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194 results on '"Ellershaw, John E."'

4. GC-MS Techniques Investigating Potential Biomarkers of Dying in the Last Weeks with Lung Cancer

Author

Chapman, Elinor, Baker, James, Aggarwal, Prashant, Hughes, David, Nwosu, Amara, Boyd, Mark, Mayland, Catriona, Mason, Stephen, Ellershaw, John E, Probert, Chris, Coyle, Seamus, Chapman, Elinor, Baker, James, Aggarwal, Prashant, Hughes, David, Nwosu, Amara, Boyd, Mark, Mayland, Catriona, Mason, Stephen, Ellershaw, John E, Probert, Chris, and Coyle, Seamus

Abstract

Predicting when a patient with advanced cancer is dying is a challenge and currently no prognostic test is available. We hypothesised that a dying process from cancer is associated with metabolic changes and specifically with changes in volatile organic compounds (VOCs). We analysed urine from patients with lung cancer in the last weeks of life by headspace gas chromatography mass spectrometry. Urine was acidified or alkalinised before analysis. VOC changes in the last weeks of life were identified using univariate, multivariate and linear regression analysis; 12 VOCs increased (11 from the acid dataset, 2 from the alkali dataset) and 25 VOCs decreased (23 from the acid dataset and 3 from the alkali dataset). A Cox Lasso prediction model using 8 VOCs predicted dying with an AUC of 0.77, 0.78 and 0.85 at 30, 20 and 10 days and stratified patients into a low (median 10 days), medium (median 50 days) or high risk of survival. Our data supports the hypothesis there are specific metabolic changes associated with the dying. The VOCs identified are potential biomarkers of dying in lung cancer and could be used as a tool to provide additional prognostic information to inform expert clinician judgement and subsequent decision making.

Published
2023

13. ILIVE Project Volunteer study. Developing international consensus for a European Core Curriculum for hospital end-of-life-care volunteer services, to train volunteers to support patients in the last weeks of life: A Delphi study

Author

McGlinchey, Tamsin, primary, Mason, Stephen R, additional, Smeding, Ruthmarijke, additional, Goosensen, Anne, additional, Ruiz-Torreras, Inmaculada, additional, Haugen, Dagny Faksvåg, additional, Bakan, Miša, additional, and Ellershaw, John E, additional

Published
2021
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17. Herausgeber und Autoren

Author

Nieland, Peter, primary, Simader, Rainer, additional, Taylor, Jenny, additional, Bausewein, Claudia, additional, van den Broek, Jacob, additional, Cobbe, Sinead, additional, Coe, Kristina, additional, Dahlin, Ylva, additional, Ellershaw, John E., additional, Eva, Gail, additional, Fiechter Lienert, Brigitte, additional, Goodhead, Andrew F., additional, Grünberger, Elisabeth, additional, Hartley, Nigel, additional, Hewitt, Bronwen, additional, Hollander, Louis, additional, Jaspers, Birgit, additional, Jennings, Rebecca, additional, Kim, In-Sun, additional, Lippka, Michael- M., additional, Malcolm, Lorna, additional, McGlinchey, Tamsin, additional, Müllauer, Eva, additional, Norman, Kate, additional, Plath, Christina, additional, Reckinger, Klaus, additional, Schönleiter, Wolf, additional, Schraut, Sabine, additional, and Sykes, Nigel P., additional

Published
2013
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18. Audit of the Liverpool Care Pathway for the Dying Patient in a Dutch Cancer Hospital

Author

Veerbeek, Laetitia, Van Zuylen, Lia, Gambles, Maureen, Van Der Heide, Agnes, Van Der Rijt, Carin C.D., and Ellershaw, John E.

Subjects
Practice guidelines (Medicine) -- Evaluation, Cancer patients -- Care and treatment, Terminally ill persons -- Care and treatment, Health, Health care industry, Social sciences
Published
2006

20. ILIVE Project Volunteer study. Developing international consensus for a European Core Curriculum for hospital end-of-life-care volunteer services, to train volunteers to support patients in the last weeks of life: A Delphi study.

Author

McGlinchey, Tamsin, Mason, Stephen R, Smeding, Ruthmarijke, Goosensen, Anne, Ruiz-Torreras, Inmaculada, Haugen, Dagny Faksvåg, Bakan, Miša, and Ellershaw, John E

Subjects
CURRICULUM evaluation, CONSENSUS (Social sciences), TERMINAL care, COURSE evaluation (Education), ATTITUDES of medical personnel, EXECUTIVES, CRITICAL care medicine, QUESTIONNAIRES, DESCRIPTIVE statistics, CURRICULUM planning, PALLIATIVE treatment, DELPHI method
Abstract

Background: Volunteers make a huge contribution to the health and wellbeing of the population and can improve satisfaction with care especially in the hospice setting. However, palliative and end-of-life-care volunteer services in the hospital setting are relatively uncommon. The iLIVE Volunteer Study, one of eight work-packages within the iLIVE Project, was tasked with developing a European Core Curriculum for End-of-Life-Care Volunteers in hospital. Aim: Establish an international consensus on the content of a European Core Curriculum for hospital end-of-life-care volunteer services which support patients in the last weeks of life. Design: Delphi Process comprising the following three stages: 1. Scoping review of literature into palliative care volunteers. 2. Two rounds of Delphi Questionnaire. 3. Nominal Group Meeting. Setting/participants: Sixty-six participants completed the Round 1 Delphi questionnaire; 75% (50/66) took part in Round 2. Seventeen participants attended the Nominal Group Meeting representing an international and multi-professional group including, clinicians, researchers and volunteer coordinators from the participating countries. Results: The scoping review identified 88 items for the Delphi questionnaire. Items encompassed organisational issues for implementation and topics for volunteer training. Three items were combined and one item added in Round 2. Following the Nominal Group Meeting 53/87 items reached consensus. Conclusion: Key items for volunteer training were agreed alongside items for implementation to embed the end-of-life-care volunteer service within the hospital. Recommendations for further research included in-depth assessment of the implementation and experiences of end-of-life-care volunteer services. The developed European Core Curriculum can be adapted to fit local cultural and organisational contexts. [ABSTRACT FROM AUTHOR]

Published
2022
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38. Issues and needs in end-of-life decision making : An international modified Delphi study

Author

Raijmakers, Natasja J. H., van Zuylen, Lia, Costantini, Massimo, Caraceni, Augusto, Clark, Jean B., De Simone, Gustavo, Lundquist, Gunilla, Voltz, Raymond, Ellershaw, John E., van der Heide, Agnes, Raijmakers, Natasja J. H., van Zuylen, Lia, Costantini, Massimo, Caraceni, Augusto, Clark, Jean B., De Simone, Gustavo, Lundquist, Gunilla, Voltz, Raymond, Ellershaw, John E., and van der Heide, Agnes

Abstract

Background: end-of-life decision making is an important aspect of end-of-life care that can have a significant impact on the process of dying and patients' comfort in the last days of life. Aim: the aim of our study was to identify issues and considerations in end-of-life decision making, and needs for more evidence among palliative care experts, across countries and professions. Participants: 90 palliative care experts from nine countries participated in a modified Delphi study. Participants were asked to identify important issues and considerations in end-of-life decision making and to rate the need for more evidence. Results: experts mentioned 219 issues in end-of-life decision making related to the medical domain, 122 issues related to the patient wishes and 92 related to relatives' wishes, regardless of profession or country (p > 0.05). In accordance, more than 90% of the experts rated the comfort and wishes of the patient and the potential futility of treatment as important considerations in end-of-life decision making, although some variation was present. When asked about issues that are in need of more evidence, 87% mentioned appropriate indications for using sedatives and effects of artificial hydration at the end of life. A total of 83% mentioned adequate communication approaches. Conclusions: palliative care experts from different professions in different countries encounter similar issues in end-of-life decision making. Adequate communication about these issues is universally experienced as a challenge, which might benefit from increased knowledge. This shared experience enables and emphasizes the need for more international research.

Published
2012
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