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203 results on '"Ellims, Andris"'

8. List of Contributors

Author

Al-Ahmad, Amin, primary, Andrade, Jason G., additional, Anter, Elad, additional, Arora, Rishi, additional, Asirvatham, Samuel J., additional, Banchs, Javier E., additional, Bassiouny, Mohamed, additional, Baykaner, Tina, additional, Bessière, Francis, additional, Bhakta, Deepak, additional, Bogun, Frank, additional, Brodt, Chad, additional, Buch, Eric, additional, Burkhardt, J. David, additional, Callans, David J., additional, Chen, Jien-Jiun, additional, Choi, Jong-Il, additional, Crawford, Thomas C., additional, Dandamudi, Gopi, additional, Das, Mithilesh K., additional, Daubert, James P., additional, Dawood, Farah Z., additional, Di Biase, Luigi, additional, Dixit, Sanjay, additional, Dubuc, Marc, additional, Dukkipati, Srinivas R., additional, Ellims, Andris, additional, Feld, Gregory K., additional, Friadi, Doni, additional, Gianni, Carola, additional, Gonzalez, Mario D., additional, Gula, Lorne J., additional, Haines, David E., additional, Haqqani, Haris M., additional, Ho, Gordon, additional, Hoffmayer, Kurt, additional, Horton, Rodney P., additional, Hranitzky, Patrick M., additional, Hsu, Jonathan, additional, Stephen Huang, Shoei K., additional, Hutchinson, Mathew D., additional, Ikeda, Atsushi, additional, Jackman, Warren M., additional, Jain, Rahul, additional, Kalman, Jonathan M., additional, Kanj, Mohamed H., additional, Kay, G. Neal, additional, Khairy, Paul, additional, Khakpour, Houman, additional, Kim, Young-Hoon, additional, Kim, Yun Gi, additional, Kiser, Andy C., additional, Kistler, Peter M., additional, Klein, George J., additional, Koruth, Jacob S., additional, Kowalewski, Christopher A.B., additional, Krummen, David E., additional, Lee, Kwang-No, additional, Leong-Sit, Peter, additional, Lerman, Bruce B., additional, Liang, Jackson J., additional, Lin, Jiunn-Lee, additional, Lin, Lian-Yu, additional, Lin, Ting-Tse, additional, Lockwood, Deborah, additional, Markowitz, Steven M., additional, Michaud, Gregory F., additional, Miller, John M., additional, Miller, Marc A., additional, Montgomery, Jay A., additional, Moukabary, Talal, additional, Mounsey, J. Paul, additional, Nademanee, Koonlawee, additional, Nakagawa, Hiroshi, additional, Naksuk, Niyada, additional, Narayan, Sanjiv M., additional, Natale, Andrea, additional, Nogami, Akihiko, additional, Oh, Suk-Kyu, additional, Oral, Hakan, additional, Padala, Santosh K., additional, Padmanabhan, Deepak, additional, Park, Hee-Soon, additional, Pathik, Bhupesh, additional, Paul, Thomas, additional, Petrellis, Basilios, additional, Reddy, Vivek Y., additional, Ringwala, Sukit, additional, Rivera, Jaime, additional, Roberts, Jason, additional, Rodrigo, Miguel, additional, Sakamoto, Yuichiro, additional, Sanchez, Javier E., additional, Santangeli, Pasquale, additional, Sauer, William H., additional, Saul, J. Philip, additional, Shepard, Richard K., additional, Shim, Jaemin, additional, Shivkumar, Kalyanam, additional, Siontis, Konstantinos, additional, Skanes, Allan C., additional, Su, Wilber W., additional, Sze, Edward, additional, Tada, Hiroshi, additional, Taneja, Taresh, additional, Tchou, Patrick J., additional, Triedman, John K., additional, Tung, Roderick, additional, Turagam, Mohit K., additional, Tzou, Wendy S., additional, Viswanathan, Mohan N., additional, Walters, Tomos E., additional, Wang, Paul J., additional, Whang, William, additional, Yamada, Takumi, additional, Yee, Raymond, additional, and Zaman, Junaid A.B., additional

Published
2019
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17. Association between pre-hospital chest pain severity and myocardial injury in ST elevation myocardial infarction: A post-hoc analysis of the AVOID study

Author

Fernando, Himawan, primary, Nehme, Ziad, additional, Peter, Karlheinz, additional, Bernard, Stephen, additional, Stephenson, Michael, additional, Bray, Janet E., additional, Myles, Paul S., additional, Stub, Romi, additional, Cameron, Peter, additional, Ellims, Andris H., additional, Taylor, Andrew J., additional, Kaye, David M., additional, Smith, Karen, additional, and Stub, Dion, additional

Published
2021
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28. Ventricular remodelling in cardiomyopathy – impact on ventricular physiology and cardiovascular outcome

Author

Ellims, Andris Harald

Subjects
cardiovascular system, cardiovascular diseases, Uncategorized
Abstract

Ventricular remodelling, defined as changes in ventricular structure and/or function in response to haemodynamic load and/or cardiac injury, is a feature of cardiomyopathy. Patterns of remodelling vary according to the specific type of cardiomyopathy, and also between individuals. Ventricular remodelling is linked to the development of systolic and diastolic heart failure as well as other adverse outcomes, including death. There is increasing interest in the potential role of novel strategies, including anti-fibrotic therapies, to enhance the treatment of patients with ventricular dysfunction. In this thesis, several cardiac imaging modalities, including cardiac magnetic resonance (CMR) imaging, are used to further evaluate both the physiological effects and clinical outcomes of ventricular remodelling in a variety of cardiomyopathies. In particular, the significance of myocardial fibrosis is explored in detail. Chapter 1 of this thesis provides an introduction and literature review encompassing current concepts of cardiomyopathy, ventricular remodelling and heart failure. Chapter 2 investigates the link between post-contrast T1 time, a CMR-derived index of diffuse myocardial fibrosis, and invasively determined measures of ventricular diastolic function in cardiac transplant recipients. For the first time, a significant correlation is revealed between post-contrast T1 time and β, the load-independent passive LV stiffness constant. The ability to non-invasively evaluate ventricular stiffness using T1 mapping may enhance our understanding of cardiomyopathies, and facilitate therapeutic trials of anti-fibrotic agents. Chapters 3 and 4 explore ventricular remodelling and the influence of genotype on phenotype in hypertrophic cardiomyopathy (HCM). Significantly more diffuse myocardial fibrosis is found in patients with HCM compared to healthy subjects, and is associated with both diastolic dysfunction and dyspnoea. Correlations between regional myocardial fibrosis by late gadolinium enhancement (LGE) and both left ventricular ejection fraction and outflow tract obstruction are also demonstrated. The presence of an identifiable pathogenic HCM mutation is associated with significantly more regional, but less diffuse myocardial fibrosis. Further research may identify links between specific pathogenic mutations and particular HCM phenotypes, and facilitate more individualised management strategies in this complex condition. Chapter 5 addresses whether peripheral byproducts of collagen metabolism can be utilised as indicators of myocardial fibrosis in HCM. Importantly, levels of these biomarkers are not found to reliably reflect either myocardial collagen metabolism or content. Chapter 6 prospectively compares electrocardiography, echocardiography and CMR for predicting response to cardiac resynchronisation therapy (CRT). While all three modalities are found to predict improvements in markers of response, only CMR is observed to predict both symptomatic and survival benefits in CRT candidates with shorter, non-LBBB QRS complexes, a subgroup known to derive less benefit from CRT. Finally, Chapter 7 explores whether novel approaches to coronary artery disease (CAD) risk stratification can predict plaque characteristics in asymptomatic, intermediate risk subjects. Plasma lipidomic profiling is shown to predict the burden of non-calcified coronary plaque in these patients. Re-stratification by this technique may enable more appropriate and effective preventative strategies against CAD, a major cause of cardiomyopathy.

Published
2017
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29. Reduction in mortality from implantable cardioverter-defibrillators in non-ischaemic cardiomyopathy patients is dependent on the presence of left ventricular scar

Author

Gutman, Sarah J, primary, Costello, Benedict T, additional, Papapostolou, Stavroula, additional, Voskoboinik, Aleksandr, additional, Iles, Leah, additional, Ja, Johnson, additional, Hare, James L, additional, Ellims, Andris, additional, Kistler, Peter M, additional, Marwick, Thomas H, additional, and Taylor, Andrew J, additional

Published
2018
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30. List of Contributors

Author

Al-Ahmad, Amin, Andrade, Jason G., Anter, Elad, Arora, Rishi, Asirvatham, Samuel J., Banchs, Javier E., Bassiouny, Mohamed, Baykaner, Tina, Bessière, Francis, Bhakta, Deepak, Bogun, Frank, Brodt, Chad, Buch, Eric, Burkhardt, J. David, Callans, David J., Chen, Jien-Jiun, Choi, Jong-Il, Crawford, Thomas C., Dandamudi, Gopi, Das, Mithilesh K., Daubert, James P., Dawood, Farah Z., Di Biase, Luigi, Dixit, Sanjay, Dubuc, Marc, Dukkipati, Srinivas R., Ellims, Andris, Feld, Gregory K., Friadi, Doni, Gianni, Carola, Gonzalez, Mario D., Gula, Lorne J., Haines, David E., Haqqani, Haris M., Ho, Gordon, Hoffmayer, Kurt, Horton, Rodney P., Hranitzky, Patrick M., Hsu, Jonathan, Stephen Huang, Shoei K., Hutchinson, Mathew D., Ikeda, Atsushi, Jackman, Warren M., Jain, Rahul, Kalman, Jonathan M., Kanj, Mohamed H., Kay, G. Neal, Khairy, Paul, Khakpour, Houman, Kim, Young-Hoon, Kim, Yun Gi, Kiser, Andy C., Kistler, Peter M., Klein, George J., Koruth, Jacob S., Kowalewski, Christopher A.B., Krummen, David E., Lee, Kwang-No, Leong-Sit, Peter, Lerman, Bruce B., Liang, Jackson J., Lin, Jiunn-Lee, Lin, Lian-Yu, Lin, Ting-Tse, Lockwood, Deborah, Markowitz, Steven M., Michaud, Gregory F., Miller, John M., Miller, Marc A., Montgomery, Jay A., Moukabary, Talal, Mounsey, J. Paul, Nademanee, Koonlawee, Nakagawa, Hiroshi, Naksuk, Niyada, Narayan, Sanjiv M., Natale, Andrea, Nogami, Akihiko, Oh, Suk-Kyu, Oral, Hakan, Padala, Santosh K., Padmanabhan, Deepak, Park, Hee-Soon, Pathik, Bhupesh, Paul, Thomas, Petrellis, Basilios, Reddy, Vivek Y., Ringwala, Sukit, Rivera, Jaime, Roberts, Jason, Rodrigo, Miguel, Sakamoto, Yuichiro, Sanchez, Javier E., Santangeli, Pasquale, Sauer, William H., Saul, J. Philip, Shepard, Richard K., Shim, Jaemin, Shivkumar, Kalyanam, Siontis, Konstantinos, Skanes, Allan C., Su, Wilber W., Sze, Edward, Tada, Hiroshi, Taneja, Taresh, Tchou, Patrick J., Triedman, John K., Tung, Roderick, Turagam, Mohit K., Tzou, Wendy S., Viswanathan, Mohan N., Walters, Tomos E., Wang, Paul J., Whang, William, Yamada, Takumi, Yee, Raymond, and Zaman, Junaid A.B.

Published
2020
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32. Reduction in mortality from implantable cardioverter-defibrillators in non-ischaemic cardiomyopathy patients is dependent on the presence of left ventricular scar.

Author

Gutman, Sarah J, Costello, Benedict T, Papapostolou, Stavroula, Voskoboinik, Aleksandr, Iles, Leah, Ja, Johnson, Hare, James L, Ellims, Andris, Kistler, Peter M, Marwick, Thomas H, and Taylor, Andrew J

Abstract

Aims In patients with non-ischaemic cardiomyopathy (NICM), the mortality benefit of a primary prevention implantable cardioverter-defibrillator (ICD) has been challenged. Left ventricular (LV) scar identified by cardiac magnetic resonance (CMR) imaging is associated with a high risk of malignant arrhythmia in NICM. We aimed to determine the impact of LV scar on the mortality benefit from a primary prevention ICD in NICM. Methods and results We recruited 452 consecutive heart failure patients [New York Heart Association (NYHA) Class II/III] with NICM and LV ejection fraction ≤35% from a state-wide CMR service. All patients fulfilled European Society of Cardiology guidelines for primary prevention ICD implantation; however, the decision to implant was at the treating physician's discretion. Baseline clinical and CMR data were recorded prospectively and heart failure mortality risk (MAGGIC score) was calculated. The primary study outcome measurement was all-cause mortality based on presence or absence of ICD, stratified by LV scar. Median follow-up was 37.9 months and there was no difference in MAGGIC score between those who did and did not receive a primary prevention ICD (19.30 ± 5.46 vs. 18.90 ± 5.67, P  = 0.50). In patients without LV scar, ICD implantation was not associated with improved mortality [hazard ratio (HR) = 1.22, 95% confidence interval (CI): 0.53–2.78, P  = 0.64]. In patients with LV scar, ICD implantation was independently associated with reduced mortality (HR = 0.45, 95% CI: 0.26–0.77, P  = 0.003). Conclusions In patients with NICM, primary prevention ICD implantation is only associated with reduced mortality in patients with LV scar. This may enable more effective selection of NICM patients for ICD implantation compared with current guidelines. View large Download slide View large Download slide [ABSTRACT FROM AUTHOR]

Published
2019
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33. Plasma Macrophage Migration Inhibitor Factor Is Elevated in Response to Myocardial Ischemia

Author

Fan, Fenling, primary, Fang, Lu, additional, Moore, Xiao‐Lei, additional, Xie, Xuegang, additional, Du, Xiao‐Jun, additional, White, David A., additional, O'Brien, Jessica, additional, Thomson, Helen, additional, Wang, Jun, additional, Schneider, Hans G., additional, Ellims, Andris, additional, Barber, Thomas W., additional, and Dart, Anthony M., additional

Published
2016
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34. 176-72: Diffuse Ventricular Fibrosis on Cardiac Magnetic Resonance Imaging Associates with Ventricular Tachycardia in Patients with Hypertrophic Cardiomyopathy

Author

Mclellan, Alex, primary, Ellims, Andris, additional, Prabhu, Sandeep, additional, Voskoboinik, Alex, additional, Iles, Leah, additional, Hare, James, additional, Kaye, David, additional, Macciocca, Ivan, additional, Mariani, Justin, additional, Kalman, Jonathan M., additional, Taylor, Andrew, additional, and Kistler, Peter, additional

Published
2016
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36. Response to Letter Regarding Article, “Air Versus Oxygen in ST-Segment–Elevation Myocardial Infarction”

Author

Stub, Dion, primary, Smith, Karen, additional, Bernard, Stephen, additional, Nehme, Ziad, additional, Stephenson, Michael, additional, Bray, Janet E., additional, Cameron, Peter, additional, Barger, Bill, additional, Ellims, Andris H., additional, Taylor, Andrew J., additional, Meredith, Ian T., additional, and Kaye, David M., additional

Published
2016
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39. Air Versus Oxygen in ST-Segment–Elevation Myocardial Infarction

Author

Stub, Dion, primary, Smith, Karen, additional, Bernard, Stephen, additional, Nehme, Ziad, additional, Stephenson, Michael, additional, Bray, Janet E., additional, Cameron, Peter, additional, Barger, Bill, additional, Ellims, Andris H., additional, Taylor, Andrew J., additional, Meredith, Ian T., additional, and Kaye, David M., additional

Published
2015
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40. Reverse cardiac remodeling after renal denervation: Atrial electrophysiologic and structural changes associated with blood pressure lowering

Author

McLellan, Alex J.A., primary, Schlaich, Markus P., additional, Taylor, Andrew J., additional, Prabhu, Sandeep, additional, Hering, Dagmara, additional, Hammond, Louise, additional, Marusic, Petra, additional, Duval, Jacqueline, additional, Sata, Yusuke, additional, Ellims, Andris, additional, Esler, Murray, additional, Peter, Karlheinz, additional, Shaw, James, additional, Walton, Antony, additional, Kalman, Jonathan M., additional, and Kistler, Peter M., additional

Published
2015
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44. Magnetic resonance post-contrast T1 mapping in the human atrium: Validation and impact on clinical outcome after catheter ablation for atrial fibrillation

Author

Ling, Liang-han, primary, McLellan, Alex J.A., additional, Taylor, Andrew J., additional, Iles, Leah M., additional, Ellims, Andris H., additional, Kumar, Saurabh, additional, Teh, Andrew, additional, Lee, Geoffrey, additional, Wong, Michael C.G., additional, Azzopardi, Sonia, additional, Sellenger, Michael A., additional, Morton, Joseph B., additional, Kalman, Jonathan M., additional, and Kistler, Peter M., additional

Published
2014
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