224 results on '"Ellis, Ruth"'
Search Results
2. What does it take to successfully retain organisational cluster sites? : a mixed-methods, collective case study examining retention processes in the Reducing Smoking Initiation in Young Adults RCT
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Simms-Ellis, Ruth Elizabeth, Madill, Anna, and Conner, Mark
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362.29 - Abstract
Achieving high retention rates in cluster trials is challenging. Evidence in the literature predominantly addresses participant-level retention and theoretical insight into the dynamics of effective retention is missing. This thesis aimed to investigate how successful cluster retention happens, and offer theoretical explanations for retention. A systematic review was conducted which identified strategies to promote cluster-level retention. Whilst some participant-level strategies were generalisable to clusters, five uniquely cluster-related, additional strategies were found. Cluster retention was found to be under-researched, particularly researchers’ experiences of managing clusters. Participants’ voices and relational aspects of retention also appeared to be under-represented. A collective case study design was used to scrutinise processes operating within a school-based, pragmatic cluster RCT with successful retention outcomes. Key stakeholders’ trial experiences were investigated through interviews, focus groups and documentation analysis. Study 1 identified that personal qualities of in-site teacher-coordinators and the researchers’ extensive investment in these relationships appeared to support retention, even in ‘unhealthy’ organisational contexts. In study 2 trial staff reported perceiving an ever-present risk of disengagement, with retention demanding complex, hidden intrapersonal and relational work. Interviews with teachers delivering the intervention/control in Study 3 highlighted their significant personal responsibility for student engagement. Student focus group findings (Study 4) suggested that school engagement builds classroom-by-classroom: student engagement was contingent on teachers’ ability/willingness to create a supportive climate and ‘make the lesson work’. Study 5 reported a positive impact on school engagement of a £39,000 Engagement Promotion Programme. Schools valued highly complex skills exchanges and services, beyond transactional objects. Evidence from the thesis suggests that multiple inter-relational complexities influence site retention, beyond traditional transactional strategies. Cluster trials are re-interpreted as inter-organisational collaborations and the task of retention more accurately defined as risk management. Retention is theorised as resulting from extensive relational work, meaningful social exchange and social influence.
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- 2020
3. The Ones Who Remember: Second-Generation Voices of the Holocaust
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Rita Benn, Julie Goldstein Ellis, Ruth Finkel Wade, Joy Wolfe Ensor, Rita Benn, Julie Goldstein Ellis, Ruth Finkel Wade, Joy Wolfe Ensor and Rita Benn, Julie Goldstein Ellis, Ruth Finkel Wade, Joy Wolfe Ensor, Rita Benn, Julie Goldstein Ellis, Ruth Finkel Wade, Joy Wolfe Ensor
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- 2022
4. Evaluating a Strategy for Implementation and Sustainability of School-Based Health Centers in 3 Disparate Communities
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Johnson, Veda, Ellis, Ruth S., and Hutcherson, Valerie
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Background: School-based health centers (SBHCs) increase access to health care and improve academic achievement for underserved students. We report on the test of a strategy to take SBHCs to scale by addressing the issues of community need and support and financial sustainability. Methods: Using mixed methods, we collected data on student enrollment, utilization, health outcomes, seat time, patient revenues, surveys and key informant interviews from SBHCs located in 3 geographically and demographically different communities over a 2-year period. Results: The 3 health centers were comparable in their capacity to implement their operations and achieve quality outcomes but varied considerably in their abilities to achieve sustainability after 2 years of operation. All participated in a planning phase and were able to achieve community buy in and support which impacted their implementation. Only one of the SBHCs which had the highest patient utilization was able to generate enough revenue from patient billings to become sustainable after the second year. Conclusion: Expanding SBHCs requires a period of planning to generate community buy in and support which is required for successful implementation. Sustainability requires sustained high clinic utilization and is enhanced by health centers that are able to receive high Medicaid reimbursements.
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- 2020
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5. Patient and Family Involvement in Serious Incident Investigations From the Perspectives of Key Stakeholders: A Review of the Qualitative Evidence
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Ramsey, Lauren, McHugh, Siobhan, Simms-Ellis, Ruth, Perfetto, Kayley, and O’Hara, Jane K.
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- 2022
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6. Reboot coaching programme: a mixed-methods evaluation assessing resilience, confidence, burnout and depression in medical students
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Johnson, Judith, primary, Pointon, Lucy, additional, Talbot, Rebecca, additional, Coleman, Rebecca, additional, Budworth, Luke, additional, Simms-Ellis, Ruth, additional, Vogt, Katharina, additional, Tsimpida, Dialechti, additional, Biyani, Chandra Shekha, additional, Harrison, Reema, additional, Cheung, Gloria, additional, Melville, Colin, additional, Jayagopal, Vijay, additional, and Lea, William, additional
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- 2023
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7. Reboot coaching programme: a mixed-methods evaluation assessing resilience, confidence, burnout and depression in medical students.
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Johnson, Judith, Pointon, Lucy, Talbot, Rebecca, Coleman, Rebecca, Budworth, Luke, Simms-Ellis, Ruth, Vogt, Katharina, Tsimpida, Dialechti, Biyani, Chandra Shekha, Harrison, Reema, Cheung, Gloria, Melville, Colin, Jayagopal, Vijay, and Lea, William
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- 2024
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8. Safety and immunogenicity of the novel tuberculosis vaccine ID93 + GLA-SE in BCG-vaccinated healthy adults in South Africa: a randomised, double-blind, placebo-controlled phase 1 trial
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Penn-Nicholson, Adam, Tameris, Michele, Smit, Erica, Day, Tracey A, Musvosvi, Munyaradzi, Jayashankar, Lakshmi, Vergara, Julie, Mabwe, Simbarashe, Bilek, Nicole, Geldenhuys, Hendrik, Luabeya, Angelique Kany-Kany, Ellis, Ruth, Ginsberg, Ann M, Hanekom, Willem A, Reed, Steven G, Coler, Rhea N, Scriba, Thomas J, and Hatherill, Mark
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- 2018
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9. Can we prepare healthcare professionals and students for involvement in stressful healthcare events? A mixed-methods evaluation of a resilience training intervention
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Johnson, Judith, Simms-Ellis, Ruth, Janes, Gillian, Mills, Thomas, Budworth, Luke, Atkinson, Lauren, and Harrison, Reema
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- 2020
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10. Evaluation of the reboot coaching workshops among urology trainees: A mixed method approach
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Al‐Ghunaim, Tmam, primary, Johnson, Judith, additional, Biyani, Chandra Shekhar, additional, Coleman, Rebecca, additional, Simms‐Ellis, Ruth, additional, and O'Connor, Daryl B., additional
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- 2023
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11. Critical care nursing workforce in crisis: A discussion paper examining contributing factors, the impact of the COVID‐19 pandemic and potential solutions.
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Vogt, Katharina Sophie, Simms‐Ellis, Ruth, Grange, Angela, Griffiths, Megan Elizabeth, Coleman, Rebecca, Harrison, Reema, Shearman, Nathan, Horsfield, Claire, Budworth, Luke, Marran, Jayne, and Johnson, Judith
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PSYCHOLOGICAL burnout , *WELL-being , *INTENSIVE care nursing , *SOCIAL support , *CHANGE management , *HEALTH facility administration , *POST-traumatic stress disorder , *FLEXTIME , *CRITICAL care nurses , *RISK assessment , *LABOR turnover , *EMPLOYEE assistance programs , *ORGANIZATIONAL change , *INDUSTRIAL hygiene , *COVID-19 pandemic , *PSYCHOLOGICAL resilience , *EMPLOYEE retention , *HOSPITAL administration - Abstract
Aims and Objectives: The critical care nursing workforce is in crisis, with one‐third of critical care nurses worldwide intending to leave their roles. This paper aimed to examine the problem from a wellbeing perspective, offering implications for research, and potential solutions for organisations. Design: Discursive/Position paper. Method: The discussion is based on the nursing and wellbeing literature. It is guided by the authors' collaborative expertise as both clinicians and researchers. Data were drawn from nursing and wellbeing peer‐reviewed literature, such as reviews and empirical studies, national surveys and government and thinktank publications/reports. Results: Critical care nurses have been disproportionately affected by the COVID‐19 pandemic with studies consistently showing critical care nurses to have the worst psychological outcomes on wellbeing measures, including depression, burnout and post‐traumatic stress disorder (PTSD). These findings are not only concerning for the mental wellbeing of critical care nurses, they also raise significant issues for healthcare systems/organisations: poor wellbeing, increased burnout and PTSD are directly linked with critical care nurses intending to leave the profession. Thus, the wellbeing of critical care nurses must urgently be supported. Resilience has been identified as a protective mechanism against the development of PTSD and burnout, thus offering evidence‐based interventions that address resilience and turnover have much to offer in tackling the workforce crisis. However, turnover data must be collected by studies evaluating resilience interventions, to further support their evidence base. Organisations cannot solely rely on the efficacy of these interventions to address their workforce crisis but must concomitantly engage in organisational change. Conclusions: We conclude that critical care nurses are in urgent need of preventative, evidence‐based wellbeing interventions, and make suggestions for research and practice. [ABSTRACT FROM AUTHOR]
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- 2023
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12. How Is Stress Reduced by a Workplace Mindfulness Intervention? A Qualitative Study Conceptualising Experiences of Change
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Hugh-Jones, Siobhan, Rose, Sally, Koutsopoulou, Gina Z., and Simms-Ellis, Ruth
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- 2018
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13. Malaria Vaccine Development
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Wu, Yimin, Ellis, Ruth, Miura, Kazutoyo, Narum, David, Miller, Louis H., and Georgiev, Vassil St., editor
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- 2010
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14. The TLR-4 agonist adjuvant, GLA-SE, improves magnitude and quality of immune responses elicited by the ID93 tuberculosis vaccine: first-in-human trial
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Coler, Rhea N., Day, Tracey A., Ellis, Ruth, Piazza, Franco M., Beckmann, Anna Marie, Vergara, Julie, Rolf, Tom, Lu, Lenette, Alter, Galit, Hokey, David, Jayashankar, Lakshmi, Walker, Robert, Snowden, Margaret Ann, Evans, Tom, Ginsberg, Ann, Reed, Steven G., and The TBVPX-113 Study Team
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- 2018
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15. Optimization and Interpretation of Serial QuantiFERON Testing to Measure Acquisition of Mycobacterium tuberculosis Infection
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Nemes, Elisa, Rozot, Virginie, Geldenhuys, Hennie, Bilek, Nicole, Mabwe, Simbarashe, Abrahams, Deborah, Makhethe, Lebohang, Erasmus, Mzwandile, Keyser, Alana, Toefy, Asma, Cloete, Yolundi, Ratangee, Frances, Blauenfeldt, Thomas, Ruhwald, Morten, Walzl, Gerhard, Smith, Bronwyn, Loxton, Andre G., Hanekom, Willem A., Andrews, Jason R., Lempicki, Maria D., Ellis, Ruth, Ginsberg, Ann M., Hatherill, Mark, and Scriba, Thomas J.
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- 2017
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16. Diagnostic Accuracy of Early Secretory Antigenic Target-6–Free Interferon-gamma Release Assay Compared to QuantiFERON-TB Gold In-tube
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Nemes, Elisa, Abrahams, Deborah, Scriba, Thomas J, Ratangee, Frances, Keyser, Alana, Makhethe, Lebohang, Erasmus, Mzwandile, Mabwe, Simbarashe, Bilek, Nicole, Rozot, Virginie, Geldenhuys, Hennie, Hatherill, Mark, Lempicki, Maria D, Holm, Line Lindebo, Bogardus, Leah, Ginsberg, Ann M, Blauenfeldt, Thomas, Smith, Bronwyn, Ellis, Ruth D, Loxton, Andre G, Walzl, Gerhard, Andersen, Peter, and Ruhwald, Morten
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Male ,Antigens, Bacterial ,Adolescent ,diagnosis ,Reproducibility of Results ,Mycobacterium tuberculosis ,bacterial infections and mycoses ,Cohort Studies ,Interferon-gamma ,Editorial Commentary ,Major Articles and Commentaries ,tuberculosis infection ,Bacterial Proteins ,ROC Curve ,IFN-γ release assay ,Humans ,Tuberculosis ,Female ,Reagent Kits, Diagnostic ,qualification ,Child ,Tuberculosis Vaccines ,Interferon-gamma Release Tests - Abstract
Background Early secretory antigenic target-6 (ESAT-6) is an immunodominant Mycobacterium tuberculosis (M.tb) antigen included in novel vaccines against tuberculosis (TB) and in interferon-gamma (IFN-γ) release assays (IGRAs). Therefore, the availability of an ESAT-6–free IGRA is essential to determine M.tb infection status following vaccination with ESAT-6–containing vaccines. We aimed to qualify a recently developed ESAT-6–free IGRA and to assess its diagnostic performance in comparison to QuantiFERON-TB Gold In-tube (QFT). Methods Participants with different levels of M.tb exposure and TB disease were enrolled to determine the ESAT-6–free IGRA cutoff, test assay performance in independent cohorts compared to standard QFT, and perform a technical qualification of antigen-coated blood collection tubes. Results ESAT-6–free IGRA antigen recognition was evaluated in QFT-positive and QFT-negative South African adolescents. The ESAT-6–free IGRA cutoff was established at 0.61 IU/mL, based on receiver operating characteristic analysis in M.tb-unexposed controls and microbiologically confirmed pulmonary TB patients. In an independent cohort of healthy adolescents, levels of IFN-γ released in QFT and ESAT-6–free IGRA were highly correlated (P < .0001, r = 0.83) and yielded comparable positivity rates, 41.5% and 43.5%, respectively, with 91% concordance between the tests (kappa = 0.82; 95% confidence interval, 0.74–0.90; McNemar test P = .48). ESAT-6–free IGRA blood collection tubes had acceptable lot-to-lot variability, precision, and stability. Conclusions The novel ESAT-6–free IGRA had diagnostic accuracy comparable to QFT and is suitable for use in clinical trials to assess efficacy of candidate TB vaccines to prevent established M.tb infection., The novel early secretory antigenic target-6 (ESAT-6)–free interferon-gamma release assay has comparable diagnostic performance for Mycobacterium tuberculosis (M.tb) infection as the QuantiFERON-TB Gold assay and is suitable for diagnosing M.tb infection in clinical trials of ESAT-6–containing tuberculosis vaccines.
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- 2019
17. Patient and family involvement in serious incident investigations
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O'Hara, Jane, primary and Simms-Ellis, Ruth, additional
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- 2021
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18. Can we prepare healthcare professionals and students for involvement in stressful healthcare events? Feasibility study of a resilience training intervention
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Johnson, Judith, Simms-Ellis, Ruth, Janes, Gillian, Mills, Thomas, Budworth, Luke, Atkinson, Lauren, and Harrison, Reema
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education - Abstract
Background Healthcare professionals are experiencing unprecedented levels of occupational stress and burnout. Higher stress and burnout in health professionals is linked with the delivery of poorer quality, less safe patient care across healthcare settings. In order to understand how we can better support healthcare professionals in the workplace, this study evaluated a tailored resilience coaching intervention comprising a workshop and one-to-one coaching session addressing the intrinsic challenges of healthcare work in health professionals and students. Methods The evaluation used an uncontrolled before-and-after design with four data-collection time points: baseline (T1); after the workshop (T2); after the coaching session (T3) and four-to-six weeks post-baseline (T4). Quantitative outcome measures were Confidence in Coping with Adverse Events (‘Confidence’), a Knowledge assessment (‘Knowledge’) and Resilience. At T4, qualitative interviews were also conducted with a subset of participants exploring participant experiences and perceptions of the intervention. Results We recruited 66 participants, retaining 62 (93.9%) at T2, 47 (71.2%) at T3, and 33 (50%) at T4. Compared with baseline, Confidence was significantly higher post-intervention: T2 (unadj. β = 2.43, 95% CI 2.08–2.79, d = 1.55, p
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- 2020
19. Multiple meanings of resilience: Health professionals' experiences of a dual element training intervention designed to help them prepare for coping with error.
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Janes, Gillian, Harrison, Reema, Johnson, Judith, Simms‐Ellis, Ruth, Mills, Thomas, and Lawton, Rebecca
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ATTITUDES of medical personnel ,WORK ,RESEARCH methodology ,MEDICAL personnel ,INTERVIEWING ,MEDICAL errors ,PRE-tests & post-tests ,PSYCHOSOCIAL factors ,EXPERIENTIAL learning ,PSYCHOLOGICAL adaptation ,THEMATIC analysis ,EMOTIONS ,PSYCHOLOGICAL resilience - Abstract
Rationale, aims and objectives: Consistent data demonstrates negative psychological effects of caregiving on front‐line health professionals. Evidence that psychological resilience factors can help minimize distress and the potential for low‐cost interventions have created interest in resilience‐based development programmes; yet evidence of perceived value amongst health professionals is lacking. This study explored health professionals' experiences and perceptions of a novel, resilience‐based intervention designed to pro‐actively prepare staff for coping with error; to investigate their perceptions of what resilience meant to them, the relevance of the intervention, and impact of participation on ability to cope with error. Methods: Semi‐structured interviews 4‐6 weeks post intervention with 23 randomly selected participants from seven cohorts (midwives, paediatricians, obstetricians/gynaecologists, paramedics) and trainees (physician associates, mammographers, sonographers). Thematic analysis of interview data. Findings: Participants reported various interpretations of, and a shift in perception regarding what the concept of psychological resilience meant to them and their practice. These included for example, resilience as a positive or negative concept and their awareness and response to a range of personal, organizational and system factors influencing personal resilience. They valued the prophylactic, clinically relevant, interactive and applied nature of the intervention; having developed and applied valuable skills beyond the context of involvement in error, noting that individuals needed to be willing to explore their own coping mechanisms and human fallibility to gain maximum benefit. There was also consensus that whilst proactively developing individual level psychological resilience is important, so too is addressing the organizational and system factors that affect staff resilience which are outside individual staff control. Conclusion: Enhancing resilience appears to be considered useful in supporting staff to prepare for coping with error and the wider emotional burden of clinical work, but such interventions require integration into wider system approaches to reduce the burden of clinical work for health professionals. [ABSTRACT FROM AUTHOR]
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- 2022
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20. Multiple meanings of resilience: Health professionals' experiences of a dual element training intervention designed to help them prepare for coping with error
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Janes, Gillian, primary, Harrison, Reema, additional, Johnson, Judith, additional, Simms‐Ellis, Ruth, additional, Mills, Thomas, additional, and Lawton, Rebecca, additional
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- 2021
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21. Association between age at first reported e‐cigarette use and subsequent regular e‐cigarette, ever cigarette and regular cigarette use
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Conner, Mark, primary, Grogan, Sarah, additional, Simms‐Ellis, Ruth, additional, Cowap, Lisa, additional, Armitage, Christopher J., additional, West, Robert, additional, Marshall, Anna‐Marie, additional, and Siddiqi, Kamran, additional
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- 2021
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22. Additional file 1 of Can we prepare healthcare professionals and students for involvement in stressful healthcare events? A mixed-methods evaluation of a resilience training intervention
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Johnson, Judith, Simms-Ellis, Ruth, Janes, Gillian, Mills, Thomas, Budworth, Luke, Atkinson, Lauren, and Harrison, Reema
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Data_FILES - Abstract
Additional file 1.
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- 2020
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23. Multiple meanings of resilience: Health professionals’ experiences of a dual element training intervention designed to help them prepare for coping with error.
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Janes, Gillian, primary, Harrison, Reema, additional, Johnson, Judith, additional, Simms-Ellis, Ruth, additional, Mills, Tom, additional, and Lawton, Rebecca, additional
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- 2020
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24. 33. Intranasal M2SR (M2-deficient Single Replication) Live H3N2 Influenza Investigational Vaccine Induces Serum HAI & Broad Immune Responses in High Proportion of Adults
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Eiden, Joseph, primary, Ellis, Ruth, additional, Fierro, Carlos, additional, Schwartz, Howard, additional, Adams, Mark, additional, Ellis, Kimberly, additional, Aitchison, Roger, additional, Herber, Renee, additional, and Bilsel, Pamuk, additional
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- 2020
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25. Can growth inhibition assays (GIA) predict blood-stage malaria vaccine efficacy?
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Duncan, Christopher J.A., Hill, Adrian V.S., and Ellis, Ruth D.
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- 2012
26. Evaluating a Strategy for Implementation and Sustainability of School‐Based Health Centers in 3 Disparate Communities
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Johnson, Veda, primary, Ellis, Ruth S., additional, and Hutcherson, Valerie, additional
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- 2020
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27. Blood stage vaccines for Plasmodium falciparum: Current status and the way forward
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Ellis, Ruth D., Sagara, Issaka, Doumbo, Ogobara, and Wu, Yimin
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- 2010
28. 2748. Single Intranasal (IN) Dose of M2SR (M2-Deficient Single Replication) Live Influenza Vaccine Protects Adults Against Subsequent Challenge with a Substantially Drifted H3N2 Strain
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Eiden, Joseph, primary, Volckaert, Bram, additional, Rudenko, Oleg, additional, Ellis, Ruth, additional, Aitchison, Roger, additional, Herber, Renee, additional, Belshe, Robert, additional, Greenberg, Harry, additional, Coelingh, Kathleen, additional, Kawaoka, Yoshihiro, additional, Neumann, Gabriele, additional, and Bilsel, Pamuk, additional
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- 2019
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29. Effectiveness and cost-effectiveness of repeated implementation intention formation plus anti-smoking messages on adolescent smoking initiation:A cluster randomized controlled trial
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Conner, Mark, Grogan, Sarah, West, Robert, Simms-Ellis, Ruth, Scholtens, Keira, Sykes-Muskett, Bianca, Cowap, Lisa, Lawton, Rebecca, Armitage, Christopher J, Meads, David, Schmitt, Laetitia, Torgerson, Carole, and Siddiqi, Kamran
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ResearchInstitutes_Networks_Beacons/MICRA ,Manchester Institute for Collaborative Research on Ageing - Abstract
Objective: Forming implementation intentions (if-then plans) about how to refuse cigarette offers plus anti-smoking messages was tested for reducing adolescent smoking.Method: Cluster randomized controlled trial with schools randomized (1:1) to receive implementation intention intervention and messages targeting not smoking (intervention) or completing homework (control). Adolescents (11-12 years at baseline) formed implementation intentions and read messages on eight occasions over four years meaning masking treatment allocation was not possible. Outcomes were: follow-up (48 months) ever smoking, any smoking in last 30 days, regular smoking, and breath carbon monoxide levels. Analyses excluded baseline ever smokers, controlled for clustering by schools and examined effects of controlling for demographic variables. Economic evaluation (incremental cost effectiveness ratio; ICER) was conducted. Trial is registered (ISRCTN27596806).Results: Schools were randomly allocated (September-October 2012) to intervention (n=25) or control (n=23). At follow-up, among 6155 baseline never smokers from 45 retained schools, ever smoking was significantly lower (RR = 0·83, 95%CI = 0·71, 0·97, p = ·016) in intervention (29·3%) compared to control (35·8%) and remained so controlling for demographics. Similar patterns observed for any smoking in last 30 days. Less consistent effects were observed for regular smoking and breath carbon monoxide levels. Economic analysis yielded an ICER of $134 per ever smoker avoided at age 15-16 years.Conclusions: This pragmatic trial supports the use of repeated implementation intentions about how to refuse the offer of a cigarette plus anti-smoking messages as an effective and cost-effective intervention to reduce smoking initiation in adolescents.
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- 2019
30. Patterns and predictors of e‐cigarette, cigarette and dual use uptake in UK adolescents: evidence from a 24‐month prospective study
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Conner, Mark, primary, Grogan, Sarah, additional, Simms‐Ellis, Ruth, additional, Scholtens, Keira, additional, Sykes‐Muskett, Bianca, additional, Cowap, Lisa, additional, Lawton, Rebecca, additional, Armitage, Christopher J., additional, Meads, David, additional, Schmitt, Laetitia, additional, Torgerson, Carole, additional, West, Robert, additional, and Siddiqi, Kamran, additional
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- 2019
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31. Evidence that an intervention weakens the relationship between adolescent electronic cigarette use and tobacco smoking: a 24-month prospective study
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Conner, Mark, primary, Grogan, Sarah, additional, Simms-Ellis, Ruth, additional, Flett, Keira, additional, Sykes-Muskett, Bianca, additional, Cowap, Lisa, additional, Lawton, Rebecca, additional, Armitage, Christopher, additional, Meads, David, additional, Schmitt, Laetitia, additional, Torgerson, Carole, additional, West, Robert, additional, and Siddiqi, Kamran, additional
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- 2019
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32. Supporting doctors who make mistakes
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Lawton, Rebecca, primary, Johnson, Judith, additional, Janes, Gillian, additional, Foy, Robbie, additional, and Simms-Ellis, Ruth, additional
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- 2019
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33. Effectiveness and cost-effectiveness of repeated implementation intention formation on adolescent smoking initiation: A cluster randomized controlled trial.
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Conner, Mark, primary, Grogan, Sarah, additional, West, Robert, additional, Simms-Ellis, Ruth, additional, Scholtens, Keira, additional, Sykes-Muskett, Bianca, additional, Cowap, Lisa, additional, Lawton, Rebecca, additional, Armitage, Christopher J., additional, Meads, David, additional, Schmitt, Laetitia, additional, Torgerson, Carole, additional, and Siddiqi, Kamran, additional
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- 2019
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34. Anaemia in a phase 2 study of a blood stage falciparum malaria vaccine
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Guindo Aldiouma, Guindo Merepen A, Miura Kazutoyo, Dicko Alassane, Sagara Issaka, Fay Michael P, Ellis Ruth D, Sissoko Mahamadou S, Doumbo Ogobara K, and Diallo Dapa
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Arctic medicine. Tropical medicine ,RC955-962 ,Infectious and parasitic diseases ,RC109-216 - Abstract
Abstract Background A Phase 1-2b study of the blood stage malaria vaccine AMA1-C1/Alhydrogel was conducted in 336 children in Donéguébougou and Bancoumana, Mali. In the Phase 2 portion of the study (n = 300), no impact on parasite density or clinical malaria was seen; however, children who received the study vaccine had a higher frequency of anaemia (defined as haemoglobin < 8.5 g/dL) compared to those who received the comparator vaccine (Hiberix). This effect was one of many tested and was not significant after adjusting for multiple comparisons. Methods To further investigate the possible impact of vaccination on anaemia, additional analyses were conducted including patients from the Phase 1 portion of the study and controlling for baseline haemoglobin, haemoglobin types S or C, alpha-thalassaemia, G6PD deficiency, and age. A multiplicative intensity model was used, which generalizes Cox regression to allow for multiple events. Frailty effects for each subject were used to account for correlation of multiple anaemia events within the same subject. Intensity rates were calculated with reference to calendar time instead of time after randomization in order to account for staggered enrollment and seasonal effects of malaria incidence. Associations of anaemia with anti-AMA1 antibody were further explored using a similar analysis. Results A strong effect of vaccine on the incidence of anaemia (risk ratio [AMA1-C1 to comparator (Hiberix)]= 2.01, 95% confidence interval [1.26,3.20]) was demonstrated even after adjusting for baseline haemoglobin, haemoglobinopathies, and age, and using more sophisticated statistical models. Anti-AMA1 antibody levels were not associated with this effect. Conclusions While these additional analyses show a robust effect of vaccination on anaemia, this is an intensive exploration of secondary results and should, therefore, be interpreted with caution. Possible mechanisms of the apparent adverse effect on haemoglobin of vaccination with AMA1-C1/Alhydrogel and implications for blood stage vaccine development are discussed. The potential impact on malaria-associated anaemia should be closely evaluated in clinical trials of AMA1 and other blood stage vaccines in malaria-exposed populations.
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- 2011
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35. Lack of allele-specific efficacy of a bivalent AMA1 malaria vaccine
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Ellis Ruth D, Duan Junhui, Niangaly Amadou, Dicko Alassane, Sagara Issaka, Saye Renion, Takala-Harrison Shannon, Mu Jianbing, Ouattara Amed, Miller Louis H, Su Xin-zhuan, Plowe Christopher V, and Doumbo Ogobara K
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Arctic medicine. Tropical medicine ,RC955-962 ,Infectious and parasitic diseases ,RC109-216 - Abstract
Abstract Background Extensive genetic diversity in vaccine antigens may contribute to the lack of efficacy of blood stage malaria vaccines. Apical membrane antigen-1 (AMA1) is a leading blood stage malaria vaccine candidate with extreme diversity, potentially limiting its efficacy against infection and disease caused by Plasmodium falciparum parasites with diverse forms of AMA1. Methods Three hundred Malian children participated in a Phase 2 clinical trial of a bivalent malaria vaccine that found no protective efficacy. The vaccine consists of recombinant AMA1 based on the 3D7 and FVO strains of P. falciparum adjuvanted with aluminum hydroxide (AMA1-C1). The gene encoding AMA1 was sequenced from P. falciparum infections experienced before and after immunization with the study vaccine or a control vaccine. Sequences of ama1 from infections in the malaria vaccine and control groups were compared with regard to similarity to the vaccine antigens using several measures of genetic diversity. Time to infection with parasites carrying AMA1 haplotypes similar to the vaccine strains with respect to immunologically important polymorphisms and the risk of infection with vaccine strain haplotypes were compared. Results Based on 62 polymorphic AMA1 residues, 186 unique ama1 haplotypes were identified among 315 ama1 sequences that were included in the analysis. Eight infections had ama1 sequences identical to 3D7 while none were identical to FVO. Several measures of genetic diversity showed that ama1 sequences in the malaria vaccine and control groups were comparable both at baseline and during follow up period. Pre- and post-immunization ama1 sequences in both groups all had a similar degree of genetic distance from FVO and 3D7 ama1. No differences were found in the time of first clinical episode or risk of infection with an AMA1 haplotype similar to 3D7 or FVO with respect to a limited set of immunologically important polymorphisms found in the cluster 1 loop of domain I of AMA1. Conclusion This Phase 2 trial of a bivalent AMA1 malaria vaccine found no evidence of vaccine selection or strain-specific efficacy, suggesting that the extreme genetic diversity of AMA1 did not account for failure of the vaccine to provide protection.
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- 2010
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36. Combining viral vectored and protein-in-adjuvant vaccines against the blood-stage malaria antigen AMA1: report on a phase 1a clinical trial
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Hodgson, Susanne H, Choudhary, Prateek, Elias, Sean C, Milne, Kathryn H, Rampling, Thomas W, Biswas, Sumi, Poulton, Ian D, Miura, Kazutoyo, Douglas, Alexander D, Alanine, Daniel GW, Illingworth, Joseph J, de Cassan, Simone C, Zhu, Daming, Nicosia, Alfredo, Long, Carole A, Moyle, Sarah, Berrie, Eleanor, Lawrie, Alison M, Wu, Yimin, Ellis, Ruth D, Hill, Adrian V S, Draper, Simon J, Hodgson, Susanne H, Choudhary, Prateek, Elias, Sean C, Milne, Kathryn H, Rampling, Thomas W, Biswas, Sumi, Poulton, Ian D, Miura, Kazutoyo, Douglas, Alexander D, Alanine, Daniel Gw, Illingworth, Joseph J, De Cassan, Simone C, Zhu, Daming, Nicosia, Alfredo, Long, Carole A, Moyle, Sarah, Berrie, Eleanor, Lawrie, Alison M, Wu, Yimin, Ellis, Ruth D, Hill, Adrian V. S, and Draper, Simon J.
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Adult ,Male ,Oligodeoxyribonucleotide ,Genetic Vectors ,Plasmodium falciparum ,Immunization, Secondary ,Aluminum Hydroxide ,Antigens, Protozoan ,Orthopoxvirus ,complex mixtures ,Young Adult ,Adjuvants, Immunologic ,Genetic ,Malaria Vaccine ,Drug Discovery ,parasitic diseases ,Malaria Vaccines ,Genetics ,Humans ,Malaria, Falciparum ,Molecular Biology ,Pharmacology ,Drug Discovery3003 Pharmaceutical Science ,Vaccination ,Orthopoxviru ,Middle Aged ,Combined Modality Therapy ,Oligodeoxyribonucleotides ,Adenoviruses, Simian ,Molecular Medicine ,Original Article ,Genetic Vector ,Human - Abstract
The development of effective vaccines against difficult disease targets will require the identification of new subunit vaccination strategies that can induce and maintain effective immune responses in humans. Here we report on a phase 1a clinical trial using the AMA1 antigen from the blood-stage Plasmodium falciparum malaria parasite delivered either as recombinant protein formulated with Alhydrogel adjuvant with and without CPG 7909, or using recombinant vectored vaccines--chimpanzee adenovirus ChAd63 and the orthopoxvirus MVA. A variety of promising "mixed-modality" regimens were tested. All volunteers were primed with ChAd63, and then subsequently boosted with MVA and/or protein-in-adjuvant using either an 8- or 16-week prime-boost interval. We report on the safety of these regimens, as well as the T cell, B cell, and serum antibody responses. Notably, IgG antibody responses primed by ChAd63 were comparably boosted by AMA1 protein vaccine, irrespective of whether CPG 7909 was included in the Alhydrogel adjuvant. The ability to improve the potency of a relatively weak aluminium-based adjuvant in humans, by previously priming with an adenoviral vaccine vector encoding the same antigen, thus offers a novel vaccination strategy for difficult or neglected disease targets when access to more potent adjuvants is not possible.
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- 2016
37. Evidence that an intervention weakens the relationship between adolescent electronic cigarette use and tobacco smoking: a 24- month prospective study.
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Conner, Mark, Grogan, Sarah, Simms-Ellis, Ruth, Flett, Keira, Sykes-Muskett, Bianca, Cowap, Lisa, Lawton, Rebecca, Armitage, Christopher, Meads, David, Schmitt, Laetitia, Torgerson, Carole, West, Robert, and Siddiqi, Kamran
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SMOKING prevention ,CONFIDENCE intervals ,LONGITUDINAL method ,SELF-evaluation ,TOBACCO products ,ELECTRONIC cigarettes ,DESCRIPTIVE statistics ,ODDS ratio ,ADOLESCENCE - Published
- 2020
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38. National Indexing Day, in the United Kingdom, Australia, New Zealand and South Africa
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Ellis, Ruth, primary, Flath, Tordis, additional, Quinn, Sherrey, additional, Thomas, Elisabeth, additional, Davis, Madeleine, additional, Coe, Mary, additional, and Burger, Marlene, additional
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- 2018
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39. Prevention of M. tuberculosis Infection with H4:IC31 Vaccine or BCG Revaccination
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Nemes, Elisa, primary, Geldenhuys, Hennie, additional, Rozot, Virginie, additional, Rutkowski, Kathryn T., additional, Ratangee, Frances, additional, Bilek, Nicole, additional, Mabwe, Simbarashe, additional, Makhethe, Lebohang, additional, Erasmus, Mzwandile, additional, Toefy, Asma, additional, Mulenga, Humphrey, additional, Hanekom, Willem A., additional, Self, Steven G., additional, Bekker, Linda-Gail, additional, Ryall, Robert, additional, Gurunathan, Sanjay, additional, DiazGranados, Carlos A., additional, Andersen, Peter, additional, Kromann, Ingrid, additional, Evans, Thomas, additional, Ellis, Ruth D., additional, Landry, Bernard, additional, Hokey, David A., additional, Hopkins, Robert, additional, Ginsberg, Ann M., additional, Scriba, Thomas J., additional, and Hatherill, Mark, additional
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- 2018
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40. Hemoglobin variants shape the distribution of malaria parasites in human populations and their transmission potential
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Gonçalves, Bronner P., primary, Sagara, Issaka, additional, Coulibaly, Mamadou, additional, Wu, Yimin, additional, Assadou, Mahamadoun H., additional, Guindo, Agnes, additional, Ellis, Ruth D., additional, Diakite, Mahamadou, additional, Gabriel, Erin, additional, Prevots, D. Rebecca, additional, Doumbo, Ogobara K., additional, and Duffy, Patrick E., additional
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- 2017
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41. Proceedings of the 8th Annual Conference on the Science of Dissemination and Implementation
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Chambers, David, Simpson, Lisa, Hill-Briggs, Felicia, Neta, Gila, Vinson, Cynthia, Beidas, Rinad, Marcus, Steven, Aarons, Gregory, Hoagwood, Kimberly, Schoenwald, Sonja, Evans, Arthur, Hurford, Matthew, Rubin, Ronnie, Hadley, Trevor, Barg, Frances, Walsh, Lucia, Adams, Danielle, Mandell, David, Martin, Lindsey, Mignogna, Joseph, Mott, Juliette, Hundt, Natalie, Kauth, Michael, Kunik, Mark, Naik, Aanand, Cully, Jeffrey, McGuire, Alan, White, Dominique, Bartholomew, Tom, McGrew, John, Luther, Lauren, Rollins, Angie, Salyers, Michelle, Cooper, Brittany, Funaiole, Angie, Richards, Julie, Lee, Amy, Lapham, Gwen, Caldeiro, Ryan, Lozano, Paula, Gildred, Tory, Achtmeyer, Carol, Ludman, Evette, Addis, Megan, Marx, Larry, Bradley, Katharine, VanDeinse, Tonya, Wilson, Amy Blank, Stacey, Burgin, Powell, Byron, Bunger, Alicia, Cuddeback, Gary, Barnett, Miya, Stadnick, Nicole, Brookman-Frazee, Lauren, Lau, Anna, Dorsey, Shannon, Pullmann, Michael, Mitchell, Shannon, Schwartz, Robert, Kirk, Arethusa, Dusek, Kristi, Oros, Marla, Hosler, Colleen, Gryczynski, Jan, Barbosa, Carolina, Dunlap, Laura, Lounsbury, David, O’Grady, Kevin, Brown, Barry, Damschroder, Laura, Waltz, Thomas, Ritchie, Mona, Atkins, David, Imel, Zac E., Xiao, Bo, Can, Doğan, Georgiou, Panayiotis, Narayanan, Shrikanth, Berkel, Cady, Gallo, Carlos, Sandler, Irwin, Brown, C. Hendricks, Wolchik, Sharlene, Mauricio, Anne Marie, Mehrotra, Sanjay, Chandurkar, Dharmendra, Bora, Siddhartha, Das, Arup, Tripathi, Anand, Saggurti, Niranjan, Raj, Anita, Hughes, Eric, Jacobs, Brian, Kirkendall, Eric, Loeb, Danielle, Trinkley, Katy, Yang, Michael, Sprowell, Andrew, Nease, Donald, Lyon, Aaron, Lewis, Cara, Boyd, Meredith, Melvin, Abigail, Nicodimos, Semret, Liu, Freda, Jungbluth, Nathanial, Flynn, Allen, Landis-Lewis, Zach, Sales, Anne, Baloh, Jure, Ward, Marcia, Zhu, Xi, Bennett, Ian, Unutzer, Jurgen, Mao, Johnny, Proctor, Enola, Vredevoogd, Mindy, Chan, Ya-Fen, Williams, Nathaniel, Green, Phillip, Bernstein, Steven, Rosner, June-Marie, DeWitt, Michelle, Tetrault, Jeanette, Dziura, James, Hsiao, Allen, Sussman, Scott, O’Connor, Patrick, Toll, Benjamin, Jones, Michael, Gassaway, Julie, Tobin, Jonathan, Zatzick, Douglas, Bradbury, Angela R., Patrick-Miller, Linda, Egleston, Brian, Olopade, Olufunmilayo I., Hall, Michael J., Daly, Mary B., Fleisher, Linda, Grana, Generosa, Ganschow, Pamela, Fetzer, Dominique, Brandt, Amanda, Farengo-Clark, Dana, Forman, Andrea, Gaber, Rikki S., Gulden, Cassandra, Horte, Janice, Long, Jessica, Chambers, Rachelle Lorenz, Lucas, Terra, Madaan, Shreshtha, Mattie, Kristin, McKenna, Danielle, Montgomery, Susan, Nielsen, Sarah, Powers, Jacquelyn, Rainey, Kim, Rybak, Christina, Savage, Michelle, Seelaus, Christina, Stoll, Jessica, Stopfer, Jill, Yao, Shirley, Domchek, Susan, Hahn, Erin, Munoz-Plaza, Corrine, Wang, Jianjin, Delgadillo, Jazmine Garcia, Mittman, Brian, Gould, Michael, Liang, Shuting, Kegler, Michelle C., Cotter, Megan, Phillips, Emily, Hermstad, April, Morton, Rentonia, Beasley, Derrick, Martinez, Jeremy, Riehman, Kara, Gustafson, David, Marsch, Lisa, Mares, Louise, Quanbeck, Andrew, McTavish, Fiona, McDowell, Helene, Brown, Randall, Thomas, Chantelle, Glass, Joseph, Isham, Joseph, Shah, Dhavan, Liebschutz, Jane, Lasser, Karen, Watkins, Katherine, Ober, Allison, Hunter, Sarah, Lamp, Karen, Ewing, Brett, Iwelunmor, Juliet, Gyamfi, Joyce, Blackstone, Sarah, Quakyi, Nana Kofi, Plange-Rhule, Jacob, Ogedegbe, Gbenga, Kumar, Pritika, Van Devanter, Nancy, Nguyen, Nam, Nguyen, Linh, Nguyen, Trang, Phuong, Nguyet, Shelley, Donna, Rudge, Sian, Langlois, Etienne, Tricco, Andrea, Ball, Sherry, Lambert-Kerzner, Anne, Sulc, Christine, Simmons, Carol, Shell-Boyd, Jeneen, Oestreich, Taryn, O’Connor, Ashley, Neely, Emily, McCreight, Marina, Labebue, Amy, DiFiore, Doreen, Brostow, Diana, Ho, P. Michael, Aron, David, Harvey, Jillian, McHugh, Megan, Scanlon, Dennis, Lee, Rebecca, Soltero, Erica, Parker, Nathan, McNeill, Lorna, Ledoux, Tracey, McIsaac, Jessie-Lee, MacLeod, Kate, Ata, Nicole, Jarvis, Sherry, Kirk, Sara, Purtle, Jonathan, Dodson, Elizabeth, Brownson, Ross, Curran, Geoffrey, Pyne, Jeffrey, Ehrhart, Mark, Torres, Elisa, Miech, Edward, Stevens, Kathleen, Hamilton, Alison, Cohen, Deborah, Padgett, Deborah, Morshed, Alexandra, Patel, Rupa, Prusaczyk, Beth, Aron, David C., Gupta, Divya, Hand, Rosa, Abram, Jenica, Wolfram, Taylor, Hastings, Molly, Moreland-Russell, Sarah, Tabak, Rachel, Ramsey, Alex, Baumann, Ana, Kryzer, Emily, Montgomery, Katherine, Lewis, Ericka, Padek, Margaret, Mamaril, Cezar Brian, Mays, Glen, Branham, Keith, Timsina, Lava, Hogg, Rachel, Fagan, Abigail, Shapiro, Valerie, Brown, Eric, Haggerty, Kevin, Hawkins, David, Oesterle, Sabrina, Catalano, Richard, McKay, Virginia, Dolcini, M. Margaret, Hoffer, Lee, Moin, Tannaz, Li, Jinnan, Duru, O. Kenrik, Ettner, Susan, Turk, Norman, Chan, Charles, Keckhafer, Abigail, Luchs, Robert, Ho, Sam, Mangione, Carol, Selby, Peter, Zawertailo, Laurie, Minian, Nadia, Balliunas, Dolly, Dragonetti, Rosa, Hussain, Sarwar, Lecce, Julia, Chinman, Matthew, Acosta, Joie, Ebener, Patricia, Malone, Patrick S., Slaughter, Mary, Freedman, Darcy, Flocke, Susan, Lee, Eunlye, Matlack, Kristen, Trapl, Erika, Ohri-Vachaspati, Punam, Taggart, Morgan, Borawski, Elaine, Parrish, Amanda, Harris, Jeffrey, Kohn, Marlana, Hammerback, Kristen, McMillan, Becca, Hannon, Peggy, Swindle, Taren, Whiteside-Mansell, Leanne, Ward, Wendy, Holt, Cheryl, Santos, Sheri Lou, Tagai, Erin, Scheirer, Mary Ann, Carter, Roxanne, Bowie, Janice, Haider, Muhiuddin, Slade, Jimmie, Wang, Min Qi, Masica, Andrew, Ogola, Gerald, Berryman, Candice, Richter, Kathleen, Shelton, Rachel, Jandorf, Lina, Erwin, Deborah, Truong, Khoa, Javier, Joyce R., Coffey, Dean, Schrager, Sheree M., Palinkas, Lawrence, Miranda, Jeanne, Johnson, Veda, Hutcherson, Valerie, Ellis, Ruth, Kharmats, Anna, Marshall-King, Sandra, LaPradd, Monica, Fonseca-Becker, Fannie, Kepka, Deanna, Bodson, Julia, Warner, Echo, Fowler, Brynn, Shenkman, Elizabeth, Hogan, William, Odedina, Folakami, De Leon, Jessica, Hooper, Monica, Carrasquillo, Olveen, Reams, Renee, Hurt, Myra, Smith, Steven, Szapocznik, Jose, Nelson, David, Mandal, Prabir, and Teufel, James
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Medicine(all) ,Health Policy ,Public Health, Environmental and Occupational Health ,Meeting Abstracts - Abstract
Table of contents A1 Introduction to the 8th Annual Conference on the Science of Dissemination and Implementation: Optimizing Personal and Population Health David Chambers, Lisa Simpson D1 Discussion forum: Population health D&I research Felicia Hill-Briggs D2 Discussion forum: Global health D&I research Gila Neta, Cynthia Vinson D3 Discussion forum: Precision medicine and D&I research David Chambers S1 Predictors of community therapists’ use of therapy techniques in a large public mental health system Rinad Beidas, Steven Marcus, Gregory Aarons, Kimberly Hoagwood, Sonja Schoenwald, Arthur Evans, Matthew Hurford, Ronnie Rubin, Trevor Hadley, Frances Barg, Lucia Walsh, Danielle Adams, David Mandell S2 Implementing brief cognitive behavioral therapy (CBT) in primary care: Clinicians' experiences from the field Lindsey Martin, Joseph Mignogna, Juliette Mott, Natalie Hundt, Michael Kauth, Mark Kunik, Aanand Naik, Jeffrey Cully S3 Clinician competence: Natural variation, factors affecting, and effect on patient outcomes Alan McGuire, Dominique White, Tom Bartholomew, John McGrew, Lauren Luther, Angie Rollins, Michelle Salyers S4 Exploring the multifaceted nature of sustainability in community-based prevention: A mixed-method approach Brittany Cooper, Angie Funaiole S5 Theory informed behavioral health integration in primary care: Mixed methods evaluation of the implementation of routine depression and alcohol screening and assessment Julie Richards, Amy Lee, Gwen Lapham, Ryan Caldeiro, Paula Lozano, Tory Gildred, Carol Achtmeyer, Evette Ludman, Megan Addis, Larry Marx, Katharine Bradley S6 Enhancing the evidence for specialty mental health probation through a hybrid efficacy and implementation study Tonya VanDeinse, Amy Blank Wilson, Burgin Stacey, Byron Powell, Alicia Bunger, Gary Cuddeback S7 Personalizing evidence-based child mental health care within a fiscally mandated policy reform Miya Barnett, Nicole Stadnick, Lauren Brookman-Frazee, Anna Lau S8 Leveraging an existing resource for technical assistance: Community-based supervisors in public mental health Shannon Dorsey, Michael Pullmann S9 SBIRT implementation for adolescents in urban federally qualified health centers: Implementation outcomes Shannon Mitchell, Robert Schwartz, Arethusa Kirk, Kristi Dusek, Marla Oros, Colleen Hosler, Jan Gryczynski, Carolina Barbosa, Laura Dunlap, David Lounsbury, Kevin O'Grady, Barry Brown S10 PANEL: Tailoring Implementation Strategies to Context - Expert recommendations for tailoring strategies to context Laura Damschroder, Thomas Waltz, Byron Powell S11 PANEL: Tailoring Implementation Strategies to Context - Extreme facilitation: Helping challenged healthcare settings implement complex programs Mona Ritchie S12 PANEL: Tailoring Implementation Strategies to Context - Using menu-based choice tasks to obtain expert recommendations for implementing three high-priority practices in the VA Thomas Waltz S13 PANEL: The Use of Technology to Improve Efficient Monitoring of Implementation of Evidence-based Programs - Siri, rate my therapist: Using technology to automate fidelity ratings of motivational interviewing David Atkins, Zac E. Imel, Bo Xiao, Doğan Can, Panayiotis Georgiou, Shrikanth Narayanan S14 PANEL: The Use of Technology to Improve Efficient Monitoring of Implementation of Evidence-based Programs - Identifying indicators of implementation quality for computer-based ratings Cady Berkel, Carlos Gallo, Irwin Sandler, C. Hendricks Brown, Sharlene Wolchik, Anne Marie Mauricio S15 PANEL: The Use of Technology to Improve Efficient Monitoring of Implementation of Evidence-based Programs - Improving implementation of behavioral interventions by monitoring emotion in spoken speech Carlos Gallo, C. Hendricks Brown, Sanjay Mehrotra S16 Scorecards and dashboards to assure data quality of health management information system (HMIS) using R Dharmendra Chandurkar, Siddhartha Bora, Arup Das, Anand Tripathi, Niranjan Saggurti, Anita Raj S17 A big data approach for discovering and implementing patient safety insights Eric Hughes, Brian Jacobs, Eric Kirkendall S18 Improving the efficacy of a depression registry for use in a collaborative care model Danielle Loeb, Katy Trinkley, Michael Yang, Andrew Sprowell, Donald Nease S19 Measurement feedback systems as a strategy to support implementation of measurement-based care in behavioral health Aaron Lyon, Cara Lewis, Meredith Boyd, Abigail Melvin, Semret Nicodimos, Freda Liu, Nathanial Jungbluth S20 PANEL: Implementation Science and Learning Health Systems: Intersections and Commonalities - Common loop assay: Methods of supporting learning collaboratives Allen Flynn S21 PANEL: Implementation Science and Learning Health Systems: Intersections and Commonalities - Innovating audit and feedback using message tailoring models for learning health systems Zach Landis-Lewis S22 PANEL: Implementation Science and Learning Health Systems: Intersections and Commonalities - Implementation science and learning health systems: Connecting the dots Anne Sales S23 Facilitation activities of Critical Access Hospitals during TeamSTEPPS implementation Jure Baloh, Marcia Ward, Xi Zhu S24 Organizational and social context of federally qualified health centers and variation in maternal depression outcomes Ian Bennett, Jurgen Unutzer, Johnny Mao, Enola Proctor, Mindy Vredevoogd, Ya-Fen Chan, Nathaniel Williams, Phillip Green S25 Decision support to enhance treatment of hospitalized smokers: A randomized trial Steven Bernstein, June-Marie Rosner, Michelle DeWitt, Jeanette Tetrault, James Dziura, Allen Hsiao, Scott Sussman, Patrick O’Connor, Benjamin Toll S26 PANEL: Developing Sustainable Strategies for the Implementation of Patient-Centered Care across Diverse US Healthcare Systems - A patient-centered approach to successful community transition after catastrophic injury Michael Jones, Julie Gassaway S27 PANEL: Developing Sustainable Strategies for the Implementation of Patient-Centered Care across Diverse US Healthcare Systems - Conducting PCOR to integrate mental health and cancer screening services in primary care Jonathan Tobin S28 PANEL: Developing Sustainable Strategies for the Implementation of Patient-Centered Care across Diverse US Healthcare Systems - A comparative effectiveness trial of optimal patient-centered care for US trauma care systems Douglas Zatzick S29 Preferences for in-person communication among patients in a multi-center randomized study of in-person versus telephone communication of genetic test results for cancer susceptibility Angela R Bradbury, Linda Patrick-Miller, Brian Egleston, Olufunmilayo I Olopade, Michael J Hall, Mary B Daly, Linda Fleisher, Generosa Grana, Pamela Ganschow, Dominique Fetzer, Amanda Brandt, Dana Farengo-Clark, Andrea Forman, Rikki S Gaber, Cassandra Gulden, Janice Horte, Jessica Long, Rachelle Lorenz Chambers, Terra Lucas, Shreshtha Madaan, Kristin Mattie, Danielle McKenna, Susan Montgomery, Sarah Nielsen, Jacquelyn Powers, Kim Rainey, Christina Rybak, Michelle Savage, Christina Seelaus, Jessica Stoll, Jill Stopfer, Shirley Yao and Susan Domchek S30 Working towards de-implementation: A mixed methods study in breast cancer surveillance care Erin Hahn, Corrine Munoz-Plaza, Jianjin Wang, Jazmine Garcia Delgadillo, Brian Mittman Michael Gould S31Integrating evidence-based practices for increasing cancer screenings in safety-net primary care systems: A multiple case study using the consolidated framework for implementation research Shuting (Lily) Liang, Michelle C. Kegler, Megan Cotter, Emily Phillips, April Hermstad, Rentonia Morton, Derrick Beasley, Jeremy Martinez, Kara Riehman S32 Observations from implementing an mHealth intervention in an FQHC David Gustafson, Lisa Marsch, Louise Mares, Andrew Quanbeck, Fiona McTavish, Helene McDowell, Randall Brown, Chantelle Thomas, Joseph Glass, Joseph Isham, Dhavan Shah S33 A multicomponent intervention to improve primary care provider adherence to chronic opioid therapy guidelines and reduce opioid misuse: A cluster randomized controlled trial protocol Jane Liebschutz, Karen Lasser S34 Implementing collaborative care for substance use disorders in primary care: Preliminary findings from the summit study Katherine Watkins, Allison Ober, Sarah Hunter, Karen Lamp, Brett Ewing S35 Sustaining a task-shifting strategy for blood pressure control in Ghana: A stakeholder analysis Juliet Iwelunmor, Joyce Gyamfi, Sarah Blackstone, Nana Kofi Quakyi, Jacob Plange-Rhule, Gbenga Ogedegbe S36 Contextual adaptation of the consolidated framework for implementation research (CFIR) in a tobacco cessation study in Vietnam Pritika Kumar, Nancy Van Devanter, Nam Nguyen, Linh Nguyen, Trang Nguyen, Nguyet Phuong, Donna Shelley S37 Evidence check: A knowledge brokering approach to systematic reviews for policy Sian Rudge S38 Using Evidence Synthesis to Strengthen Complex Health Systems in Low- and Middle-Income Countries Etienne Langlois S39 Does it matter: timeliness or accuracy of results? The choice of rapid reviews or systematic reviews to inform decision-making Andrea Tricco S40 Evaluation of the veterans choice program using lean six sigma at a VA medical center to identify benefits and overcome obstacles Sherry Ball, Anne Lambert-Kerzner, Christine Sulc, Carol Simmons, Jeneen Shell-Boyd, Taryn Oestreich, Ashley O'Connor, Emily Neely, Marina McCreight, Amy Labebue, Doreen DiFiore, Diana Brostow, P. Michael Ho, David Aron S41 The influence of local context on multi-stakeholder alliance quality improvement activities: A multiple case study Jillian Harvey, Megan McHugh, Dennis Scanlon S42 Increasing physical activity in early care and education: Sustainability via active garden education (SAGE) Rebecca Lee, Erica Soltero, Nathan Parker, Lorna McNeill, Tracey Ledoux S43 Marking a decade of policy implementation: The successes and continuing challenges of a provincial school food and nutrition policy in Canada Jessie-Lee McIsaac, Kate MacLeod, Nicole Ata, Sherry Jarvis, Sara Kirk S44 Use of research evidence among state legislators who prioritize mental health and substance abuse issues Jonathan Purtle, Elizabeth Dodson, Ross Brownson S45 PANEL: Effectiveness-Implementation Hybrid Designs: Clarifications, Refinements, and Additional Guidance Based on a Systematic Review and Reports from the Field - Hybrid type 1 designs Brian Mittman, Geoffrey Curran S46 PANEL: Effectiveness-Implementation Hybrid Designs: Clarifications, Refinements, and Additional Guidance Based on a Systematic Review and Reports from the Field - Hybrid type 2 designs Geoffrey Curran S47 PANEL: Effectiveness-Implementation Hybrid Designs: Clarifications, Refinements, and Additional Guidance Based on a Systematic Review and Reports from the Field - Hybrid type 3 designs Jeffrey Pyne S48 Linking team level implementation leadership and implementation climate to individual level attitudes, behaviors, and implementation outcomes Gregory Aarons, Mark Ehrhart, Elisa Torres S49 Pinpointing the specific elements of local context that matter most to implementation outcomes: Findings from qualitative comparative analysis in the RE-inspire study of VA acute stroke care Edward Miech S50 The GO score: A new context-sensitive instrument to measure group organization level for providing and improving care Edward Miech S51 A research network approach for boosting implementation and improvement Kathleen Stevens, I.S.R.N. Steering Council S52 PANEL: Qualitative methods in D&I Research: Value, rigor and challenge - The value of qualitative methods in implementation research Alison Hamilton S53 PANEL: Qualitative methods in D&I Research: Value, rigor and challenge - Learning evaluation: The role of qualitative methods in dissemination and implementation research Deborah Cohen S54 PANEL: Qualitative methods in D&I Research: Value, rigor and challenge - Qualitative methods in D&I research Deborah Padgett S55 PANEL: Maps & models: The promise of network science for clinical D&I - Hospital network of sharing patients with acute and chronic diseases in California Alexandra Morshed S56 PANEL: Maps & models: The promise of network science for clinical D&I - The use of social network analysis to identify dissemination targets and enhance D&I research study recruitment for pre-exposure prophylaxis for HIV (PrEP) among men who have sex with men Rupa Patel S57 PANEL: Maps & models: The promise of network science for clinical D&I - Network and organizational factors related to the adoption of patient navigation services among rural breast cancer care providers Beth Prusaczyk S58 A theory of de-implementation based on the theory of healthcare professionals’ behavior and intention (THPBI) and the becker model of unlearning David C. Aron, Divya Gupta, Sherry Ball S59 Observation of registered dietitian nutritionist-patient encounters by dietetic interns highlights low awareness and implementation of evidence-based nutrition practice guidelines Rosa Hand, Jenica Abram, Taylor Wolfram S60 Program sustainability action planning: Building capacity for program sustainability using the program sustainability assessment tool Molly Hastings, Sarah Moreland-Russell S61 A review of D&I study designs in published study protocols Rachel Tabak, Alex Ramsey, Ana Baumann, Emily Kryzer, Katherine Montgomery, Ericka Lewis, Margaret Padek, Byron Powell, Ross Brownson S62 PANEL: Geographic variation in the implementation of public health services: Economic, organizational, and network determinants - Model simulation techniques to estimate the cost of implementing foundational public health services Cezar Brian Mamaril, Glen Mays, Keith Branham, Lava Timsina S63 PANEL: Geographic variation in the implementation of public health services: Economic, organizational, and network determinants - Inter-organizational network effects on the implementation of public health services Glen Mays, Rachel Hogg S64 PANEL: Building capacity for implementation and dissemination of the communities that care prevention system at scale to promote evidence-based practices in behavioral health - Implementation fidelity, coalition functioning, and community prevention system transformation using communities that care Abigail Fagan, Valerie Shapiro, Eric Brown S65 PANEL: Building capacity for implementation and dissemination of the communities that care prevention system at scale to promote evidence-based practices in behavioral health - Expanding capacity for implementation of communities that care at scale using a web-based, video-assisted training system Kevin Haggerty, David Hawkins S66 PANEL: Building capacity for implementation and dissemination of the communities that care prevention system at scale to promote evidence-based practices in behavioral health - Effects of communities that care on reducing youth behavioral health problems Sabrina Oesterle, David Hawkins, Richard Catalano S68 When interventions end: the dynamics of intervention de-adoption and replacement Virginia McKay, M. Margaret Dolcini, Lee Hoffer S69 Results from next-d: can a disease specific health plan reduce incident diabetes development among a national sample of working-age adults with pre-diabetes? Tannaz Moin, Jinnan Li, O. Kenrik Duru, Susan Ettner, Norman Turk, Charles Chan, Abigail Keckhafer, Robert Luchs, Sam Ho, Carol Mangione S70 Implementing smoking cessation interventions in primary care settings (STOP): using the interactive systems framework Peter Selby, Laurie Zawertailo, Nadia Minian, Dolly Balliunas, Rosa Dragonetti, Sarwar Hussain, Julia Lecce S71 Testing the Getting To Outcomes implementation support intervention in prevention-oriented, community-based settings Matthew Chinman, Joie Acosta, Patricia Ebener, Patrick S Malone, Mary Slaughter S72 Examining the reach of a multi-component farmers’ market implementation approach among low-income consumers in an urban context Darcy Freedman, Susan Flocke, Eunlye Lee, Kristen Matlack, Erika Trapl, Punam Ohri-Vachaspati, Morgan Taggart, Elaine Borawski S73 Increasing implementation of evidence-based health promotion practices at large workplaces: The CEOs Challenge Amanda Parrish, Jeffrey Harris, Marlana Kohn, Kristen Hammerback, Becca McMillan, Peggy Hannon S74 A qualitative assessment of barriers to nutrition promotion and obesity prevention in childcare Taren Swindle, Geoffrey Curran, Leanne Whiteside-Mansell, Wendy Ward S75 Documenting institutionalization of a health communication intervention in African American churches Cheryl Holt, Sheri Lou Santos, Erin Tagai, Mary Ann Scheirer, Roxanne Carter, Janice Bowie, Muhiuddin Haider, Jimmie Slade, Min Qi Wang S76 Reduction in hospital utilization by underserved patients through use of a community-medical home Andrew Masica, Gerald Ogola, Candice Berryman, Kathleen Richter S77 Sustainability of evidence-based lay health advisor programs in African American communities: A mixed methods investigation of the National Witness Project Rachel Shelton, Lina Jandorf, Deborah Erwin S78 Predicting the long-term uninsured population and analyzing their gaps in physical access to healthcare in South Carolina Khoa Truong S79 Using an evidence-based parenting intervention in churches to prevent behavioral problems among Filipino youth: A randomized pilot study Joyce R. Javier, Dean Coffey, Sheree M. Schrager, Lawrence Palinkas, Jeanne Miranda S80 Sustainability of elementary school-based health centers in three health-disparate southern communities Veda Johnson, Valerie Hutcherson, Ruth Ellis S81 Childhood obesity prevention partnership in Louisville: creative opportunities to engage families in a multifaceted approach to obesity prevention Anna Kharmats, Sandra Marshall-King, Monica LaPradd, Fannie Fonseca-Becker S82 Improvements in cervical cancer prevention found after implementation of evidence-based Latina prevention care management program Deanna Kepka, Julia Bodson, Echo Warner, Brynn Fowler S83 The OneFlorida data trust: Achieving health equity through research & training capacity building Elizabeth Shenkman, William Hogan, Folakami Odedina, Jessica De Leon, Monica Hooper, Olveen Carrasquillo, Renee Reams, Myra Hurt, Steven Smith, Jose Szapocznik, David Nelson, Prabir Mandal S84 Disseminating and sustaining medical-legal partnerships: Shared value and social return on investment James Teufel
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42. How Is Stress Reduced by a Workplace Mindfulness Intervention? A Qualitative Study Conceptualising Experiences of Change
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Hugh-Jones, Siobhan, primary, Rose, Sally, additional, Koutsopoulou, Gina Z., additional, and Simms-Ellis, Ruth, additional
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- 2017
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43. Do electronic cigarettes increase cigarette smoking in UK adolescents? Evidence from a 12-month prospective study
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Conner, Mark, primary, Grogan, Sarah, additional, Simms-Ellis, Ruth, additional, Flett, Keira, additional, Sykes-Muskett, Bianca, additional, Cowap, Lisa, additional, Lawton, Rebecca, additional, Armitage, Christopher J, additional, Meads, David, additional, Torgerson, Carole, additional, West, Robert, additional, and Siddiqi, Kamran, additional
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- 2017
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44. Malaria Infection and Gametocyte Carriage Rates in Preparation for Transmission Blocking Vaccine Trials in Bancoumana, Mali
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Assadou, Mahamadoun Hamady, primary, Doucoure, M’Bouye, additional, Sanogo, Sintry, additional, Kone, Mamady, additional, Guindo, Merepen Agnes, additional, Doumbo, Ogobara K., additional, Healy, Sara A., additional, Duffy, Patrick E., additional, Ellis, Ruth D., additional, Sagara, Issaka, additional, Omaswa, Freda, additional, Keita, Sekouba, additional, and Wu, Yimin, additional
- Published
- 2017
- Full Text
- View/download PDF
45. UK National Indexing Day, 30 March 2017
- Author
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Ellis, Ruth, primary
- Published
- 2017
- Full Text
- View/download PDF
46. Safety and Immunogenicity of Pfs25-EPA/Alhydrogel®, a Transmission Blocking Vaccine against Plasmodium falciparum: An Open Label Study in Malaria Naïve Adults
- Author
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Talaat, Kawsar R., primary, Ellis, Ruth D., additional, Hurd, Janet, additional, Hentrich, Autumn, additional, Gabriel, Erin, additional, Hynes, Noreen A., additional, Rausch, Kelly M., additional, Zhu, Daming, additional, Muratova, Olga, additional, Herrera, Raul, additional, Anderson, Charles, additional, Jones, David, additional, Aebig, Joan, additional, Brockley, Sarah, additional, MacDonald, Nicholas J., additional, Wang, Xiaowei, additional, Fay, Michael P., additional, Healy, Sara A., additional, Durbin, Anna P., additional, Narum, David L., additional, Wu, Yimin, additional, and Duffy, Patrick E., additional
- Published
- 2016
- Full Text
- View/download PDF
47. Do electronic cigarettes increase cigarette smoking in UK adolescents? Evidence from a 12-month prospective study.
- Author
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Conner, Mark, Grogan, Sarah, Simms-Ellis, Ruth, Flett, Keira, Sykes-Muskett, Bianca, Cowap, Lisa, Lawton, Rebecca, Armitage, Christopher J., Meads, David, Torgerson, Carole, West, Robert, and Siddiqi, Kamran
- Subjects
AGE distribution ,ANALYSIS of covariance ,CARBON monoxide ,CHILDREN of people with mental illness ,CONFIDENCE intervals ,HEALTH attitudes ,LONGITUDINAL method ,RISK-taking behavior ,SELF-evaluation ,SEX distribution ,SMOKING ,AFFINITY groups ,SOCIOECONOMIC factors ,ELECTRONIC cigarettes ,ODDS ratio ,ADOLESCENCE - Published
- 2018
- Full Text
- View/download PDF
48. Combining Viral Vectored and Protein-in-adjuvant Vaccines Against the Blood-stage Malaria Antigen AMA1: Report on a Phase 1a Clinical Trial
- Author
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Hodgson, Susanne H, primary, Choudhary, Prateek, additional, Elias, Sean C, additional, Milne, Kathryn H, additional, Rampling, Thomas W, additional, Biswas, Sumi, additional, Poulton, Ian D, additional, Miura, Kazutoyo, additional, Douglas, Alexander D, additional, Alanine, Daniel GW, additional, Illingworth, Joseph J, additional, de Cassan, Simone C, additional, Zhu, Daming, additional, Nicosia, Alfredo, additional, Long, Carole A, additional, Moyle, Sarah, additional, Berrie, Eleanor, additional, Lawrie, Alison M, additional, Wu, Yimin, additional, Ellis, Ruth D, additional, Hill, Adrian V S, additional, and Draper, Simon J, additional
- Published
- 2014
- Full Text
- View/download PDF
49. Safety and Immunogenicity of Pfs25-EPA/Alhydrogel®, a Transmission Blocking Vaccine against Plasmodium falciparum: An Open Label Study in Malaria Naïve Adults.
- Author
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Talaat, Kawsar R., Ellis, Ruth D., Hurd, Janet, Hentrich, Autumn, Gabriel, Erin, Hynes, Noreen A., Rausch, Kelly M., Zhu, Daming, Muratova, Olga, Herrera, Raul, Anderson, Charles, Jones, David, Aebig, Joan, Brockley, Sarah, MacDonald, Nicholas J., Wang, Xiaowei, Fay, Michael P., Healy, Sara A., Durbin, Anna P., and Narum, David L.
- Subjects
- *
IMMUNOGENETICS , *PLASMODIUM falciparum , *VACCINATION , *MALARIA prevention , *PSEUDOMONAS aeruginosa , *INFECTIOUS disease transmission - Abstract
Transmission-blocking vaccines (TBVs) that target sexual stage parasite development could be an integral part of measures for malaria elimination. Pfs25 is a leading TBV candidate, and previous studies conducted in animals demonstrated an improvement of its functional immunogenicity after conjugation to EPA, a recombinant, detoxified ExoProtein A from Pseudomonas aeruginosa. In this report, we describe results of an open-label, dose-escalating Phase 1 trial to assess the safety and immunogenicity of Pfs25-EPA conjugates formulated with Alhydrogel®. Thirty malaria-naïve healthy adults received up to four doses of the conjugate vaccine, with 8, 16, or 47 μg of conjugated Pfs25 mass, at 0, 2, 4, and 10 months. Vaccinations were generally well tolerated. The majority of solicited adverse events were mild in severity with pain at the injection site the most common complaint. Anemia was the most common laboratory abnormality, but was considered possibly related to the study in only a minority of cases. No vaccine-related serious adverse events occurred. The peak geometric mean anti-Pfs25 antibody level in the highest dose group was 88 (95% CI 53, 147) μg/mL two weeks after the 4th vaccination, and declined to near baseline one year later. Antibody avidity increased over successive vaccinations. Transmission blocking activity demonstrated in a standard membrane feeding assay (SMFA) also increased from the second to the third dose, and correlated with antibody titer and, after the final dose, with antibody avidity. These results support the further evaluation of Pfs25-EPA/Alhydrogel® in a malaria-endemic population. [ABSTRACT FROM AUTHOR]
- Published
- 2016
- Full Text
- View/download PDF
50. Study protocol: A cluster randomised controlled trial of implementation intentions to reduce smoking initiation in adolescents
- Author
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Conner, Mark, primary, Grogan, Sarah, additional, Lawton, Rebecca, additional, Armitage, Christopher, additional, West, Robert, additional, Siddiqi, Kamran, additional, Gannon, Brenda, additional, Torgerson, Carole, additional, Flett, Keira, additional, and Simms-Ellis, Ruth, additional
- Published
- 2013
- Full Text
- View/download PDF
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