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3 results on '"Elisa Santoro"'

1. Vitamin K deficiency: a case report and review of current guidelines

Author

Maria Rosaria Marchili, Elisa Santoro, Alessandra Marchesi, Simona Bianchi, Lelia Rotondi Aufiero, and Alberto Villani

Subjects
Vitamin K, Deficiency, Bleeding, Breastfeeding, Case report, Pediatrics, RJ1-570
Abstract

Abstract Background Vitamin K, a fat soluble vitamin, is a necessary cofactor for the activation of coagulation factors II, VII, IX, X, and protein C and S. In neonatal period, vitamin K deficiency may lead to Vitamin K Deficiency Bleeding (VKDB). Case presentation We present the case of a 2 months and 20 days Caucasian male, presented for bleeding from the injections sites of vaccines. At birth oral vitamin K prophylaxis was administered. Neonatal period was normal. He was exclusively breastfed and received a daily oral supplementation with 25 μg of vitamin K. A late onset vitamin K deficiency bleeding was suspected. Intravenous Vitamin K was administered with complete recovery. Conclusions Nevertheless the oral prophylaxis, our case developed a VKDB: it is necessary to revise the current guidelines in order to standardize timing and dosage in different clinical conditions.

Published
2018
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2. Low-Level Radiofrequency Exposure Does Not Induce Changes in MSC Biology: An in vitro Study for the Prevention of NIR-Related Damage

Author

Elisa Santoro, Massimo Briccola, Tiziana Squillaro, Nicola Alessio, Monica Lamberti, Domenico Aprile, Raffaella Marchesani, Paolo Giubbini, and Maria Rosaria Muoio

Subjects
Senescence, DNA repair, Adverse health effect, Rf exposure, Mesenchymal stem cell, Rf radiation, Medicine (miscellaneous), In vitro study, Cell Biology, Stem cell, Biology, Cell biology
Abstract

Background The ubiquitous diffusion of radiofrequency (RF) radiation across human living environments has attracted the attention of scientists. Though the adverse health effects of RF exposure remain debatable, it has been reported that the interaction of such radiation with biological macromolecular structures can be deleterious for stem cells, inducing impairment of their main functions involving self-renewal and differentiation. Purpose The purpose of this study was to determine whether exposure to RF of 169 megahertz (MHz) that is part of very high radiofrequency (VHF) range 30-300 MHz, could cause damage to stem cells by inducing senescence and loss of regenerative and DNA repair capacity. Methods The study was conducted on mesenchymal stromal cells (MSCs) containing a subpopulation of stem cells. The MSCs were exposed to RFs of 169 MHz administered via an open meter 2G "Smart Meter" for different durations of time. Result We did not observe modifications in MSC biology as a result of the RF exposure conducted in our experiments. Conclusion We concluded that MSCs are insensitive to RF radiation exposure at 169 MHz for various time intervals, including longer durations.

Published
2019
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3. Follow-Up Study of Over Three Years of Patients with Uveitis after Cataract Phacoemulsification: Outcomes and Complications

Author

Maurizio La Cava, Federica De Marco, Elisa Santoro, Lucia Restivo, Alessandro Abbouda, and Paolo Tortorella

Subjects
Adult, Male, medicine.medical_specialty, Pseudophakia, medicine.medical_treatment, Visual Acuity, After cataract, Kaplan-Meier Estimate, Macular Edema, Uveitis, Young Adult, Postoperative Complications, Lens Implantation, Intraocular, cataract IOL, phacoemulsification, uveitis, Risk Factors, Ophthalmology, Medicine, Humans, Risk factor, Intraoperative Complications, Macular edema, Aged, Proportional Hazards Models, Aged, 80 and over, Phacoemulsification, business.industry, Hazard ratio, Follow up studies, General Medicine, Capsule Opacification, Middle Aged, medicine.disease, eye diseases, Surgery, Chronic anterior uveitis, Female, Ocular Hypertension, business, Follow-Up Studies
Abstract

To evaluate the rate and onset of intraoperative and postoperative complications post-phacoemulsification.One hundred sixty-two eyes of 145 patients with uveitis who underwent phacoemulsification between 2006 and 2009 were identified through surgical record review. Fifty-nine eyes of 46 patients met the inclusion criteria. Hazard ratio (HR) and Kaplan-Meier survival probability were calculated for each class of uveitis.Macular edema (ME) resulted to be associated to chronic postoperative inflammation (r = 0.6; p = 0.00) and mostly related to patients who presented more than one postoperative relapse/year (r = 0.2; p = 0.02). Fuchs uveitis resulted to be a risk factor for posterior capsule opacification (PCO) (HR 3.36 IC95%1.0-10.5; p = 0.03). Hypotony and elevated intraocular pressure (IOP) were detected in the anterior uveitis group (0.02 EY).The HR to develop ME was significantly related to chronic anterior uveitis. PCO and elevated IOP are most frequent in Fuchs uveitis. The postoperative visual acuity result was good among all the uveitis groups.

Published
2015

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