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This issue of Psychoanalytic Inquiry has been designed to address the new directions that have emerged in self-psychology after Kohut, and the product has demonstrated just how alive and well, how ...

From the beginning, self psychology has been criticized for failing to adequately address aggression. This critique is explored beginning with Heinz Kohut’s position on aggression and then moving t...

This discussion of Dr. Kathy Marks’s paper, In the Nick of Time: Motherhood and the Analytic Pair, centers on a patient’s need to probe the analyst’s subjectivity. Clinical processes involving the ...

One of the essential features of a therapeutic change process is the ability to establish, within the therapeutic relationship, a sense of safety from which patients can engage and explore the many issues that bring them into therapy. Efforts to gain our patients’ trust so that they feel safe enough to expose their vulnerabilities and engage in a healing process remain at the center of the analytic enterprise, no matter the theoretical position of the therapist. In fact, in an otherwise diverse and sometimes fractious psychoanalytic field, the importance of safety is one of the few areas of near consensus. In our approach, we acknowledge the intersubjective nature of all relational experience and appreciate the powerful processes of mutual influence that reverberate between the analytic couple. As we see it, clinical engagement requires both partners to take risks, tolerate a sense of danger, learn to trust each other, and seek emotional safety through connection and understanding. In this article...

Robert Emde describes the appealing qualities of playfulness and aliveness that Daniel Stern brought to living and to his life’s work. Having been both a friend and a collaborator, Emde summarizes ...

We are very grateful to the contributors of “The Many Faces of Self Psychology” for providing a group of articles which, individually and collectively, honor Kohut’s original contributions while of...

In the 1960s, after completing medical school, Dan Stern conducted psychopharmacology research at the National Institutes of Health in Bethesda, MD, and then completed his psychiatry residency and ...

Exposure of airway smooth muscle (ASM) cells to the cytokine IL-1β results in an induction of PGE2 synthesis that affects numerous cell functions. Current dogma posits induction of COX-2 protein as the critical, obligatory event in cytokine-induced PGE2 production, although PGE2 induction can be inhibited without a concomitant inhibition of COX-2. To explore other putative regulatory features we examined the role of phospholipase A2 (PLA2) and PGE synthase (PGES) enzymes in IL-1β-induced PGE2 production. Treatment of human ASM cultures with IL-1β caused a time-dependent induction of both cytosolic PLA2 (cPLA2) and microsomal PGES (mPGES) similar to that observed for COX-2. Regulation of COX-2 and mPGES induction was similar, being significantly reduced by inhibition of p42/p44 or p38, whereas cPLA2 induction was only minimally reduced by inhibition of p38 or PKC. COX-2 and mPGES induction was subject to feed-forward regulation by PKA, whereas cPLA2 induction was not. SB-202474, an SB-203580 analog lacking the ability to inhibit p38 but capable of inhibiting IL-1β-induced PGE2 production, was effective in inhibiting mPGES but not COX-2 or cPLA2 induction. These data suggest that although COX-2, cPLA2, and mPGES are all induced by IL-β in human ASM cells, regulatory features of cPLA2 are dissociated, whereas those of COX-2 and mPGES are primarily associated, with regulation of PGE2 production. mPGES induction and, possibly, cPLA2 induction appear to cooperate with COX-2 to determine IL-1β-mediated PGE2 production in human ASM cells.

Four black children with Spitz nevi are presented. The initial clinical diagnosis was pyogenic granuloma for three patients. One child had two Spitz nevi. Histologic examination revealed melanocytic dendritic hyperplasia in all cases.