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1. Understanding the Molecular Mechanisms of Incomptine A in Treating Non-Hodgkin Lymphoma Associated with U-937 Cells: Bioinformatics Approaches, Part I

Author

Fernando Calzada, Normand García-Hernández, Elihú Bautista, José Manuel Sánchez-López, Miguel Valdes, Claudia Velázquez, and Elizabeth Barbosa

Subjects
incomptine A, sesquiterpene lactone, Decachaeta incompta, cancer, non-Hodgkin lymphoma, TMT, Medicine, Pharmacy and materia medica, RS1-441
Abstract

Background: Incomptine A (IA) has been reported to have cytotoxic activity in non-Hodgkin lymphoma cancer cell lines and have effects on U-937 cells, including the induction of apoptosis, the production of reactive oxygen species, and the inhibition of glycolytic enzymes. Also, IA has cytotoxic activity in the triple-negative subtypes, HER2+, and luminal A of breast cancer cells, with its properties being associated with an effect on the antiapoptotic function of Hexokinase II (HKII). Objectives: In this research, we reviewed the altered levels of proteins present in the lymph nodes of male Balb/c mice inoculated with U-937 cells and treated with IA or methotrexate, as well as mice only inoculated with cancer cells. Methods: Five approaches, including Tandem Mass Tag (TMT), Gene ontology (GO), Reactome, KEGG pathway analysis, and molecular docking, were used. Results: TMT showed that 74 proteins were differentially expressed, out of which 12 presented overexpression (FC ≥ 1.5) and 62 were under expressed (FC ≤ 0.67). In general, the TMT approach showed that IA had a better effect on proteins than methotrexate. Gene ontology, Reactome, and KEGG pathway analysis showed that proteins with altered levels may be implicated in several processes, including gene silencing by RNA, oxidative phosphorylation, glycolysis/gluconeogenesis, cytoskeleton organization, and ATP metabolic and energetic processes. The molecular docking analysis, which used 23 altered proteins as targets, revealed that IA interacted with all the proteins used. Conclusions: The results obtained using the five bioinformatic approaches provide information and show that IA could be used to treat non-Hodgkin lymphoma induced with the U-937 cell line. Also, it could provide a basis for future research and the development of clinical trials.

Published
2024
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2. Antiprotozoal Activity Against Entamoeba hystolitica and Giardia lamblia of Cyclopeptides Isolated from Annona diversifolia Saff

Author

Ulises Murrieta-Dionicio, Fernando Calzada, Elizabeth Barbosa, Miguel Valdés, Benito Reyes-Trejo, Holber Zuleta-Prada, Diana Guerra-Ramírez, and Federico del Río-Portilla

Subjects
cherimolacyclopeptide D, squamines C and D, cyclopeptides, NMR, molecular docking, antiprotozoal activity, Organic chemistry, QD241-441
Abstract

Diseases caused by intestinal parasites such as protozoa represent a worldwide problem mainly for developing countries. From morbidity in different groups of people to cases of mortality in children and/or immunocompromised patients. In addition to the above, there is growing resistance to the drugs used in the treatment of these diseases, as well as undesirable side effects in patients. Therefore, there is an interest in the search for new alternatives for the base and/or development of new drugs with antiparasitic activities without harmful effects. In this sense, natural products offer to be a diverse source of compounds with biological activities. In this work, we describe the isolation and elucidation by 1D and 2D NMR spectroscopy of three cyclopeptides obtained from seeds of A. diversifolia Saff.: cherimolacyclopeptide D (1), squamin D (2), and squamin C (3). The fractions enriched in cyclopeptides, as well as a pure compound (1), showed antiprotozoal activity against E. hystolitica Schaudinn and Giardia lamblia Kunstler in vitro assays, with values of IC50 = 3.49 and 5.39 μg mL−1, respectively. The molecular docking study revealed that 1 has a strong interaction with targets used, including aldose reductase and PFOR enzymes. The antiprotozoal activity of cherimolacyclopeptide D is reported for the first time in this study.

Published
2024
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3. In Vivo, In Vitro and In Silico Anticancer Activity of Ilama Leaves: An Edible and Medicinal Plant in Mexico

Author

Jesica Ramírez-Santos, Fernando Calzada, Rosa María Ordoñez-Razo, Jessica Elena Mendieta-Wejebe, José Antonio Velázquez-Domínguez, Raúl Argüello-García, Claudia Velázquez, and Elizabeth Barbosa

Subjects
agri-food waste, ilama leaves, Annona macroprophyllata, acyclic terpenoids, cancer, morphological analysis, Organic chemistry, QD241-441
Abstract

Ilama leaves are an important source of secondary metabolites with promising anticancer properties. Cancer is a disease that affects a great number of people worldwide. This work aimed to investigate the in vivo, in vitro and in silico anticancer properties of three acyclic terpenoids (geranylgeraniol, phytol and farnesyl acetate) isolated from petroleum ether extract of ilama leaves. Their cytotoxic activity against U-937 cells was assessed using flow cytometry to determine the type of cell death and production of reactive oxygen species (ROS). Also, a morphological analysis of the lymph nodes and a molecular docking study using three proteins related with cancer as targets, namely, Bcl-2, Mcl-1 and VEGFR-2, were performed. The flow cytometry and histomorphological analysis revealed that geranylgeraniol, phytol and farnesyl acetate induced the death of U-937 cells by late apoptosis and necrosis. Geranylgeraniol and phytol induced a significant increase in ROS production. The molecular docking studies showed that geranylgeraniol had more affinity for Bcl-2 and VEGFR-2. In the case of farnesyl acetate, it showed the best affinity for Mcl-1. This study provides information that supports the anticancer potential of geranylgeraniol, phytol and farnesyl acetate as compounds for the treatment of cancer, particularly with the potential to treat non-Hodgkin’s lymphoma.

Published
2024
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4. Annona cherimola Miller and Its Flavonoids, an Important Source of Products for the Treatment of Diabetes Mellitus: In Vivo and In Silico Evaluations

Author

Fernando Calzada, Miguel Valdes, Jesús Martínez-Solís, Claudia Velázquez, and Elizabeth Barbosa

Subjects
Annona cherimola Miller, antihyperglycemic activity, flavonoids, in vivo assays, in silico assays, Medicine, Pharmacy and materia medica, RS1-441
Abstract

The antihyperglycemic activity of ethanolic extract from Annona cherimola Miller (EEAch) and its products were evaluated using in vivo and in silico assays. An α-glucosidase inhibition was evaluated with oral sucrose tolerance tests (OSTT) and molecular docking studies using acarbose as the control. SGLT1 inhibition was evaluated with an oral glucose tolerance test (OGTT) and molecular docking studies using canagliflozin as the control. Among all products tested, EEAc, the aqueous residual fraction (AcRFr), rutin, and myricetin reduced the hyperglycemia in DM2 mice. During the carbohydrate tolerance tests, all the treatments reduced the postprandial peak such as the control drugs. In the molecular docking studies, rutin showed more affinity in inhibiting α-glucosidase enzymes and myricetin in inhibiting the SGLT1 cotransporter, showing ∆G values of −6.03 and −3.32 kcal/mol−1, respectively, in α-glucosidase enzymes. In the case of the SGLT1 cotransporter, molecular docking showed ∆G values of 22.82 and −7.89 in rutin and myricetin, respectively. This research sorts in vivo and in silico pharmacological studies regarding the use of A. cherimola leaves as a source for the development of new potential antidiabetic agents for T2D control, such as flavonoids rutin and myricetin.

Published
2023
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5. Antidiabetic and Toxicological Effects of the Tea Infusion of Summer Collection from Annona cherimola Miller Leaves

Author

Jesús Martínez-Solís, Fernando Calzada, Elizabeth Barbosa, and Juan Manuel Gutiérrez-Meza

Subjects
Annona cherimola Miller, tea infusion, antihyperglycemic activity, subchronic oral toxicity, HPLC-DAD analysis, flavonoid glycosides, Botany, QK1-989
Abstract

Annona cherimola Miller (Ac) is a plant used in Mexican traditional medicine for the treatment of diabetes. In this work, the tea infusion extracts obtained from 1.5 g of leaf powder from Ac collected in May (AcMa), June (AcJun), July (AcJul), and August (AcAu) were evaluated on streptozocin-induced diabetic (STID) mice and for subchronic toxicity in STID and non-diabetic (ND) mice. In addition, extracts were subjected to high-performance liquid chromatography with diode array detection (HPLC-DAD). Results showed that the tea infusion extract of the sample collected in August (AcAu) exhibited the most significant antihyperglycemic activity during all acute assays. The analysis of the extracts (AcMa, AcJu, AcJul, and AcAu) by HPLC-DAD revealed that flavonoid glycosides, rutin, narcissin, and nicotiflorin were the major components. In addition, the sample AcAu contained the best concentration of flavonoids. In the case of subchronic oral toxicity, the AcAu sample did not cause mortality in STID mice, and histopathological analysis revealed significant improvement in the changes associated with diabetes in the liver and kidneys. These findings suggest that the Ac leaves collected in August may be a source of flavonoids such as rutin, with antidiabetic potential. In addition, these findings support the use of Ac to treat diabetes in traditional medicine.

Published
2022
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6. Linearolactone Induces Necrotic-like Death in Giardia intestinalis Trophozoites: Prediction of a Likely Target

Author

Raúl Argüello-García, Fernando Calzada, Bibiana Chávez-Munguía, Audifás-Salvador Matus-Meza, Elihú Bautista, Elizabeth Barbosa, Claudia Velazquez, Marta Elena Hernández-Caballero, Rosa Maria Ordoñez-Razo, and José Antonio Velázquez-Domínguez

Subjects
neo-clerodane diterpenes, Giardia intestinalis, ROS production, ultrastructural alterations, docking analysis, aldose reductase, Medicine, Pharmacy and materia medica, RS1-441
Abstract

Linearolactone (LL) is a neo-clerodane type diterpene that has been shown to exert giardicidal effects; however, its mechanism of action is unknown. This work analyzes the cytotoxic effect of LL on Giardia intestinalis trophozoites and identifies proteins that could be targeted by this active natural product. Increasing concentrations of LL and albendazole (ABZ) were used as test and reference drugs, respectively. Cell cycle progression, determination of reactive oxygen species (ROS) and apoptosis/necrosis events were evaluated by flow cytometry (FCM). Ultrastructural alterations were analyzed by transmission electron microscopy (TEM). Ligand–protein docking analyses were carried out using the LL structure raised from a drug library and the crystal structure of an aldose reductase homologue (GdAldRed) from G. intestinalis. LL induced partial arrest at the S phase of trophozoite cell cycle without evidence of ROS production. LL induced pronecrotic death in addition to inducing ultrastructural alterations as changes in vacuole abundances, appearance of perinuclear and periplasmic spaces, and deposition of glycogen granules. On the other hand, the in silico study predicted that GdAldRed is a likely target of LL because it showed a favored change in Gibbs free energy for this complex.

Published
2022
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7. Expanding the Study of the Cytotoxicity of Incomptines A and B against Leukemia Cells

Author

Fernando Calzada, Normand Garcia-Hernandez, Sergio Hidalgo-Figueroa, Elihú Bautista, Elizabeth Barbosa, Claudia Velázquez, and Marta Elena Hernández-Caballero

Subjects
incomptine A, incomptine B, sesquiterpene lactones, cytotoxic activity, human cancer cell lines, leukemia, Organic chemistry, QD241-441
Abstract

Heliangolide-type sesquiterpene lactones (HTSLs) are phytocompounds with several pharmacological activities including cytotoxic and antitumor activity. Both bioactivities are related to an α-methylene-γ-lactone moiety and an ester group on carbon C-8 in the sesquiterpene lactone (SL) structure. Two HTSLs, incomptines A (AI) and B (IB) isolated from Decachaeta incompta, were evaluated for their cytotoxic activity on three leukemia cell lines: HL-60, K-562, and REH cells. Both compounds were subjected to a molecular docking study using target proteins associated with cancer such as topoisomerase IIα, topoisomerase IIβ, dihydrofolate reductase, methylenetetrahydrofolate dehydrogenase, and Bcl-2-related protein A1. Results show that IA and IB exhibit cytotoxic activity against all cell lines used. The CC50 value of IA was 2–4-fold less than etoposide and methotrexate, two anticancer drugs used as positive controls. The cytotoxic activity of IB was close to that of etoposide and methotrexate. The molecular docking analysis showed that IA and IB have important interaction on all targets used. These findings suggest that IA and IB may serve as scaffolds for the development of new treatments for different types of leukemia.

Published
2022
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8. Understanding the Anti-Diarrhoeal Properties of Incomptines A and B: Antibacterial Activity against Vibrio cholerae and Its Enterotoxin Inhibition

Author

Fernando Calzada, Elihu Bautista, Sergio Hidalgo-Figueroa, Normand García-Hernández, Claudia Velázquez, Elizabeth Barbosa, Miguel Valdes, and Jesús Iván Solares-Pascasio

Subjects
incomptine A, incomptine B, sesquiterpene lactones, Decachaeta incompta, Vibrio cholerae, cholera toxin, Medicine, Pharmacy and materia medica, RS1-441
Abstract

Incomptines A (IA) and B (IB) are two sesquiterpene lactones with antiprotozoal, antibacterial, cytotoxic, antitumor, spermicidal, and phytotoxic properties. The antibacterial activity of IA and IB against bacteria causing diarrhoea have been reported; however, no information is available regarding their antibacterial activity on Vibrio cholerae. In this work, both compounds were evaluated for their anti-diarrhoeal potential using the bacterium V. cholerae, sodium dodecyl sulphate–polyacrylamide gel electrophoresis (SDS-PAGE) analysis on cholera toxin, and a cholera toxin-induced diarrhoea model in male Balb/c mice. In addition, a molecular docking study was carried out to understand the interaction of IA and IB with cholera toxin. In terms of antibacterial activity, IB was three times more active than IA on V. cholerae. In the case of SDS-PAGE analysis and the in silico study, IA was most effective, revealing its potential binding mode at a molecular level. In terms of anti-diarrhoeal activity, IA was 10 times more active than IB and racecadotril, an antisecretory drug used as positive control; the anti-diarrheal activity of IB was also closer than racecadotril. The results obtained from in vitro, in vivo, and computational studies on V. cholerae and cholera toxin support the potential of IA and IB as new anti-diarrhoeal compounds.

Published
2022
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9. Antihyperglycemic Effects of Salvia polystachya Cav. and Its Terpenoids: α-Glucosidase and SGLT1 Inhibitors

Author

Rocio Ortega, Miguel Valdés, Francisco J. Alarcón-Aguilar, Ángeles Fortis-Barrera, Elizabeth Barbosa, Claudia Velazquez, and Fernando Calzada

Subjects
Salvia polystachya, antihyperglycemic activity, α-glucosidase inhibitor, SGLT1 inhibitor, acute oral toxicity, docking analysis, Botany, QK1-989
Abstract

The antihyperglycemic activity of ethanolic extract from Salvia polystachya (EESpS) and its products was evaluated using in vivo, ex vivo and in silico assays; additionally, an acute toxicity assay was evaluated. EESpS was classified as a nontoxic class 5 drug. EESpS, ethyl acetate fraction (EtOAcFr), secondary-6-fraction (SeFr6), ursolic acid (UA), and oleanolic acid (OA) reduced the hyperglycemia in DM2 mice. α-glucosidase inhibition was evaluated with oral sucrose and starch tolerance tests (OSuTT and OStTT), an intestinal sucrose hydrolysis (ISH) assay and molecular docking studies using acarbose as control. SGLT1 inhibition was evaluated with oral glucose and galactose tolerance tests (OGTT and OGaTT), an intestinal glucose absorption (IGA) assay and molecular docking studies using canagliflozin as the control. During the carbohydrate tolerance tests, all the treatments reduced the postprandial peak, similar to the control drugs. During the ISH, IC50 values of 739.9 and 726.3 µM for UA and OA, respectively, were calculated. During the IGA, IC50 values of 966.6 and 849.3 for UA, OA respectively, were calculated. Finally, during the molecular docking studies, UA and OA showed ∆G values of −6.41 and −5.48 kcal/mol−1, respectively, on α-glucosidase enzymes. During SGLT1, UA and OA showed ∆G values of −10.55 and −9.65, respectively.

Published
2022
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10. Antitumor Potential of Annona muricata Linn. An Edible and Medicinal Plant in Mexico: In Vitro, In Vivo, and Toxicological Studies

Author

Verenice Merlín-Lucas, Rosa María Ordoñez-Razo, Fernando Calzada, Aida Solís, Normand García-Hernández, Elizabeth Barbosa, and Miguel Valdés

Subjects
Annona muricata, antitumor potential, cytotoxic activity, 4T1 cells, brine shrimp lethality, acute oral toxicity, Organic chemistry, QD241-441
Abstract

Annona muricata (Am) is a plant used in traditional Mexican medicine to treat cancer. In this study, ethanol extracts of Am collected in Acapulco and Tecpan from Guerrero state were evaluated orally on Balb/c mice inoculated with 4T1 cells, for cytotoxic activity (CA) on 4T1 cells, in brine shrimp lethality assay (BSLA), and for acute oral toxicity in mice. In addition, ethanol extracts were subjected to high-performance liquid chromatography (HPLC) with diode array detection. Results showed that the extracts collected in December in Acapulco (AcDe) and Tecpan (TeDe) exhibited the most significant antitumor and cytotoxic activity. In the BSLA, the most important effect was observed in the extracts from Acapulco and Tecpan collected in June (AcJu) and August (TeAg), respectively. The samples from Acapulco (AcJu, and AcAg) and Tecpan (TeJu and TeAg) showed the highest toxicity. The analysis of the extracts, AcDe and TeDe, by HPLC revealed that flavonoids, rutin, narcissin, and nicotinflorin were the major components. These findings suggest that extracts from Am collected in Acapulco and Tecpan in the month of December may be an important source to obtain flavonoid glycosides with anticancer potential specifically against breast cancer. This also supports the use of Am to treat cancer in Mexican traditional medicine.

Published
2021
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11. Antilymphoma Effect of Incomptine A: In Vivo, In Silico, and Toxicological Studies

Author

Fernando Calzada, Elihú Bautista, Sergio Hidalgo-Figueroa, Normand García-Hernández, Elizabeth Barbosa, Claudia Velázquez, Rosa María Ordoñez-Razo, and Angel Giovanni Arietta-García

Subjects
incomptine A, antilymphoma activity, molecular docking, acute toxicity, brine shrimp lethality, cancer, Organic chemistry, QD241-441
Abstract

Incomptine A (IA) is a sesquiterpene lactone isolated from Decachaeta incompta that induces apoptosis, reactive oxygen species production, and a differential protein expression on the U-937 (diffuse histiocytic lymphoma) cell line. In this work, the antitumor potential of IA was investigated on Balb/c mice inoculated with U-937 cells and through the brine shrimp lethality (BSL) test. Furthermore, IA was subjected to molecular docking study using as targets proteins associated with processes of cancer as apoptosis, oxidative stress, and glycolytic metabolism. In addition to determining the potential toxicity of IA in human, its acute toxicity was performed in mice. Results reveals that IA showed high antilymphoma activity and BSL with an EC50 of 2.4 mg/kg and LC50 16.7 µg/mL, respectively. The molecular docking study revealed that IA has strong interaction on all targets used. In the acute oral toxicity, IA had a LD50 of 149 mg/kg. The results showed that the activities of IA including antilymphoma activity, BSL, acute toxicity, and in silico interactions were close to the methotrexate, an anticancer drug used as positive control. These findings suggest that IA may serve as a candidate for the development of a new drug to combat lymphoma.

Published
2021
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12. Antihyperglycemic and Antilipidemic Properties of a Tea Infusion of the Leaves from Annona cherimola Miller on Streptozocin-Induced Type 2 Diabetic Mice

Author

Jesús Martínez-Solís, Fernando Calzada, Elizabeth Barbosa, and Miguel Valdés

Subjects
Annona cherimola Miller, antihyperglycemic activity, antilipidemic activity, HPLC analysis, toxicity, Organic chemistry, QD241-441
Abstract

The antihyperglycemic and antilipidemic effects of the tea infusion extracts of leaves from Annona cherimola Miller (IELAc-0.5, IELAc-1.5, and IELAc-3.0) were evaluated on normoglycemic (NG) and streptozocin-induced diabetic (STID) mice. In the acute test, IELAc-1.5 at 300 mg/kg bodyweight (bw) exhibited antihyperglycemic activity on STID mice since the first hour of treatment. Then, its antidiabetic potential was analyzed in a subchronic evaluation. IELAc-1.5 was able to reduce the blood glucose level, glycated hemoglobin (HbA1c), cholesterol (CHO), and triglycerides (TG); high-density lipoprotein (HDL) showed an increase at the end of treatment. IELAc-1.5 did not modify the urine profile at the end of the evaluation, and neither toxicity nor macroscopic organ damage were observed in acute and subchronic assays. In addition, a major flavonol glycoside present in the tea infusion extracts was identified using high-performance liquid chromatography with diode array detection (HPLC-DAD). The analysis of the tea infusion extracts by HPLC revealed that rutin was the major component. This study supports the use of tea infusions from Annona cherimola for the treatment of diabetes and suggests that rutin could be responsible, at least in part, for their antidiabetic properties.

Published
2021
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13. Antihyperglycemic and Lipid Profile Effects of Salvia amarissima Ortega on Streptozocin-Induced Type 2 Diabetic Mice

Author

Jesus Ivan Solares-Pascasio, Guillermo Ceballos, Fernando Calzada, Elizabeth Barbosa, and Claudia Velazquez

Subjects
Salvia amarissima Ortega, diabetes mellitus, antihyperglycemic activity, lipid profile, Organic chemistry, QD241-441
Abstract

Salvia amarissima Ortega was evaluated to determinate its antihyperglycemic and lipid profile properties. Petroleum ether extract of fresh aerial parts of S. amarissima (PEfAPSa) and a secondary fraction (F6Sa) were evaluated to determine their antihyperglycemic activity in streptozo-cin-induced diabetic (STID) mice, in oral tolerance tests of sucrose, starch, and glucose (OSTT, OStTT, and OGTT, respectively), in terms of glycated hemoglobin (HbA1c), triglycerides (TG), and high-density lipoprotein (HDL). In acute assays at doses of 50 mg/kg body weight (b.w.), PEfAPSa and F6Sa showed a reduction in hyperglycemia in STID mice, at the first and fifth hour after of treatment, respectively, and were comparable with acarbose. In the sub-chronic test, PEfAPSa and F6Sa showed a reduction of glycemia since the first week, and the effect was greater than that of the acarbose control group. In relation to HbA1c, the treatments prevented the increase in HbA1c. In the case of TG and HDL, PEfAPSa and F6Sa showed a reduction in TG and an HDL increase from the second week. OSTT and OStTT showed that PEfAPSa and F6Sa significantly lowered the postprandial peak at 1 h after loading but only in sucrose or starch such as acarbose. The results suggest that S. amarissima activity may be mediated by the inhibition of disaccharide hydrolysis, which may be associated with an α-glucosidase inhibitory effect.

Published
2021
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14. Antihyperglycemic Effects of Annona diversifolia Safford and Its Acyclic Terpenoids: α-Glucosidase and Selective SGLT1 Inhibitiors

Author

Miguel Valdés, Fernando Calzada, Jessica Elena Mendieta-Wejebe, Verenice Merlín-Lucas, Claudia Velázquez, and Elizabeth Barbosa

Subjects
diabetes mellitus, antihyperglycemic activity, Annona diversifolia Safford, Organic chemistry, QD241-441
Abstract

Annona diversifolia Safford and two acyclic terpenoids were evaluated to determine their antihyperglycemic activity as potential α-glucosidase and selective SGLT-1 inhibitiors. Ethanolic extract (EEAd), chloroformic (CHCl3Fr), ethyl acetate (EtOAcFr), aqueous residual (AcRFr), secondary 5 (Fr5) fractions, farnesal (1), and farnesol (2) were evaluated on normoglycemic and streptozocin-induced diabetic mice. EEAd, CHCl3Fr, Fr5, (1) and (2) showed antihyperglycemic activity. The potential as α-glucosidase inhibitors of products was evaluated with oral sucrose and lactose tolerance (OSTT and OLTT, respectively) and intestinal sucrose hydrolysis (ISH) tests; the potential as SGLT-1 inhibitors was evaluated using oral glucose tolerance (OGTT), intestinal glucose absorption (IGA), and urinary glucose excretion (UGE) tests. In OSTT and OLTT, all treatments showed significant activity at two and four hours. In ISH, half maximal effective concentrations (CE50) of 565, 662 and 590 μg/mL, 682 and 802 μM were calculated, respectively. In OGTT, all treatments showed significant activity at two hours. In IGA, CE50 values of 1059, 783 and 539 μg/mL, 1211 and 327 μM were calculated, respectively. In UGE Fr5, (1) and (2) showed significant reduction of the glucose excreted compared with canagliflozin. These results suggest that the antihyperglycemic activity is mediated by α-glucosidase and selective SGLT-1 inhibition.

Published
2020
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18. Doença cerebrovascular no Brasil de 1990 a 2015: Global Burden of Disease 2015

Author

Paulo Andrade Lotufo, Alessandra Carvalho Goulart, Valéria Maria de Azeredo Passos, Fabio Mitsuhiro Satake, Maria de Fátima Marinho de Souza, Elizabeth Barbosa França, Antônio Luiz Pinho Ribeiro, and Isabela Judith Martins Bensenõr

Subjects
Social inequality, Stroke, Hypertension, Primary Prevention, Mortality, Public aspects of medicine, RA1-1270
Abstract

RESUMO: Objetivo: Verificar as tendências temporais das taxas de mortalidade, dos anos de vida perdidos (years of life lost - YLL) e dos anos de vida perdidos devido à incapacidade (years lost due to disability - YLD) motivadas pela doença cerebrovascular no Brasil entre 1990 e 2015. Métodos: Utilizou-se as informações do Global Burden of Diseases 2015 (GBD 2015) para analisar a magnitude e as tendências das taxas de mortalidade e dos anos de vida ajustados por incapacidade (DALY - disability-adjusted life years) nas 27 unidades da Federação, entre 1990 e 2015, pela doença cerebrovascular (CID-10: I-60-69). Os estados brasileiros foram analisados pelo índice de desenvolvimento social (IDS), composto por renda per capita, proporção de escolaridade formal aos 15 anos e taxa de fecundidade. Resultados: Apesar do aumento do número absoluto de mortes pela doença cerebrovascular, a proporção de mortes abaixo dos 70 anos de idade reduziu pela metade entre 1990 e 2015. A aceleração da queda foi maior entre as mulheres, e mais acentuada no período de 1990 e 2005 do que de 2005 a 2015. O risco de morte reduziu-se à metade em todo o país; porém, os estados no tercil inferior tiveram reduções menos expressivas para homens e mulheres (respectivamente, -1,23 e -1,84% ao ano), comparados aos no tercil médio (-1,94 e -2,22%) e no tercil superior (-2,85 e -2,82%). Os anos perdidos por incapacidade também apresentam redução entre os estados, mas de forma menos expressiva. Conclusão: Apesar da redução das taxas ajustadas por idade em todo o país, a doença cerebrovascular ainda apresenta alta carga de doença, principalmente nos estados com menor desenvolvimento socioeconômico.

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19. Proteolytic potential of psychrotrophic microorganisms isolated from fresh cheese

Author

Dara Elizabeth Barbosa Rodrigues, Leonardo Lima da Paixão, Valdirene Rodrigues Santana, Roberta Magalhães Dias Cardozo, and Solimar Gonçalves Machado

Subjects
proteolysis, spoilage, quality, raw milk., Dairy processing. Dairy products, SF250.5-275
Abstract

Given the economic importance of the dairy industry, product quality should be a constant concern. Some sensorial and technological properties of milk and dairy products are related to the spoilage contaminant microbiota, which is mainly represented by psychrotrophic proteolytic bacteria producing thermoresistant enzymes. Fresh artisanal cheeses are generally produced with raw milk, so it is of great importance to know the microbiota of these products. Therefore, the objective of this work was to count and isolate the psychrotrophic proteolytic bacteria and to evaluate the spoilage potential of these microorganisms isolated from fresh cheeses handcrafted and commercialized in Salinas, MG, Brazil. After the isolation of psychrotrophic proteolytic bacteria present in fresh cheese, the isolates were characterized in terms of Gram staining, shape, and oxidase activity. The proteolytic activity of the isolates was confirmed by a spot halo test using specific agar. The results highlighted the predominance of Gram-positive psychrotrophic proteolytic bacteria when the spoilage microbiota of the fresh cheese samples was evaluated. Considering the proteolytic potential, 34% of the isolates were considered highly proteolytic. The results showed that the initial contamination of fresh cheeses may interfere with the microbiological quality of these products.

Published
2021
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20. Cardiologia - Teoria e Prática volume 2

Author

LIMA, CINDY STEPHANIE ESTEVES DE, primary, DEMIAN, GABRIEL ALVES MENDES, additional, CORDEIRO, GABRIEL COSTA, additional, LUCCA, GABRIEL TRANCOSO DE, additional, ASSIS, ISABELA ALMEIDA DE, additional, ESTEVAM, JÚLIA SPINELLI, additional, BLASSIOLI, VITOR COURI, additional, MAGALHÃES, LORENA SOARES MAIA DE WERNA, additional, BARBOSA, MARIA EDUARDA SOARES, additional, MIRANDA, SOFIA BROGNARA CARAN, additional, Pereira, Mateus de Souza Silva, additional, Lanna, Matheus Martins, additional, Oliveira, Bárbara Cardoso de, additional, Gonzaga, Thiago Chinchilla, additional, Mares, Victor Souza, additional, Santos, Brenda Pereira Nogueira, additional, Batista, Danielle Eleuterio, additional, Denizar, João Gabriel Medina, additional, Oliveira, Paulo Vitor Kelmon Silva de, additional, Peixoto, José Maria, additional, Lima, Cindy Stephanie Esteves de, additional, Assis, Isabela Almeida de, additional, Santos, Gustavo Ryan Martins, additional, Pires, Hugo Antonio Gonçalves, additional, FREITAS, MARCELA BORTOLETO, additional, Estevam, Júlia Spinelli, additional, Miranda, Maria Eduarda Soares, additional, Miranda, Sofia Brognara Caran, additional, Allvares, Sophia Fraga Waldolato, additional, Bacha, Felipe Lage, additional, Blassioli, Vitor Couri, additional, Cunha, Admardo Raniere de Assis, additional, Mansur, Amanda de Cássia Dutra, additional, Mendes, Anna Laura França Gontijo, additional, Morais, Érika Esther Teixeira, additional, Ávila, Isabela Campos Oliveira de, additional, Issa, Isadora Teixeira, additional, Ribeiro, Júlia Palma Avelar, additional, Kiepper, Karenn Tavares, additional, RODRIGUES, MARIANNE NETO, additional, Campos, Tamara Araújo Pereira, additional, Braoios, Isabella Resck, additional, Andrade, Carolina de Paula, additional, Vaz, Ana Cecília Johas Marques da Silveira Leão, additional, Souza, Paulo Sérgio Moura de, additional, Henrique, Thaynara Stefaninne Lima de Assis, additional, Ferreira, Isadora Mota, additional, Cortez, Elisa Borges, additional, Cortez, Jordana Borges, additional, Cruvinel, Maria Eduarda Martins, additional, Lima, Amanda Silva, additional, França, Beatriz Cabral, additional, Oliveira, Micaela Teodoro, additional, Ozaki, Milena Yumi Cometti, additional, Lima, Geraldo Soares de, additional, Cunha, Liana Andreza Dias da, additional, Donalonso, Rafaela Andrade, additional, Castilho, Lucas Ribeiro de, additional, Perdigão, Daniel Henrique Rodrigues, additional, Soares, Janeisa, additional, Santos, Irvely Luana Muniz, additional, Moraes, Amanda Barbosa, additional, Costa, Ana Luísa Mendes Pinheiro, additional, Furtado, Lívia Amaral Salomé, additional, Guimarães, Luísa Prado, additional, Ambrósio, Marcos Flávio Spínola, additional, Medeiros, Carlos Henrique Moraes de, additional, Alvim, Mariana Linhares Oliveira, additional, Cypriano, Rafael Vago, additional, Cançado, Renata Pittella, additional, Ambrósio, Victor Vasconcelos Spínola, additional, Estephanin, Vitor Vieira, additional, Santos, José Rodrigues dos, additional, Fernandes, Thalita Baptisteli, additional, Ambrosio, Marcos Flavio Spinola, additional, Silva, Luara Moreira da, additional, Souza, Ana Paula Machado, additional, Pinheiro, Paloma Andrade, additional, Dayrell, Sophia Perrupato, additional, Silva, Clarice Roman Nascimento e, additional, ANDRADE, CLARICE MARQUES MOTTA, additional, Oliveira, Felipe Zampirolli Dornas de, additional, Vieira, Luisa Trindade, additional, Camargo, Fernanda Lio Rocha, additional, Paiva, Elisa Duarte, additional, Pires, Luiza de Barros Mendes, additional, SANTOS, Lucas dos, additional, Cardoso, Aila Fernandes Oliveira, additional, Franco, Ana Clara Silva de Melo, additional, Meneses, Gustavo Henrique Rodrigues, additional, Souza, Hertiquiano Jerônimo dos Santos, additional, Maia, João Pedro Feijó, additional, Ribeiro, Raquel Barbosa, additional, Silva, Eduardo Augusto dos Santos Moreira, additional, Almeida, Juliana Vieira Queiroz, additional, Tavares, Ana Tereza Teixeira, additional, Jesus, Ana Clara Fonsêca Souza de, additional, Silva, Henrique Figueiredo, additional, Coelho, Pedro Moraes, additional, Siqueira, Maria Luiza Andrade, additional, Araújo, Liliane Diniz de, additional, Marcante, Martina, additional, Signori, Giovanna Maiolli, additional, Pias, Manoella Cardinal, additional, Teixeira, Marcela Menezes, additional, Schneider, Geórgia Savicki, additional, Paviani, Luzia Bulla, additional, Dacroce, Vitória Tischer, additional, Duarte, Melissa Nadal, additional, Moutinho, Darlan Zamblano, additional, Martins, Erick Roberto Silvério, additional, Stanford, Gustavo de Albuquerque, additional, Batista, Kawanny Kennedy de Arruda, additional, ELY, CAROLINA SCHEER, additional, Oliveira, Maria Eduarda Tavares de, additional, Aguiar, Milena Maria da Silva, additional, Marafante, Maria Eduarda Osório, additional, Penha, Weslley Jonathan Lopes da, additional, Santos, Thayane Rebeca Alves dos, additional, Jesus, Ana Clara Fonsêca Souza De, additional, Oliveira, Helena Diniz, additional, Moura, Ana Raquel De, additional, Pires, Laila Mameri, additional, Pereira, Lívia Leandro de Souza, additional, Ely, Carolina Scheer, additional, Kreutz, Diogo Noronha Menezes, additional, Mayer, Lucas Granville Garcia, additional, Costa, Lara Letycia Araujo, additional, Rodrigues, Henrique Cássio Silva, additional, Souza, Júllia Beatriz Araujo, additional, Sena, Larissa Emily Ogando de Jesus, additional, Menezes, Marília Alves, additional, Figueiredo, Pedro Alves de, additional, Goes, Vinicius, additional, Andrade, Carlos Eduardo de, additional, GOMES, LUIS HENRIQUE ALVES, additional, SILVA, CAIO CÉZAR TENÓRIO ALVES DA, additional, GUIMARÃES, CAMILLA MONIELYCK MENDONÇA, additional, ROCHA, ALICE WANDERLEY, additional, IDALINO, CECILIA CONDE PLÁCIDO, additional, FERREIRA, EDVALDO XAVIER, additional, ROSA, ALFREDO AURÉLIO MARINHO, additional, ANDRADE, ALANA DARLY SANTOS, additional, VALADARES, FABIANA TORRES, additional, SANTANA, IANNE JESUS, additional, SILVEIRA, ISABELE DANTAS, additional, MENEZES, MARÍLIA ALVES, additional, SANTOS, SARA MIKAELE SOUZA, additional, BARBOSA, ANDERSON DOS SANTOS, additional, ALMEIDA-SANTOS, MARCOS ANTONIO, additional, Gomes, Luis H A, additional, Simões, Beatriz de Oliveira, additional, Guimarães, Camilla Monielyck Mendonça, additional, Guimarães, Danielle Aparecida, additional, Idalino, Cecília Conde Plácido, additional, Costa, Mariana Tenório, additional, Macedo, Lara Antunes Martins, additional, Ferreira, Giovanna Mendonça, additional, Nogueira, Hortência Garcia, additional, Portugal, Fernanda Freire Dantas, additional, Santos, Giovanna Mendonça dos, additional, Santos, Jéssica Lara Cipriano dos, additional, Santos, Mateus Araújo dos, additional, Gomes, Alves, additional, Oliveira, Olívia de Araújo Rezende, additional, Moreira, Beatriz de Moura, additional, Fernandes, Gustavo Soares, additional, Lima, Ana Gabriela Campos, additional, SIMÕES, BEATRIZ DE OLIVEIRA, additional, RAMOS, LARISSA CRISTIANO, additional, Coura, Karen Abrantes, additional, Maior, Letícia Gomes Souto, additional, Galindo, Natália Victória Guedes, additional, Queiroz, Rayana Tavares De, additional, Cruz, Eduardo Franco Correia, additional, Lima, Camila Araújo Novais, additional, Albuquerque, Daniel Gustavo Guedes Pereira de, additional, Pires, Francisco Augusto Santana, additional, Soares, Júlia Dutra, additional, Tenório, Manuela Magalhães Dardenne, additional, Silva, Marcela Lukerli Araujo Paulina da, additional, Nóbrega, Clara, additional, Cabral, Anna Julie Medeiros, additional, Gambarra, Bruna Furtado, additional, Melo, Fernando de Paiva, additional, Costa, Filipe Eduardo Aguiar, additional, Soares, Gabriel Lucena de Carvalho, additional, Espínola, Paulo Francisco Lucena de Araújo, additional, Abrantes, Samuel Estrela de, additional, Kumamoto, Francisco Ítalo, additional, Magalhães, Ryanne Monteiro, additional, Deininger, Maurilio Onofre, additional, Amaral, Anderson Ricardo, additional, Silva, Karoline Barbosa da, additional, Toricelli, Letícia Martins, additional, Xavier, Patrícia Vieira, additional, Oliveira, Taynara Carvalho de, additional, Santos, João Gabriel Ribeiro dos, additional, Araújo, Francisco Hallison Nascimento de, additional, Pacífico, Débora Lia Almeida, additional, Branco, Dalleth de Alencar Farias Castelo, additional, Sousa, Raíssa Amélia Moreno, additional, Ribeiro, Ana Luísa Mendes, additional, Pereira, Myrelle Crislane da Silva, additional, Gomes, Clara Luisy Duarte, additional, Sousa, José Samuel Teixeira de, additional, Pimenta, Gustavo Felix, additional, Pera, Marina Lobe Durieux, additional, Speretta, Guilherme Fleury Fina, additional, Meira, Pedro Reges Pereira, additional, Bittencourt, Anna Lillian Canuto, additional, Cavalcanti, Ana Claudia Leal, additional, Reis, Fernanda Fontes Prado, additional, Amorim, José Milton Machado do, additional, Leal, Iane Brito, additional, SANTOS, EMERSON DE SANTANA, additional, MELO, BRÁULIO CRUZ, additional, SOARES, BEATRIZ LUDUVICE, additional, DINIZ, JÚLIA SOUZA, additional, OLIVEIRA, JOSELINA LUZIA MENEZES, additional, GURGEL, RICARDO QUEIROZ, additional, Machado, Lucas Henrique de Carvalho, additional, Dias, Mariana Nunes Lima, additional, Martins, Joao Henrique Santos, additional, MEIRA, PEDRO REGES PEREIRA, additional, Urtiga, Lívia Maria Pordeus Coura, additional, Arruda, Maria Isabella Machado, additional, Palitot, Jessica de Medeiros Guedes, additional, Nóbrega, Cynthia Maria Moreira de, additional, Costa, Maria Alice Santos Falconi da, additional, Santos, Emerson De Santana, additional, FERREIRA, ANDRÉ LUIZ CARVALHO, additional, Oliveira, Bruno Gomes Netto de, additional, GOSALAN, GABRIELA CORDASSO, additional, Soares, Beatriz Luduvice, additional, Neuenschwander, Alice Campos, additional, Oliveira, Joselina Luzia Menezes, additional, Rodrigues, Alícia Zeferino, additional, DIAS, MARIANA NUNES LIMA, additional, Messias, Beatriz Chiari, additional, Paiva, Bruna Stancioli, additional, Campos, Bruna Vivian Antunes, additional, Brandão, Liliane Vilela, additional, Carvalho, Sophia Campos Salles Silva de, additional, Paula, Bruna Marquez Rodrigues de, additional, Martins, Kamilla Mayr, additional, Ventura, Maria Luiza Samia, additional, Maquigussa, Edgar, additional, Boim, Mirian Aparecida, additional, Sales, Elizabeth Barbosa de Oliveira, additional, Oliveira-Sales, Elizabeth Barbosa de, additional, Santos, Vitória Dias dos, additional, Brito, Leticia Ferreira Santos, additional, Moraes, Luzia Reis Rabelo de, additional, Morais, Vanessa Maria Oliveira, additional, Tavares, Anna Beatriz Lopes, additional, Chaves, Ana Resende, additional, Alves, Rebeca Feitosa Dória, additional, Santos, Lucas Siqueira dos, additional, Torres, Erivelton Cunha, additional, Silva, Francielly Azevedo da, additional, Almeida, Andreza Oliveira, additional, Sanchez, Elen Rizzi, additional, Chaves, Ana Clara Dias Resende, additional, Annuzzo, Miguel de Sousa e, additional, Gusmão, João Henrique Carvalho Zacour Almeida, additional, Marcondes, Carla Miranda, additional, Félix, Nicole Santos, additional, Macêdo, Diana Isis Ribeiro, additional, Ribeiro, Rebeca Karollyne Rolim, additional, Diniz, Radamés Vieira, additional, Santos, Lucas dos, additional, Pedreira, Rhaine Borges Santos, additional, Macedo, Lucas Augusto Rocha de, additional, Azevedo, Alda Cristina Alves de, additional, Cruz, Mateus Rufino de Andrade, additional, Fernandes, Flávio Formiga, additional, Mello, Maria Eduarda Andrade de, additional, Caldas, Mônica Maria Costa, additional, Santos, Áleff Edrei Gomes, additional, Santos, Henriky Santana, additional, Santos, Mateus Araújo, additional, Sousa, Rebeca Apolinário, additional, Campos, Milena dos Santos Barros, additional, Ramos, Larissa Cristiano, additional, Gomes, Luís Henrique Alves, additional, Teotonio, Elizabeth de Oliveira, additional, Vaz, Gabrielle Dantas Soares Galindo, additional, Henriques, Hugo Limeira, additional, Henrique, Hugo Limeira, additional, Santos, Arthur Hebert Dantas, additional, Belém, José Oliveira, additional, Nóbrega, Letícia de Sousa Costa, additional, Shiroma, Yuri Brito, additional, Vieira, Andressa Lílian Fernandes, additional, Clemente, Alice França, additional, Padua, Bárbara Isidoro Faria de, additional, Santos, Gabriel Amaral dos, additional, Almeida, Gustavo Chaves de, additional, Macedo, Gisa da Costa, additional, Alves, Manuela Roque, additional, Cavalcante, Jéssica Araújo, additional, Sampaio, Lucas Barbosa, additional, Gervásio, Daniel Monte de Andrade, additional, Moreira, Humberto Lucca Andrade, additional, Assunção, Karinne da Silva, additional, Lira, Marcela Maria Cavalcanti, additional, Nunes, Gabriela Pessoa de Brito, additional, Rocha, Letícia Maria Queiroz, additional, Batista, Antonio de Medeiros, additional, Barbosa, Felipe Silva, additional, Lacerda, Germânia Bandeira, additional, Almeida, Josiherbethy Rodrigues de, additional, Negrão, Larissa Viviane Sampaio, additional, Lima, Maria Karolayne Oliveira, additional, Gomes, Luis Henrique Alves, additional, Bueno, Ronaldo Machado, additional, Macedo, Gisa da Costa de, additional, Chaves, Ana Clara Resende, additional, and Rizzi, Elen, additional

Published
2021
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21. Cardiologia- Teoria e Prática volume 1

Author

Gewehr, Douglas Mesadri, primary, Neiverth, Alan, additional, Cavalcanti, Marcela Santos, additional, Maestri, Thiago Ceschin, additional, Haurani, Semi, additional, Araújo, Kelre Wannlen Campos Silva, additional, Kubrusly, Fernando Bermudez, additional, Kubrusly, Luiz Fernando, additional, Lucindo, Ana Laura Martins Marra Magno, additional, TISSIANI, AMANDA APOLORI, additional, Ferreira, Amanda Emanuela Machado, additional, SILVA, ANA CAROLINA DE MENEZES FIGUEIRÊDO, additional, LINS, JOHRANNA HEMILY GALDINO, additional, MAGALHAES, KECIA SILVA, additional, SILVA, LUZIA MAYARA PEREIRA CUSTÓDIO DA, additional, CRUZ, NAYARA ALVES OLIVEIRA DA, additional, BEZERRA, RAISSA GOUVEIA LUCENA DE, additional, GADELHA, LAÍS DANIELLE GOMES, additional, Bezerra, Breno da Nóbrega, additional, Albuquerque, Bruna Caló, additional, Barbosa, Cleyciana Mayara, additional, Uchôa, Ednara Pontes de Avelar Didier, additional, Weinberg, Guilherme Gondim, additional, Lima, Laura Rachel Amorim Ferreira, additional, Oliveira, Matheus Henrique Santos Lira, additional, Franco, Maria Paula de Lemos, additional, Pessanha, Rodrigo Filipe de Vasconcelos, additional, Queiroz, Thayane Rose Cavalcante de, additional, ROCHA, JOANA ÉRICA LIMA, additional, FURTADO, MARIELY MENDES, additional, MELLO, RENATO SAMPAIO, additional, MENDES, ANA VICTÓRIA DA SILVA, additional, BRITO, ANA KAROLINNE DA SILVA, additional, ALMEIDA, JOSÉ OTÁVIO CARVALHO SENA DE, additional, QUEIROZ, EMERSON IURI RODRIGUES, additional, FRANÇA, JOSÉ VINICIUS DE SOUSA, additional, ARCANO, DANIEL DIAS RUFINO, additional, MARTINS, MARIA DO CARMO DE CARVALHO E, additional, Costa, Mariana Tenório, additional, Santos, Jéssica Lara Cipriano, additional, Nogueira, Hortência Garcia, additional, Ferreira, Giovanna Mendonça, additional, Idalino, Cecília Conde Plácido, additional, Oliveira, Olívia de Araújo Rezende, additional, Macêdo, Lara Antunes Martins, additional, Santos, Giovanna Mendonça dos, additional, Lopes, Arthur Eduardo Martins, additional, Rezende, Giovanna Aparecida Marques, additional, Azulay, Vitor Gonzalez Ouaknin, additional, Oliveira, Fernanda Caetano Solano, additional, Brommonschenkel, Alexandre De Castro, additional, Santos, Fernando Batista Nigri Dos, additional, Oliveira, Alícia Nathália Terra Perígolo, additional, Carvalho, Nathália Ferreira, additional, SOUZA, CAIO FERREIRA FILGUEIRAS DE, additional, Silva, Isabella Juliana Nascimento da, additional, Fonsceca, Lucas Peixoto de Sousa, additional, Murad, Nicole Modesto, additional, Catricala, Brunie da Silva, additional, Fonseca, Lucas Peixoto de Sousa, additional, Marx, Pedro Henrique Sulz, additional, Chaves, Welsher Braga Ribeiro, additional, Gonçalves, Lucas Lobato Isaac, additional, Nascimento, Gustavo L T, additional, Santos, Luiz Eduardo Canton, additional, Abreu, Amanda Gonçalves Mazochi, additional, Alves, Ana Eloísa Silva, additional, Merlo, Antonietta Saldanha Alves Bortolone, additional, Farkasvolgyi, Bárbara, additional, Cunha, Dara Paschoal da, additional, Viegas, Gabriela de Almeida, additional, Amaral, Hélio do, additional, Bianchi, Mylena Pastore, additional, Netto, Manoel da Silva Barbosa, additional, Santana, Illa Katrini Ladeia, additional, Souza, Phellipe Teixeira de, additional, Terassini, Flávio Aparecido, additional, Trombone, Beatriz Scarin, additional, Menezes, João Daniel de Souza, additional, Mota, Maria Eduarda Dóro, additional, Brandão, Vânia Zaqueu, additional, KLOSS, CAMILA PADILHA, additional, ABDULLAH, NICOLE, additional, Borges, Beatriz E, additional, Furlam, Tiago de Oliveira, additional, Prates, Ana Beatriz Cordeiro, additional, Silva, Ewelin Wasner Machado da, additional, Ferreira, Henrique de Oliveira, additional, Roque, Isadora Gonçalves, additional, Pires, Laura Gregório, additional, Abreu, Luciana Helena Dolabela de, additional, Gomes, Luiza Moreira, additional, Heyden, Maria Cecília Jardim, additional, Prado, Marina Rocha do, additional, Rodrigues, Natália Abdo, additional, Oliveira, Nathan Shuenck Silva de, additional, JACOB, Bruna Mundin Veloso, additional, Machado, Carla Jorge, additional, Glória, Rafaela Resende da, additional, Glória, Isabela Resende da, additional, Araújo, Henrique Fagundes dos Anjos, additional, Araújo, Rafael Fagundes dos Anjos, additional, Araújo, Lívia Fagundes dos Anjos, additional, Laranjeira, João Vitor Fortuna, additional, Rebouças, Gabrielly Maria Moreira, additional, Santos, Erika Araújo dos, additional, Bosso, Henrique, additional, Netto, Mauricio Lopes da Silva, additional, Bisoni, Matheus Aires, additional, Hubaide, Ana Laura Rezende, additional, Saes, Anna Flora Martins, additional, Bosso, Evandro Portaluppe, additional, Sabino, Isadora Borges, additional, Figueredo, Nathalya Porto, additional, Watanabe, Yoshimara Oliveira, additional, Neves, Flávia Caroline Silva, additional, Melo, Rafaela Cristina Sousa, additional, Castro, Henrique Ulisses Duarte De, additional, Mascarenhas, Natália Batista, additional, Santos, Arthur Soares, additional, Brommonschemkel, Alexandre de Castro, additional, Lucchesi, Carolina Basilio, additional, Aguiar, Maria Clara Albuquerque Sette, additional, Pereira, George Lucas Santos, additional, Castro, Henrique Ulisses Duarte de, additional, Cardozo, Ana Beatriz Pegoraro, additional, Gouveia, Levi Albuquerque, additional, Marcello, Lucas Augusto Walter, additional, Carneiro, Sarah Arruda Furtado, additional, LUCCHESI, CAROLINA BASILIO, additional, SANTOS, EVELEN ROUSE DE SOUZA, additional, PEREIRA, GEORGE LUCAS SANTOS, additional, MACEDO, PAULO HENRIQUE FONTES DE, additional, SILVA, SHEYLA CRISTINA TONHEIRO FERRO DA, additional, QUAGLIO, LAURA SBEGHEN, additional, MENEZES, RAISSA MENDONÇA, additional, VOLPE, ALEXANDRE CATENA, additional, VENTURA, MARIA LUIZA SAMIA, additional, MAQUIGUSSA, EDGAR, additional, BOIM, MIRIAN APARECIDA, additional, OLIVEIRA-SALES, ELIZABETH BARBOSA DE, additional, REZENDE, LUCAS DALVI ARMOND, additional, SILVA, LAVÍNYA MOREIRA, additional, SOUZA, THALYNE KRETTLY, additional, Bacha, Felipe Lage, additional, MAWANDJI, NINA BRUNA DE SOUZA, additional, FRANÇA, LARA NASCIMENTO, additional, FIORIN, BRUNO HENRIQUE, additional, FREITAS, MARCELA BORTOLETO, additional, NEVES, CATARINA ITHO PIAZZINI, additional, CERQUEIRA, PATRICK HENKERT, additional, Faria, Bárbara Elloar Dellabrida de Andrade e, additional, Nascimento, Gabriel Maia, additional, Bessa, Giulia Maria Menezes, additional, Santos, Gustavo Ryan Martins, additional, Pires, Hugo Antonio Gonçalves, additional, Jesus, Isabela Ferreira de, additional, Silva, João Fernando Oliveira Pereira, additional, Pereira, João Pedro Ferreira, additional, Alvares, Sophia Fraga Waldolato, additional, MILITÃO, BRUNO VÍTOR PEIXOTO, additional, VAZ, SÍLVIO HENRIQUE DA SILVA, additional, Marchiori, Beatriz Tesoni, additional, REZENDE, LARISSA CAROLINE, additional, SANTOS, TALITA MIRANDA, additional, CAMARGO, MARIANA FONSECA FRANCO DE, additional, OLIVEIRA, GABRIELA BRAGA LAZARCHIC, additional, Bacha, Karimi Mohamed El, additional, SOUSA, VINÍCIUS LÚCIO DE, additional, Mazzoni, Barbara, additional, Arruda, Evaldo Gabriel Maravi de, additional, Pedro, Jamile Quadros Bent Moussa, additional, Fontes, Júlia Fernanda Rodrigues, additional, Martins, Juliana Tanaka, additional, Schio, Laura Raíssa, additional, Lopes, Sálua Elisandra, additional, Comtesse, Yann-Luc Patrick, additional, Minuzzo, Luiz, additional, Camargos, Ana Júlia Faria, additional, Oliveira, Ana Luiza Faleiro Vale, additional, Silva, Barbara Lins, additional, Castro, Gabriela Amorim de, additional, Seixas, Júlia Maia, additional, Camargos, Kamila Castro Oliveira, additional, Marques, Lara Silveira, additional, Lopes, Maria Alice Rocha, additional, Silva, Mariana Lacerda, additional, Souza, Maria Tereza Nogueira Fonseca e, additional, SALES, ELIZABETH BARBOSA DE OLIVEIRA, additional, Militão, Bruno Vítor Peixoto, additional, Oliveira, Gabriela Braga Lazarchic, additional, Rezende, Larissa Caroline, additional, Prado, Luciana Rodrigues Ferreira, additional, Camargo, Mariana Fonseca Franco de, additional, Vaz, Sílvio Henrique da Silva, additional, Santos, Talita Miranda, additional, Mourão, Thamires de Freitas, additional, RODRIGUES, JOÃO VÍCTOR CORDEIRO, additional, Fagundes, Daniella Soares, additional, PARAÍSO, ROSA MARIA RUAS, additional, Porto, Daniella Patrícia de Oliveira, additional, Oliveira, Bárbara Cardoso de, additional, Ferreira, João Vítor Gonçalves, additional, Rocha, Josiane Santos Brant, additional, Rocha, Ana Clara Camargo, additional, Vale, Arthur Vasconcelos do, additional, Simião, Caroline Marinho, additional, VIDAL, MARIA LUIZA MOTA, additional, Tuyama, Marina Gontijo, additional, Annuzzo, Miguel de Sousa e, additional, Silveira, Nicolas Semaan, additional, Silveira, Rachel Pimentel Romano, additional, Machado, Tamyres Karen Fagundes, additional, CARVALHO, PEDRO SADDI DE, additional, SIMIÃO, CAROLINE MARINHO, additional, ANDRADE, CLARICE MARQUES MOTTA, additional, ALVES, CAMILA SOUSA BRAGUNCE, additional, BICALHO, BRUNA DE OLIVEIRA, additional, DUARTE, LIDIA COSTA, additional, SILVA, RAÍSSA LOPES, additional, MEIRELES, MARIO HENRIQUE VEIGA, additional, SILVA, ANA LUÍSA LOPES, additional, LOPESFERREIRA, IANCA, additional, Mota, Francisco Rogério Cavalcante, additional, ANDRADE, LUCAS ADAILTON VIANA DE, additional, PARREIRAS, MAYARA MORAIS, additional, FORMIGA, PAULA ALVES, additional, DANTAS, PRISCILA TEIX EIRA, additional, RODRIGUES, SABRINA CORDEIRO ABRANTES, additional, MEIRELES, MÁRIO HENRIQUE VEIGA, additional, SILVA, José Dilbery Oliveira da Silva, additional, Medeiros, Isabela Alice Soares de, additional, Estrela, Yahanna da Costa Anacleto, additional, Destefani, Isabella Rodrigues, additional, Correia, Jásny Pintor de Assis, additional, Bezerra, Elvis Félix Severo, additional, Lima, Vitória Freire, additional, SILVA, JOSÉ DILBERY OLIVEIRA DA, additional, Pinto, Natália Bitú, additional, Bustos, Gustavo Oliveira Piedade, additional, Andrade, Maria Clara Vasconcelos, additional, Sasaki, Mayara Seyko Kaczorowski, additional, Silva, Guilherme Oliveira, additional, Pisciottano, Natascha, additional, Cortez, Ana Beatriz Motta Aragão, additional, Vieira, Ana Beatriz Maciel, additional, Cleto, Laryssa Soares, additional, Oliveira, Pedro Henrique Amorim, additional, Guerra, Bárbara Lima, additional, Silveira, Breno Amin de Lima, additional, Holanda, Giovanna Pereira de, additional, Kierpel, Mauro, additional, MOURTHÉ, VICTORIA CRISTINA GUIMARÃES PEDRAS, additional, OLIVEIRA, MARCELA MARINHO DE, additional, CARIM, LARA LORENZON, additional, ALEIXO, THALES PESSOA CHRISTO, additional, GOMES, CLARA DE SOUSA, additional, MOREIRA, VITOR DA CUNHA, additional, VIEIRA, YASMIN PEREIRA, additional, Oliveira, Halley Ferraro, additional, Oliveira, Marcela Marinho De, additional, Castilho, Luiza Coimbra, additional, Toledo, Lenander Fernandes de, additional, Santos, Mateus Araújo dos, additional, Faria, Ana Beatriz Mesquita Marques De Araújo, additional, Gonçalves, Aldinei Luigi Sousa, additional, Michels, Catarina Depieri, additional, Ferreira, Isabela Junqueira, additional, Lamas, Júlia Maria Morena Afonso Campos e, additional, Santos, Larissa Fernandes de Souza, additional, Furtado, Leonardo Reis Couto, additional, Froes, Luiz Eduardo Vieira, additional, Guiotti, Marcos, additional, Buratto, Matheus Santos, additional, Rodrigues, Yasmin Rosa Storck Rocha, additional, Braga, Francisca Ivina Leite, additional, Lourenço, Heitor Fernandes, additional, Nascimento, José Paulo Lima do, additional, Mamede, Iascara Vitória de Oliveira, additional, Silva, Marcos Paulo Da, additional, Araujo, Maria Isadora Benedito de, additional, Duarte, Rany Magnaelle Rodrigues, additional, Ribeiro, Luana da Hora, additional, Batista, Matheus Neres, additional, Veloso, Eliana A N, additional, Dias, Karolinne Dorneles, additional, Gomes, Pedro Vinícius Teles, additional, Gonçalves, Amanda Carolina de Melo, additional, S, Joel A, additional, Ungarelli, Isabella Mota, additional, Sousa, Joel Alves De, additional, Araújo, Vitória Gabriele Barros de, additional, Rios, Marcella Maciel, additional, Silva, Bárbara Leite da, additional, Nascimento, Alice Benicio Do, additional, Barrinha, Maria Clara Falcão, additional, Costa, Jorgyanne Gonzalez, additional, Silva, Danyele Holanda da, additional, Alves, Nágila Silva, additional, Silva, Danyele Holanda Da, additional, Rocha, André Versiani Caldeira, additional, Siqueira, Camila Bruck de, additional, Avelar, Gabriel Trindade, additional, Minucci, Giulia Rocha, additional, Souza, Marta Bhering Pereira de, additional, Paiva, Paula Costa Vieira, additional, Matos, Victor Augusto Melo de, additional, GORINO, ALESSANDRA SOICA, additional, GEWEHR, DOUGLAS MESADRI, additional, KUBRUSLY, FERNANDO BERMUDEZ, additional, KUBRUSLY, LUIZ FERNANDO, additional, SILVA, MARCIO PEIXOTO ROCHA DA, additional, KASHIWAGUI, MARIANA NAOMI, additional, MARTINEZ, MARINA TAYZ, additional, Fontes, Rafael Barros, additional, SARAIVA, JAYANE MENDES, additional, Porazzi, Gabriela Massafra, additional, Lima, Monique Veloso, additional, Rodrigues, Amanda Oliveira Sousa, additional, Lima, Thalilhia Souza, additional, CARVALHO, LUMA MATOS, additional, Caldas, Leonardo Estevan Rosa, additional, Luchetti, Ligia, additional, Luchetti, Lauana, additional, Gomes, Maria Paula Rabelo, additional, Costa, Weber Tobias, additional, Dorneles, Stella Gontijo Sant Anna Vaz de Melo, additional, Fraga, Victória Braga e, additional, Pereira, Renata de Melo, additional, Alvim, Rafael Bastos, additional, Coelho, Victor Sarmento, additional, Fantini, Marina Pinheiro Rocha, additional, Marra, Ana Laura, additional, Negrão, Vivian Ivone Pereira, additional, Silva, Victor Raggazzi Hohne da, additional, RIBEIRO, GUILHERME AUGUSTO TURBINO, additional, Oliveira, Beatriz Dias, additional, Silva, Iara, additional, Santana, Fabya Andressa Mendonça, additional, Lima, Francisco Jadson, additional, Costa, Stéfany Fernandes da, additional, Sena, Daniel Martucheli, additional, Coimbra, Marcela Chaves, additional, Soares, Victor Araújo, additional, Cunha, Victor Neves, additional, Ferreira, Ianca Lopes, additional, Santos, José Rodrigues dos, additional, Correia, Jásny Pinto de Assis, additional, Guimarães, Josemery Pinho, additional, Prado, Luciana Ferreira Rodrigues, additional, Batista, Pedro Machado, additional, Costa, Raissa Gomes Alves da, additional, Vieira, Igor Antônio Galvão, additional, Santos, Nathaly Silva, additional, Oliveira, Isabella Ferreira Estevam de, additional, Macedo, Marylia da Costa, additional, Oliveira, Lílian Maria Magalhães Costa de, additional, Silva, Indiara Lorena Barros Ribeiro da, additional, Oliveira, Maribene Bahia de, additional, Mendes, André Luiz de Jesus, additional, Silva, José Dilbery Oliveira da, additional, Dantas, Priscila Teixeira, additional, Souza, Gabriella Soares de, additional, Leite, Thais Gontigo Goulart, additional, Guimarães, Victória Moreira Hannas, additional, Gomes, Clara e Sousa, additional, Andrade, Alana Darly Santos, additional, Almeida, Camila Rocha, additional, Moreira, Gabrielle dos Santos, additional, Santana, Ianne Jesus, additional, Menezes, Isabella Sales, additional, Santos, Sayron Natanael Lopes Pereira, additional, Passos, Maria Karollina Almeida, additional, Santana, Fábya Andressa Mendonça, additional, Vieira, Alberto Calson Alves, additional, Gois, Breno Oliveira, additional, Souza, Camilla Radimack Santos de, additional, Matias, Gabriel Ferreira Setton, additional, Sobral, Marina Prado Santos, additional, Araújo, Sabrina Layra Souza, additional, Araujo, Sabrina Layra Souza, additional, Feijó, Walter Aguiar, additional, Silva, Sheyla Cristina Tonheiro Ferro da, additional, and Faria, Sanny Cristina de Castro, additional

Published
2021
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24. Synthesis and In vitro and In silico Anti-inflammatory Activity of New Thiazolidinedione-quinoline Derivatives

Author

da Silva, Sandra Elizabeth Barbosa, primary, da Silva Moura, José Arion, additional, Branco Júnior, Jeann Fabiann, additional, de Moraes Gomes, Paulo André Teixeira, additional, de Paula, Simão Kalebe Silva, additional, Francisco Viana, Douglas Carvalho, additional, de Freitas Ramalho, Eduardo Augusto Vasconcelos, additional, de Melo Gomes, João Victor, additional, Pereira, Michelly Cristiny, additional, da Rocha Pitta, Maira Galdino, additional, da Rocha Pitta, Ivan, additional, and da Rocha Pitta, Marina Galdino, additional

Published
2024
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25. Monitoramento Ecotoxicológico com Bioensaios Allium Cepa L no Rio Pouca Saúde Durante Diferentes Estações Localizado na Região Portuária de Santos/SP

Author

Ventura, Maria Luiza Samia, primary, Curraladas, Isadora Dicher Reimão, additional, Santos, Marco Antônio dos, additional, Boim, Mirian Aparecida, additional, Maquigussa, Edgar, additional, Colovati, Mileny Esbravatti Stephano, additional, Bastos, Paula Andrea de Santis, additional, and Oliveira-Sales, Elizabeth Barbosa de, additional

Published
2021
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26. UTILIZAÇÃO DE METODOLOGIAS ATIVAS E TECNOLOGIAS LEVES COMO PROCESSO FACILITADOR NO AUTOCUIDADO DO IDOSO: RELATO DE EXPERIÊNCIA

Author

Pantoja, Amanda Carolina Rozario, primary, Mercês, Danilo Sousa das, additional, Santos, Bruno de Jesus Castro dos, additional, Silva, Andreza Calorine Gonçalves da, additional, Valente, Elizabeth Barbosa, additional, Pastana, Elaine Cristina Pinheiro Viana, additional, Ribeiro, Caroline das Graças dos Santos, additional, Moraes, Larissa Emily de Carvalho, additional, Lago, Josilene Nascimento do, additional, and Ramos, Aline Maria Pereira Cruz, additional

Published
2019
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27. SISTEMATIZAÇÃO DA ASSISTÊNCIA DE ENFERMAGEM APLICADO A UM PACIENTE COM GLOMERULONEFRITE AGUDA EM UM SETOR HOSPITALAR: RELATO DE EXPERIÊNCIA

Author

Pantoja, Amanda Carolina Rozario, primary, Mercês, Danilo Sousa das, additional, Santos, Bruno de Jesus Castro dos, additional, Silva, Andreza Calorine Gonçalves da, additional, Pastana, Elaine Cristina Pinheiro Viana, additional, Ribeiro, Vera Lúcia Lima, additional, Valente, Elizabeth Barbosa, additional, Alves, Leticia Barbosa, additional, Ferreira, Jéssica das Mercês, additional, Marquês, Edivone do Nascimento, additional, and Soares, Tamires de Nazaré, additional

Published
2019
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28. Camperol induce un efecto prooxidante y cambios ultraestructurales como mecanismo amebicida

Author

Rosa Adriana Jarillo-Luna, Juan Manuel Gutiérrez-Meza, Elizabeth Barbosa-Cabrera, Gabriela Rebeca Luna-Palencia, Martha Cecilia Rosales-Hernández, Mario Nequiz, and Judith Pacheco-Yepez

Subjects
General Medicine
Abstract

Objetivo: Realizar un análisis comparativo in vitro de la actividad anti-amibiana del flavonoide Camperol comparado con la droga de referencia, el Metronidazol y determinar si el mecanismo de daño es oxidativo. --- Metodología: Se aplicaron diferentes concentraciones de Camperol y Metronidazol a trofozoítos de Entamoeba histolytica, analizando mediante microscopia electrónica el daño estructural ocasionado, por métodos colorimétricos el efecto antiamibiano en y sin condiciones de oxigenación, daño al DNA por método fluorométrico, la citotoxicidad de los fármacos en células HeLa por métodos colorimétrico y la producción de anión superóxido mediante resonancia paramagnética electrónica. Resultados: El grado de destrucción amibiana depende del tiempo y concentración del flavonoide. Camperol mostro una actividad antiambiana contra Entamoeba histolytica similar a la del Metronidazol; indujo cambios ultraestructurales en el citoplasma de los trofozoítos de Entamoeba histolytica, y alteración de la membrana celular, indujo daño al DNA, mostro un efecto prooxidante y mantuvo su actividad anti-amibiana en un medio altamente oxigenado. Finalmente, el Camperol no mostro toxicidad contra células HeLa. --- Conclusiones: Los efectos antiamibianos se deben a las características prooxidantes del Camperol, efecto que supera los mecanismos anti-oxidantes de la amiba, sugiriendo que in vivo sería un mejor amebicida que el Metronidazol. Palabras clave: Entamoeba histolytica, Camperol, anti-amibiana prooxidante, cambios ultraestructurales

Published
2022
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29. How Are Warm-Season Pastures’ Nutritive Value and Fermentation Characteristics Affected by Open Pasture, Silvopasture, and Sward Herbage Maturity?

Author

Ruggieri, Mariane Rodrigues Ferreira, Abmael da Silva Cardoso, Marina Elizabeth Barbosa Andrade, Thais Ribeiro Brito, and Ana Cláudia

Subjects
Guinea Massai grass, forage management, integrated systems, nutritive value
Abstract

This study aimed to evaluate the forage mass and nutritional value (NV) of Guinea Massai grass (Megathyrsus maximus × Megathyrsus infestum) in an open pasture (OP) or the silvopastoral system (SPS) at different stages of development (SDs). The experimental design was completely randomized, with five replications. The treatments were distributed in a factorial scheme 2 × 4, corresponding to types of systems (OP and SPS) and four SD (vegetative stage—S1, pre-flowering—S2, full flowering—S3 and maturity after flowering—S4). There was no interaction of the system × stage of plant development in any of the variables evaluated. The production of forage mass and Guinea Massai grass morphological components did not differ (p > 0.05) between SPS and OP. However, they differed between the SDs (p ≤ 0.05), with an increasing linear effect for forage mass, percentage of the stem, and dead material, and decreasing for leaf percentage and leaf: stem ratio. Only protein content differed (p < 0.05) among the chemical composition variables between culture systems. The shading caused by the SPS did not decrease the forage mass, NV, and in vitro dry matter digestibility of Guinea Massai grass compared to the system in OP. The advance of the SD of Guinea Massai grass increases the forage mass, with higher proportions of morphological components of low NV, such as stem and dead material. Silvopastoral system of Guinea Massai grass and eucalyptus is effective to prolongate the grazing season, with a greater amount of green leaves in the sward and better NV, without compromising herbage mass production in the forage growing season.

Published
2023
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30. Função cognitiva e controle da pressão arterial em idosos hipertensos

Author

Elizabeth Barbosa, Ester Souto, Alyne Leal de Alencar Luz, Larissa Pruner Marques, Aline Silva-Costa, and Rosane Harter Griep

Subjects
Aging, Elderly, Cognition, Envelhecimento, Idoso, Health Policy, Hypertension, Public Health, Environmental and Occupational Health, Family Health Strategy Primary healthcare, Estratégia Saúde da Família, Cognição, Hipertensão, Atenção primária à saúde
Abstract

Resumo O objetivo deste artigo é estimar a prevalência de comprometimento cognitivo e analisar sua associação com o controle da pressão arterial em idosos hipertensos. Trata-se de um estudo transversal realizado com 383 idosos hipertensos no estado do Piauí, Brasil. Foram coletados dados sociodemográficos, clínicos, realizada aferição da pressão arterial e avaliação da função cognitiva utilizando o teste Montreal Cognitive Assessment (MoCA). Utilizou-se regressão de Poisson com variância robusta. A prevalência de comprometimento cognitivo foi de 74,4%, sendo maior na faixa etária entre 80 anos ou mais de idade e naqueles com menor escolaridade. A prevalência de pressão arterial não controlada foi de 61,6%, com maior proporção entre os idosos com comprometimento cognitivo. Observou-se associação entre o comprometimento cognitivo e pressão arterial não controlada (RPAjustada: 3,98; IC95% = 2,51-6,33). A associação significativa entre função cognitiva e controle pressórico sugere que comprometimento cognitivo é um importante fator de risco para pressão arterial não controlada em pessoas idosas. A inclusão de medidas de rastreamento para possíveis déficits cognitivos podem ser úteis para melhor monitoramento da elevação dos níveis pressóricos entre idosos hipertensos. Abstract This article aims to estimate the prevalence of cognitive impairment and analyze its association with blood pressure control in elderly hypertensive individuals. Cross-sectional study of 383 elderly hypertensive individuals in the state of Piauí, Brazil. The authors collected sociodemographic and clinical data, performed blood pressure measurement, and assessed cognitive function using the Montreal Cognitive Assessment (MoCA) test. Poisson regression with robust variance was used. Overall prevalence of cognitive impairment was 74.4%, higher in the age group 80 years and over and among older persons with less schooling. Prevalence of uncontrolled blood pressure was 61.6%, with a higher proportion in the elderly with cognitive impairment. An association was observed between cognitive impairment and uncontrolled blood pressure (aPR: 3.98; 95%CI = 2.51-6.33). The significant association between cognitive function and blood pressure control suggest that cognitive impairment is an important risk factor for uncontrolled blood pressure in older persons. The inclusion of screening measures for possible cognitive deficits may be useful for better monitoring blood pressure levels among elderly hypertensive individuals.

Published
2022
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36. Proteolytic potential of psychrotrophic microorganisms isolated from fresh cheese

Author

Valdirene Rodrigues Santana, Dara Elizabeth Barbosa Rodrigues, Solimar Gonçalves Machado, Roberta Magalhães Dias Cardozo, and Leonardo Lima da Paixão

Subjects
proteolysis, food.ingredient, raw milk, Microorganism, spoilage, Food spoilage, General Engineering, Bacteria Present, Biology, Raw milk, Isolation (microbiology), biology.organism_classification, SF250.5-275, deterioração, qualidade, leite cru, proteólise, law.invention, Gram staining, food, law, quality, Microbiologia/Deterioração, Agar, Food science, Bacteria, Dairy processing. Dairy products
Abstract

Given the economic importance of the dairy industry, product quality should be a constant concern. Some sensorial and technological properties of milk and dairy products are related to the spoilage contaminant microbiota, which is mainly represented by psychrotrophic proteolytic bacteria producing thermoresistant enzymes. Fresh artisanal cheeses are generally produced with raw milk, so it is of great importance to know the microbiota of these products. Therefore, the objective of this work was to count and isolate the psychrotrophic proteolytic bacteria and to evaluate the spoilage potential of these microorganisms isolated from fresh cheeses handcrafted and commercialized in Salinas, MG, Brazil. After the isolation of psychrotrophic proteolytic bacteria present in fresh cheese, the isolates were characterized in terms of Gram staining, shape, and oxidase activity. The proteolytic activity of the isolates was confirmed by a spot halo test using specific agar. The results highlighted the predominance of Gram-positive psychrotrophic proteolytic bacteria when the spoilage microbiota of the fresh cheese samples was evaluated. Considering the proteolytic potential, 34% of the isolates were considered highly proteolytic. The results showed that the initial contamination of fresh cheeses may interfere with the microbiological quality of these products. Devido a importância econômica da indústria de laticínios, a qualidade dos derivados lácteos deve ser uma preocupação constante. Algumas propriedades sensoriais e tecnológicas do leite e derivados estão relacionadas à microbiota deterioradora contaminante, representada, principalmente, por bactérias psicrotróficas proteolíticas que produzem enzimas termoresistentes. Os queijos frescos produzidos artesanalmente são geralmente fabricados com leite cru, por isso, é de grande importância conhecer a microbiota desses produtos. Portanto, o objetivo deste trabalho foi enumerar e isolar as bactérias psicrotróficas proteolíticas além de avaliar o potencial deteriorador desses microrganismos isolados de queijos frescos artesanais comercializados em Salinas, MG, Brasil. Após o isolamento das bactérias psicrotróficas proteolíticas presentes no queijo fresco, os isolados foram caracterizados em termos de coloração de Gram, forma e atividade de oxidase. A atividade proteolítica dos isolados foi confirmada pela formação de halo de hidrólise em meio de cultura específico. Os resultados destacaram a predominância de bactérias proteolíticas psicrotróficas Gram-positivas quando foi avaliada a microbiota deterioradora das amostras de queijo fresco. Considerando o potencial proteolítico, 34% dos isolados foram classificados como altamente proteolíticos. Os resultados mostraram que a contaminação inicial de queijos frescos pode interferir na qualidade microbiológica destes produtos.

Published
2021

37. Uma visão sobre o extrativismo na flora de briófitas

Author

Leandro Almeida Amelio, Maria Elizabeth Barbosa de Sousa, and Emilia Brito Valente

Subjects
General Medicine
Abstract

A exploração excessiva dos recursos naturais vem causando um impacto significativo no meio ambiente, um exemplo é a extração de produtos de origem vegetal. O extrativismo no Brasil é seriamente discutido com relação às espécies nativas e com risco de extinção, tais considerações são de extrema importância para salientar a necessidade da preservação da flora e do meio ambiente. Sendo assim, este estudo teve como objetivo rever na literatura as pesquisas de extrativismo em relação à flora de briófitas. Foi elaborada uma rede bibliométrica com relação às publicações da base SCOPUS sobre os assuntos mais tratados nos estudos com briófitas nos últimos 10 anos. Incluímos também no estudo uma tabela com o registro de 20 espécies de briófitas mais propensas a sofrerem com o extrativismo, de acordo com as informações disponíveis na literatura e com suporte de estudos taxonômicos para identificação.

Published
2021
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38. CONSUMO, DIGESTIBILIDADE E PARÂMETROS FISIOLÓGICOS DE OVELHAS SUPLEMENTADAS COM NÍVEIS CRESCENTES DE PROPILENOGLICOL NA ÁGUA

Author

Wendell Fernando Guimarães da Cruz, Gilberto de Lima Macedo, Marina Elizabeth Barbosa Andrade, Érica Beatriz Shultz, Vitor Jorge Cardoso Rodrigues, and Simone Pedro da Silva

Subjects
Biodiesel, Gluconeogenic, Supplement, Veterinary medicine, SF600-1100
Abstract

The aim of this study was to evaluate the intake, digestibility and physiologic parameters of sheep supplemented with increasing levels of propylene glycol. The research and data collection were performed in the Capim Branco experimental farm, which belongs to the Federal University of Uberlândia, lasting 75 days. Therefore, five sheep were used, housed in metabolic cages with slatted floor, feeder and drinker. Corn silage and mineral core specific for the species were used as feed. The rations were divided into two meals and offered to the animals at 08:00 h and at 16:00 h. Water was supplied ad libitum and already mixed with propylene glycol. The inclusion levels of propylene glycol were 0, 1.5, 3.0, 4.5 and 6.0%. The variables studied were: feed intake, feeding behavior, water intake, propylene glycol consumption, fecal score, digestibility, physiologic parameters, ruminal pH and temperature of the rumen fluid. The inclusion of propylene glycol at increasing levels reduced water consumption and did not change the intake and digestibility of matter. Furthermore, the inclusion of propylene glycol did not alter the physiological parameters of sheep, such as ruminal movements, rectal temperature and respiratory rate, which shows that this compound may be added to the diet of sheep to the level of 6%.

Published
2014
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39. How Are Warm-Season Pastures' Nutritive Value and Fermentation Characteristics Affected by Open Pasture, Silvopasture, and Sward Herbage Maturity?

Author

Ferreira, Mariane Rodrigues, Cardoso, Abmael da Silva, Andrade, Marina Elizabeth Barbosa, Brito, Thais Ribeiro, and Ruggieri, Ana Cláudia

Subjects
GUINEA grass, GRASSES, SILVOPASTORAL systems, PASTURES, MASS production
Abstract

This study aimed to evaluate the forage mass and nutritional value (NV) of Guinea Massai grass (Megathyrsus maximus × Megathyrsus infestum) in an open pasture (OP) or the silvopastoral system (SPS) at different stages of development (SDs). The experimental design was completely randomized, with five replications. The treatments were distributed in a factorial scheme 2 × 4, corresponding to types of systems (OP and SPS) and four SD (vegetative stage—S1, pre-flowering—S2, full flowering—S3 and maturity after flowering—S4). There was no interaction of the system × stage of plant development in any of the variables evaluated. The production of forage mass and Guinea Massai grass morphological components did not differ (p > 0.05) between SPS and OP. However, they differed between the SDs (p ≤ 0.05), with an increasing linear effect for forage mass, percentage of the stem, and dead material, and decreasing for leaf percentage and leaf: stem ratio. Only protein content differed (p < 0.05) among the chemical composition variables between culture systems. The shading caused by the SPS did not decrease the forage mass, NV, and in vitro dry matter digestibility of Guinea Massai grass compared to the system in OP. The advance of the SD of Guinea Massai grass increases the forage mass, with higher proportions of morphological components of low NV, such as stem and dead material. Silvopastoral system of Guinea Massai grass and eucalyptus is effective to prolongate the grazing season, with a greater amount of green leaves in the sward and better NV, without compromising herbage mass production in the forage growing season. [ABSTRACT FROM AUTHOR]

Published
2023
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40. Antiprotozoal Activity of Secondary Metabolites from Salvia circinata

Author

Emmanuel Pina Jiménez, Luis Salazar-Olivo, Fernando Calzada, Eva Margarita Alvidrez Armendariz, ELIZABETH BARBOSA CABRERA, Elihú Bautista, and Lilián Yépez-Mulia

Subjects
chemistry.chemical_classification, biology, Traditional medicine, 010405 organic chemistry, medicine.drug_class, Emetine, Salvia, biology.organism_classification, medicine.disease_cause, 01 natural sciences, Flavones, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Entamoeba histolytica, chemistry.chemical_compound, chemistry, Apigenin, medicine, Antiprotozoal, Giardia lamblia, Lamiaceae, General Pharmacology, Toxicology and Pharmaceutics, medicine.drug
Abstract

Salvia circinata Cav., Lamiaceae, is commonly used in Mexican traditional medicine to treat gastrointestinal ailments, including diarrhea. An acetone-soluble extract from the aerial parts of S. circinata was suspended in a 9:1 methanol–water mixture and fractionated by partition with hexane and EtOAc. The hexane, EtOAc, and aqueous fractions were evaluated for their antiprotozoal activities, where the EtOAc-soluble fraction displayed the best antiprotozoal activity. Resolution of this fraction by chromatographic methods afforded the known diterpenoids amarissinins A–C (1–3), teotihuacanin (4), and amarisolide F (5), along with two flavones, apigenin (6) and 5,6-dihydroxy-7,3′,4′-trimethoxy flavone (7). Compound 7 was the most active one, with IC50 values of 0.05 μM and 0.13 μM against Entamoeba histolytica and Giardia lamblia, respectively. Interestingly, it was even more active than metronidazole and emetine, used as positive controls. Compounds 1–6 showed moderate antiprotozoal activity with IC50 values ranging from 23.9 to 67.8 μM against Entamoeba histolytica, and 39.4 to 127 μM against Giardia lamblia. These results provide evidence-based support for the traditional use of S. circinata, and suggest that the 5,6-dihydroxy-7,3′,4′-trimethoxy flavone (7) may have an important role in the antidiarrheal activity of the plant.

Published
2020
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41. In vitro and In Vivo Evaluation of Quinoxaline 1,4-di-N-oxide Against Giardia lamblia

Author

Elizabeth Barbosa-Cabrera, Antonio Monge, Virgilio Bocanegra-García, Rosa Moo-Puc, Gildardo Rivera, and Alma D Paz-González

Subjects
chemistry.chemical_compound, Quinoxaline, chemistry, In vivo, Drug Discovery, medicine, Oxide, Pharmaceutical Science, Molecular Medicine, Giardia lamblia, medicine.disease_cause, Molecular biology, In vitro
Abstract

Background: Giardiasis is an important public health problem. However, its pharmacological treatment is limited mainly to two drugs, metronidazole and nitazoxanide. Objectives: Screening four series of esters (methyl, ethyl, isopropyl and n-propyl) of quinoxaline-7- carboxylate 1,4-di-N-oxide in in vitro and in vivo models as antigiardiasis agents. Objectives: Screening four series of esters (methyl, ethyl, isopropyl and n-propyl) of quinoxaline-7- carboxylate 1,4-di-N-oxide in in vitro and in vivo models as antigiardiasis agents. Methods: Briefly, 4 × 104 trophozoites of G. lamblia were incubated for 48 h at 37 °C with different concentrations of esters of quinoxaline-7-carboxylate 1,4-di-N-oxide, albendazole, metronidazole and nitazoxanide. Afterwards, trophozoites were counted and the half maximal inhibitory concentration (IC50) was calculated by Probit analysis. The in vivo antigiardial activity of the compounds was demonstrated using experimental infections of G. lamblia in suckling female CD-1 mice. Results: Compound T-069 with a thienyl, a trifluoromethyl and an isopropyl group at R1-, R2- and R3-position, respectively, on the quinoxaline 1,4-di-N-oxide ring in an in vitro model showed an IC50 value of 0.0014 µM, and 3502 and 1108 times more giardicidal activity than nitazoxanide and metronidazole in an in vivo model. Conclusion: Isopropyl ester of quinoxaline-7-carboxylate 1,4-di-N-oxide derivatives showed better giardicidal activity than the reference drugs; therefore, these compounds are good candidates to develop new pharmacological treatment for giardiasis.

Published
2020
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42. Secondary metabolites and biological properties of Annona muricata

Author

Rosa María Ordoñez-Razo, Verenice I. Merlin-Lucas, Emmanuel Pina-Jiménez, Miguel Valdes, Claudia Velázquez, Normand García-Hernández, Lilián Yépez-Mulia, Jesús Ivan Solares-Pascasio, Fernando Calzada, and Elizabeth Barbosa

Subjects
Chromatography, Aqueous solution, Chloroform, biology, medicine.drug_class, Extraction (chemistry), Brine shrimp, biology.organism_classification, Rutin, chemistry.chemical_compound, chemistry, Annonaceae, Antiprotozoal, medicine, lipids (amino acids, peptides, and proteins), General Pharmacology, Toxicology and Pharmaceutics, Annona muricata
Abstract

Annona muricata L., Annonaceae, is extensively used in Mexican traditional medicine for the treatment of gastrointestinal disorders, diabetes mellitus, and as antitumor. The ethanol extract of the leaves from A. muricata was suspended in 10% ethanol water and fractionated by organic solvent extraction with chloroform. The chloroform and aqueous residual fractions were tested for antiprotozoal, antipropulsive, antihyperglycemic, and antilymphoma activities, as well as brine shrimp lethality. While for the antiprotozoal, antilymphoma, and antihiperglycemic activities as well as brine shrimp lethality the chloroform fraction was the most active, the aqueous residual fraction provided better result for the antipropulsive activity. The aqueous residual and chloroform fractions were purified by chromatographic methods to give rutin, nicotinflorin, narcissin, and cis-reticulatacin, as well as β-sitosterol.

Published
2020
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43. Cardiologia - Teoria e Prática volume 2

Author

CINDY STEPHANIE ESTEVES DE LIMA, GABRIEL ALVES MENDES DEMIAN, GABRIEL COSTA CORDEIRO, GABRIEL TRANCOSO DE LUCCA, ISABELA ALMEIDA DE ASSIS, JÚLIA SPINELLI ESTEVAM, VITOR COURI BLASSIOLI, LORENA SOARES MAIA DE WERNA MAGALHÃES, MARIA EDUARDA SOARES BARBOSA, SOFIA BROGNARA CARAN MIRANDA, Mateus de Souza Silva Pereira, Matheus Martins Lanna, Bárbara Cardoso de Oliveira, Thiago Chinchilla Gonzaga, Victor Souza Mares, Brenda Pereira Nogueira Santos, Danielle Eleuterio Batista, João Gabriel Medina Denizar, Paulo Vitor Kelmon Silva de Oliveira, José Maria Peixoto, Cindy Stephanie Esteves de Lima, Isabela Almeida de Assis, Gustavo Ryan Martins Santos, Hugo Antonio Gonçalves Pires, MARCELA BORTOLETO FREITAS, Júlia Spinelli Estevam, Maria Eduarda Soares Miranda, Sofia Brognara Caran Miranda, Sophia Fraga Waldolato Allvares, Felipe Lage Bacha, Vitor Couri Blassioli, Admardo Raniere de Assis Cunha, Amanda de Cássia Dutra Mansur, Anna Laura França Gontijo Mendes, Érika Esther Teixeira Morais, Isabela Campos Oliveira de Ávila, Isadora Teixeira Issa, Júlia Palma Avelar Ribeiro, Karenn Tavares Kiepper, MARIANNE NETO RODRIGUES, Tamara Araújo Pereira Campos, Isabella Resck Braoios, Carolina de Paula Andrade, Ana Cecília Johas Marques da Silveira Leão Vaz, Paulo Sérgio Moura de Souza, Thaynara Stefaninne Lima de Assis Henrique, Isadora Mota Ferreira, Elisa Borges Cortez, Jordana Borges Cortez, Maria Eduarda Martins Cruvinel, Amanda Silva Lima, Beatriz Cabral França, Micaela Teodoro Oliveira, Milena Yumi Cometti Ozaki, Geraldo Soares de Lima, Liana Andreza Dias da Cunha, Rafaela Andrade Donalonso, Lucas Ribeiro de Castilho, Daniel Henrique Rodrigues Perdigão, Janeisa Soares, Irvely Luana Muniz Santos, Amanda Barbosa Moraes, Ana Luísa Mendes Pinheiro Costa, Lívia Amaral Salomé Furtado, Luísa Prado Guimarães, Marcos Flávio Spínola Ambrósio, Carlos Henrique Moraes de Medeiros, Mariana Linhares Oliveira Alvim, Rafael Vago Cypriano, Renata Pittella Cançado, Victor Vasconcelos Spínola Ambrósio, Vitor Vieira Estephanin, José Rodrigues dos Santos, Thalita Baptisteli Fernandes, Marcos Flavio Spinola Ambrosio, Luara Moreira da Silva, Ana Paula Machado Souza, Paloma Andrade Pinheiro, Sophia Perrupato Dayrell, Clarice Roman Nascimento e Silva, CLARICE MARQUES MOTTA ANDRADE, Felipe Zampirolli Dornas de Oliveira, Luisa Trindade Vieira, Fernanda Lio Rocha Camargo, Elisa Duarte Paiva, Luiza de Barros Mendes Pires, Lucas dos SANTOS, Aila Fernandes Oliveira Cardoso, Ana Clara Silva de Melo Franco, Gustavo Henrique Rodrigues Meneses, Hertiquiano Jerônimo dos Santos Souza, João Pedro Feijó Maia, Raquel Barbosa Ribeiro, Eduardo Augusto dos Santos Moreira Silva, Juliana Vieira Queiroz Almeida, Ana Tereza Teixeira Tavares, Ana Clara Fonsêca Souza de Jesus, Henrique Figueiredo Silva, Pedro Moraes Coelho, Maria Luiza Andrade Siqueira, Liliane Diniz de Araújo, Martina Marcante, Giovanna Maiolli Signori, Manoella Cardinal Pias, Marcela Menezes Teixeira, Geórgia Savicki Schneider, Luzia Bulla Paviani, Vitória Tischer Dacroce, Melissa Nadal Duarte, Darlan Zamblano Moutinho, Erick Roberto Silvério Martins, Gustavo de Albuquerque Stanford, Kawanny Kennedy de Arruda Batista, CAROLINA SCHEER ELY, Maria Eduarda Tavares de Oliveira, Milena Maria da Silva Aguiar, Maria Eduarda Osório Marafante, Weslley Jonathan Lopes da Penha, Thayane Rebeca Alves dos Santos, Ana Clara Fonsêca Souza De Jesus, Helena Diniz Oliveira, Ana Raquel De Moura, Laila Mameri Pires, Lívia Leandro de Souza Pereira, Carolina Scheer Ely, Diogo Noronha Menezes Kreutz, Lucas Granville Garcia Mayer, Lara Letycia Araujo Costa, Henrique Cássio Silva Rodrigues, Júllia Beatriz Araujo Souza, Larissa Emily Ogando de Jesus Sena, Marília Alves Menezes, Pedro Alves de Figueiredo, Vinicius Goes, Carlos Eduardo de Andrade, LUIS HENRIQUE ALVES GOMES, CAIO CÉZAR TENÓRIO ALVES DA SILVA, CAMILLA MONIELYCK MENDONÇA GUIMARÃES, ALICE WANDERLEY ROCHA, CECILIA CONDE PLÁCIDO IDALINO, EDVALDO XAVIER FERREIRA, ALFREDO AURÉLIO MARINHO ROSA, ALANA DARLY SANTOS ANDRADE, FABIANA TORRES VALADARES, IANNE JESUS SANTANA, ISABELE DANTAS SILVEIRA, MARÍLIA ALVES MENEZES, SARA MIKAELE SOUZA SANTOS, ANDERSON DOS SANTOS BARBOSA, MARCOS ANTONIO ALMEIDA-SANTOS, Luis H A Gomes, Beatriz de Oliveira Simões, Camilla Monielyck Mendonça Guimarães, Danielle Aparecida Guimarães, Cecília Conde Plácido Idalino, Mariana Tenório Costa, Lara Antunes Martins Macedo, Giovanna Mendonça Ferreira, Hortência Garcia Nogueira, Fernanda Freire Dantas Portugal, Giovanna Mendonça dos Santos, Jéssica Lara Cipriano dos Santos, Mateus Araújo dos Santos, Alves Gomes, Olívia de Araújo Rezende Oliveira, Beatriz de Moura Moreira, Gustavo Soares Fernandes, Ana Gabriela Campos Lima, BEATRIZ DE OLIVEIRA SIMÕES, LARISSA CRISTIANO RAMOS, Karen Abrantes Coura, Letícia Gomes Souto Maior, Natália Victória Guedes Galindo, Rayana Tavares De Queiroz, Eduardo Franco Correia Cruz, Camila Araújo Novais Lima, Daniel Gustavo Guedes Pereira de Albuquerque, Francisco Augusto Santana Pires, Júlia Dutra Soares, Manuela Magalhães Dardenne Tenório, Marcela Lukerli Araujo Paulina da Silva, Clara Nóbrega, Anna Julie Medeiros Cabral, Bruna Furtado Gambarra, Fernando de Paiva Melo, Filipe Eduardo Aguiar Costa, Gabriel Lucena de Carvalho Soares, Paulo Francisco Lucena de Araújo Espínola, Samuel Estrela de Abrantes, Francisco Ítalo Kumamoto, Ryanne Monteiro Magalhães, Maurilio Onofre Deininger, Anderson Ricardo Amaral, Karoline Barbosa da Silva, Letícia Martins Toricelli, Patrícia Vieira Xavier, Taynara Carvalho de Oliveira, João Gabriel Ribeiro dos Santos, Francisco Hallison Nascimento de Araújo, Débora Lia Almeida Pacífico, Dalleth de Alencar Farias Castelo Branco, Raíssa Amélia Moreno Sousa, Ana Luísa Mendes Ribeiro, Myrelle Crislane da Silva Pereira, Clara Luisy Duarte Gomes, José Samuel Teixeira de Sousa, Gustavo Felix Pimenta, Marina Lobe Durieux Pera, Guilherme Fleury Fina Speretta, Pedro Reges Pereira Meira, Anna Lillian Canuto Bittencourt, Ana Claudia Leal Cavalcanti, Fernanda Fontes Prado Reis, José Milton Machado do Amorim, Iane Brito Leal, EMERSON DE SANTANA SANTOS, BRÁULIO CRUZ MELO, BEATRIZ LUDUVICE SOARES, JÚLIA SOUZA DINIZ, JOSELINA LUZIA MENEZES OLIVEIRA, RICARDO QUEIROZ GURGEL, Lucas Henrique de Carvalho Machado, Mariana Nunes Lima Dias, Joao Henrique Santos Martins, PEDRO REGES PEREIRA MEIRA, Lívia Maria Pordeus Coura Urtiga, Maria Isabella Machado Arruda, Jessica de Medeiros Guedes Palitot, Cynthia Maria Moreira de Nóbrega, Maria Alice Santos Falconi da Costa, Emerson De Santana Santos, ANDRÉ LUIZ CARVALHO FERREIRA, Bruno Gomes Netto de Oliveira, GABRIELA CORDASSO GOSALAN, Beatriz Luduvice Soares, Alice Campos Neuenschwander, Joselina Luzia Menezes Oliveira, Alícia Zeferino Rodrigues, MARIANA NUNES LIMA DIAS, Beatriz Chiari Messias, Bruna Stancioli Paiva, Bruna Vivian Antunes Campos, Liliane Vilela Brandão, Sophia Campos Salles Silva de Carvalho, Bruna Marquez Rodrigues de Paula, Kamilla Mayr Martins, Maria Luiza Samia Ventura, Edgar Maquigussa, Mirian Aparecida Boim, Elizabeth Barbosa de Oliveira Sales, Elizabeth Barbosa de Oliveira-Sales, Vitória Dias dos Santos, Leticia Ferreira Santos Brito, Luzia Reis Rabelo de Moraes, Vanessa Maria Oliveira Morais, Anna Beatriz Lopes Tavares, Ana Resende Chaves, Rebeca Feitosa Dória Alves, Lucas Siqueira dos Santos, Erivelton Cunha Torres, Francielly Azevedo da Silva, Andreza Oliveira Almeida, Elen Rizzi Sanchez, Ana Clara Dias Resende Chaves, Miguel de Sousa e Annuzzo, João Henrique Carvalho Zacour Almeida Gusmão, Carla Miranda Marcondes, Nicole Santos Félix, Diana Isis Ribeiro Macêdo, Rebeca Karollyne Rolim Ribeiro, Radamés Vieira Diniz, Lucas dos Santos, Rhaine Borges Santos Pedreira, Lucas Augusto Rocha de Macedo, Alda Cristina Alves de Azevedo, Mateus Rufino de Andrade Cruz, Flávio Formiga Fernandes, Maria Eduarda Andrade de Mello, Mônica Maria Costa Caldas, Áleff Edrei Gomes Santos, Henriky Santana Santos, Mateus Araújo Santos, Rebeca Apolinário Sousa, Milena dos Santos Barros Campos, Larissa Cristiano Ramos, Luís Henrique Alves Gomes, Elizabeth de Oliveira Teotonio, Gabrielle Dantas Soares Galindo Vaz, Hugo Limeira Henriques, Hugo Limeira Henrique, Arthur Hebert Dantas Santos, José Oliveira Belém, Letícia de Sousa Costa Nóbrega, Yuri Brito Shiroma, Andressa Lílian Fernandes Vieira, Alice França Clemente, Bárbara Isidoro Faria de Padua, Gabriel Amaral dos Santos, Gustavo Chaves de Almeida, Gisa da Costa Macedo, Manuela Roque Alves, Jéssica Araújo Cavalcante, Lucas Barbosa Sampaio, Daniel Monte de Andrade Gervásio, Humberto Lucca Andrade Moreira, Karinne da Silva Assunção, Marcela Maria Cavalcanti Lira, Gabriela Pessoa de Brito Nunes, Letícia Maria Queiroz Rocha, Antonio de Medeiros Batista, Felipe Silva Barbosa, Germânia Bandeira Lacerda, Josiherbethy Rodrigues de Almeida, Larissa Viviane Sampaio Negrão, Maria Karolayne Oliveira Lima, Luis Henrique Alves Gomes, Ronaldo Machado Bueno, Gisa da Costa de Macedo, Ana Clara Resende Chaves, and Elen Rizzi

Published
2021
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44. Cardiologia- Teoria e Prática volume 1

Author

Douglas Mesadri Gewehr, Alan Neiverth, Marcela Santos Cavalcanti, Thiago Ceschin Maestri, Semi Haurani, Kelre Wannlen Campos Silva Araújo, Fernando Bermudez Kubrusly, Luiz Fernando Kubrusly, Ana Laura Martins Marra Magno Lucindo, AMANDA APOLORI TISSIANI, Amanda Emanuela Machado Ferreira, ANA CAROLINA DE MENEZES FIGUEIRÊDO SILVA, JOHRANNA HEMILY GALDINO LINS, KECIA SILVA MAGALHAES, LUZIA MAYARA PEREIRA CUSTÓDIO DA SILVA, NAYARA ALVES OLIVEIRA DA CRUZ, RAISSA GOUVEIA LUCENA DE BEZERRA, LAÍS DANIELLE GOMES GADELHA, Breno da Nóbrega Bezerra, Bruna Caló Albuquerque, Cleyciana Mayara Barbosa, Ednara Pontes de Avelar Didier Uchôa, Guilherme Gondim Weinberg, Laura Rachel Amorim Ferreira Lima, Matheus Henrique Santos Lira Oliveira, Maria Paula de Lemos Franco, Rodrigo Filipe de Vasconcelos Pessanha, Thayane Rose Cavalcante de Queiroz, JOANA ÉRICA LIMA ROCHA, MARIELY MENDES FURTADO, RENATO SAMPAIO MELLO, ANA VICTÓRIA DA SILVA MENDES, ANA KAROLINNE DA SILVA BRITO, JOSÉ OTÁVIO CARVALHO SENA DE ALMEIDA, EMERSON IURI RODRIGUES QUEIROZ, JOSÉ VINICIUS DE SOUSA FRANÇA, DANIEL DIAS RUFINO ARCANO, MARIA DO CARMO DE CARVALHO E MARTINS, Mariana Tenório Costa, Jéssica Lara Cipriano Santos, Hortência Garcia Nogueira, Giovanna Mendonça Ferreira, Cecília Conde Plácido Idalino, Olívia de Araújo Rezende Oliveira, Lara Antunes Martins Macêdo, Giovanna Mendonça dos Santos, Arthur Eduardo Martins Lopes, Giovanna Aparecida Marques Rezende, Vitor Gonzalez Ouaknin Azulay, Fernanda Caetano Solano Oliveira, Alexandre De Castro Brommonschenkel, Fernando Batista Nigri Dos Santos, Alícia Nathália Terra Perígolo Oliveira, Nathália Ferreira Carvalho, CAIO FERREIRA FILGUEIRAS DE SOUZA, Isabella Juliana Nascimento da Silva, Lucas Peixoto de Sousa Fonsceca, Nicole Modesto Murad, Brunie da Silva Catricala, Lucas Peixoto de Sousa Fonseca, Pedro Henrique Sulz Marx, Welsher Braga Ribeiro Chaves, Lucas Lobato Isaac Gonçalves, Gustavo L T Nascimento, Luiz Eduardo Canton Santos, Amanda Gonçalves Mazochi Abreu, Ana Eloísa Silva Alves, Antonietta Saldanha Alves Bortolone Merlo, Bárbara Farkasvolgyi, Dara Paschoal da Cunha, Gabriela de Almeida Viegas, Hélio do Amaral, Mylena Pastore Bianchi, Manoel da Silva Barbosa Netto, Illa Katrini Ladeia Santana, Phellipe Teixeira de Souza, Flávio Aparecido Terassini, Beatriz Scarin Trombone, João Daniel de Souza Menezes, Maria Eduarda Dóro Mota, Vânia Zaqueu Brandão, CAMILA PADILHA KLOSS, NICOLE ABDULLAH, Beatriz E Borges, Tiago de Oliveira Furlam, Ana Beatriz Cordeiro Prates, Ewelin Wasner Machado da Silva, Henrique de Oliveira Ferreira, Isadora Gonçalves Roque, Laura Gregório Pires, Luciana Helena Dolabela de Abreu, Luiza Moreira Gomes, Maria Cecília Jardim Heyden, Marina Rocha do Prado, Natália Abdo Rodrigues, Nathan Shuenck Silva de Oliveira, Bruna Mundin Veloso JACOB, Carla Jorge Machado, Rafaela Resende da Glória, Isabela Resende da Glória, Henrique Fagundes dos Anjos Araújo, Rafael Fagundes dos Anjos Araújo, Lívia Fagundes dos Anjos Araújo, João Vitor Fortuna Laranjeira, Gabrielly Maria Moreira Rebouças, Erika Araújo dos Santos, Henrique Bosso, Mauricio Lopes da Silva Netto, Matheus Aires Bisoni, Ana Laura Rezende Hubaide, Anna Flora Martins Saes, Evandro Portaluppe Bosso, Isadora Borges Sabino, Nathalya Porto Figueredo, Yoshimara Oliveira Watanabe, Flávia Caroline Silva Neves, Rafaela Cristina Sousa Melo, Henrique Ulisses Duarte De Castro, Natália Batista Mascarenhas, Arthur Soares Santos, Alexandre de Castro Brommonschemkel, Carolina Basilio Lucchesi, Maria Clara Albuquerque Sette Aguiar, George Lucas Santos Pereira, Henrique Ulisses Duarte de Castro, Ana Beatriz Pegoraro Cardozo, Levi Albuquerque Gouveia, Lucas Augusto Walter Marcello, Sarah Arruda Furtado Carneiro, CAROLINA BASILIO LUCCHESI, EVELEN ROUSE DE SOUZA SANTOS, GEORGE LUCAS SANTOS PEREIRA, PAULO HENRIQUE FONTES DE MACEDO, SHEYLA CRISTINA TONHEIRO FERRO DA SILVA, LAURA SBEGHEN QUAGLIO, RAISSA MENDONÇA MENEZES, ALEXANDRE CATENA VOLPE, MARIA LUIZA SAMIA VENTURA, EDGAR MAQUIGUSSA, MIRIAN APARECIDA BOIM, ELIZABETH BARBOSA DE OLIVEIRA-SALES, LUCAS DALVI ARMOND REZENDE, LAVÍNYA MOREIRA SILVA, THALYNE KRETTLY SOUZA, Felipe Lage Bacha, NINA BRUNA DE SOUZA MAWANDJI, LARA NASCIMENTO FRANÇA, BRUNO HENRIQUE FIORIN, MARCELA BORTOLETO FREITAS, CATARINA ITHO PIAZZINI NEVES, PATRICK HENKERT CERQUEIRA, Bárbara Elloar Dellabrida de Andrade e Faria, Gabriel Maia Nascimento, Giulia Maria Menezes Bessa, Gustavo Ryan Martins Santos, Hugo Antonio Gonçalves Pires, Isabela Ferreira de Jesus, João Fernando Oliveira Pereira Silva, João Pedro Ferreira Pereira, Sophia Fraga Waldolato Alvares, BRUNO VÍTOR PEIXOTO MILITÃO, SÍLVIO HENRIQUE DA SILVA VAZ, Beatriz Tesoni Marchiori, LARISSA CAROLINE REZENDE, TALITA MIRANDA SANTOS, MARIANA FONSECA FRANCO DE CAMARGO, GABRIELA BRAGA LAZARCHIC OLIVEIRA, Karimi Mohamed El Bacha, VINÍCIUS LÚCIO DE SOUSA, Barbara Mazzoni, Evaldo Gabriel Maravi de Arruda, Jamile Quadros Bent Moussa Pedro, Júlia Fernanda Rodrigues Fontes, Juliana Tanaka Martins, Laura Raíssa Schio, Sálua Elisandra Lopes, Yann-Luc Patrick Comtesse, Luiz Minuzzo, Ana Júlia Faria Camargos, Ana Luiza Faleiro Vale Oliveira, Barbara Lins Silva, Gabriela Amorim de Castro, Júlia Maia Seixas, Kamila Castro Oliveira Camargos, Lara Silveira Marques, Maria Alice Rocha Lopes, Mariana Lacerda Silva, Maria Tereza Nogueira Fonseca e Souza, ELIZABETH BARBOSA DE OLIVEIRA SALES, Bruno Vítor Peixoto Militão, Gabriela Braga Lazarchic Oliveira, Larissa Caroline Rezende, Luciana Rodrigues Ferreira Prado, Mariana Fonseca Franco de Camargo, Sílvio Henrique da Silva Vaz, Talita Miranda Santos, Thamires de Freitas Mourão, JOÃO VÍCTOR CORDEIRO RODRIGUES, Daniella Soares Fagundes, ROSA MARIA RUAS PARAÍSO, Daniella Patrícia de Oliveira Porto, Bárbara Cardoso de Oliveira, João Vítor Gonçalves Ferreira, Josiane Santos Brant Rocha, Ana Clara Camargo Rocha, Arthur Vasconcelos do Vale, Caroline Marinho Simião, MARIA LUIZA MOTA VIDAL, Marina Gontijo Tuyama, Miguel de Sousa e Annuzzo, Nicolas Semaan Silveira, Rachel Pimentel Romano Silveira, Tamyres Karen Fagundes Machado, PEDRO SADDI DE CARVALHO, CAROLINE MARINHO SIMIÃO, CLARICE MARQUES MOTTA ANDRADE, CAMILA SOUSA BRAGUNCE ALVES, BRUNA DE OLIVEIRA BICALHO, LIDIA COSTA DUARTE, RAÍSSA LOPES SILVA, MARIO HENRIQUE VEIGA MEIRELES, ANA LUÍSA LOPES SILVA, IANCA LOPESFERREIRA, Francisco Rogério Cavalcante Mota, LUCAS ADAILTON VIANA DE ANDRADE, MAYARA MORAIS PARREIRAS, PAULA ALVES FORMIGA, PRISCILA TEIX EIRA DANTAS, SABRINA CORDEIRO ABRANTES RODRIGUES, MÁRIO HENRIQUE VEIGA MEIRELES, José Dilbery Oliveira da Silva SILVA, Isabela Alice Soares de Medeiros, Yahanna da Costa Anacleto Estrela, Isabella Rodrigues Destefani, Jásny Pintor de Assis Correia, Elvis Félix Severo Bezerra, Vitória Freire Lima, JOSÉ DILBERY OLIVEIRA DA SILVA, Natália Bitú Pinto, Gustavo Oliveira Piedade Bustos, Maria Clara Vasconcelos Andrade, Mayara Seyko Kaczorowski Sasaki, Guilherme Oliveira Silva, Natascha Pisciottano, Ana Beatriz Motta Aragão Cortez, Ana Beatriz Maciel Vieira, Laryssa Soares Cleto, Pedro Henrique Amorim Oliveira, Bárbara Lima Guerra, Breno Amin de Lima Silveira, Giovanna Pereira de Holanda, Mauro Kierpel, VICTORIA CRISTINA GUIMARÃES PEDRAS MOURTHÉ, MARCELA MARINHO DE OLIVEIRA, LARA LORENZON CARIM, THALES PESSOA CHRISTO ALEIXO, CLARA DE SOUSA GOMES, VITOR DA CUNHA MOREIRA, YASMIN PEREIRA VIEIRA, Halley Ferraro Oliveira, Marcela Marinho De Oliveira, Luiza Coimbra Castilho, Lenander Fernandes de Toledo, Mateus Araújo dos Santos, Ana Beatriz Mesquita Marques De Araújo Faria, Aldinei Luigi Sousa Gonçalves, Catarina Depieri Michels, Isabela Junqueira Ferreira, Júlia Maria Morena Afonso Campos e Lamas, Larissa Fernandes de Souza Santos, Leonardo Reis Couto Furtado, Luiz Eduardo Vieira Froes, Marcos Guiotti, Matheus Santos Buratto, Yasmin Rosa Storck Rocha Rodrigues, Francisca Ivina Leite Braga, Heitor Fernandes Lourenço, José Paulo Lima do Nascimento, Iascara Vitória de Oliveira Mamede, Marcos Paulo Da Silva, Maria Isadora Benedito de Araujo, Rany Magnaelle Rodrigues Duarte, Luana da Hora Ribeiro, Matheus Neres Batista, Eliana A N Veloso, Karolinne Dorneles Dias, Pedro Vinícius Teles Gomes, Amanda Carolina de Melo Gonçalves, Joel A S, Isabella Mota Ungarelli, Joel Alves De Sousa, Vitória Gabriele Barros de Araújo, Marcella Maciel Rios, Bárbara Leite da Silva, Alice Benicio Do Nascimento, Maria Clara Falcão Barrinha, Jorgyanne Gonzalez Costa, Danyele Holanda da Silva, Nágila Silva Alves, Danyele Holanda Da Silva, André Versiani Caldeira Rocha, Camila Bruck de Siqueira, Gabriel Trindade Avelar, Giulia Rocha Minucci, Marta Bhering Pereira de Souza, Paula Costa Vieira Paiva, Victor Augusto Melo de Matos, ALESSANDRA SOICA GORINO, DOUGLAS MESADRI GEWEHR, FERNANDO BERMUDEZ KUBRUSLY, LUIZ FERNANDO KUBRUSLY, MARCIO PEIXOTO ROCHA DA SILVA, MARIANA NAOMI KASHIWAGUI, MARINA TAYZ MARTINEZ, Rafael Barros Fontes, JAYANE MENDES SARAIVA, Gabriela Massafra Porazzi, Monique Veloso Lima, Amanda Oliveira Sousa Rodrigues, Thalilhia Souza Lima, LUMA MATOS CARVALHO, Leonardo Estevan Rosa Caldas, Ligia Luchetti, Lauana Luchetti, Maria Paula Rabelo Gomes, Weber Tobias Costa, Stella Gontijo Sant Anna Vaz de Melo Dorneles, Victória Braga e Fraga, Renata de Melo Pereira, Rafael Bastos Alvim, Victor Sarmento Coelho, Marina Pinheiro Rocha Fantini, Ana Laura Marra, Vivian Ivone Pereira Negrão, Victor Raggazzi Hohne da Silva, GUILHERME AUGUSTO TURBINO RIBEIRO, Beatriz Dias Oliveira, Iara Silva, Fabya Andressa Mendonça Santana, Francisco Jadson Lima, Stéfany Fernandes da Costa, Daniel Martucheli Sena, Marcela Chaves Coimbra, Victor Araújo Soares, Victor Neves Cunha, Ianca Lopes Ferreira, José Rodrigues dos Santos, Jásny Pinto de Assis Correia, Josemery Pinho Guimarães, Luciana Ferreira Rodrigues Prado, Pedro Machado Batista, Raissa Gomes Alves da Costa, Igor Antônio Galvão Vieira, Nathaly Silva Santos, Isabella Ferreira Estevam de Oliveira, Marylia da Costa Macedo, Lílian Maria Magalhães Costa de Oliveira, Indiara Lorena Barros Ribeiro da Silva, Maribene Bahia de Oliveira, André Luiz de Jesus Mendes, José Dilbery Oliveira da Silva, Priscila Teixeira Dantas, Gabriella Soares de Souza, Thais Gontigo Goulart Leite, Victória Moreira Hannas Guimarães, Clara e Sousa Gomes, Alana Darly Santos Andrade, Camila Rocha Almeida, Gabrielle dos Santos Moreira, Ianne Jesus Santana, Isabella Sales Menezes, Sayron Natanael Lopes Pereira Santos, Maria Karollina Almeida Passos, Fábya Andressa Mendonça Santana, Alberto Calson Alves Vieira, Breno Oliveira Gois, Camilla Radimack Santos de Souza, Gabriel Ferreira Setton Matias, Marina Prado Santos Sobral, Sabrina Layra Souza Araújo, Sabrina Layra Souza Araujo, Walter Aguiar Feijó, Sheyla Cristina Tonheiro Ferro da Silva, and Sanny Cristina de Castro Faria

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2021
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47. Antihyperglycemic Effects of

Author

Rocio, Ortega, Miguel, Valdés, Francisco J, Alarcón-Aguilar, Ángeles, Fortis-Barrera, Elizabeth, Barbosa, Claudia, Velazquez, and Fernando, Calzada

Abstract

The antihyperglycemic activity of ethanolic extract from

Published
2022

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