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1. Design of cell-type-specific hyperstable IL-4 mimetics via modular de novo scaffolds.

Author

Yang, Huilin, Ulge, Umut, Quijano-Rubio, Alfredo, Bernstein, Zachary, Maestas, David, Chun, Jung-Ho, Wang, Wentao, Lin, Jian-Xin, Jude, Kevin, Singh, Srujan, Orcutt-Jahns, Brian, Li, Peng, Mou, Jody, Chung, Liam, Kuo, Yun-Huai, Ali, Yasmin, Meyer, Aaron, Grayson, Warren, Heller, Nicola, Garcia, K, Leonard, Warren, Silva, Daniel-Adriano, Elisseeff, Jennifer, Baker, David, and Spangler, Jamie

Subjects
Animals, Interleukin-4, Cytokines, Signal Transduction
Abstract

The interleukin-4 (IL-4) cytokine plays a critical role in modulating immune homeostasis. Although there is great interest in harnessing this cytokine as a therapeutic in natural or engineered formats, the clinical potential of native IL-4 is limited by its instability and pleiotropic actions. Here, we design IL-4 cytokine mimetics (denoted Neo-4) based on a de novo engineered IL-2 mimetic scaffold and demonstrate that these cytokines can recapitulate physiological functions of IL-4 in cellular and animal models. In contrast with natural IL-4, Neo-4 is hyperstable and signals exclusively through the type I IL-4 receptor complex, providing previously inaccessible insights into differential IL-4 signaling through type I versus type II receptors. Because of their hyperstability, our computationally designed mimetics can directly incorporate into sophisticated biomaterials that require heat processing, such as three-dimensional-printed scaffolds. Neo-4 should be broadly useful for interrogating IL-4 biology, and the design workflow will inform targeted cytokine therapeutic development.

Published
2023

3. Transfer learning in a biomaterial fibrosis model identifies in vivo senescence heterogeneity and contributions to vascularization and matrix production across species and diverse pathologies

Author

Cherry, Christopher, Andorko, James I., Krishnan, Kavita, Mejías, Joscelyn C., Nguyen, Helen Hieu, Stivers, Katlin B., Gray-Gaillard, Elise F., Ruta, Anna, Han, Jin, Hamada, Naomi, Hamada, Masakazu, Sturmlechner, Ines, Trewartha, Shawn, Michel, John H., Davenport Huyer, Locke, Wolf, Matthew T., Tam, Ada J., Peña, Alexis N., Keerthivasan, Shilpa, Le Saux, Claude Jordan, Fertig, Elana J., Baker, Darren J., Housseau, Franck, van Deursen, Jan M., Pardoll, Drew M., and Elisseeff, Jennifer H.

Published
2023
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6. Using proteolysis-targeting chimera technology to reduce navitoclax platelet toxicity and improve its senolytic activity.

Author

He, Yonghan, Zhang, Xuan, Chang, Jianhui, Kim, Ha-Neui, Zhang, Peiyi, Wang, Yingying, Khan, Sajid, Liu, Xingui, Zhang, Xin, Lv, Dongwen, Song, Lin, Li, Wen, Thummuri, Dinesh, Yuan, Yaxia, Wiegand, Janet S, Ortiz, Yuma T, Budamagunta, Vivekananda, Elisseeff, Jennifer H, Campisi, Judith, Almeida, Maria, Zheng, Guangrong, and Zhou, Daohong

Subjects
Blood Platelets, Cell Line, Animals, Mice, Transgenic, Humans, Mice, Sulfonamides, Aniline Compounds, Adaptor Proteins, Signal Transducing, Models, Animal, Aging, Female, Male, bcl-X Protein, Primary Cell Culture, Proteolysis, Cellular Senescence, Transgenic, Adaptor Proteins, Signal Transducing, Models, Animal
Abstract

Small molecules that selectively kill senescent cells (SCs), termed senolytics, have the potential to prevent and treat various age-related diseases and extend healthspan. The use of Bcl-xl inhibitors as senolytics is largely limited by their on-target and dose-limiting platelet toxicity. Here, we report the use of proteolysis-targeting chimera (PROTAC) technology to reduce the platelet toxicity of navitoclax (also known as ABT263), a Bcl-2 and Bcl-xl dual inhibitor, by converting it into PZ15227 (PZ), a Bcl-xl PROTAC, which targets Bcl-xl to the cereblon (CRBN) E3 ligase for degradation. Compared to ABT263, PZ is less toxic to platelets, but equally or slightly more potent against SCs because CRBN is poorly expressed in platelets. PZ effectively clears SCs and rejuvenates tissue stem and progenitor cells in naturally aged mice without causing severe thrombocytopenia. With further improvement, Bcl-xl PROTACs have the potential to become safer and more potent senolytic agents than Bcl-xl inhibitors.

Published
2020

11. Corneal reshaping: an experiment with a type I collagen-based vitrigel for remodeling porcine corneas.

Author

Carolina Marquezan, Maria, de Freitas, Denise, Majumdar, Shoumyo, Xiaokun Wang, Elisseeff, Jennifer, Guyton, David L., Scot Bower, Kraig, Skurski, Zachary P., Regina Chalita, Maria, Belfort Jr, Rubens, and Jun, Albert S.

Subjects
CORNEA, OPTICAL coherence tomography, CORNEAL topography, EXCIMER lasers, BIOMEDICAL materials
Abstract

Copyright of Arquivos Brasileiros de Oftalmologia is the property of Arquivos Brasileiros de Oftalmologia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2024
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13. Contributors

Author

Abid, Shariq, primary, Adnot, Serge, additional, Agusti, Alvar, additional, Beaulieu, Delphine, additional, Bhushan, Anil, additional, Bird, Thomas G., additional, Born, Emmanuelle, additional, Breau, Marielle, additional, Chin, Alexander F., additional, Elisseeff, Jennifer H., additional, Erlangga, Zulrahman, additional, Evangelou, Konstantinos, additional, Faner, Rosa, additional, Farr, Joshua N., additional, Georgakopoulou, Eleni, additional, González-Gualda, Estela, additional, Gorgoulis, Vassilis G., additional, Gray-Gaillard, Elise, additional, Han, Jin, additional, Hernandez-Gonzalez, Fernanda, additional, Houssaini, Amal, additional, Jensen, Michael D., additional, Jurk, Diana, additional, Katsuumi, Goro, additional, Khosla, Sundeep, additional, Kiourtis, Christos, additional, Kirkland, James L., additional, Kovatcheva, Marta, additional, Lipskaia, Larissa, additional, López-Domínguez, Jose Alberto, additional, Macías, David, additional, Marcos, Elisabeth, additional, Maus, Mate, additional, Melk, Anette, additional, Meyer, Kathleen, additional, Michel, John, additional, Minamino, Tohru, additional, Miwa, Satomi, additional, Monroe, David G., additional, Muñoz-Espín, Daniel, additional, Ou, Hui-Ling, additional, Palmer, Allyson K., additional, Saito, Nayuta, additional, Schmitt, Roland, additional, Sellares, Jacobo, additional, Serrano, Manuel, additional, Sung, Myong-Hee, additional, Tchkonia, Tamara, additional, Thompson, Peter J., additional, von Zglinicki, Thomas, additional, Wan, Tengfei, additional, and Zhang, Peisu, additional

Published
2022
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16. Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment

Author

Jeon, Ok Hee, Kim, Chaekyu, Laberge, Remi-Martin, Demaria, Marco, Rathod, Sona, Vasserot, Alain P, Chung, Jae Wook, Kim, Do Hun, Poon, Yan, David, Nathaniel, Baker, Darren J, van Deursen, Jan M, Campisi, Judith, and Elisseeff, Jennifer H

Subjects
Musculoskeletal, Animals, Anterior Cruciate Ligament, Anterior Cruciate Ligament Injuries, Antiviral Agents, Cartilage, Articular, Cellular Senescence, Chondrocytes, Cyclin-Dependent Kinase Inhibitor p16, Extracellular Matrix Proteins, Fluorescent Antibody Technique, Ganciclovir, Glycosaminoglycans, Humans, Immunoblotting, Immunohistochemistry, In Vitro Techniques, Mice, Mice, Transgenic, Osteoarthritis, Knee, Real-Time Polymerase Chain Reaction, Regeneration, Reverse Transcriptase Polymerase Chain Reaction, Weight-Bearing, Medical and Health Sciences, Immunology
Abstract

Senescent cells (SnCs) accumulate in many vertebrate tissues with age and contribute to age-related pathologies, presumably through their secretion of factors contributing to the senescence-associated secretory phenotype (SASP). Removal of SnCs delays several pathologies and increases healthy lifespan. Aging and trauma are risk factors for the development of osteoarthritis (OA), a chronic disease characterized by degeneration of articular cartilage leading to pain and physical disability. Senescent chondrocytes are found in cartilage tissue isolated from patients undergoing joint replacement surgery, yet their role in disease pathogenesis is unknown. To test the idea that SnCs might play a causative role in OA, we used the p16-3MR transgenic mouse, which harbors a p16INK4a (Cdkn2a) promoter driving the expression of a fusion protein containing synthetic Renilla luciferase and monomeric red fluorescent protein domains, as well as a truncated form of herpes simplex virus 1 thymidine kinase (HSV-TK). This mouse strain allowed us to selectively follow and remove SnCs after anterior cruciate ligament transection (ACLT). We found that SnCs accumulated in the articular cartilage and synovium after ACLT, and selective elimination of these cells attenuated the development of post-traumatic OA, reduced pain and increased cartilage development. Intra-articular injection of a senolytic molecule that selectively killed SnCs validated these results in transgenic, non-transgenic and aged mice. Selective removal of the SnCs from in vitro cultures of chondrocytes isolated from patients with OA undergoing total knee replacement decreased expression of senescent and inflammatory markers while also increasing expression of cartilage tissue extracellular matrix proteins. Collectively, these findings support the use of SnCs as a therapeutic target for treating degenerative joint disease.

Published
2017

18. IL-17 and immunologically induced senescence regulate response to injury in osteoarthritis

Author

Faust, Heather J., Zhang, Hong, Han, Jin, Wolf, Matthew T., Jeon, Ok Hee, Sadtler, Kaitlyn, Pena, Alexis N., Chung, Liam, Maestas, David R., Jr., Tam, Ada J., Pardoll, Drew M., Campisi, Judith, Housseau, Franck, Zhou, Daohong, Bingham, Clifton O., III, and Elisseeff, Jennifer H.

Subjects
Thermo Fisher Scientific Inc., Osteoarthritis -- Health aspects, Cytokines -- Health aspects, Transforming growth factors -- Health aspects, Immune response -- Health aspects, Scientific equipment industry -- Health aspects, T cells -- Health aspects, Health care industry, Johns Hopkins University. School of Medicine
Abstract

Senescent cells (SnCs) are implicated in the pathogenesis of age-related diseases including osteoarthritis (OA), in part via expression of a senescence-associated secretory phenotype (SASP) that includes immunologically relevant factors and cytokines. In a model of posttraumatic OA (PTOA), anterior cruciate ligament transection (ACLT) induced a type 17 immune response in the articular compartment and draining inguinal lymph nodes (LNs) that paralleled expression of the senescence marker [p16.sup.INK4a] (Cdkn2a) and p21 (Cdkn1a). Innate lymphoid cells, [gamma][delta].sup.+] T cells, and [CD4.sup.+] T ells contributed to IL-17 expression. Intra-articular injection of IL-17-neutralizing antibody reduced joint degeneration and decreased expression of the senescence marker Cdkn1a. Local and systemic senolysis was required to attenuate tissue damage in aged animals and was associated with decreased IL-17 and increased IL-4 expression in the articular joint and draining LNs. In vitro, we found that Th17 cells induced senescence in fibroblasts and that SnCs skewed naive T cells toward Th17 or Th1, depending on the presence of TGF-[beta]. The SASP profile of the inflammation-induced SnCs included altered Wnt signaling, tissue remodeling, and cell-cycle pathways not previously implicated in senescence. These findings provide molecular targets and mechanisms for senescence induction and therapeutic strategies to support tissue healing in an aged environment., Introduction Regenerative medicine strategies aim to promote new tissue development but are often limited by systemic and environmental inhibitory factors such as aging or infection. Cellular senescence is associated with [...]

Published
2020
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20. Age‐associated Senescent – T Cell Signaling Promotes Type 3 Immunity that Inhibits the Biomaterial Regenerative Response

Author

Han, Jin, primary, Cherry, Christopher, additional, Mejias, Joscelyn C., additional, Krishnan, Kavita, additional, Ruta, Anna, additional, Maestas, David R., additional, Peña, Alexis N., additional, Nguyen, Helen Hieu, additional, Nagaraj, Sushma, additional, Yang, Brenda, additional, Gray‐Gaillard, Elise, additional, Rutkowski, Natalie, additional, Browne, Maria, additional, Tam, Ada J., additional, Fertig, Elana J., additional, Housseau, Franck, additional, Ganguly, Sudipto, additional, Moore, Erika M., additional, Pardoll, Drew M., additional, and Elisseeff, Jennifer H., additional

Published
2023
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21. Regulating the proinflammatory response to implanted composite biomaterials comprising polylactide and hydroxyapatite by targeting immunometabolism

Author

Maduka, Chima V, primary, Makela, Ashley V, additional, Ural, Evran, additional, Stivers, Katlin B, additional, Kuhnert, Maxwell M, additional, Tundo, Anthony, additional, Alhaj, Mohammed, additional, Hoque Apu, Ehsanul, additional, Ashammakhi, Nureddin, additional, Hankenson, Kurt D, additional, Narayan, Ramani, additional, Elisseeff, Jennifer H, additional, and Contag, Christopher H, additional

Published
2023
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26. Immunometabolic cues recompose and reprogram the microenvironment around biomaterials

Author

Maduka, Chima V, primary, Schmitter-Sanchez, Axel D, additional, Makela, Ashley V, additional, Ural, Evran, additional, Stivers, Katlin B, additional, Pope, Hunter, additional, Kuhnert, Maxwell M, additional, Habeeb, Oluwatosin M, additional, Tundo, Anthony, additional, Alhaj, Mohammed, additional, Kiselev, Artem, additional, Chen, Shoue, additional, Olive, Andrew J, additional, Hankenson, Kurt D D, additional, Narayan, Ramani, additional, Park, Sangbum, additional, Elisseeff, Jennifer H, additional, and Contag, Christopher H, additional

Published
2023
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28. Targeting mTOR with a sirolimus-eluting airway stent reduces pro-fibrotic TH17-cells and inhibits laryngotracheal stenosis

Author

Motz, Kevin M., primary, Lina, Ioan A., additional, Samad, Idris, additional, Murphy, Michael K., additional, Duvvuri, Madhavi, additional, Davis, Ruth J., additional, Gelbard, Alexander, additional, Chung, Liam, additional, Chan-Li, Yee, additional, Collins, Samuel, additional, Powell, Jonathan D., additional, Elisseeff, Jennifer H., additional, Horton, Maureen R., additional, and Hillel, Alexander T., additional

Published
2023
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34. Senescent cells and osteoarthritis: a painful connection

Author

Jeon, Ok Hee, David, Nathaniel, Campisi, Judith, and Elisseeff, Jennifer H.

Subjects
Osteoarthritis -- Development and progression -- Risk factors -- Care and treatment, Immune response -- Health aspects, Cell aging -- Health aspects -- Causes of, Knee injuries -- Complications and side effects, Health care industry
Abstract

Senescent cells (SnCs) are associated with age-related pathologies. Osteoarthritis is a chronic disease characterized by pain, loss of cartilage, and joint inflammation, and its incidence increases with age. For years, the presence of SnCs in cartilage isolated from patients undergoing total knee artificial implants has been noted, but these cells' relevance to disease was unclear. In this Review, we summarize current knowledge of SnCs in the multiple tissues that constitute the articular joint. New evidence for the causative role of SnCs in the development of posttraumatic and age-related arthritis is reviewed along with the therapeutic benefit of SnC clearance. As part of their senescence- associated secretory phenotype, SnCs secrete cytokines that impact the immune system and its response to joint tissue trauma. We present concepts of the immune response to tissue trauma as well as the interactions with SnCs and the local tissue environment. Finally, we discuss therapeutic implications of targeting SnCs in treating osteoarthritis., Introduction Osteoarthritis (OA), the most common joint disease of late life, affects 80% of individuals over age 65 (1). Women and obese individuals are more susceptible to this chronic disease [...]

Published
2018
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36. Helminth egg derivatives as proregenerative immunotherapies

Author

Maestas, David R., primary, Chung, Liam, additional, Han, Jin, additional, Wang, Xiaokun, additional, Sommerfeld, Sven D., additional, Kelly, Sean H., additional, Moore, Erika, additional, Nguyen, Helen Hieu, additional, Mejías, Joscelyn C., additional, Peña, Alexis N., additional, Zhang, Hong, additional, Hooks, Joshua S. T., additional, Chin, Alexander F., additional, Andorko, James I., additional, Berlinicke, Cynthia A., additional, Krishnan, Kavita, additional, Choi, Younghwan, additional, Anderson, Amy E., additional, Mahatme, Ronak, additional, Mejia, Christopher, additional, Eric, Marie, additional, Woo, JiWon, additional, Ganguly, Sudipto, additional, Zack, Donald J., additional, Zhao, Liang, additional, Pearce, Edward J., additional, Housseau, Franck, additional, Pardoll, Drew M., additional, and Elisseeff, Jennifer H., additional

Published
2023
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37. Spatial transcriptomics analysis of neoadjuvant cabozantinib and nivolumab in advanced hepatocellular carcinoma identifies independent mechanisms of resistance and recurrence

Author

Zhang, Shuming, primary, Yuan, Long, additional, Danilova, Ludmila, additional, Mo, Guanglan, additional, Zhu, Qingfeng, additional, Deshpande, Atul, additional, Bell, Alexander T.F., additional, Elisseeff, Jennifer, additional, Popel, Aleksander S., additional, Anders, Robert A., additional, Jaffee, Elizabeth M., additional, Yarchoan, Mark, additional, Fertig, Elana J., additional, and Kagohara, Luciane T., additional

Published
2023
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39. Corneal reshaping: an experiment with a type I collagen-based vitrigel for remodeling porcine corneas

Author

Marquezan, Maria Carolina, primary, Freitas, Denise de, additional, Majumdar, Shoumyo, additional, Wang, Xiaokun, additional, Elisseeff, Jennifer, additional, Guyton, David L., additional, Bower, Kraig Scot, additional, Skurski, Zachary P., additional, Chalita, Maria Regina, additional, Belfort Jr, Rubens, additional, and Jun, Albert S., additional

Published
2023
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42. Remodelamento corneano: relato de um experimento com um vitrigel a base de colágeno tipo I para remodelamento de córneas porcinas

Author

Marquezan, Maria Carolina, Freitas, Denise de, Majumdar, Shoumyo, Wang, Xiaokun, Elisseeff, Jennifer, Guyton, David L., Bower, Kraig Scot, Skurski, Zachary P., Chalita, Maria Regina, Belfort Jr, Rubens, and Jun, Albert S.

Subjects
Corneal stroma, Swine, Corneal surgery, Proteses e implantes, Animais, Suínos, Substância própria, Materiais bio-compatíveis, laser, Cornea, Córnea, Prostheses and implants, Lasers de excimer, Animals, Corneal topography, Biocompatible materials, Lasers excimer, Cirurgia da córnea a laser
Abstract

Purpose: This study aimed to report an experiment designed to determine anatomical changes in porcine corneas following placement of a novel polymer implant into the cornea. Methods: An ex vivo porcine eye model was used. A novel type I collagen-based vitrigel implant (6 mm in diameter) was shaped with an excimer laser on the posterior surface to create three planoconcave shapes. Implants were inserted into a manually dissected stromal pocket at a depth of approximately 200 μm. Three treatment groups were defined: group A (n=3), maximal ablation depth 70 μm; Group B (n=3), maximal ablation depth 64 μm; and group C (n=3), maximal ablation depth 104 μm, with a central hole. A control group (D, n=3) was included, in which a stromal pocket was created but biomaterial was not inserted. Eyes were evaluated by optical coherence tomography (OCT) and corneal tomography. Results: Corneal tomography showed a trend for a decreased mean keratometry in all four groups. Optical coherence tomography showed corneas with implants placed within the anterior stroma and visible flattening, whereas the corneas in the control group did not qualitatively change shape. Conclusions: The novel planoconcave biomaterial implant described herein could reshape the cornea in an ex vivo model, resulting in the flattening of the cornea. Further studies are needed using in vivo animal models to confirm such findings. RESUMO Objetivo: Relatar um experimento projetado para determinar alterações anatômicas em córneas porcinas após a colocação de um novo implante de polímero na córnea. Métodos: Foi utilizado olho de porco ex vivo. Um novo agente modelador biocompatível, de colágeno tipo 1, com 6mm de diâmetro foi moldado com excimer laser em sua face posterior, para criar três formatos planocôncavos. Os implantes foram inseridos dentro de um bolsão, dissecado manualmente, a 200 micrômetros (μm). Foram definidos três grupos de tratamento: grupo A (n=3), teve a profundidade máxima de ablação de 70 μm; o grupo B (n=3), profundidade máxima de ablação de 64 μm; e o grupo C (n=3), profundidade máxima de ablação de 104 μm, com buraco central. O grupo controle, D (n=3), foi incluído, com a criação do bolsão estromal, porém sem inserir o material. A avaliação desses olhos foi realizada por tomografia de coerência óptica (OCT) e por tomografia corneana. Resultados: A tomografia corneana mostrou uma tendência para diminuição da ceratometria média em todos os 4 grupos. A tomografia de coerência óptica mostrou córneas com implantes localizados no estroma anterior e aplanamento visível, enquanto as córneas não mudaram qualitativamente o formato no grupo controle. Conclusões: O novo implante de biomaterial planocôncavo descrito aqui foi capaz de remodelar a córnea em modelo de animal ex vivo, resultando no aplanamento corneano. Novos estudos são necessários usando modelos animais in vivo para confirmar tais achados.

Published
2023

44. Contributors

Author

Agarwal, Rachit, primary, Ahlstrom, Jon D., additional, Ahmad, Rafiq, additional, Alarcon, Emilio I., additional, Almarza, Alejandro J., additional, Almeida-Porada, Graça, additional, Almeida, Manuel, additional, Alvarado-Velez, Melissa, additional, Anderson, James M., additional, Arcidiacono, Judith, additional, Atala, Anthony, additional, Badylak, Stephen F., additional, Balkan, Wayne, additional, Ballios, Brian G., additional, Baptista, Pedro M., additional, Baumann, M. Douglas, additional, Bedi, Supinder S., additional, Bellamkonda, Ravi V., additional, Bergmann, Nicole M., additional, Blau, Helen M., additional, Boerckel, Joel D., additional, Bratt-Leal, Andres M., additional, Brown, James C., additional, Brubaker, Scott, additional, Brunette, Isabelle, additional, Calderon, Gisele A., additional, Caplan, Arnold I., additional, Castner, David G., additional, Chang, Cynthia, additional, Chawla, Aditya, additional, Chen, Xuguang, additional, Cohen, Paul, additional, Cooke, Michael J., additional, Copus, Joshua S., additional, Correlo, Vitor M., additional, Cox, Charles S., additional, Dahl, Abritee, additional, Day, Richard M., additional, De Coppi, Paolo, additional, Dodla, Mahesh C., additional, Elisseeff, Jennifer H., additional, Emamaullee, Juliet A., additional, Esa, Adam, additional, Fang, Yunlan, additional, Faust, Heather J., additional, Fisher, John P., additional, Fisher, Matthew B., additional, Francois, Elvis L., additional, García, Andrés J., additional, Gavrilov, Svetlana, additional, Gazit, Dan, additional, Gazit, Zulma, additional, Gemmiti, Christopher V., additional, Gillispie, Gregory J., additional, Gilpin, Sarah E., additional, Godbey, W.T., additional, Gray, Andrea, additional, Green, Ronald M., additional, Griffith, May, additional, Guldberg, Robert E., additional, Guo, Qiongyu, additional, Gurtner, Geoffrey C., additional, Hacker, Michael C., additional, Hanna, Issa A., additional, Hare, Joshua M., additional, Hatzistergos, Konstantinos E., additional, Herber, Ralf-Peter, additional, Hilborn, Jöns, additional, Humes, H. David, additional, Hunsberger, Joshua G., additional, Iwasa, Kenjiro, additional, Jackson, John D., additional, Jackson, Margaret L., additional, Jang, Hae Lin, additional, Jansen, John A., additional, Johnston, Josephine, additional, Jorns, Carl, additional, Kang, Huijun, additional, Kaplan, David L., additional, Kaplan, David S., additional, Katz, Adam J., additional, Kelley, Matthew W., additional, Kennedy, Kelsey, additional, Khademhosseini, Ali, additional, Khang, Gilson, additional, Kim, Jinho, additional, Klein, Rachel H., additional, Klimanskaya, Irina, additional, Knoepfler, Paul S., additional, Ko, In Kap, additional, Kolambkar, Yash M., additional, Krieghoff, Jan, additional, Kucko, Nathan W., additional, Kumar, Manoj, additional, Kurtzberg, Joanne, additional, Kwilas, Anna, additional, Landry, Donald W., additional, Langhans, Mark T., additional, Lanza, Robert, additional, Lanzoni, Giacomo, additional, Lee, Sang Jin, additional, Leeuwenburgh, Sander C.G., additional, Leong, Kam W., additional, Liang, Rui, additional, Liaudanskaya, Volha, additional, Lin, Hang, additional, Longaker, Michael T., additional, Lorenz, Hermann P., additional, Loring, Jeanne F., additional, Lu, Shi-Jiang, additional, Lue, Alberto, additional, Ma, Peter X., additional, Magalhaes, Renata S., additional, Mandla, Serena, additional, Marshall, Clement D., additional, Martins-Green, Manuela, additional, Mason, Devon E., additional, Mau, Jonquil R., additional, McFarland, Richard, additional, McHale, Melissa K., additional, Melville, James C., additional, Meyers, Jason R., additional, Mikos, Antonios G., additional, Miller, Jordan S., additional, Mittermiller, Paul A., additional, Miyachi, Hideki, additional, Miyamoto, Shinka, additional, Monteiro, Nelson, additional, Moore, Alessandra L., additional, Morini, Sara, additional, Moser, Philipp T., additional, Mukhatyar, Vivek J., additional, Murdock, Mark, additional, Nagiel, Aaron, additional, Naughton, Gail K., additional, Nauta, Allison, additional, Navarro, Javier, additional, Newton, Jared M., additional, Nori, Aparna, additional, Okano, Teruo, additional, Oliveira, Joaquim M., additional, Ott, Harald C., additional, Padmanabhan, Jagannath, additional, Page, Kristin M., additional, Pallickaveedu Rajan Asari, Anil Kumar, additional, Papaioannou, Virginia E., additional, Park, Jihoon, additional, Payne, Samantha L., additional, Pelled, Gadi, additional, Pepper, Andrew, additional, Perumal, Elumalai, additional, Petreaca, Melissa, additional, Pino, Christopher J., additional, Pirosa, Alessandro, additional, Pla-Palacín, Iris, additional, Pokrywczynska, Marta, additional, Porada, Christopher D., additional, Porter, Blaise D., additional, Radisic, Milica, additional, Rambhia, Kunal J., additional, Raquel Maia, F., additional, Ratner, Buddy D., additional, Reddi, A.H., additional, Reis, Rui L., additional, Ricles, Laura, additional, Ricordi, Camillo, additional, Rizwan, Muhammad, additional, Robinson, Rebecca, additional, Rodrigues, Melanie, additional, Rothrauff, Benjamin B., additional, Sadri-Ardekani, Hooman, additional, Sainz-Arnal, Pilar, additional, Sambathkumar, Rangarajan, additional, Sánchez-Romero, Natalia, additional, Scarritt, Michelle, additional, Schneider, Christopher M., additional, Schwartz, Steven D., additional, Selem, Sarah, additional, Serrano-Aulló, Trinidad, additional, Shapiro, A.M. James, additional, Sheyn, Dmitriy, additional, Shimizu, Tatsuya, additional, Shinoka, Toshiharu, additional, Shoichet, Molly S., additional, Shoji, Toshihiro, additional, Shupe, Thomas, additional, Sikora, Andrew G., additional, Simpson, Fiona, additional, Skardal, Aleksander, additional, Skuk, Daniel, additional, Smith, Brandon T., additional, Sohn, Jihee, additional, Soker, Shay, additional, Solanas, Estela, additional, Song, Jeong Eun, additional, Sood, Disha, additional, Stocum, David L., additional, Strom, Stephen C., additional, Sun, Jessica M., additional, Takahashi, Hironobu, additional, Tremblay, Jacques P., additional, Tripathy, Nirmalya, additional, Tse, John W., additional, Tuan, Rocky S., additional, Verfaillie, Catherine M., additional, Vunjak-Novakovic, Gordana, additional, Wagner, William R., additional, Wang, Yanling, additional, Watson, Emma, additional, West, Jennifer L., additional, Williams, David F., additional, Williams, James K., additional, Wong, Mark E., additional, Woo, Savio L-Y., additional, Wood, Fiona M., additional, Xu, Lei, additional, Yakubovich, Doron C., additional, Yang, Yafeng, additional, Yaszemski, Michael J., additional, Yelick, Pamela C., additional, Yim, Evelyn K.F., additional, Yong, Carolyn, additional, Yoo, James J., additional, Young, Simon, additional, Yucel, Nora, additional, Zacharias, Rachel L., additional, Zhang, Yuanyuan, additional, Zhang, Ai, additional, Zhang, Jin, additional, and Zhu, Yang, additional

Published
2018
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45. Creation and preclinical evaluation of a novel mussel-inspired, biomimetic, bioactive bone graft scaffold: direct comparison with Infuse bone graft using a rat model of spinal fusion.

Author

Cottrill, Ethan, Pennington, Zach, Wolf, Matthew T., Dirckx, Naomi, Ehresman, Jeff, Perdomo-Pantoja, Alexander, Rajkovic, Christian, Lin, Jessica, Maestas Jr., David R., Mageau, Ashlie, Lambrechts, Dennis, Stewart, Veronica, Sciubba, Daniel M., Theodore, Nicholas, Elisseeff, Jennifer H., and Witham, Timothy

Published
2023
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50. Mimicking biological functionality with polymers for biomedical applications

Author

Green, Jordan J. and Elisseeff, Jennifer H.

Subjects
Biopolymers -- Health aspects -- Usage, Biomedical engineering -- Methods, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

The vast opportunities for biomaterials design and functionality enabled by mimicking nature continue to stretch the limits of imagination. As both biological understanding and engineering capabilities develop, more sophisticated biomedical materials can be synthesized that have multifaceted chemical, biological and physical characteristics designed to achieve specific therapeutic goals. Mimicry is being used in the design of polymers for biomedical applications that are required locally in tissues, systemically throughout the body, and at the interface with tissues., Author(s): Jordan J. Green [1]; Jennifer H. Elisseeff (corresponding author) [1] The footpads of a gecko. The adhesive used by mussels to cling to rocks. The infectivity of a virus. [...]

Published
2016
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