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1. Maternal age is related to offspring DNA methylation: A meta‐analysis of results from the PACE consortium

Author

Yeung, Edwina, Biedrzycki, Richard J, Herrera, Laura C Gómez, Issarapu, Prachand, Dou, John, Marques, Irene Fontes, Mansuri, Sohail Rafik, Page, Christian Magnus, Harbs, Justin, Khodasevich, Dennis, Poisel, Eric, Niu, Zhongzheng, Allard, Catherine, Casey, Emma, Berstein, Fernanda Morales, Mancano, Giulia, Elliott, Hannah R, Richmond, Rebecca, He, Yiyan, Ronkainen, Justiina, Sebert, Sylvain, Bell, Erin M, Sharp, Gemma, Mumford, Sunni L, Schisterman, Enrique F, Chandak, Giriraj R, Fall, Caroline HD, Sahariah, Sirazul A, Silver, Matt J, Prentice, Andrew M, Bouchard, Luigi, Domellof, Magnus, West, Christina, Holland, Nina, Cardenas, Andres, Eskenazi, Brenda, Zillich, Lea, Witt, Stephanie H, Send, Tabea, Breton, Carrie, Bakulski, Kelly M, Fallin, M Daniele, Schmidt, Rebecca J, Stein, Dan J, Zar, Heather J, Jaddoe, Vincent WV, Wright, John, Grazuleviciene, Regina, Gutzkow, Kristine Bjerve, Sunyer, Jordi, Huels, Anke, Vrijheid, Martine, Harlid, Sophia, London, Stephanie, Hivert, Marie‐France, Felix, Janine, Bustamante, Mariona, and Guan, Weihua

Subjects
Biological Sciences, Biomedical and Clinical Sciences, Genetics, Prevention, Human Genome, Clinical Research, Women's Health, Aging, Pediatric, Good Health and Well Being, DNA Methylation, Humans, Female, Maternal Age, Infant, Newborn, Child, Adult, Male, Child, Preschool, CpG Islands, Pregnancy, aging, child, DNA methylation, melatonin, receptor, Medical and Health Sciences, Developmental Biology, Biological sciences, Biomedical and clinical sciences
Abstract

Worldwide trends to delay childbearing have increased parental ages at birth. Older parental age may harm offspring health, but mechanisms remain unclear. Alterations in offspring DNA methylation (DNAm) patterns could play a role as aging has been associated with methylation changes in gametes of older individuals. We meta-analyzed epigenome-wide associations of parental age with offspring blood DNAm of over 9500 newborns and 2000 children (5-10 years old) from the Pregnancy and Childhood Epigenetics consortium. In newborns, we identified 33 CpG sites in 13 loci with DNAm associated with maternal age (PFDR

Published
2024

3. Blood-based epigenome-wide analyses of chronic low-grade inflammation across diverse population cohorts

Author

Hillary, Robert F., Ng, Hong Kiat, McCartney, Daniel L., Elliott, Hannah R., Walker, Rosie M., Campbell, Archie, Huang, Felicia, Direk, Kenan, Welsh, Paul, Sattar, Naveed, Corley, Janie, Hayward, Caroline, McIntosh, Andrew M., Sudlow, Cathie, Evans, Kathryn L., Cox, Simon R., Chambers, John C., Loh, Marie, Relton, Caroline L., Marioni, Riccardo E., Yousefi, Paul D., and Suderman, Matthew

Published
2024
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4. Genome-wide association studies identify 137 genetic loci for DNA methylation biomarkers of aging

Author

McCartney, Daniel L, Min, Josine L, Richmond, Rebecca C, Lu, Ake T, Sobczyk, Maria K, Davies, Gail, Broer, Linda, Guo, Xiuqing, Jeong, Ayoung, Jung, Jeesun, Kasela, Silva, Katrinli, Seyma, Kuo, Pei-Lun, Matias-Garcia, Pamela R, Mishra, Pashupati P, Nygaard, Marianne, Palviainen, Teemu, Patki, Amit, Raffield, Laura M, Ratliff, Scott M, Richardson, Tom G, Robinson, Oliver, Soerensen, Mette, Sun, Dianjianyi, Tsai, Pei-Chien, van der Zee, Matthijs D, Walker, Rosie M, Wang, Xiaochuan, Wang, Yunzhang, Xia, Rui, Xu, Zongli, Yao, Jie, Zhao, Wei, Correa, Adolfo, Boerwinkle, Eric, Dugué, Pierre-Antoine, Durda, Peter, Elliott, Hannah R, Gieger, Christian, de Geus, Eco JC, Harris, Sarah E, Hemani, Gibran, Imboden, Medea, Kähönen, Mika, Kardia, Sharon LR, Kresovich, Jacob K, Li, Shengxu, Lunetta, Kathryn L, Mangino, Massimo, Mason, Dan, McIntosh, Andrew M, Mengel-From, Jonas, Moore, Ann Zenobia, Murabito, Joanne M, Ollikainen, Miina, Pankow, James S, Pedersen, Nancy L, Peters, Annette, Polidoro, Silvia, Porteous, David J, Raitakari, Olli, Rich, Stephen S, Sandler, Dale P, Sillanpää, Elina, Smith, Alicia K, Southey, Melissa C, Strauch, Konstantin, Tiwari, Hemant, Tanaka, Toshiko, Tillin, Therese, Uitterlinden, Andre G, Van Den Berg, David J, van Dongen, Jenny, Wilson, James G, Wright, John, Yet, Idil, Arnett, Donna, Bandinelli, Stefania, Bell, Jordana T, Binder, Alexandra M, Boomsma, Dorret I, Chen, Wei, Christensen, Kaare, Conneely, Karen N, Elliott, Paul, Ferrucci, Luigi, Fornage, Myriam, Hägg, Sara, Hayward, Caroline, Irvin, Marguerite, Kaprio, Jaakko, Lawlor, Deborah A, Lehtimäki, Terho, Lohoff, Falk W, Milani, Lili, Milne, Roger L, Probst-Hensch, Nicole, Reiner, Alex P, Ritz, Beate, and Rotter, Jerome I

Subjects
Prevention, Nutrition, Aging, Human Genome, Genetics, Generic health relevance, Inflammatory and immune system, Good Health and Well Being, Adiposity, Biomarkers, C-Reactive Protein, CpG Islands, DNA Methylation, Educational Status, Epigenesis, Genetic, Genetic Loci, Genetic Markers, Genome, Human, Genome-Wide Association Study, Granulocytes, Humans, Immunity, Innate, Lipid Metabolism, Multifactorial Inheritance, Plasminogen Activator Inhibitor 1, DNA methylation, GWAS, Epigenetic clock, Genetics of DNA Methylation Consortium, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Environmental Sciences, Biological Sciences, Information and Computing Sciences, Bioinformatics
Abstract

BackgroundBiological aging estimators derived from DNA methylation data are heritable and correlate with morbidity and mortality. Consequently, identification of genetic and environmental contributors to the variation in these measures in populations has become a major goal in the field.ResultsLeveraging DNA methylation and SNP data from more than 40,000 individuals, we identify 137 genome-wide significant loci, of which 113 are novel, from genome-wide association study (GWAS) meta-analyses of four epigenetic clocks and epigenetic surrogate markers for granulocyte proportions and plasminogen activator inhibitor 1 levels, respectively. We find evidence for shared genetic loci associated with the Horvath clock and expression of transcripts encoding genes linked to lipid metabolism and immune function. Notably, these loci are independent of those reported to regulate DNA methylation levels at constituent clock CpGs. A polygenic score for GrimAge acceleration showed strong associations with adiposity-related traits, educational attainment, parental longevity, and C-reactive protein levels.ConclusionThis study illuminates the genetic architecture underlying epigenetic aging and its shared genetic contributions with lifestyle factors and longevity.

Published
2021

6. TechTrends

Author

Curry, John, primary, Peacock, Rebeca, additional, and Digges-Elliott, Hannah, additional

Published
2023
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8. DNA methylation at the suppressor of cytokine signaling 3 (SOCS3) gene influences height in childhood

Author

Issarapu, Prachand, Arumalla, Manisha, Elliott, Hannah R., Nongmaithem, Suraj S., Sankareswaran, Alagu, Betts, Modupeh, Sajjadi, Sara, Kessler, Noah J., Bayyana, Swati, Mansuri, Sohail R., Derakhshan, Maria, Krishnaveni, G. V., Shrestha, Smeeta, Kumaran, Kalyanaraman, Di Gravio, Chiara, Sahariah, Sirazul A., Sanderson, Eleanor, Relton, Caroline L., Ward, Kate A., Moore, Sophie E., Prentice, Andrew M., Lillycrop, Karen A., Fall, Caroline H. D., Silver, Matt J., and Chandak, Giriraj R.

Published
2023
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11. Radical care in displacement: Rohingya women’s activism amidst neoliberal humanitarianism and repression.

Author

Ayhan, Tutku and Colpitts-Elliott, Hannah

Subjects
*POLITICAL persecution, *SOCIAL ecology, *REFUGEE camps, *FEMINIST ethics, *WOMEN refugees, *CARE ethics (Philosophy), *HUMANITARIANISM
Abstract

This paper examines the activism and care work of Rohingya women in displacement settings, focusing on grassroots efforts in Cox’s Bazar refugee camps and transnational advocacy by diaspora activists. Drawing on 43 in-depth interviews and applying a feminist ethics of care framework, we argue that these women's activism constitutes a form of radical care that challenges both neoliberal humanitarian practices and repressive state policies. Rohingya women activists forge networks of solidarity and empowerment that extend beyond conventional humanitarian interventions, providing emotional support and shared experiences that contribute to the social ecology of care for refugee women. Their grassroots work contests the neoliberal emphasis on individual self-reliance, instead highlighting the vital role of relational care in fostering collective resilience. However, these activists face significant risks from multiple sources, including state repression, community backlash, and online harassment. They employ strategies such as ‘strategic invisibility’ and digital activism to navigate these dangers. Despite the transformative potential of their work, it remains systematically undervalued, leaving activists vulnerable to burnout and depletion. By centering the experiences and agency of Rohingya women, this study reveals a complex landscape of resistance, care, and empowerment, offering insights into how refugee women create change amidst intersecting forms of oppression. [ABSTRACT FROM AUTHOR]

Published
2024
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13. Optimising Function

Author

Stevenson, Kay, Bicker, Greg, Jeeves, Ben, Elliott, Hannah, Santy-Tomlinson, Julie, Series Editor, Falaschi, Paolo, Series Editor, Hertz, Karen, Series Editor, and Ryan, Sarah, editor

Published
2020
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14. Epigenetic-age acceleration in the emerging burden of cardiometabolic diseases among migrant and non-migrant African populations: a population-based cross-sectional RODAM substudy

Author

Chilunga, Felix P, Henneman, Peter, Elliott, Hannah R, Cronjé, H Toinét, Walia, Gagandeep K, Meeks, Karlijn A C, Requena-Mendez, Ana, Venema, Andrea, Bahendeka, Silver, Danquah, Ina, Adeyemo, Adebowale, Klipstein-Grobusch, Kerstin, Pieters, Marlien, Mannens, Marcels M A M, and Agyemang, Charles

Published
2021
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15. Maternal age is related to offspring DNA methylation:A meta-analysis of results from the PACE consortium

Author

Yeung, Edwina, Biedrzycki, Richard J., Gómez Herrera, Laura C., Issarapu, Prachand, Dou, John, Marques, Irene Fontes, Mansuri, Sohail Rafik, Page, Christian Magnus, Harbs, Justin, Khodasevich, Dennis, Poisel, Eric, Niu, Zhongzheng, Allard, Catherine, Casey, Emma, Berstein, Fernanda Morales, Mancano, Giulia, Elliott, Hannah R., Richmond, Rebecca, He, Yiyan, Ronkainen, Justiina, Sebert, Sylvain, Bell, Erin M., Sharp, Gemma, Mumford, Sunni L., Schisterman, Enrique F., Chandak, Giriraj R., Fall, Caroline H.D., Sahariah, Sirazul A., Silver, Matt J., Prentice, Andrew M., Bouchard, Luigi, Domellof, Magnus, West, Christina, Holland, Nina, Cardenas, Andres, Eskenazi, Brenda, Zillich, Lea, Witt, Stephanie H., Send, Tabea, Breton, Carrie, Bakulski, Kelly M., Fallin, M. Daniele, Schmidt, Rebecca J., Stein, Dan J., Zar, Heather J., Jaddoe, Vincent W.V., Wright, John, Grazuleviciene, Regina, Gutzkow, Kristine Bjerve, Sunyer, Jordi, Huels, Anke, Vrijheid, Martine, Harlid, Sophia, London, Stephanie, Hivert, Marie France, Felix, Janine, Bustamante, Mariona, Guan, Weihua, Yeung, Edwina, Biedrzycki, Richard J., Gómez Herrera, Laura C., Issarapu, Prachand, Dou, John, Marques, Irene Fontes, Mansuri, Sohail Rafik, Page, Christian Magnus, Harbs, Justin, Khodasevich, Dennis, Poisel, Eric, Niu, Zhongzheng, Allard, Catherine, Casey, Emma, Berstein, Fernanda Morales, Mancano, Giulia, Elliott, Hannah R., Richmond, Rebecca, He, Yiyan, Ronkainen, Justiina, Sebert, Sylvain, Bell, Erin M., Sharp, Gemma, Mumford, Sunni L., Schisterman, Enrique F., Chandak, Giriraj R., Fall, Caroline H.D., Sahariah, Sirazul A., Silver, Matt J., Prentice, Andrew M., Bouchard, Luigi, Domellof, Magnus, West, Christina, Holland, Nina, Cardenas, Andres, Eskenazi, Brenda, Zillich, Lea, Witt, Stephanie H., Send, Tabea, Breton, Carrie, Bakulski, Kelly M., Fallin, M. Daniele, Schmidt, Rebecca J., Stein, Dan J., Zar, Heather J., Jaddoe, Vincent W.V., Wright, John, Grazuleviciene, Regina, Gutzkow, Kristine Bjerve, Sunyer, Jordi, Huels, Anke, Vrijheid, Martine, Harlid, Sophia, London, Stephanie, Hivert, Marie France, Felix, Janine, Bustamante, Mariona, and Guan, Weihua

Abstract

Worldwide trends to delay childbearing have increased parental ages at birth. Older parental age may harm offspring health, but mechanisms remain unclear. Alterations in offspring DNA methylation (DNAm) patterns could play a role as aging has been associated with methylation changes in gametes of older individuals. We meta-analyzed epigenome-wide associations of parental age with offspring blood DNAm of over 9500 newborns and 2000 children (5–10 years old) from the Pregnancy and Childhood Epigenetics consortium. In newborns, we identified 33 CpG sites in 13 loci with DNAm associated with maternal age (PFDR < 0.05). Eight of these CpGs were located near/in the MTNR1B gene, coding for a melatonin receptor. Regional analysis identified them together as a differentially methylated region consisting of 9 CpGs in/near MTNR1B, at which higher DNAm was associated with greater maternal age (PFDR = 6.92 × 10−8) in newborns. In childhood blood samples, these differences in blood DNAm of MTNR1B CpGs were nominally significant (p < 0.05) and retained the same positive direction, suggesting persistence of associations. Maternal age was also positively associated with higher DNA methylation at three CpGs in RTEL1-TNFRSF6B at birth (PFDR < 0.05) and nominally in childhood (p < 0.0001). Of the remaining 10 CpGs also persistent in childhood, methylation at cg26709300 in YPEL3/BOLA2B in external data was associated with expression of ITGAL, an immune regulator. While further study is needed to establish causality, particularly due to the small effect sizes observed, our results potentially support offspring DNAm as a mechanism underlying associations of maternal age with child health.

Published
2024

17. Use of a 0.55T 80cm-wide Bore Scanner for Cardiac Imaging in Bariatric and Claustrophobic Patients: A Preliminary Single Centre Experience

Author

Kaushal, Anmol, primary, Richard Crawley, MD, BSc, additional, Jeljeli, Sami, additional, Tiago Sequeiros, BSc, additional, Valapil, Ramesh, additional, Bolla, Rosemarie, additional, Cifra, Elna, additional, Cha, Mina, additional, Elliott, Hannah, additional, Evans, Carl, additional, Kunze, Karl P., additional, Giese, Daniel, additional, Thornley, Rebecca, additional, Garcia Ropero, Alvaro, additional, Giles, Sharon, additional, Ismail, Tevfik, additional, Razavi, Reza, additional, Hajnal, Joseph, additional, Ourselin, Sebastien, additional, and Chiribiri, Amedeo, additional

Published
2024
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26. SHIFTING UP.

Author

Elliott, Hannah

Subjects
CHIEF technical officers, FASHION stylists, CHIEF marketing officers, AUTOMATIC automobile transmissions, ELECTRIC automobiles
Abstract

The article discusses the resurgence of manual transmissions in the automotive industry. While automatic SUVs, paddle-shift coupes, and gearless electric vehicles have dominated the market, a class of consumers is seeking a more visceral connection to driving and asking for manual transmissions. Established automakers and newcomers have responded by rolling out models designed to recapture this experience. Although manual transmissions only make up 2% of new vehicles sold in the US, there are still loyalists who appreciate the sensory pleasures and maneuverability that manual transmissions offer. These manual variants are also becoming more desirable in the collector market, with prices for manual cars often higher than their automatic counterparts. [Extracted from the article]

Published
2024

31. Identifying epigenetic biomarkers of established prognostic factors and survival in a clinical cohort of individuals with oropharyngeal cancer

Author

Langdon, Ryan, Richmond, Rebecca, Elliott, Hannah R., Dudding, Tom, Kazmi, Nabila, Penfold, Chris, Ingarfield, Kate, Ho, Karen, Bretherick, Andrew, Haley, Chris, Zeng, Yanni, Walker, Rosie M., Pawlita, Michael, Waterboer, Tim, Gaunt, Tom, Smith, George Davey, Suderman, Matthew, Thomas, Steve, Ness, Andy, and Relton, Caroline

Published
2020
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34. ECMR 1-19 - Use of a 0.55T 80cm-wide Bore Scanner for Cardiac Imaging in Bariatric and Claustrophobic Patients: A Preliminary Single Centre Experience

Author

Kaushal, Anmol, Richard Crawley, MD, BSc, Jeljeli, Sami, Tiago Sequeiros, BSc, Valapil, Ramesh, Bolla, Rosemarie, Cifra, Elna, Cha, Mina, Elliott, Hannah, Evans, Carl, Kunze, Karl P., Giese, Daniel, Thornley, Rebecca, Garcia Ropero, Alvaro, Giles, Sharon, Ismail, Tevfik, Razavi, Reza, Hajnal, Joseph, Ourselin, Sebastien, and Chiribiri, Amedeo

Published
2024
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36. Epigenome-wide association of DNA methylation markers in peripheral blood from Indian Asians and Europeans with incident type 2 diabetes: a nested case-control study

Author

Chambers, John C, Loh, Marie, Lehne, Benjamin, Drong, Alexander, Kriebel, Jennifer, Motta, Valeria, Wahl, Simone, Elliott, Hannah R, Rota, Federica, Scott, William R, Zhang, Weihua, Tan, Sian-Tsung, Campanella, Gianluca, Chadeau-Hyam, Marc, Yengo, Loic, Richmond, Rebecca C, Adamowicz-Brice, Martyna, Afzal, Uzma, Bozaoglu, Kiymet, Mok, Zuan Yu, Ng, Hong Kiat, Pattou, François, Prokisch, Holger, Rozario, Michelle Ann, Tarantini, Letizia, Abbott, James, Ala-Korpela, Mika, Albetti, Benedetta, Ammerpohl, Ole, Bertazzi, Pier Alberto, Blancher, Christine, Caiazzo, Robert, Danesh, John, Gaunt, Tom R, de Lusignan, Simon, Gieger, Christian, Illig, Thomas, Jha, Sujeet, Jones, Simon, Jowett, Jeremy, Kangas, Antti J, Kasturiratne, Anuradhani, Kato, Norihiro, Kotea, Navaratnam, Kowlessur, Sudhir, Pitkäniemi, Janne, Punjabi, Prakash, Saleheen, Danish, Schafmayer, Clemens, Soininen, Pasi, Tai, E-Shyong, Thorand, Barbara, Tuomilehto, Jaakko, Wickremasinghe, Ananda Rajitha, Kyrtopoulos, Soterios A, Aitman, Timothy J, Herder, Christian, Hampe, Jochen, Cauchi, Stéphane, Relton, Caroline L, Froguel, Philippe, Soong, Richie, Vineis, Paolo, Jarvelin, Marjo-Riitta, Scott, James, Grallert, Harald, Bollati, Valentina, Elliott, Paul, McCarthy, Mark I, and Kooner, Jaspal S

Published
2015
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38. Ones To Watch.

Author

Tarmy, James, Boudway, Ira, Smith, Gerry, Buckley, Thomas, Leonard, Devin, D'Anastasio, Cecilia, Krader, Kate, Elliott, Hannah, Begun, Bret, and Carman, Ashley

Abstract

The article features several figures who are anticipated to play roles in arts, culture and entertainment business. They include artist Buck Ellison, ESPN executive vice president Rosalyn Durant, AEG Presents chief digital officer Brooke Michael Kain, Burbank co-chairman and co-chief executive officers (CEO) James Gunn and Peter Safran, Rimas Entertainment LLC CEO Noah Assad, Twitch streamer and YouTuber Kai Cenat, and Yess Restaurant chef Junya Yamasaki.

Published
2023

41. THE BEST OF THE REST.

Author

Krader, Kate, Rovzar, Chris, Tarmy, James, Rappaport, Sarah, Elliott, Hannah, Ekstein, Nikki, Newman, Kara, and McCoy, Elin

Subjects
COOKS, RYE whiskey
Abstract

The article reviews a selection of products, including the space bread at the Alchemist restaurant in Copenhagen, Denmark, the Nomos Glashütte Tangente 38 wrist watch, and the 2020 Quinta da Fonte Souto Taifa premium white wine.

Published
2024

42. The EWAS Catalog: a database of epigenome-wide association studies

Author

Battram, Thomas, primary, Yousefi, Paul, additional, Crawford, Gemma, additional, Prince, Claire, additional, Sheikhali Babaei, Mahsa, additional, Sharp, Gemma, additional, Hatcher, Charlie, additional, Vega-Salas, María Jesús, additional, Khodabakhsh, Sahar, additional, Whitehurst, Oliver, additional, Langdon, Ryan, additional, Mahoney, Luke, additional, Elliott, Hannah R., additional, Mancano, Giulia, additional, Lee, Matthew A., additional, Watkins, Sarah H., additional, Lay, Abigail C., additional, Hemani, Gibran, additional, Gaunt, Tom R., additional, Relton, Caroline L., additional, Staley, James R., additional, and Suderman, Matthew, additional

Published
2022
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44. Characterisation of ethnic differences in DNA methylation between UK resident South Asians and Europeans

Author

Elliott, Hannah R., primary, Burrows, Kimberley, additional, Min, Josine L., additional, Tillin, Therese, additional, Mason, Dan, additional, Wright, John, additional, Santorelli, Gillian, additional, Smith, George Davey, additional, Lawlor, Deborah A., additional, Hughes, Alun D., additional, Chaturvedi, Nishi, additional, and Relton, Caroline L., additional

Published
2022
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45. Additional file 2 of Characterisation of ethnic differences in DNA methylation between UK-resident South Asians and Europeans

Author

Elliott, Hannah R., Burrows, Kimberley, Min, Josine L., Tillin, Therese, Mason, Dan, Wright, John, Santorelli, Gillian, Davey Smith, George, Lawlor, Deborah A., Hughes, Alun D., Chaturvedi, Nishi, and Relton, Caroline L.

Abstract

Additional file 2. Figure S2. Principal component analysis of SABRE DNA methylation data. The upper panel shows PCs 1 and 2 generated from the 1000 most variant probes in SABRE or BiB. The lower panel shows PCs 1 and 2 generated from the 10000 most variant probes in SABRE or BiB. Colours indicate self-reported ethnic subgrouping (SABRE, BiB). Axis labels show the variance explained by each PC.

Published
2022
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46. Additional file 5 of Characterisation of ethnic differences in DNA methylation between UK-resident South Asians and Europeans

Author

Elliott, Hannah R., Burrows, Kimberley, Min, Josine L., Tillin, Therese, Mason, Dan, Wright, John, Santorelli, Gillian, Davey Smith, George, Lawlor, Deborah A., Hughes, Alun D., Chaturvedi, Nishi, and Relton, Caroline L.

Abstract

Additional file 5. Figure S3. Comparison of effect sizes for cell composition adjustment of EWAS. Each CpG is represented by a point on the graph with 95% confidence intervals for effect estimates. Red dashed line: linear regression between data sets. Black dashed line: line of equality. Orange highlighted estimates: p ≤ 1.03 × 10−7 cell adjusted EWAS (n = 3922/16,344 CpG sites).

Published
2022
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47. OK, But How Does It Drive?

Author

Elliott, Hannah

Subjects
FORD F-Series trucks, ELECTRIC trucks
Abstract

The article evaluates the electric pickup truck Cybertruck built by technology firm Tesla, Inc.

Published
2024

48. Cross-Ancestry DNA Methylation Marks of Insulin Resistance in Pregnancy: An Integrative Epigenome-Wide Association Study.

Author

Fragoso-Bargas, Nicolas, Elliott, Hannah R., Lee-Ødegård, Sindre, Opsahl, Julia O., Sletner, Line, Jenum, Anne Karen, Drevon, Christian A., Qvigstad, Elisabeth, Moen, Gunn-Helen, Birkeland, Kåre I., Prasad, Rashmi B., and Sommer, Christine

Subjects
*DNA methylation, *INSULIN resistance, *EPIGENOMICS, *LOCUS (Genetics), *GENETIC variation, *SOUTH Asians
Abstract

Although there are some epigenome-wide association studies (EWAS) of insulin resistance, for most of them authors did not replicate their findings, and most are focused on populations of European ancestry, limiting the generalizability. In the Epigenetics in Pregnancy (EPIPREG; n = 294 Europeans and 162 South Asians) study, we conducted an EWAS of insulin resistance in maternal peripheral blood leukocytes, with replication in the Born in Bradford (n = 879; n = 430 Europeans and 449 South Asians), Methyl Epigenome Network Association (MENA) (n = 320), and Botnia (n = 56) cohorts. In EPIPREG, we identified six CpG sites inversely associated with insulin resistance across ancestry, of which five were replicated in independent cohorts (cg02988288, cg19693031, and cg26974062 in TXNIP; cg06690548 in SLC7A11; and cg04861640 in ZSCAN26). From methylation quantitative trait loci analysis in EPIPREG, we identified gene variants related to all five replicated cross-ancestry CpG sites, which were associated with several cardiometabolic phenotypes. Mediation analyses suggested that the gene variants regulate insulin resistance through DNA methylation. To conclude, our cross-ancestry EWAS identified five CpG sites related to lower insulin resistance. [ABSTRACT FROM AUTHOR]

Published
2023
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