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The capacity for human exercise performance can be enhanced with prolonged exercise training, whether it is endurance- or strength-based. The ability to adapt through exercise training allows individuals to perform at the height of their sporting event and/or maintain peak physical condition throughout the life span. Our continued drive to understand how to prescribe exercise to maximize health and/or performance outcomes means that our knowledge of the adaptations that occur as a result of exercise continues to evolve. This review will focus on current and new insights into endurance and strength-training adaptations and will highlight important questions that remain as far as how we adapt to training.

Muscle strength and power are important determinants of soldiers' performance in modern warfare. Here, we compare the efficacy of 22 weeks of whole-body resistance training with high load (HL, 10 repetitions maximum/RM) and low load (LL, 30RM) for developing maximal muscle strength and power, performance, and muscle mass in moderately trained cadets (20 ± 1 year, f; n = 5, m; n = 22). Outcome measures were assessed at baseline and at week 22, in addition to a mid-intervention assessment at week 10. Twenty-two weeks of HL led to greater increases in muscle strength (upper limb, Δ 10%, 95% CI [2.8, 17.1], p = 0.01; lower limb, Δ 9.9%, CI [1.1,18.6], p = 0.029), jump height (Δ 5.5%, CI [1.4,9.6], p = 0.011), and upper limb lean mass (Δ 5.2%, CI [1,9.4], p = 0.018) compared with LL. HL and LL led to similar changes in agility, muscle endurance performance, lower limb muscle mass, and cross-sectional area in m. vastus lateralis. For all variables, training-associated changes occurred primarily during the initial 10 weeks of the intervention, including the differential responses to HL and LL. In conclusion, although 22 weeks of HL led to greater increases in lower and upper limb muscle strength, power, and upper limb lean mass than LL, the 2 load conditions led to similar improvements in agility performance and lower limb muscle mass. Our results thus indicate that both loading regimes elicit multifaceted physiological improvements important for military readiness. [ABSTRACT FROM AUTHOR]

Purpose: Accumulated time at a high percentage of peak oxygen consumption (VO2peak) is important for improving performance in endurance athletes. The present study compared the acute physiological and perceived effects of performing high-intensity intervals with roller ski double poling containing work intervals with (1) fast start followed by decreasing speed (DEC), (2) systematic variation in exercise intensity (VAR), and (3) constant speed (CON). Methods: Ten well-trained cross-country skiers (double-poling VO2peak 69.6 [3.5] mL·min−1·kg−1) performed speed- and duration-matched DEC, VAR, and CON on 3 separate days in a randomized order (5 × 5-min work intervals and 3-min recovery). Results: DEC and VAR led to longer time ≥90% VO2peak (P =.016 and P =.033, respectively) and higher mean %VO2peak (P =.036, and P =.009) compared with CON, with no differences between DEC and VAR (P =.930 and P =.759, respectively). VAR, DEC, and CON led to similar time ≥90% of peak heart rate (HRpeak), mean HR, mean breathing frequency, mean ventilation, and mean blood lactate concentration ([La−]). Furthermore, no differences between sessions were observed for perceptual responses, such as mean rate of perceived exertion, session rate of perceived exertion or pain score (all Ps >.147). Conclusions: In well-trained XC skiers, DEC and VAR led to longer time ≥90% of VO2peak compared with CON, without excessive perceptual effort, indicating that these intervals can be a good alternative for accumulating more time at a high percentage of VO2peak and at the same time mimicking the pronounced variation in exercise intensities experienced during XC-skiing competitions. [ABSTRACT FROM AUTHOR]

The crucian carp (Carassius carassius) tolerates anoxia for days to months depending on temperature. During episodes of stress, heat shock proteins (HSPs) are important for limiting cellular damage, mainly by ensuring protein function. Accordingly, we hypothesized that anoxia would change the expression of HSPs and that this response would be temperature dependent. Real-time RT-PCR was used to investigate the effects of 1 and 7 days anoxia (A1 and A7) on the expression of HSP70a, HSP70b, HSC70, HSP90, and HSP30 in the brain and heart of 8[degrees]C- and 13[degrees]C-acclimated crucian carp. In general, the expression of all HSPs changed in response to anoxia, although varying in size and direction, and with organ and temperature. HSP70a expression increased drastically (~10-fold) in A7 brains and hearts at 13[degrees]C but not at 8[degrees]C. HSC70 and HSP90 expression decreased in A7 brains (by 60-70%), but not in A7 hearts. HSC70 expression increased in A1 brains and hearts at both temperatures (by 60-160%), and HSP30 expression decreased in A7 brains and hearts at both temperatures (by 50-80%). Notably, normoxic fish showed 7- and l l-fold higher HSP70a expression in the brain and heart at 8[degrees]C compared with 13[degrees]C. This difference disappeared during anoxia, suggesting that cold may function as a cue for preconditioning the crucian carp's HSP70a expression to the approaching anoxic winter period. heart; brain; temperature; preconditioning; teleost doi: l0.1152/ajpregu.00675.2009.

We investigated whether two kinases critical for survival during periods of energy deficiency in anoxia-intolerant mammalian species, AMP-activated kinase (AMPK), and protein kinase B (AKT), are equally important for hypoxic/anoxic survival in the extremely anoxia-tolerant crucian carp (Carassius carassius). We report that phosphorylation of AMPK and AKT in heart and brain showed small changes after 10 days of severe hypoxia (0.3 mg [O.sub.2]/l at 9[degrees]C). In contrast, anoxia exposure (0.01 mg [O.sub.2]/l at 8[degrees]C) substantially increased AMPK phosphorylation but decreased AKT phosphorylation in carp heart and brain, indicating activation of AMPK and deactivation of AKT. In agreement, blocking the activity of AMPK in anoxic fish in vivo with 20 mg/kg Compound C resulted in an elevated metabolic rate (as indicated by increased ethanol production) and tended to reduce energy charge. This is the first in vivo experiment with Compound C in a nonmammalian vertebrate, and it appears that AMPK plays a role in mediating anoxic metabolic depression in crucian carp. Real-time RT-PCR analysis of the investigated AMPK subunit revealed that the most likely composition of subunits in the carp heart is [[alpha].sub.2], [[beta].sub.1B], [[gamma].sub.2a], whereas a more even expression of subunits was found in the brain. In the heart, expression of the regulatory [[gamma].sub.2]-subunit increased in the heart during anoxia. In the brain, expression of the [[alpha].sub.1]-, [[alpha].sub.2]- and [[gamma].sub.1]-subunits decreased with anoxia exposure, but expression of the [[gamma].sub.2]-subunit remained constant. Combined, our findings suggest that AMPK and AKT may play important, but opposing roles for hypoxic/anoxic survival in the anoxia-tolerant crucian carp. metabolism; hypoxia; ATP; ADP; ethanol

Postactivation-potentiation exercise with added whole-body vibration (WBV) has been suggested as a potential way to acutely improve sprint performance. In cycling, there are many competitions and situations where sprinting abilities are important. Purpose: To investigate the effect of adding WBV to warm-up procedures on subsequent cycle sprint performance. Methods: Eleven well-trained cyclists participated in the study. All cyclists performed a familiarization session before 2 separate test sessions in randomized order. Each session included a standardized warm-up followed by 1 of the following preconditioning exercises: 30 s of half-squats without WBV or 30 s of half-squats with WBV at 40 Hz. A 15-s Wingate sprint was performed 1 min after the preconditioning exercise. Results: Performing preconditioning exercise with WBV at 40 Hz resulted in superior peak power output compared with preconditioning exercise without WBV (1413 ± 257 W vs 1353 ± 213 W, P = .04) and a tendency toward superior mean power output during a 15-second all-out sprint (850 ± 119 W vs 828 ± 101 W, P = .08). Effect sizes showed a moderate practical effect of WBV vs no WBV on both peak and mean power output. Conclusions: Preconditioning exercise performed with WBV at 40 Hz seems to have a positive effect on cycling sprint performance in young well-trained cyclists. This suggests that athletes can incorporate body-loaded squats with WBV in preparations to specific sprint training to improve the quality of the sprint training and also to improve sprint performance in relevant competitions. [ABSTRACT FROM AUTHOR]

The current study investigated the effects of 8 wk of strength-training cessation after 25 wk of strength training on strength- and cycling-performance characteristics. Elite cyclists were randomly assigned to either 25 wk of endurance training combined with heavy strength training (EXP, n = 7, maximal oxygen uptake [...O2max] 77 ± 6 mL ⋅ kg-1 ⋅ min-1; 3 x 4-10 RM, 1 to 2 d/wk) or to endurance training only (CON, n = 7, ...O2max 73 ± 5 mL ⋅ kg-1 ⋅ min-1). Thereafter, both groups performed endurance training only for 8 wk, coinciding with the initial part of the competition season. Data were assessed for practical significance using magnitude-based inferences. During the 25-wk preparatory period, EXP had a larger positive impact on maximal isometric half-squat force, squat jump (SJ), maximal aerobic power (Wmax), power output at 4 mmol/L [La], and mean power in 30-s Wingate test than did CON (ES = 0.46-0.74). Conversely, during the 8-wk competition period EXP had a reduction in SJ, Wmax, and mean power in the 30-s Wingate test compared with CON (ES = 0.49-0.84). The present findings suggest rapid decline of adaptations on termination of strength training during the first 8 wk of the competition period in elite cyclists. [ABSTRACT FROM AUTHOR]

Abstract Background The effect on performance of protein ingestion during or after exercise is not clear. This has largely been attributed to the utilization of different scientific protocols and the neglection of accounting for factors such as differences in physical and chemical properties of protein supplements and differences in athletic performance level. Methods We hypothesized that ingestion of unprocessed whey protein (15.3 g·h-1) together with carbohydrate (60 g·h-1), would provide no ergogenic effect on 5-min mean-power performance following 120 min cycling at 50% of maximal aerobic power (2.8 ± 0.2 W·kg-1, corresponding to 60 ± 4% of VO2max), compared to CHO alone (60 g·h-1). Conversely, we hypothesized that ingestion of the hydrolyzed marine protein supplement NutriPeptin™ (Np, 2.7 g·h-1), a processed protein supplement with potentially beneficial amino acid composition, together with a PROCHO beverage (12.4 g·h-1 and 60 g·h-1, respectively) would provide an ergogenic effect on mean-power performance. We also hypothesized that the magnitude of the ergogenic effect of NpPROCHO would be dependent on athletic performance. As for the latter analysis, performance level was defined according to a performance factor, calculated from individual pre values of Wmax, VO2max and 5-min mean-power performance, wherein the performance of each subject was ranked relative to the superior cyclist whos performance was set to one. Twelve trained male cyclists (VO2max = 65 ± 4 ml·kg-1·min-1) participated in a randomized double-blinded cross-over study. Results and conclusions Overall, no differences were found in 5-min mean-power performance between either of the beverages (CHO 5.4 ± 0.5 W·kg-1; PROCHO 5.3 ± 0.5 W·kg-1; NpPROCHO 5.4 ± 0.3 W·kg-1) (P = 0.29). A negative correlation was found between NpPROCHO mean-power performance and athletic performance level (using CHO-performance as reference; Pearson R = -0.74, P = 0.006). Moreover, ingestion of NpPROCHO resulted in improved 5-min mean-power performance relative to ingestion of CHO in the six lesser performing subjects compared to the six superior performing subjects (P < 0.05). This suggests that with the current protocol, NpPROCHO provided an ergogenic effect on 5-min mean-power performance in athletes with a lower performance level.