeyakumar, Angeline, Jha, Anil K, Jiang, Heng, Jin, Yinzi, Jonas, Jost B, Joo, Tamas, Joseph, Abel, Joseph, Nitin, Joshua, Charity Ehimwenma, Jozwiak, Jacek Jerzy, Jürisson, Mikk, K, Vaishali, Kaambwa, Billingsley, Kabir, Ali, Kabir, Zubair, Kadashetti, Vidya, Kalani, Rizwan, Kalankesh, Leila R, Kaliyadan, Feroze, Kalra, Sanjay, Kamenov, Kaloyan, Kamyari, Naser, Kanagasabai, Thanigaivelan, Kandel, Himal, Kanmanthareddy, Arun R, Kanmodi, Kehinde Kazeem, Kantar, Rami S, Karaye, Ibraheem M, Karim, Asima, Karimi, Salah Eddin, Karimi, Yeganeh, Kasraei, Hengameh, Kassel, Molly B, Kauppila, Joonas H, Kawakami, Norito, Kayode, Gbenga A, Kazemi, Foad, Kazemian, Sina, Keikavoosi-Arani, Leila, Keller, Cathleen, Kempen, John H, Kerr, Jessica A, Keshtkar, Kamyab, Kesse-Guyot, Emmanuelle, Keykhaei, Mohammad, Khajuria, Himanshu, Khalaji, Amirmohammad, Khalid, Asaad, Khalid, Nauman, Khalilian, Alireza, Khamesipour, Faham, Khan, Asaduzzaman, Khan, Ikramullah, Khan, Maseer, Khan, Moien AB, Khanmohammadi, Shaghayegh, Khatab, Khaled, Khatami, Fatemeh, Khatatbeh, Moawiah Mohammad, Khater, Amir M, Khayat Kashani, Hamid Reza, Khidri, Feriha Fatima, Khodadoust, Elaheh, Khormali, Moein, Khorrami, Zahra, Kifle, Zemene Demelash, Kim, Min Seo, Kimokoti, Ruth W, Kisa, Adnan, Kisa, Sezer, Knudsen, Ann Kristin Skrindo, Kocarnik, Jonathan M, Kochhar, Sonali, Koh, Hyun Yong, Kolahi, Ali-Asghar, Kompani, Farzad, Koren, Gerbrand, Korzh, Oleksii, Kosen, Soewarta, Koulmane Laxminarayana, Sindhura Lakshmi, Krishan, Kewal, Krishna, Varun, Krishnamoorthy, Vijay, Kuate Defo, Barthelemy, Kuddus, Md Abdul, Kuddus, Mohammed, Kuitunen, Ilari, Kulkarni, Vishnutheertha, Kumar, Manasi, Kumar, Nithin, Kumar, Rakesh, Kurmi, Om P, Kusuma, Dian, Kyu, Hmwe Hmwe, La Vecchia, Carlo, Lacey, Ben, Ladan, Muhammad Awwal, Laflamme, Lucie, Lafranconi, Alessandra, Lahariya, Chandrakant, Lai, Daphne Teck Ching, Lal, Dharmesh Kumar, Lalloo, Ratilal, Lallukka, Tea, Lám, Judit, Lan, Qing, Lan, Tuo, Landires, Iván, Lanfranchi, Francesco, Langguth, Berthold, Laplante-Lévesque, Ariane, Larijani, Bagher, Larsson, Anders O, Lasrado, Savita, Lauriola, Paolo, Le, Huu-Hoai, Le, Long Khanh Dao, Le, Nhi Huu Hanh, Le, Trang Diep Thanh, Leasher, Janet L, Ledda, Caterina, Lee, Munjae, Lee, Paul H, Lee, Sang-woong, Lee, Seung Won, Lee, Wei-Chen, Lee, Yo Han, LeGrand, Kate E, Lenzi, Jacopo, Leong, Elvynna, Leung, Janni, Li, Ming-Chieh, Li, Wei, Li, Xiaopan, Li, Yichong, Li, Yongze, Lim, Lee-Ling, Lim, Stephen S, Lindstrom, Megan, Linn, Shai, Liu, Gang, Liu, Runben, Liu, Shiwei, Liu, Wei, Liu, Xiaofeng, Liu, Xuefeng, Llanaj, Erand, Lo, Chun-Han, López-Bueno, Rubén, Loreche, Arianna Maever, Lorenzovici, László, Lozano, 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Biresaw, Ng, Marie, Nguefack-Tsague, Georges, Ngunjiri, Josephine W, Nguyen, Dang H, Nguyen, Hien Quang, Niazi, Robina Khan, Nikolouzakis, Taxiarchis Konstantinos, Nikoobar, Ali, Nikoomanesh, Fatemeh, Nikpoor, Amin Reza, Nnaji, Chukwudi A, Nnyanzi, Lawrence Achilles, Noman, Efaq Ali, Nomura, Shuhei, Norrving, Bo, Nri-Ezedi, Chisom Adaobi, Ntaios, George, Ntsekhe, Mpiko, Nurrika, Dieta, Nzoputam, Chimezie Igwegbe, Nzoputam, Ogochukwu Janet, Oancea, Bogdan, Odetokun, Ismail A, O'Donnell, Martin James, Oguntade, Ayodipupo Sikiru, Oguta, James Odhiambo, Okati-Aliabad, Hassan, Okeke, Sylvester Reuben, Okekunle, Akinkunmi Paul, Okonji, Osaretin Christabel, Olagunju, Andrew T, Olasupo, Omotola O, Olatubi, Matthew Idowu, Oliveira, Gláucia Maria Moraes, Olufadewa, Isaac Iyinoluwa, Olusanya, Bolajoko Olubukunola, Olusanya, Jacob Olusegun, Omar, Hany A, Omer, Goran Latif, Omonisi, Abidemi E Emmanuel, Onie, Sandersan, Onwujekwe, Obinna E, Ordak, Michal, Orish, Verner N, Ortega-Altamirano, Doris V, 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Hoang Tran, Philip, Anil K, Phillips, Michael R, Pigeolet, Manon, Pigott, David M, Pillay, Julian David, Piracha, Zahra Zahid, Pirouzpanah, Saeed, Plass, Dietrich, Plotnikov, Evgenii, Poddighe, Dimitri, Polinder, Suzanne, Postma, Maarten J, Pourtaheri, Naeimeh, Prada, Sergio I, Pradhan, Pranil Man Singh, Prakash, V, Prasad, Manya, Prates, Elton Junio Sady, Priscilla, Tina, Pritchett, Natalie, Puri, Pooja, Puvvula, Jagadeesh, Qasim, Nameer Hashim, Qattea, Ibrahim, Qazi, Asma Saleem, Qian, Gangzhen, Rabiee Rad, Mehrdad, Radhakrishnan, Raghu Anekal, Radhakrishnan, Venkatraman, Raeisi Shahraki, Hadi, Rafferty, Quinn, Raggi, Alberto, Raghav, Pankaja Raghav, Rahim, Md Jillur, Rahman, Md Mosfequr, Rahman, Mohammad Hifz Ur, Rahman, Mosiur, Rahman, Muhammad Aziz, Rahmani, Shayan, Rahmanian, Mohammad, Rahmawaty, Setyaningrum, Rajaa, Sathish, Ramadan, Mahmoud Mohammed, Ramasamy, Shakthi Kumaran, Ramasubramani, Premkumar, Ramazanu, Sheena, Rana, Kritika, Ranabhat, Chhabi Lal, Rancic, Nemanja, Rane, Amey, Rao, Chythra R, Rao, Kumuda, Rao, Mithun, Rao, Sowmya J, Rashidi, Mohammad-Mahdi, Rathnaiah Babu, Giridhara, Rauniyar, Santosh Kumar, Rawaf, David Laith, Rawaf, Salman, Razo, Christian, Reddy, Murali Mohan Rama Krishna, Redwan, Elrashdy Moustafa Mohamed, Reifels, Lennart, Reiner Jr, Robert C, Remuzzi, Giuseppe, Renzaho, Andre M N, Reshmi, Bhageerathy, Reyes, Luis Felipe, Rezaei, Nazila, Rezaei, Negar, Rezaei, Nima, Rezaei Hachesu, Peyman, Rezaeian, Mohsen, Rickard, Jennifer, Rodrigues, Célia Fortuna, Rodriguez, Jefferson Antonio Buendia, Roever, Leonardo, Ronfani, Luca, Roshandel, Gholamreza, Rotimi, Kunle, Rout, Himanshu Sekhar, Roy, Bedanta, Roy, Nitai, Roy, Priyanka, Rubagotti, Enrico, S N, Chandan, Saad, Aly M A, Saber-Ayad, Maha Mohamed, Sabour, Siamak, Sacco, Simona, Sachdev, Perminder S, Saddik, Basema, Saddler, Adam, Sadee, Bashdar Abuzed, Sadeghi, Erfan, Sadeghi, Masoumeh, Saeb, Mohammad Reza, Saeed, Umar, Safi, Sher Zaman, Sagar, Rajesh, Sagoe, Dominic, Saif, Zahra, Sajid, Mirza Rizwan, Sakshaug, Joseph W, Salam, Nasir, Salami, Afeez Abolarinwa, Salaroli, Luciane B, Saleh, Mohamed A, Salem, Marwa Rashad, Salem, Mohammed Z Y, Sallam, Malik, Samadzadeh, Sara, Samargandy, Saad, Samodra, Yoseph Leonardo, Samy, Abdallah M, Sanabria, Juan, Sanna, Francesca, Santos, Itamar S, Santric-Milicevic, Milena M, Sarasmita, Made Ary, Sarikhani, Yaser, Sarmiento-Suárez, Rodrigo, Sarode, Gargi Sachin, Sarode, Sachin C, Sarveazad, Arash, Sathian, Brijesh, Sathyanarayan, Anudeep, Satpathy, Maheswar, Sawhney, Monika, Scarmeas, Nikolaos, Schaarschmidt, Benedikt Michael, Schmidt, Maria Inês, Schneider, Ione Jayce Ceola, Schumacher, Austin E, Schwebel, David C, Schwendicke, Falk, Sedighi, Mansour, Senapati, Sabyasachi, Senthilkumaran, Subramanian, Sepanlou, Sadaf G, Sethi, Yashendra, Setoguchi, Soko, Seylani, Allen, Shadid, Jamileh, Shafie, Mahan, Shah, Humaira, Shah, Nilay S, Shah, Pritik A, Shahbandi, Ataollah, Shahid, Samiah, Shahid, Wajeehah, Shahwan, Moyad Jamal, Shaikh, Masood Ali, Shakeri, Alireza, Shalash, Ali S, Sham, Sunder, Shamim, Muhammad Aaqib, Shamshirgaran, Mohammad Ali, Shamsi, Mohammad Anas, Shanawaz, Mohd, Shankar, Abhishek, Shannawaz, Mohammed, Sharath, Medha, Sharifan, Amin, Sharifi-Rad, Javad, Sharma, Manoj, Sharma, Rajesh, Sharma, Saurab, Sharma, Ujjawal, Sharma, Vishal, Shastry, Rajesh P, Shavandi, Amin, Shayan, Amir Mehdi, Shayan, Maryam, Shehabeldine, Amr Mohamed Elsayed, Shetty, Pavanchand H, Shibuya, Kenji, Shifa, Jemal Ebrahim, Shiferaw, Desalegn, Shiferaw, Wondimeneh Shibabaw, Shigematsu, Mika, Shiri, Rahman, Shitaye, Nebiyu Aniley, Shittu, Aminu, Shivakumar, K M, Shivarov, Velizar, Shokati Eshkiki, Zahra, Shool, Sina, Shrestha, Sunil, Shuval, Kerem, Sibhat, Migbar Mekonnen, Siddig, Emmanuel Edwar, Sigfusdottir, Inga Dora, Silva, Diego Augusto Santos, Silva, João Pedro, Silva, Luís Manuel Lopes Rodrigues, Silva, Soraia, Simpson, Colin R, Singal, Anjali, Singh, Abhinav, Singh, Balbir Bagicha, Singh, Harmanjit, Singh, Jasvinder A, Singh, Mahendra, Singh, Paramdeep, Skou, Søren T, Sleet, David A, Slepak, Erica Leigh N, Solanki, Ranjan, Soliman, Sameh S M, Song, Suhang, Song, Yimeng, Sorensen, Reed J D, Soriano, Joan B, Soyiri, Ireneous N, Spartalis, Michael, Sreeramareddy, Chandrashekhar T, Stark, Benjamin A, Starodubova, Antonina V, Stein, Caroline, Stein, Dan J, Steiner, Caitlyn, Steiner, Timothy J, Steinmetz, Jaimie D, Steiropoulos, Paschalis, Stockfelt, Leo, Stokes, Mark A, Subedi, Narayan Subedi, Subramaniyan, Vetriselvan, Suemoto, Claudia Kimie, Suleman, Muhammad, Suliankatchi Abdulkader, Rizwan, Sultana, Abida, Sundström, Johan, Swain, Chandan Kumar, Szarpak, Lukasz, Tabaee Damavandi, Payam, Tabarés-Seisdedos, Rafael, Tabatabaei Malazy, Ozra, Tabatabaeizadeh, Seyed-Amir, Tabatabai, Shima, Tabche, Celine, Tabish, Mohammad, Tadakamadla, Santosh Kumar, Taheri Abkenar, Yasaman, Taheri Soodejani, Moslem, Taherkhani, Amir, Taiba, Jabeen, Talaat, Iman M, Talukder, Ashis, Tampa, Mircea, Tamuzi, Jacques Lukenze, Tan, Ker-Kan, Tandukar, Sarmila, Tang, Haosu, Tavakoli Oliaee, Razieh, Tavangar, Seyed Mohammad, Teimoori, Mojtaba, Temsah, Mohamad-Hani, Teramoto, Masayuki, Thangaraju, Pugazhenthan, Thankappan, Kavumpurathu Raman, Thapar, Rekha, Thayakaran, Rasiah, Thirunavukkarasu, Sathish, Thomas, Nihal, Thomas, Nikhil Kenny, Thum, Chern Choong Chern, Tichopad, Ales, Ticoalu, Jansje Henny Vera, Tillawi, Tala, Tiruye, Tenaw Yimer, Tobe-Gai, Ruoyan, Tonelli, Marcello, Topor-Madry, Roman, Torre, Anna E, Touvier, Mathilde, Tovani-Palone, Marcos Roberto, Tran, Jasmine T, Tran, Mai Thi Ngoc, Tran, Nghia Minh, Tran, Ngoc-Ha, Trico, Domenico, Tromans, Samuel Joseph, Truyen, Thien Tan Tri Tai, Tsatsakis, Aristidis, Tsegay, Guesh Mebrahtom, Tsermpini, Evangelia Eirini, Tumurkhuu, Munkhtuya, Tyrovolas, Stefanos, Udoh, Arit, Umair, Muhammad, Umakanthan, Srikanth, Umar, Tungki Pratama, Undurraga, Eduardo A, Unim, Brigid, Unnikrishnan, Bhaskaran, Unsworth, Carolyn Anne, Upadhyay, Era, Urso, Daniele, Usman, Jibrin Sammani, Vahabi, Seyed Mohammad, Vaithinathan, Asokan Govindaraj, Van den Eynde, Jef, Varga, Orsolya, Varma, Ravi Prasad, Vart, Priya, Vasankari, Tommi Juhani, Vasic, Milena, Vaziri, Siavash, Vellingiri, Balachandar, Venketasubramanian, Narayanaswamy, Veroux, Massimiliano, Verras, Georgios-Ioannis, Vervoort, Dominique, Villafañe, Jorge Hugo, Violante, Francesco S, Vlassov, Vasily, Vollset, Stein Emil, Volovat, Simona Ruxandra, Vongpradith, Avina, Waheed, Yasir, Wang, Cong, Wang, Fang, Wang, Ning, Wang, Shu, Wang, Yanzhong, Wang, Yuan-Pang, Ward, Paul, Wassie, Emebet Gashaw, Weaver, Marcia R, Weerakoon, Kosala Gayan, Weintraub, Robert G, Weiss, Daniel J, Weldemariam, Abrha Hailay, Wells, Katherine M, Wen, Yi Feng, Whisnant, Joanna L, Whiteford, Harvey A, Wiangkham, Taweewat, Wickramasinghe, Dakshitha Praneeth, Wickramasinghe, Nuwan Darshana, Wilandika, Angga, Wilkerson, Caroline, Willeit, Peter, Wimo, Anders, Woldegebreal, Demewoz H, Wolf, Axel Walter, Wong, Yen Jun, Woolf, Anthony D, Wu, Chenkai, Wu, Felicia, Wu, Xinsheng, Wu, Zenghong, Wulf Hanson, Sarah, Xia, Yanjie, Xiao, Hong, Xu, Xiaoyue, Xu, Yvonne Yiru, Yadav, Lalit, Yadollahpour, Ali, Yaghoubi, Sajad, Yamagishi, Kazumasa, Yang, Lin, Yano, Yuichiro, Yao, Yao, Yaribeygi, Habib, Yazdanpanah, Mohammad Hosein, Ye, Pengpeng, Yehualashet, Sisay Shewasinad, Yesuf, Subah Abderehim, Yezli, Saber, Yiğit, Arzu, Yiğit, Vahit, Yigzaw, Zeamanuel Anteneh, Yismaw, Yazachew, Yon, Dong Keon, Yonemoto, Naohiro, Younis, Mustafa Z, Yu, Chuanhua, Yu, Yong, Yusuf, Hadiza, Zahid, Mondal Hasan, Zakham, Fathiah, Zaki, Leila, Zaki, Nazar, Zaman, Burhan Abdullah, Zamora, Nelson, Zand, Ramin, Zandieh, Ghazal G Z, Zar, Heather J, Zarrintan, Armin, Zastrozhin, Mikhail Sergeevich, Zhang, Haijun, Zhang, Ning, Zhang, Yunquan, Zhao, Hanqing, Zhong, Chenwen, Zhong, Panliang, Zhou, Juexiao, Zhu, Zhaohua, Ziafati, Makan, Zielińska, Magdalena, Zimsen, Stephanie R M, Zoladl, Mohammad, Zumla, Alimuddin, Zyoud, Samer H, Vos, Theo, and Murray, Christopher J L

Published
2024
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20. 3D computer-aided single stage correction of Crouzon related craniofacial and occlusal deformities: A case series of three adult patients

Author

Hossam Hassan Fawzy, Hesham Abo Rahma, Moaz Elsheikh, Mohamed Abdalla Elnahas, Khaled Adel Eid, and Yasser Elsheikh

Subjects
Computer-assisted surgery, 3D printing, Craniofacial dysostosis, Craniosynostosis, Hypertelorism, Crouzon disease, Surgery, RD1-811
Abstract

Background: Single-stage surgical correction of Crouzon syndrome aims to remodel the cranial vault to achieve a morphology approaching age-matched norms. Virtual surgical planning (VSP) and computer-aided design (CAD) technology are recently used in craniofacial surgery. We aimed to determine the value of 3D planning tools and VSP in guiding different steps of surgical correction in craniofacial deformities in patients with untreated Crouzon syndrome. Methods: This study included three patients with delayed presentation of untreated Crouzon syndrome who underwent cranial vault remodeling preoperatively guided by VSP techniques between Jan 2021 and Feb 2023. Preoperative evaluation included all patients' physical examinations and 3D computed tomography (CT) scans. The constructed 3D files from the CT data were subsequently used for preoperative measurements. DICOM files of both preoperative and postoperative data were introduced into the medical 3D software. Results: The patients' ages at surgery were 18, 20, and 23 years. All patients had satisfactory aesthetic and functional outcomes with no major complications. The average operative time was 8.35 ± 2.53 hours. There was an improvement regarding cephalometric analysis and orbital morphology. The Presimulation movement distance regarding the frontal and zygomatic bone advancement showed a significant increment with a degree of overcorrection, significantly different from the preplanned. Conclusion: In conclusion, VSP is revolutionizing the surgical approach to complex craniofacial and occlusal malformations. This study successfully reports the use and applicability of VSP in untreated adult patients in a single stage. Combining the surgeon's experience and the appropriate use of computer-assisted surgery ultimately leads to successful surgery.

Published
2024
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23. Smartphone addiction and its relation to social phobia in female university students

Author

Zainab Khaled Mohamed, Gihan Medhat ElNahas, Hesham Abdel-Mageed Hatata, Doha Mostafa El-Serafi, and Dalia Abdel-Moneim Mahmoud

Subjects
Social phobia, Smartphone, Addiction, Female students, Psychiatry, RC435-571
Abstract

Abstract Background The problematic smartphone use has emerged with negative mental health consequences. The current study aims to assess the rate of occurrence of smartphone addiction and the relationship between smartphone addiction and social phobia and its severity in a sample of female university students. Results Out of 540 female students, 28.7% have severe smartphone addiction with higher number in students of academic faculties; also, 71.86% of the whole sample have social phobia with 22.78%, 21.85%, 16.3%, and 10.93% reported mild, moderate, severe, and very severe social phobia scores respectively. The number of students reporting very severe social phobia in the academic group is higher than that in the practical group; also, the study shows a significant relation between smartphone addiction and social phobia. Conclusion and implications There is a high rate of distribution of social phobia in young adult females, which is accompanied with increased in a high rate of occurrence of smartphone addiction; so, there is a need for raising the public awareness regarding hazards of problematic smartphone use in students and the importance of screening of different psychiatric disorders, as social phobia in such population.

Published
2023
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24. Sperm chromosomal abnormalities in infertile men with failed intracytoplasmic sperm injection (ICSI)

Author

Rania Fathy Elnahas, Amal Kotb Behery, Soha Kholeif, Yasser Ibrahim Orief, and Ghada Mohamed Elhady

Subjects
Infertility, FISH, ICSI, Medicine (General), R5-920, Reproduction, QH471-489
Abstract

Abstract Background Male infertility is a major health problem with multi-factorial etiology. Intracytoplasmic sperm injection (ICSI) has revolutionized the treatment of men with severely compromised semen parameters and improved their chances of achieving pregnancy. However, many concerns have been raised about ICSI safety; in part owing to utilizing aneuploid sperms from infertile men, which may be associated with an increased incidence of chromosomal aneuploidies in ICSI pregnancies. The aim of the study was to determine the incidence of sperm aneuploidies for chromosomes 13, 18, 21, X, and Y in semen of infertile males with failed ICSI. This will assist infertile couples and enable them to make informed decisions. For this purpose, sperm aneuploidy frequency for chromosomes 13, 18, 21, X, and Y was evaluated by multicolor fluorescence in-situ hybridization (FISH) in 35 patients with abnormal semen parameters, and 10 normozoospermic healthy men who served as controls. Results Sperm aneuploidies for chromosomes 13, 18, 21, X, and Y in semen from infertile men with failed ICSI were detected at higher frequencies than controls. Patients had significantly higher disomy, nullisomy, diploidy, and polyploidy frequencies compared to controls. Conclusions Infertile men with failed ICSI have a significantly increased frequency of sperm chromosome abnormalities compared to controls. Fluorescence in situ hybridization facilitated the study of numerical chromosomal abnormalities in human sperm nuclei (sperm FISH). Sperm FISH, prior to the application of assisted reproductive techniques, saves a considerable amount of time and resources.

Published
2023
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28. FinnGen provides genetic insights from a well-phenotyped isolated population

Author

Kurki, Mitja I., Karjalainen, Juha, Palta, Priit, Sipilä, Timo P., Kristiansson, Kati, Donner, Kati M., Reeve, Mary P., Laivuori, Hannele, Aavikko, Mervi, Kaunisto, Mari A., Loukola, Anu, Lahtela, Elisa, Mattsson, Hannele, Laiho, Päivi, Della Briotta Parolo, Pietro, Lehisto, Arto A., Kanai, Masahiro, Mars, Nina, Rämö, Joel, Kiiskinen, Tuomo, Heyne, Henrike O., Veerapen, Kumar, Rüeger, Sina, Lemmelä, Susanna, Zhou, Wei, Ruotsalainen, Sanni, Pärn, Kalle, Hiekkalinna, Tero, Koskelainen, Sami, Paajanen, Teemu, Llorens, Vincent, Gracia-Tabuenca, Javier, Siirtola, Harri, Reis, Kadri, Elnahas, Abdelrahman G., Sun, Benjamin, Foley, Christopher N., Aalto-Setälä, Katriina, Alasoo, Kaur, Arvas, Mikko, Auro, Kirsi, Biswas, Shameek, Bizaki-Vallaskangas, Argyro, Carpen, Olli, Chen, Chia-Yen, Dada, Oluwaseun A., Ding, Zhihao, Ehm, Margaret G., Eklund, Kari, Färkkilä, Martti, Finucane, Hilary, Ganna, Andrea, Ghazal, Awaisa, Graham, Robert R., Green, Eric M., Hakanen, Antti, Hautalahti, Marco, Hedman, Åsa K., Hiltunen, Mikko, Hinttala, Reetta, Hovatta, Iiris, Hu, Xinli, Huertas-Vazquez, Adriana, Huilaja, Laura, Hunkapiller, Julie, Jacob, Howard, Jensen, Jan-Nygaard, Joensuu, Heikki, John, Sally, Julkunen, Valtteri, Jung, Marc, Junttila, Juhani, Kaarniranta, Kai, Kähönen, Mika, Kajanne, Risto, Kallio, Lila, Kälviäinen, Reetta, Kaprio, Jaakko, Kerimov, Nurlan, Kettunen, Johannes, Kilpeläinen, Elina, Kilpi, Terhi, Klinger, Katherine, Kosma, Veli-Matti, Kuopio, Teijo, Kurra, Venla, Laisk, Triin, Laukkanen, Jari, Lawless, Nathan, Liu, Aoxing, Longerich, Simonne, Mägi, Reedik, Mäkelä, Johanna, Mäkitie, Antti, Malarstig, Anders, Mannermaa, Arto, Maranville, Joseph, Matakidou, Athena, Meretoja, Tuomo, Mozaffari, Sahar V., Niemi, Mari E. K., Niemi, Marianna, Niiranen, Teemu, O´Donnell, Christopher J., Obeidat, Ma´en, Okafo, George, Ollila, Hanna M., Palomäki, Antti, Palotie, Tuula, Partanen, Jukka, Paul, Dirk S., Pelkonen, Margit, Pendergrass, Rion K., Petrovski, Slavé, Pitkäranta, Anne, Platt, Adam, Pulford, David, Punkka, Eero, Pussinen, Pirkko, Raghavan, Neha, Rahimov, Fedik, Rajpal, Deepak, Renaud, Nicole A., Riley-Gillis, Bridget, Rodosthenous, Rodosthenis, Saarentaus, Elmo, Salminen, Aino, Salminen, Eveliina, Salomaa, Veikko, Schleutker, Johanna, Serpi, Raisa, Shen, Huei-yi, Siegel, Richard, Silander, Kaisa, Siltanen, Sanna, Soini, Sirpa, Soininen, Hilkka, Sul, Jae Hoon, Tachmazidou, Ioanna, Tasanen, Kaisa, Tienari, Pentti, Toppila-Salmi, Sanna, Tukiainen, Taru, Tuomi, Tiinamaija, Turunen, Joni A., Ulirsch, Jacob C., Vaura, Felix, Virolainen, Petri, Waring, Jeffrey, Waterworth, Dawn, Yang, Robert, Nelis, Mari, Reigo, Anu, Metspalu, Andres, Milani, Lili, Esko, Tõnu, Fox, Caroline, Havulinna, Aki S., Perola, Markus, Ripatti, Samuli, Jalanko, Anu, Laitinen, Tarja, Mäkelä, Tomi P., Plenge, Robert, McCarthy, Mark, Runz, Heiko, Daly, Mark J., and Palotie, Aarno

Published
2023
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30. Robust Clock Synchronization via Low Rank Approximation in Wireless Networks

Author

Elnahas, Osama and Quan, Zhi

Subjects
Electrical Engineering and Systems Science - Signal Processing
Abstract

Clock synchronization has become a key design objective in wireless networks for its essential importance in many applications. However, as the wireless link is prone to random network delays due to unreliable channel conditions, it is in general difficult to achieve accurate clock synchronization among wireless nodes. This letter proposes robust clock synchronization algorithms based on low rank matrix approximation, which are able to correct timestamps in the presence of random network delays. We design a low rank approximation based maximum likelihood estimator (MLE) to jointly estimate the clock offset and clock skew under the two-way message exchange mechanism assuming Gaussian delay distribution. By formulating the timestamp correction problem into a low rank approximation problem, we can solve the problem in the singular value decomposition (SVD) domain and also via nuclear norm minimization. Numerical results show that the proposed schemes can correct noisy timestamps and thus achieve more robust synchronization performance than the MLE., Comment: 5 pages, 3 figures

Published
2020

31. Real-world treatment patterns and clinical outcomes in patients with stage III non-small cell lung cancer: results of KINDLE-Egypt cohort

Author

Rasha Aboelhassan, Mohamed Emam Sobeih, Mohamed Alm El-Din, Ramy R. Ghali, Ibtessam Saad El-Din, Ola Khorshid, Mohsen Mokhtar, Ahmed Magdy Rabea, Abdelaziz Belal, Hamdy A. Azim, Mohamed Abdullah, Tamer Elnahas, Hesham Tawfik, Sherif Abdelwahab, Amr Abdelaziz Elsaid, Tarek Hashem, Mohamed Mancy, and Heba Farag

Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Background: Stage III non-small cell lung cancer (NSCLC) being highly heterogeneous requires multimodal therapeutic strategies for optimal management. We present findings on treatment patterns and their associated survival outcomes in patients with stage III NSCLC from the Egypt subset of the KINDLE global real-world study conducted across countries from Asia, Middle East, Africa, and Latin America. Method: Retrospective data from the Egypt subset (21 centers) of adult patients diagnosed with stage III NSCLC between January 2013 and December 2017 were analyzed. Descriptive and inferential statistics summarized treatment modalities, progression-free survival (PFS), and overall survival (OS). Results: Of 421 patients enrolled (median age: 59.0 years), 77.9% were males, 53.5% had stage IIIA disease, 60.8% had adenocarcinoma, 78.4% had an unresectable disease, and 81.5% had Eastern Cooperative Oncology Group performance status ⩽1. Overall, chemotherapy alone (40.4%) was predominantly used in the initial line, whereas definite radiotherapy was used in only 5.0% of patients. In resectable patients, chemotherapy plus surgery (33.8%), surgery alone (20.6%), or other surgery (20.6%) were the top three modalities used in initial line of treatment. Chemotherapy alone was most preferred (48.8%) in unresectable patients, followed by sequential chemoradiotherapy (CRT) (17.6%) and concurrent CRT (9.3%). The overall median PFS was 10.3 months [95% confidence interval (CI), 9.43–12.02], whereas the median OS was 18.5 months (95% CI, 16.46–21.88). Overall, female gender, adenocarcinoma histology, and radical therapy as surgery or CRT predicted significantly longer OS (all p < 0.05). Conclusion: KINDLE-Egypt cohort revealed wide heterogeneities in the treatment patterns of stage III NSCLC. Although deemed resectable, few patients did not undergo surgery, probably due to high smoking rates leading to poor lung function. Lower survival outcomes than other published real-world studies highlight the need for timely approval and availability of novel targeted and immunotherapies to enhance patient outcomes. Trial registration: NCT03725475

Published
2023
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35. Association of SLC22A1, SLC47A1, and KCNJ11 polymorphisms with efficacy and safety of metformin and sulfonylurea combination therapy in Egyptian patients with type 2 diabetes

Author

Aya Ahmed, Hany M Elsadek, Sally M Shalaby, and Hanan M Elnahas

Subjects
metformin and sulfonylurea combination therapy, single nucleotide polymorphisms, type 2 diabetes mellitus., Pharmacy and materia medica, RS1-441
Abstract

Background and purpose: Multidrug and toxin extrusion transporter 1 (MATE1), encoded by the SLC47A1 gene and single nucleotide polymorphisms of organic cation transport 1, may impact metformin's responsiveness and side effects. Inward-rectifier potassium channel 6.2 (Kir 6.2) subunits encoded by KCNJ11 may affect the response to sulfonylurea. This study aimed to evaluate the association between SLC22A1 rs72552763 and rs628031, SLC47A1 rs2289669 and KCNJ11 rs5219 genetic variations with sulfonylurea and metformin combination therapy efficacy and safety in Egyptian type 2 diabetes mellitus patients. Experimental approach: This study was conducted on 100 cases taking at least one year of sulfonylurea and metformin combination therapy. Patients were genotyped via the polymerase chain reaction-restriction fragment length polymorphism technique. Then, according to their glycated hemoglobin level, cases were subdivided into non-responders or responders. Depending on metformin-induced gastrointestinal tract side effects incidence, patients are classified as tolerant or intolerant. Findings/Results: KCNJ11 rs5219 heterozygous and homozygous mutant genotypes, SLC47A1 rs2289669 heterozygous and homozygous mutant genotypes (AA and AG), and mutant alleles of both polymorphisms were significantly related with increased response to combined therapy. Individuals with the SLC22A1 (rs72552763) GAT/del genotype and the SLC22A1 (rs628031) AG and AA genotypes were at a higher risk for metformin-induced gastrointestinal tract adverse effects. Conclusion and implications: The results implied a role for SLC47A1 rs2289669 and KCNJ11 rs5219 in the responsiveness to combined therapy. SLC22A1 (rs628031) and (rs72552763) polymorphisms may be associated with increased metformin adverse effects in type 2 diabetes mellitus patients.

Published
2023
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39. Effect of Stroke Rotation on Discomfort for Assembly Tasks

Author

Bano, Farheen, Mallick, Zulquernain, Khan, Abid Ali, Elnahas, Nabila, Cavas-Martínez, Francisco, Series Editor, Chaari, Fakher, Series Editor, di Mare, Francesca, Series Editor, Gherardini, Francesco, Series Editor, Haddar, Mohamed, Series Editor, Ivanov, Vitalii, Series Editor, Kwon, Young W., Series Editor, Trojanowska, Justyna, Series Editor, Vashista, Meghanshu, editor, Manik, Gaurav, editor, Verma, Om Prakash, editor, and Bhardwaj, Bhuvnesh, editor

Published
2022
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40. Segmüller Flap

Author

Elnahas, Maher, Alfawzan, Mohammed, Almeshal, Obaid, editor, Aldekhayel, Salah, editor, and Alshomer, Feras, editor

Published
2022
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41. Esophageal obstruction due to trichobezoar in a she-camel (Camelus dromedarius)

Author

Isam Eljalii, Mohamed Zabady, Ayman Elnahas, and Turke Shawaf

Subjects
camel, oesophageal obstruction, trichobezoar, Zoology, QL1-991
Abstract

This report describes oesophageal obstruction in camel due to trichobezoar. She camel of two-year-old presented to Veterinary Teaching Hospital, King Faisal University, with a history of inability to swallow and there was food and water regurgitation for one day before. Palpation revealed clear visible mass on neck region about 105 cm caudal to the head. Radiography and endoscopic examination revealed an oval-shaped foreign body embedded in the oesophageal lumen in the level distal third of neck. The foreign body was successfully removed using cervical esophagotomy under general anesthesia. Successful oesophagostomy revealed trichobezoar of 45 g weight and 85X75X42 mm volume. The trichobezoar removed from the oesophagus was the cause of oesophageal obstruction. [Open Vet J 2022; 12(6.000): 855-858]

Published
2022
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42. Optimization of mirtazapine loaded into mesoporous silica nanostructures via Box-Behnken design: in-vitro characterization and in-vivo assessment

Author

Abeer A. Musallam, M. A. Mahdy, Hanan M. Elnahas, and Reem A. Aldeeb

Subjects
Mirtazapine, mesoporous silica nanostructures, box-behnken design, oral bioavailability, in-vivo study, Therapeutics. Pharmacology, RM1-950
Abstract

Employment of mesoporous silica nanostructures (MSNs) in the drug delivery field has shown a significant potential for improving the oral delivery of active pharmaceutical products with low solubility in water. Mirtazapine (MRT) is a tetracyclic antidepressant with poor water solubility (BCS Class II), which was recently approved as a potent drug used to treat severe depression. The principle of this research is to optimize the incorporation of Mirtazapine into MSNs to improve its aqueous solubility, loading efficiency, release performance, and subsequent bioavailability. The formulation was optimized by using of Box-Behnken Design, which allows simultaneous estimation of the impact of different types of silica (SBA-15, MCM-41, and Aluminate-MCM-41), a different drug to silica ratios (33.33%, 49.99%, and 66.66%), and different drug loading procedures (Incipient wetness, solvent evaporation, and solvent impregnation) on the MRT loading efficiency, aqueous solubility and dissolution rate. The optimized formula was achieved by loading MRT into SBA-15 at 33.33% drug ratio prepared by the incipient wetness method, which displayed a loading efficiency of 104.05%, water solubility of 0.2 mg/ml, and 100% dissolution rate after 30 min. The pharmacokinetic profile of the optimized formula was obtained by conducting the in-vivo study in rabbits which showed a marked improvement (2.14-fold) in oral bioavailability greater than plain MRT. The physicochemical parameters and morphology of the optimized formula were characterized by; gas adsorption manometry, scanning electron microscopy (SEM), polarized light microscopy (PLM), Fourier-transform infrared spectroscopy (FT-IR), differential scanning calorimetry (DSC), and X-ray powder diffraction (XRPD).

Published
2022
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44. Prediction of local breast cancer recurrence after surgery: the added value of diffusion tensor imaging

Author

Mohamed Magdy Mohamed El Rakhawy, Nermin Soliman, Waleed Elnahas, Rasha Karam, and Ahmed Mohamed Abdel-Khalek

Subjects
Breast, DTI, Postoperative, MRI, Cancer, Recurrence, Medical physics. Medical radiology. Nuclear medicine, R895-920
Abstract

Abstract Background There is considerable overlap between benign postoperative changes and recurrent breast cancer imaging features in patients surgically treated for breast cancer. This study aims to evaluate the value of adding multiple diffusion tensor imaging (DTI) parameters, including mean diffusivity (MD), fractional anisotropy (FA), radial diffusivity (RD), axial diffusivity, (AD), and relative anisotropy (RA) in differentiating breast cancer recurrence from postoperative changes in patients who were surgically treated for breast cancer and to also evaluate the role of these parameters in characterizing the different pathologies seen in the postoperative breast. Results This is a prospective study that was performed on female patients who were surgically treated for breast cancer. The study was done on 60 cases having 77 breast lesions. (Sixty-two of them were described as mass lesions and 15 of them were described as non-mass enhancement on MRI.) Among analyzed DTI parameters, MD showed the highest sensitivity (97.1%), specificity (88.1%), and accuracy (92.2%) in predicting recurrent breast cancer. FA, AD, and RD showed sensitivity (77.1%, 85.7%, and 88.6%) and specificity (83.3%, 83.3%, and 73.8%) in predicting recurrent breast cancer, respectively. The median MD values were lower in grade III recurrent breast cancers when compared to its values in recurrent grade II breast cancers and recurrent DCIS (0.6 × 10–3 mm2/s vs. 0.8 × 10–3 mm2/s and 0.9 × 10–3 mm2/s), respectively. FA also showed median values in grade III recurrent breast cancer higher than its values in grade II recurrent breast cancer and recurrent DCIS (0.6 vs. 0.5 and 0.39), respectively. The sensitivity, specificity, PPV, NPV, accuracy, F1 score, and MCC of DCE-MRI alone versus DCE-MRI plus combined DTI parameters were 88.6% versus 100%, 88.1% versus 90.5%, 86.1% versus 89.7%, 90.2% versus 100%, 88.3% versus 94.6%, 87.3% versus 94.6%, and 76.5% versus 90.1%, respectively. Conclusions DTI may play an important role as a complementary method to discriminate recurrent breast cancer from postoperative changes in patients surgically treated for previous breast cancer.

Published
2022
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46. The Exploitation of pH-Responsive Eudragit-Coated Mesoporous Silica Nanostructures in the Repurposing of Terbinafine Hydrochloride for Targeted Colon Cancer Inhibition: Design Optimization, In Vitro Characterization, and Cytotoxicity Assessment

Author

Mohammad H. Alyami, Abeer A. Musallam, Tarek M. Ibrahim, Mahmoud A. Mahdy, Hanan M. Elnahas, and Reem A. Aldeeb

Subjects
terbinafine hydrochloride, drug repurposing, pH-responsive mesoporous silica nanostructures, Eudragit, DiSupLo technique, targeted therapy, Pharmacy and materia medica, RS1-441
Abstract

Targeted drug delivery is achieving great success in cancer therapy due to its potential to deliver drugs directly to the action site. Terbinafine hydrochloride (TER) is a broad-spectrum anti-fungal drug that has been found to have some potential anti-tumor effects in the treatment of colon cancer. We aimed here to design and develop pH-sensitive Eudragit (Eud)-coated mesoporous silica nanostructures (MSNs) to control drug release in response to changes in pH. The diffusion-supported loading (DiSupLo) technique was applied for loading TER into the MSNs. The formulation was optimized by a D-optimal design, which permits the concurrent assessment of the influence of drug/MSN%, coat concentration, and MSN type on the drug entrapment efficiency (EE) and its release performance. The optimal formula displayed a high EE of 96.49%, minimizing the release in pH 1.2 to 16.15% and maximizing the release in pH 7.4 to 78.09%. The cytotoxicity of the optimal formula on the colon cancer cells HT-29 was higher than it was with TER alone by 2.8-fold. Apoptosis in cancer cells exposed to the optimum formula was boosted as compared to what it was with the plain TER by 1.2-fold and it was more efficient in arresting cells during the G0/G1 and S stages of the cell cycle. Accordingly, the repurposing of TER utilizing Eud/MSNs is a promising technique for targeted colon cancer therapy.

Published
2023
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