6 results on '"Elisabeth Hernandez"'
Search Results
2. Effect of bariatric surgery in the body burden of persistent and non-persistent pollutants: longitudinal study in a cohort of morbidly obese patients
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B. Vanessa Díaz-González, Álvaro Ramos-Luzardo, Luis Alberto Henríquez-Hernández, Lluis Serra-Majem, Inmaculada Bautista-Castaño, Andrea Acosta-Dacal, Octavio P. Luzardo, Elisabeth Hernández-García, Judith Cornejo-Torre, Juan Ramón Hernández-Hernández, and Pilar Fernández-Valerón
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obesity ,bariatric surgery ,persistent organic pollutants ,weight loss ,obesogens ,Diseases of the endocrine glands. Clinical endocrinology ,RC648-665 - Abstract
IntroductionObesity is a pathological state that involves the dysregulation of different metabolic pathways and adipose tissue cells, constituting a risk factor for the development of other diseases. Bariatric surgery is the most effective treatment. The study of the behavior of pollutants in situations of extreme weight loss can provide biomonitoring information and tools to manage diseases of environmental etiology.AimTo determine the prevalence of serum persistent and non-persistent pollutants in obese patients subjected to bariatric surgery and analyze the impact of sociodemographic variables on these changes.MethodsGC-MS/MS and UHPLC-MS/MS were utilized to determine the detection rates and concentrations of 353 compounds, including persistent organic pollutants (POPs), pesticides, pharmaceuticals, and rodenticide, in serum samples of 59 obese patients before and after undergoing bariatric surgery.ResultsDetection rates of p,p’-DDE, HCB, β-HCH, naphthalene, phenanthrene and PCB congeners 138, 153 and 180 significantly increased due to surgery-induced weight loss. Serum levels of p,p’-DDE, PCB-138, PCB-153 and PCB-180 also increased after surgery. Correlations between naphthalene levels, weight loss, variation of total lipids and time after surgery were found. Additionally, correlations were observed between concentrations of PCB-138 and weight loss, and between phenanthrene levels and reduction of total lipids. No statistically significant differences were observed for other groups of contaminants, pharmaceuticals and other chemicals included in the quantification methods.ConclusionsIncrement of POPs was observed after bariatric surgery. Serum concentrations of POPs after surgery were influenced by adiposity-related variables. Although biomonitoring studies show a decreasing tendency of exposure, rapid weight loss leads to an increase of circulating POPs. Further research on the interplay between adipose tissue, POPs and peripheral organs is required.
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- 2024
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3. Fauna of molluscs from Planes de Son and Mata de València (Alt Àneu, Pallars Sobirà, Catalan Pyrenees): bibliographic survey and new data
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Jordi Nebot, Jordi Cadevall, Francesc Uribe, Elisabeth Hernandez, Albert Orozco, and V. Bros
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Fauna ,Mollusca ,pirineu ,Pyrenees ,lcsh:Zoology ,Animal Science and Zoology ,lcsh:QL1-991 - Abstract
La revisió de citacions bibliogràfiques situades a les Planes de Son i la Mata de València (municipi d’Alt Àneu, Pallars Sobirà) ha permès identificar 33 espècies de mol·luscs (set de les quals corresponents a llimacs) presents històricament en la zona. Una campanya de camp portada a terme recentment (2006–2007) ha detectat 50 espècies de mol·luscs no-llimacs, dues de les quals representades amb dues subespècies cadascuna. Es proporcionen les dades detallades dels dos inventaris faunístics. Paraules clau: Pirineus, Fauna, Mollusca., The survey of bibliograpic information on the presence of molluscs at the Planes de Son and Mata de València (municipality of Alt Àneu, county of Pallars Sobirà, Catalan Pyrenees) has accounted for a list of 33 species of molluscs (seven of them are slugs) inhabiting historically this area. A current field survey (2006-2007) has detected 50 species of molluscs not slugs, two of these species are splitted in two subspecies. Detailed data from both faunistic inventories are provided. Key words: Pyrenees, Fauna, Mollusca., La revisión de las citas bibliográficas situadas en Les Planes de Son y La Mata de València (municipio de Alt Àneu, comarca del Pallars Sobirà, Pirineo Catalán) ha permitido identificar 33 especies de moluscos (siete de ellas correspondientes a babosas) presentes históricamente en la zona. Una reciente campaña de campo (2006-2007) ha detectado 50 especies de moluscos no babosas, dos de ellas representadas con dos subespecies cada una. Se proporcionan los datos detallados de los dos inventarios faunísticos. Palabras clave: Pirineo, Fauna, Mollusca.
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- 2008
4. The emerging importance of DNA mapping and other comprehensive screening techniques, as tools to identify new drug targets and as a means of (cancer) therapy personalisation
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Iran Rashedi, Marek Los, Esteban Alberti, Elisabeth Hernandez, Jarosław Baran, Subbareddy Maddika, Tadeusz Kroczak, Juliusz Pryjma, and Marcin Siedlar
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Drug ,medicine.medical_specialty ,factor-kappa-b ,media_common.quotation_subject ,proteome ,Clinical Biochemistry ,Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy) ,Single-nucleotide polymorphism ,Translational research ,Antineoplastic Agents ,Biology ,Bioinformatics ,Proteomics ,prostate-cancer ,Metabolomics ,Drug Delivery Systems ,single nucleotide polymorphism (SNP) ,Neoplasms ,transcription factors ,Drug Discovery ,single-nucleotide polymorphisms ,medicine ,Genetics ,Humans ,Genetic Testing ,personalised therapy ,Genetik ,single strand conformation polymorphism (SSCP) ,Medicinsk bioteknologi (med inriktning mot cellbiologi (inklusive stamcellsbiologi), molekylärbiologi, mikrobiologi, biokemi eller biofarmaci) ,breast-cancer ,media_common ,seldi-tof ,Pharmacology ,estrogen-receptor ,Cancer och onkologi ,Chromosome Mapping ,mass-spectrometry ,apoptotic pathways ,gene-expression ,Pharmacogenetics ,Cancer and Oncology ,Proteome ,nuclear-factor ,Molecular Medicine ,Medical genetics ,Human genome ,transcriptome ,invader assay ,matrix-assisted laser desorption ionisation (MALDI) - Abstract
Every human being is genetically unique and this individuality is not only marked by morphologic and physical characteristics but also by an individual's response to a particular drug. Single nucleotide polymorphisms (SNPs) are largely responsible for one's individuality. A drug may be ineffective in one patient, whereas the exact same drug may cure another patient. Recent advances in DNA mapping and other screening technologies have provided researchers and drug developers with crucial information needed to create drugs that are specific for a given individual. In the future, physicians will be able to prescribe individualised drugs adjusted to, for example, activities of specific enzymatic pathways that would either be targeted by these drugs, or would be responsible for drug conversion or inactivation. Furthermore, the mapping of the human genome allows broader development and application of drugs that act on the level of gene transcription rather than as simple biochemical inhibitors or activators of certain enzymes. Such new approaches will maximise desired therapeutic results and may completely eliminate severe side effects. To illustrate the potential of genetic translational research, the authors discuss available analytical methodologies such as; gene arrays, flow cytometry-based screening for SNPs, proteomics, metabolomics, real-time PCR, and other methods capable of detecting both SNPs, as well as more profound changes in cell metabolism. Finally, the authors provide several examples that focus mostly on targeting protein-DNA interactions, but also other processes.
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- 2006
5. Petroleum Systems and Reservoir Appraisal in the Sub-Andean Basins (Eastern Venezuela and Eastern Colombian Foothills)
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Philippe Robion, Jaime Toro, Nathalie Bordas-Lefloch, Charles Aubourg, Elisabeth Hernandez, Carlos Rivero, François Roure, William Sassi, Sophie Lecornec-Lance, and Nicole Guilhaumou
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Allochthon ,chemistry.chemical_compound ,Source rock ,chemistry ,Geochemistry ,Petroleum ,Sedimentary rock ,Pressure solution ,Diachronous ,Foreland basin ,Geomorphology ,Geology ,Diagenesis - Abstract
Major oil discoveries in the foothills of the Venezuelan and Colombian Andes have recently focused the interest of exploration companies toward sub-Andean basins. Seismic, well, and core data from the El Furrial (Venezuela) and Cusiana (Colombia) productive fields have been integrated herein with other regional information to document the evolution of the thrust belt and the history of the petroleum systems, and to propose practical guidelines for prediction of sandstone reservoir quality in such a complex geodynamic environment. Although timing of deformation is slightly different in these areas of eastern Venezuela and Colombia, sedimentary and tectonic burial of the foreland autochthon in both regions led to the maturation of prolific Cretaceous marine source rocks, resulting in successive and diachronous hydrocarbon migration and trapping episodes. Early sedimentary burial at the current location of the Serrana del Interior (Venezuela) and the Eastern Cordillera (Colombia) resulted in long-range migration of early-generated hydrocarbons toward the foreland, forming the large accumulation of hydrocarbon along the Faja Petrolifera (Eastern Venezuela). Early entrapped hydrocarbons also have been preserved in pre-Andean prospects of the Andean foothills, as evidenced by the complex charge history of the Cusiana field. However, wide areas of source rocks in the Andean foothills and adjacent foreland reached the oil window only during the late Neogene and Pliocene-Quaternary, when maximum burial was attained. This produced a second migration episode, coeval with the growth of frontal anticlinal prospects. The main reservoir in Cusiana is fluvial sandstone of the Mirador Formation (Eocene); in El Furrial, it is sandstone of the Naricual-Merecure Formation (Oligocene). Pressure solution and quartz cementation decreased permeability of these sandstones. Results of studies of the anisotropy of the magnetic susceptibility (AMS), coupled with studies of fluid inclusions in quartz overgrowths and thermal modeling, demonstrate that sandstone reservoirs of these oil fields were compacted both vertically, by the load of the synflexural sequence, and horizontally, by tectonic stress (layer-parallel shortening) prior to being tectonically emplaced into the allochthon. Layer-parallel shortening by pressure solution is a major source of silica in the underthrust foreland. Venezuelan and Colombian sandstones still have reasonably good reservoir characteristics, although they have been buried to great depths. Overpressure that developed in these reservoirs as a result of rapid foredeep sedimentation probably caused a delay in compaction. Early carbonate cements also may have contributed locally to prevent compaction until secondary porosity developed as a result of dissolution of this early diagenetic phase. Finally, development of structural closures and hydrocarbon trapping has resulted progressively in the shutting down of the hydraulic system, preventing the transport of exotic silica by regional fluid flow.
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- 2003
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6. Influencia de la altitud en la riqueza de especies de moluscos: variaciones en el valle de Alinyà, Alt Urgell, Lleida
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Albert Orozco, V. Bros, Elisabeth Hernandez, Jordi Cadevall, Francesc Uribe, and Jordi Nebot
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gradient altitudinal ,elevació ,Range (biology) ,Ecology ,Forestry ,Biology ,Altitude ,Mollusca ,Elevation ,lcsh:Zoology ,Animal Science and Zoology ,Species richness ,lcsh:QL1-991 ,Altitudinal gradient ,riquesa d’espècies - Abstract
The species richness of land molluscs is negatively correlated with altitude, while the altitudinal range of the species inhabiting at higher elevations is greater than in low levels. At the low scale of this study factors other than elevation may account better for the species richness., La riqueza de especies de moluscos terrestres está negativamente correlacionada con la altitud, mientras que el rango altitudinal de las especies lo está positivamente. En estudios locales como éste la altitud no explica suficientemente la distribución de la riqueza de especies.
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- 2003
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