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Peptic ulcer disease, because of its high incidence in the population is an unsolved problem of public health. The aim of this study is the description of the pathology and its etiology. Several studies have demonstrated the relationship between the presence of Helicobacter pylori and gastroduodenal diseases such as antral gastritis, peptic ulcer , and gastric cancer . The infection rate can reach 80% in developing countries. Low socioeconomic levels and overcrowding are factors favoring infection by H. pylori.The infection causes inflammation in the gastric mucosa. The eradication induces a marked regression of gastric inflammation and a better response to medical treatment of peptic ulcer. [ABSTRACT FROM AUTHOR]