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234 results on '"Elliott, Jonathan T."'

2. Perspective on optical imaging for functional assessment in musculoskeletal extremity trauma surgery.

Author

Gitajn, Ida L, Slobogean, Gerard P, Henderson, Eric R, von Keudell, Arvind G, Harris, Mitchel B, Scolaro, John A, O'Hara, Nathan N, Elliott, Jonathan T, Pogue, Brian W, and Jiang, Shudong

Subjects
Extremities, Humans, Musculoskeletal Diseases, Indocyanine Green, Orthopedic Procedures, Prospective Studies, Adult, Aged, Optical Imaging, bone perfusion, fluorescence imaging, indocyanine green, optical imaging, orthopaedic surgery, Clinical Research, Bioengineering, Injury (total) Accidents/Adverse Effects, Regenerative Medicine, Biomedical Imaging, Musculoskeletal, Optics, Optical Physics, Biomedical Engineering, Opthalmology and Optometry
Abstract

SignificanceExtremity injury represents the leading cause of trauma hospitalizations among adults under the age of 65 years, and long-term impairments are often substantial. Restoring function depends, in large part, on bone and soft tissue healing. Thus, decisions around treatment strategy are based on assessment of the healing potential of injured bone and/or soft tissue. However, at the present, this assessment is based on subjective clinical clues and/or cadaveric studies without any objective measure. Optical imaging is an ideal method to solve several of these issues.AimThe aim is to highlight the current challenges in assessing bone and tissue perfusion/viability and the potentially high impact applications for optical imaging in orthopaedic surgery.ApproachThe prospective will review the current challenges faced by the orthopaedic surgeon and briefly discuss optical imaging tools that have been published. With this in mind, it will suggest key research areas that could be evolved to help make surgical assessments more objective and quantitative.ResultsOrthopaedic surgical procedures should benefit from incorporation of methods to measure functional blood perfusion or tissue metabolism. The types of measurements though can vary in the depth of tissue sampled, with some being quite superficial and others sensing several millimeters into the tissue. Most of these intrasurgical imaging tools represent an ideal way to improve surgical treatment of orthopaedic injuries due to their inherent point-of-care use and their compatibility with real-time management.ConclusionWhile there are several optical measurements to directly measure bone function, the choice of tools can determine also the signal strength and depth of sampling. For orthopaedic surgery, real-time data regarding bone and tissue perfusion should lead to more effective patient-specific management of common orthopaedic conditions, requiring deeper penetrance commonly seen with indocyanine green imaging. This will lower morbidity and result in decreased variability associated with how these conditions are managed.

Published
2020

11. Automatic correction of motion artifact in dynamic contrast-enhanced fluorescence imaging during open orthopedic surgery.

Author

Yue Tang, Gitajn, Ida Leah, Xu Cao, Xinyue Han, Elliott, Jonathan T., Bateman, Logan M., Malskis, Bethany S., Fisher, Lillian A., Sin, Jessica M., Henderson, Eric R., and Shudong Jiang

Subjects
CONTRAST-enhanced magnetic resonance imaging, ORTHOPEDIC surgery, FLUORESCENCE, PERFUSION, RESPIRATION, INDOCYANINE green
Abstract

Significance: Indocyanine green-based dynamic contrast-enhanced fluorescence imaging (DCE-FI) can objectively assess bone perfusion intraoperatively. However, it is susceptible to motion artifact due to patients' involuntary respiration and mechanical disturbance. Reducing motion artifacts would significantly improve DCE-FI for orthopedic surgical guidance. Aim: Our primary objective is to develop an automated correction method to reduce motion artifacts in DCE-FI and improve the accuracy of bone perfusion assessment. Approach: We developed an automated motion correction approach based on frame-by-frame mutual information (MI) and validated the effectiveness of this approach in various phantom studies and patient images from 45 imaging sessions of fifteen amputees. Results: The MI-based correction reduced motion artifacts by 93% for mechanical disturbances and 76% for simulated respiration in phantom studies. Patient images show improved alignment, improved kinetic curves, and restored bone perfusionrelated parameters with an average correction of 4.3 and 9.6 mm in x- and y-axes per session. Conclusions: The automated MI-based motion correction was able to eliminate motion artifacts effectively and significantly improved the quantitative assessment of bone perfusion by DCE-FI. [ABSTRACT FROM AUTHOR]

Published
2024
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12. Proceduralist criteria for evaluating interface utility of novel imaging modalities in early phase clinical trials: evaluating the need for standardized criteria

Author

Henderson, Eric R., primary, Elliott, Jonathan T., additional, Jiang, Shudong, additional, Gitajn, Ida L., additional, Lee, John Y. K., additional, Gibbs, Summer L., additional, Bouvet, Michael, additional, Mahadevan-Jansen, Anita, additional, Daly, Michael, additional, Streeter, Samuel S., additional, Paulsen, Keith D., additional, Pogue, Brian W., additional, Samkoe, Kimberley S., additional, and Singhal, Sunil, additional

Published
2023
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13. Early identification of life-threatening soft-tissue infection using dynamic fluorescence imaging: first-in-kind clinical study of first-pass kinetics

Author

Streeter, Samuel S., primary, Ray, Gabrielle S., additional, Bateman, Logan M., additional, Hebert, Kendra A., additional, Bushee, Fallon E., additional, Rodi, Scott W., additional, Gitajn, I. Leah, additional, Ahn, Jaimo, additional, Singhal, Sunil, additional, Martin, Neils D., additional, Bernthal, Nicholas M., additional, Lee, Christopher, additional, Obremskey, William T., additional, Shoenecker, Jonathan G., additional, Elliott, Jonathan T., additional, and Henderson, Eric R., additional

Published
2023
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17. Automated motion artifact correction for dynamic contrast-enhanced fluorescence imaging during open orthopedic surgery

Author

Tang, Yue, primary, Gitajn, I. Leah, additional, Cao, Xu, additional, Han, Xinyue, additional, Elliott, Jonathan T., additional, Yu, Xiaohan, additional, Bateman, Logan M., additional, Malskis, Bethany S., additional, Fisher, Lillian A., additional, Sin, Jessica M., additional, Henderson, Eric R., additional, Pogue, Brian W., additional, and Jiang, Shudong, additional

Published
2023
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23. Detection of subclinical hemorrhage using electrical impedance: a porcine study

Author

Murphy, Ethan K, primary, Klein, Samuel B, additional, Hamlin, Alexandra, additional, Anderson, Justin E, additional, Minichiello, Joseph M, additional, Lindqwister, Alexander L, additional, Moodie, Karen L, additional, Wanken, Zachary J, additional, Read, Jackson T, additional, Borza, Victor A, additional, Elliott, Jonathan T, additional, Halter, Ryan J, additional, Vaze, Vikrant S, additional, and Paradis, Norman A, additional

Published
2022
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25. Dynamic contrast-enhanced fluorescence imaging compared with MR imaging in evaluating bone perfusion during open orthopedic surgery

Author

Tang, Yue, Sin, Jessica M., Gitajn, I. Leah, Cao, Xu, Han, Xinyue, Elliott, Jonathan T., Yu, Xiaohan, Christian, Melanie L., Bateman, Logan, Chockbengboun, Theresa, Henderson, Eric R., Pogue, Brian W., and Jiang, Shudong

Subjects
Article
Abstract

ICG-based dynamic contrast-enhanced fluorescence imaging (DCE-FI) and intraoperative DCE- magnetic resonance imaging (MRI) have been carried out nearly simultaneously in three lower extremity bone infection cases to investigate the relationship between these two imaging modalities for assessing bone blood perfusion during open orthopedic surgeries. Time-intensity curves in the corresponding regions of interest of two modalities were derived for comparison. The results demonstrated that ICG-based DCE-FI has higher sensitivity to perfusion changes while DCE-MRI provides superior and supplemental depth-related perfusion information. Research applying the depth-related perfusion information derived from MRI to improve the overall analytic modeling of intraoperative DCE-FI is ongoing.

Published
2022
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44. Vision 20/20: Molecular-guided surgical oncology based upon tumor metabolism or immunologic phenotype: Technological pathways for point of care imaging and intervention

Author

Pogue, Brian W., Paulsen, Keith D., Samkoe, Kimberley S., Elliott, Jonathan T., Hasan, Tayyaba, Strong, Theresa V., Draney, Daniel R., and Feldwisch, Joachim

Subjects
Vision 20/20
Abstract

Surgical guidance with fluorescence has been demonstrated in individual clinical trials for decades, but the scientific and commercial conditions exist today for a dramatic increase in clinical value. In the past decade, increased use of indocyanine green based visualization of vascular flow, biliary function, and tissue perfusion has spawned a robust growth in commercial systems that have near-infrared emission imaging and video display capabilities. This recent history combined with major preclinical innovations in fluorescent-labeled molecular probes, has the potential for a shift in surgical practice toward resection guidance based upon molecular information in addition to conventional visual and palpable cues. Most surgical subspecialties already have treatment management decisions partially based upon the immunohistochemical phenotype of the cancer, as assessed from molecular pathology of the biopsy tissue. This phenotyping can inform the surgical resection process by spatial mapping of these features. Further integration of the diagnostic and therapeutic value of tumor metabolism sensing molecules or immune binding agents directly into the surgical process can help this field mature. Maximal value to the patient would come from identifying the spatial patterns of molecular expression in vivo that are well known to exist. However, as each molecular agent is advanced into trials, the performance of the imaging system can have a critical impact on the success. For example, use of pre-existing commercial imaging systems are not well suited to image receptor targeted fluorophores because of the lower concentrations expected, requiring orders of magnitude more sensitivity. Additionally the imaging system needs the appropriate dynamic range and image processing features to view molecular probes or therapeutics that may have nonspecific uptake or pharmacokinetic issues which lead to limitations in contrast. Imaging systems need to be chosen based upon objective performance criteria, and issues around calibration, validation, and interpretation need to be established before a clinical trial starts. Finally, as early phase trials become more established, the costs associated with failures can be crippling to the field, and so judicious use of phase 0 trials with microdose levels of agents is one viable paradigm to help the field advance, but this places high sensitivity requirements on the imaging systems used. Molecular-guided surgery has truly transformative potential, and several key challenges are outlined here with the goal of seeing efficient advancement with ideal choices. The focus of this vision 20/20 paper is on the technological aspects that are needed to be paired with these agents.

Published
2016

48. Application of Fluorescence-Guided Surgery to Subsurface Cancers Requiring Wide Local Excision

Author

Samkoe, Kimberley S., primary, Bates, Brent D., additional, Elliott, Jonathan T., additional, LaRochelle, Ethan, additional, Gunn, Jason R., additional, Marra, Kayla, additional, Feldwisch, Joachim, additional, Ramkumar, Dipak B., additional, Bauer, David F., additional, Paulsen, Keith D., additional, Pogue, Brian W., additional, and Henderson, Eric R., additional

Published
2018
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