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9 results on '"Ellis, Crystal N"'

1. Human Gut Microbiota Predicts Susceptibility to Vibrio cholerae Infection

Author

Midani, Firas S., Weil, Ana A., Chowdhury, Fahima, Begum, Yasmin A., Khan, Ashraful I., Debela, Meti D., Durand, Heather K., Reese, Aspen T., Nimmagadda, Sai N., Silverman, Justin D., Ellis, Crystal N., Ryan, Edward T., Calderwood, Stephen B., Harris, Jason B., Qadri, Firdausi, David, Lawrence A., and LaRocque, Regina C.

Published
2018

3. Posttranslational Regulation of IL-23 Production Distinguishes the Innate Immune Responses to Live Toxigenic versus Heat-Inactivated Vibrio cholerae

Author

Weil, Ana A., primary, Ellis, Crystal N., additional, Debela, Meti D., additional, Bhuiyan, Taufiqur R., additional, Rashu, Rasheduzzaman, additional, Bourque, Daniel L., additional, Khan, Ashraful I., additional, Chowdhury, Fahima, additional, LaRocque, Regina C., additional, Charles, Richelle C., additional, Ryan, Edward T., additional, Calderwood, Stephen B., additional, Qadri, Firdausi, additional, and Harris, Jason B., additional

Published
2019
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4. Analysis of the Human Mucosal Response to Cholera Reveals Sustained Activation of Innate Immune Signaling Pathways

Author

Bourque, Daniel L., primary, Bhuiyan, Taufiqur Rahman, additional, Genereux, Diane P., additional, Rashu, Rasheduzzaman, additional, Ellis, Crystal N., additional, Chowdhury, Fahima, additional, Khan, Ashraful I., additional, Alam, Nur Haq, additional, Paul, Anik, additional, Hossain, Lazina, additional, Mayo-Smith, Leslie M., additional, Charles, Richelle C., additional, Weil, Ana A., additional, LaRocque, Regina C., additional, Calderwood, Stephen B., additional, Ryan, Edward T., additional, Karlsson, Elinor K., additional, Qadri, Firdausi, additional, and Harris, Jason B., additional

Published
2018
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5. Experimental adaptation of Burkholderia cenocepacia to onion medium reduces host range

Author

Ellis, Crystal N. and Cooper, Vaughn S.

Subjects
Burkholderia -- Environmental aspects, Burkholderia -- Physiological aspects, Cystic fibrosis -- Causes of, Quorum sensing -- Usage, Rhizosphere -- Environmental aspects, Biological sciences
Abstract

A soil isolate of Burcholderia cenocepacia, a species that normally inhabits the rhizosphere was examined to understand its association with the onion pathogen B. cepacia that could infect the lungs of cystic fibrosis patients. Most phenotypes which varied significantly among replicate populations suggested that adaptation to the onion model may follow several different pathways.

Published
2010

6. Comparative Proteomic Analysis Reveals Activation of Mucosal Innate Immune Signaling Pathways during Cholera

Author

Ellis, Crystal N., primary, LaRocque, Regina C., additional, Uddin, Taher, additional, Krastins, Bryan, additional, Mayo-Smith, Leslie M., additional, Sarracino, David, additional, Karlsson, Elinor K., additional, Rahman, Atiqur, additional, Shirin, Tahmina, additional, Bhuiyan, Taufiqur R., additional, Chowdhury, Fahima, additional, Khan, Ashraful Islam, additional, Ryan, Edward T., additional, Calderwood, Stephen B., additional, Qadri, Firdausi, additional, and Harris, Jason B., additional

Published
2015
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9. Analysis of the Human Mucosal Response to Cholera Reveals Sustained Activation of Innate Immune Signaling Pathways

Author

Bourque, Daniel L., Bhuiyan, Taufiqur Rahman, Genereux, Diane P., Rashu, Rasheduzzaman, Ellis, Crystal N., Chowdhury, Fahima, Khan, Ashraful I., Alam, Nur Haq, Paul, Anik, Hossain, Lazina, Mayo-Smith, Leslie M., Charles, Richelle C., Weil, Ana A., LaRocque, Regina C., Calderwood, Stephen B., Ryan, Edward T., Karlsson, Elinor K., Qadri, Firdausi, and Harris, Jason B.

Abstract

ABSTRACTTo better understand the innate immune response to Vibrio choleraeinfection, we tracked gene expression in the duodenal mucosa of 11 Bangladeshi adults with cholera, using biopsy specimens obtained immediately after rehydration and 30 and 180 days later. We identified differentially expressed genes and performed an analysis to predict differentially regulated pathways and upstream regulators. During acute cholera, there was a broad increase in the expression of genes associated with innate immunity, including activation of the NF-κB, mitogen-activated protein kinase (MAPK), and Toll-like receptor (TLR)-mediated signaling pathways, which, unexpectedly, persisted even 30 days after infection. Focusing on early differences in gene expression, we identified 37 genes that were differentially expressed on days 2 and 30 across the 11 participants. These genes included the endosomal Toll-like receptor gene TLR8, which was expressed in lamina propria cells. Underscoring a potential role for endosomal TLR-mediated signaling in vivo, our pathway analysis found that interferon regulatory factor 7 and beta 1 and alpha 2 interferons were among the top upstream regulators activated during cholera. Among the innate immune effectors, we found that the gene for DUOX2, an NADPH oxidase involved in the maintenance of intestinal homeostasis, was upregulated in intestinal epithelial cells during cholera. Notably, the observed increases in DUOX2and TLR8expression were also modeled in vitrowhen Caco-2 or THP-1 cells, respectively, were stimulated with live V. choleraebut not with heat-killed organisms or cholera toxin alone. These previously unidentified features of the innate immune response to V. choleraeextend our understanding of the mucosal immune signaling pathways and effectors activated in vivofollowing cholera.

Published
2017
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