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1. Handgrip strength assessment at baseline in addition to bone parameters could potentially predict the risk of curve progression in adolescent idiopathic scoliosis

Author

Rufina Wing Lum Lau, Ka Yee Cheuk, Vivian Wing Yin Hung, Fiona Wai Ping Yu, Elisa Man Shan Tam, Lyn Lee Ning Wong, Jiajun Zhang, Wayne Yuk Wai Lee, Jack Chun Yiu Cheng, Tsz Ping Lam, and Adam Yiu Chung Lau

Subjects
adolescent idiopathic scoliosis, handgrip, strength, bone, curve progression, Pediatrics, RJ1-570
Abstract

IntroductionAdolescent idiopathic scoliosis (AIS) is characterized by deranged bone and muscle qualities, which are important prognostic factors for curve progression. This retrospective case–control study aims to investigate whether the baseline muscle parameters, in addition to the bone parameters, could predict curve progression in AIS.MethodsThe study included a cohort of 126 female patients diagnosed with AIS who were between the ages of 12 and 14 years old at their initial clinical visit. These patients were longitudinally followed up every 6 months (average 4.08 years) until they reached skeletal maturity. The records of these patients were thoroughly reviewed as part of the study. The participants were categorized into two sub-groups: the progressive AIS group (increase in Cobb angle of ≥6°) and the stable AIS group (increase in Cobb angle

Published
2023
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3. Effects of a Home-Based Exercise Intervention (E-Fit) on Bone Density, Muscle Function, and Quality of Life in Girls with Adolescent Idiopathic Scoliosis (AIS): A Pilot Randomized Controlled Trial

Author

Elisa Man-Shan Tam, Bobby K. W. Ng, Jack C. Y. Cheng, Stanley Sai-chuen Hui, Rufina W. L. Lau, Ka-Yee Cheuk, Tsz Ping Lam, and Alec Lik-Hang Hung

Subjects
medicine.medical_specialty, Adolescent, Bone density, Health, Toxicology and Mutagenesis, physical activity, Pilot Projects, Idiopathic scoliosis, Article, Interval training, law.invention, home-based exercise intervention, Quality of life, Randomized controlled trial, law, medicine, Humans, self-image, high-intensity interval training, Bone mineral, business.industry, Muscles, Public Health, Environmental and Occupational Health, bone density, Exercise Therapy, Bone Diseases, Metabolic, Scoliosis, adolescent idiopathic scoliosis, Quality of Life, Lean body mass, Physical therapy, Medicine, Female, business, High-intensity interval training
Abstract

Background: Adolescent idiopathic scoliosis (AIS) patients have lower physical activity levels than normal adolescents, and there is an association with poorer bone and muscle health. This study evaluated the effects of a home-based exercise intervention (E-Fit) on bone mineral density (BMD), muscle function, and quality of life (QoL) in AIS-affected girls. Methods: A total of 40 AIS females aged 11 to 14 years were randomly assigned to the E-Fit or control group. The E-Fit group performed modified 7-min high-intensity interval training (HIIT) 5 days per week for 6 months. Outcome measures including BMD using dual-energy X-ray absorptiometry (DXA), muscle strength and endurance tests, physical activity levels, and QoL using self-reported questionnaires were assessed at baseline and at 6-month and 12-month follow-up. Results: In total, 14 patients in the E-Fit and 16 in the control group completed the study. The E-Fit group showed a marginally significant interaction effect in the whole body areal BMD at the 6- (p = 0.096) and 12-month follow-ups (p = 0.085). The left arm lean mass in the E-Fit group showed a statistically significant interaction effect between the 6- and 12-month follow-ups (p = 0.046). The E-Fit group showed improvements in physical activity participation, as measured by the Modified Baecke Questionnaire (MBQ), with a significant interaction effect in work index (p = 0.043), sport index (p = 0.050), and total score (p = 0.016) from baseline to the 12-month follow-up. Improvement on self-image were noted in E-Fit group across time. Conclusions: The present results provided some evidence to support the positive benefits of E-Fit for bone health and muscle function in AIS girls.

Published
2021
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4. Abnormal Osteoblastic Response to Leptin in Patients with Adolescent Idiopathic Scoliosis

Author

Zhen Liu, Tsz Ping Lam, Yi shun Wong, Tzi Bun Ng, Elisa Man-Shan Tam, Gene Chi Wai Man, Zongshan Hu, Wing-Hoi Cheung, Zezhang Zhu, Jack C. Y. Cheng, Yong Qiu, and Vivian Wing-Ying Hung

Subjects
Adult, Leptin, Male, medicine.medical_specialty, Adolescent, lcsh:Medicine, Idiopathic scoliosis, Hormone receptors, Article, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Western blot, 030502 gerontology, Internal medicine, medicine, Humans, Young adult, Child, lcsh:Science, Receptor, Cell Proliferation, Osteoblasts, Multidisciplinary, Leptin receptor, medicine.diagnostic_test, business.industry, Cell growth, digestive, oral, and skin physiology, lcsh:R, Infant, Cell Differentiation, Spine, Endocrinology, Scoliosis, Child, Preschool, Etiology, Osteoporosis, Receptors, Leptin, Female, lcsh:Q, 0305 other medical science, business, hormones, hormone substitutes, and hormone antagonists, 030217 neurology & neurosurgery
Abstract

Adolescent idiopathic scoliosis (AIS) is a complex three-dimensional structural deformity of the spine with unknown etiology. Although leptin has been postulated as one of the etiologic factors in AIS, its effects on osteoblastic activity remain unknown. Herein, we conducted this study to investigate whether there are abnormal functional responses to leptin and abnormal expression of leptin receptor in AIS osteoblasts. In vitro assays were performed with osteoblasts isolated from 12 severe AIS girls and 6 non-AIS controls. The osteoblasts were exposed to different concentrations of leptin (0, 10, 100, 1000 ng/mL). The effects of leptin on cell proliferation, differentiation and mineralization were determined. Protein expressions of leptin receptor (LEP-R) under basal and osteogenic conditions were also evaluated by Western blot. Our results showed that leptin significantly stimulated osteoblasts from non-AIS subjects to proliferate, differentiate and mineralized. However, in the AIS group, the stimulatory effects of leptin on cell proliferation, differentiation, and mineralization were not observed. In addition, no statistically significant difference in the expression of leptin receptor under both basal and osteogenic conditions was found between AIS and control group. In conclusion, these findings might help to explain the low bone mass and deranged bone quality that is clinically associated with AIS girls.

Published
2019
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5. Sexual Dimorphism in Cortical and Trabecular Bone Microstructure Appears During Puberty in Chinese Children

Author

Ali Ghasem-Zadeh, Ka Yee Cheuk, Zhendong Zhang, Ji Wang, X. Edward Guo, Roger Zebaze, Tracy Y. Zhu, Fiona Wai Ping Yu, Tsz Ping Lam, Vivian Wing-Yin Hung, Wayne Yuk-Wai Lee, Jack C. Y. Cheng, Xiaofang Wang, Elisa Man Shan Tam, and Ego Seeman

Subjects
0301 basic medicine, Male, Adolescent, Endocrinology, Diabetes and Metabolism, microstructure, Physical activity, 030209 endocrinology & metabolism, bone, 03 medical and health sciences, 0302 clinical medicine, Asian People, Cortical Bone, sex, Medicine, Humans, Orthopedics and Sports Medicine, Quantitative computed tomography, Child, Life Style, Bone mineral, Sex Characteristics, Chinese, medicine.diagnostic_test, business.industry, Puberty, Anatomy, Organ Size, Biomechanical Phenomena, Sexual dimorphism, Trabecular bone, 030104 developmental biology, medicine.anatomical_structure, Cancellous Bone, Cortical bone, Female, business, Linear growth, Cancellous bone
Abstract

Distal forearm fractures during growth are more common in males than females. Because metaphyseal cortical bone is formed by coalescence of trabeculae emerging from the periphery of the growth plate, we hypothesized that the later onset of puberty in males produces a longer delay in trabecular bone formation and coalescence, which leaves a transient phase of high cortical porosity, low matrix mineral density, and high trabecular density relative to females. We quantified the nondominant distal radial microstructure using high‐resolution peripheral quantitative computed tomography in 214 healthy Chinese boys and 219 Chinese girls aged between 7 and 17 years living in Hong Kong. Measurements of 110 slices (9.02 mm) were acquired 5 mm proximal to the growth plate of the nondominant distal radius. Porosity was measured using StrAx1.0 (Straxcorp, Melbourne, VIC, Australia) and trabecular plate and rod structure were measured using individual trabecula segmentation (ITS). Mechanical properties were estimated using finite element analysis (FEA). Results were adjusted for age, total bone cross‐sectional area (CSA), dietary calcium intake, and physical activity. In boys, total bone CSA was 17.2% to 22.9% larger throughout puberty, cortical/total bone CSA was 5.1% smaller in Tanner stage 2 only, cortical porosity was 9.4% to 17.5% higher, and matrix mineral density was 1.0% to 2.5% lower in Tanner stage 2 to 5, than girls. Boys had higher trabecular rod BV/TV in Tanner stage 3 and 4, but higher trabecular plate BV/TV and plate to rod ratio in Tanner stage 5, than girls. Boys had 17.0% lower apparent modulus than girls in Tanner stage 2. A transient phase of higher porosity due to dissociation between bone mineral accrual and linear growth may contribute to higher distal radial bone fragility in Chinese boys compared to girls. © 2018 American Society for Bone and Mineral Research.

Published
2018

6. Effective therapeutic control of curve progression using calcium and vitamin D supplementation for adolescent idiopathic scoliosis - a randomized double-blinded placebo-controlled trial

Author

Bobby K. W. Ng, Gene Chi Wai Man, Wayne Yw Lee, Jack C. Y. Cheng, Benjamin Hon Kei Yip, Elisa Man Shan Tam, Kwong Man Lee, Tsz Ping Lam, and Fiona Wai Ping Yu

Subjects
030222 orthopedics, medicine.medical_specialty, Vitamin d supplementation, Double blinded, business.industry, Placebo-controlled study, chemistry.chemical_element, Idiopathic scoliosis, General Medicine, Calcium, Gastroenterology, 03 medical and health sciences, 0302 clinical medicine, chemistry, Internal medicine, medicine, Curve progression, 030212 general & internal medicine, business
Published
2017
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7. 13th International Conference on Conservative Management of Spinal Deformities and First Joint Meeting of the International Research Society on Spinal Deformities and the Society on Scoliosis Orthopaedic and Rehabilitation Treatment – SOSORT-IRSSD 2016 meeting

Author

Aria Bagheri, Xue-Cheng Liu, Channing Tassone, John Thometz, Amie Chaloupka, Sergey Tarima, Larry Cohen, Milena Simic, Sarah Dennis, Kathryn Refshauge, Evangelos Pappas, Eric C. Parent, Matthew Pietrosanu, Emily Redford, Sheri Schmidt, Douglas Hill, Marc Moreau, Douglas Hedden, Samer Adeeb, Edmond Lou, Rob C. Brink, Tom P. C. Schlösser, Dino Colo, Koen L. Vincken, Marijn van Stralen, Steve C. N. Hui, Winnie C. W. Chu, Jack C. Y. Cheng, René M. Castelein, Vasileios Kechagias, Theodoros B. Grivas, Konstantinos Vlasis, Konstantinos Michas, Elisa M. S. Tam, Fiona W. P. Yu, Vivian W. Y. Hung, Lin Shi, Ling Qin, Bobby K. W. Ng, James Griffith, Tsz Ping Lam, Cindy Xue, Jean-Philippe Pialasse, Judy Y. H. Wong, Quang N. Vo, Lawrence H. Le, Edmond H. M. Lou, Rui Zheng, Douglas L. Hill, Marc J. Moreau, Douglas M. Hedden, James K. Mahood, Sarah Southon, Arnaud Brignol, Farida Cheriet, Marie-Claude Miron, Catherine Laporte, Yong Qiu, Hao Liu, Zhen Liu, Ze-zhang Zhu, Bang-ping Qian, XueCheng Liu, Robert Rizza, Derek Rosol, Paula North, Fabio Zaina, Francesca Pesenti, Stefano Negrini, Luca Persani, Paolo Capodaglio, Nicoletta Polli, Benjamin Hon Kei Yip, Fiona Wai Ping Yu, Vivian Wing Yin Hung, Bobby Kin Wah Ng, Jack Chun Yiu Cheng, Jiajun Zhang, Wayne Yuk Wai Lee, Huanxiong Chen, Elisa Man Shan Tam, Gene Chiwai Man, Zezhang Zhu, Bang Ping Qian, P. Harasymczuk, M. Andrusiewicz, P. Janusz, P. Biecek, T. Kotwicki, M. Kotwicka, Jung Sub Lee, Jong Ki Shin, Tae Sik Goh, Seung Min Son, Gene Chi Wai Man, Mark Schwartz, Sarah Gilday, Donita I. Bylski-Austrow, David L. Glos, Lindsay Schultz, Sara O’Hara, Viral V. Jain, Peter F. Sturm, Xiaoyu Wang, Dennis G. Crandall, Stefan Parent, Noelle Larson, Hubert Labelle, Carl-Eric Aubin, Negar Behzadi Fard, Kajsa Duke, Leeann Lukenchuk, Matthew Kerslake, Geraldine Huynh, Jill Chorney, Ban Tsui, Daniel Tobert, Prachi Bakarania, Hagit Berdishevsky, Kelly Grimes, Hiroko Matsumoto, Joshua Hyman, Benjamin Roye, David Roye, Michael Vitale, Jason Black, Michael Bradley, Shawn Drake, David Glynn, Erika Maude, Amelia Lindgren, Nicholas Feinberg, Zachary Bloom, Sarah Dupuis, Carole Fortin, Christiane Caouette, Carl-Éric Aubin, Gozde Gur, Yavuz Yakut, Nikola Jevtić, Sanja Schreiber, Axel Hennes, Milan Pantović, Jean-Claude de Mauroy, Frédéric Barral, Sophie Pourret, Angelo Gabriele Aulisa, Vincenzo Guzzanti, Marco Galli, Francesco Falciglia, Lorenzo Aulisa, Jean-Claude Bernard, Julie Deceuninck, Eric Berthonnaud, Adrien Rougelot, Marie-Eva Pickering, Emmanuelle Chaleat-Valayer, Richard Webb, Josette Bettany-Saltikov, Barbara Neil, Martina Poggio, Sabrina Donzelli, Monia Lusini, Salvatore Minnella, Alith Hoang, Saihu Mao, Benlong Shi, Bangping Qian, Xu Sun, Nikita Cobetto, Soraya Barch, Isabelle Turgeon, Hasan Md Arif Raihan, Datta Tarit Kumar, Chapal Khasnabis, Ameed Equbal, Ashis Kumar Chakraborty, Abhishek Biswas, Burcu Dilek, Cigdem Ayhan, Engin Simsek, Ozgen Aras, Songul Aksoy, Doug Hill, Andreas Donauer, Melissa Tilburn, Jim Raso, Marc Morau, He Chen, Wong Man-Sang, Sarah Kobayashi, Fatemeh Aslanzadeh, Brian MacIntosh, Emmanouil G. Maragkoudakis, Ioannis D. Gelalis, Christina Mazioti, Gerasimos Tsilimidos, R. Geoffrey Burwell, Yu Zheng, Xiao-Jun Wu, Yi-Ni Dang, Ning Sun, Yan Yang, Tao Wang, Cheng-Qi He, Man-Sang Wong, Gregorio Martinez, Alberto Negrini, Matthew Shirley, Hasani Swindell, David P. Roye, Behrooz A. Akbarnia, Sumeet Garg, James O. Sanders, David L. Skaggs, John T. Smith, Michael G. Vitale, Children’s Spine Study Group, Growing Spine Study Group, Aoife Healy, Sybil Farmer, Nachiappan Chockalingam, Paolo Pizzetti, Toru Maruyama, Yosuke Kobayashi, Yusuke Nakao, Sai-hu Mao, Bin Wang, Yang Yu, Amelia M. Lindgren, Melvin C. Makhni, Jamal Shillingford, Abbie Turland, Antonio Caronni, Luciana Sciumè, Elham Khodayari Moez, Elise M. Watkins, Sarah C. Southon, Preston Sloan, Douglass Hedden, Elise Watkins, Maliheh Ghaneei, Nikos Karavidas, Despoina Dritsa, Nigel Hanchard, Donghyun Kim, Junlae Kim, Amy Sbihli, Eric Parent, Lauren Levey, Mark Holowka, Leigh Davis, Lori A Dolan, Stuart L. Weinstein, BrAIST Study Group, Jill E. Larson, Maximilian A. Meyer, Barrett Boody, John F. Sarwark, Benjamin Gundlach, Alison Grant, Raman Kalyan, Waleed Hekal, Cheryl Honeyman, Tim Cook, Scott Murray, Morena Pitruzzella, Jennifer Hope, Julie Yoshimachi, Julie Touchette, Anissa St-Jean, Danica Brousseau, Louise Marcotte, Jean Théroux, Chantal Doucet, Yangmin Lin, Man Sang Wong, John MacMahon, Edward MacMahon, Jeremy Boyette, Luke Stikeleather, Andrea Lebel, Victoria Ashley Lebel, Chintan A. Pancholi-Parekh, Lise Stolze, Marissa Selthafner, Kaitlin Hong, Pamela R. Morrison, Timothy A. Hanke, Patrick Knott, Nathaniel D. Krumdick, Thomas Shannon, Ryan Davenhill, Robert Needham, Vinay Jasani, El-Nasri Ahmed, Marco Gordano, Giuseppe Mastantuoni, Michail Chandrinos, Paweł Głowka, Dominik Gaweł, Bartosz Kasprzak, Michał Nowak, Marek Morzyński, Tomasz Kotwicki, Cyril Lecante, Jean-François Aubin-Fournier, Debbie Ehrmann Feldman, Wen Zhang, Zongshan Hu, Weiguo Zhu, Mengran Jin, Xiao Han, Jing Guo, Tao Wu, Feng Zhu, Jian Jiang, Huang Yan, Francesca Di Felice, Robert A Needham, Panagiotis Chatzistergos, Joseph E. Reynolds, Eric J. Wall, Vasilios G. Igoumenou, Panayiotis D. Megaloikonomos, Konstantinos Tsiavos, Georgios N. Panagopoulos, Andreas F. Mavrogenis, Konstantinos Soultanis, Panayiotis J. Papagelopoulos, Andrew Chan, Sho Kobayashi, Daisuke Togawa, Tomohiko Hasegawa, Yu Yamato, Shin Oe, Tomohiro Banno, Yuuki Mihara, and Yukihiro Matsuyama

Subjects
International research, 030222 orthopedics, medicine.medical_specialty, lcsh:Diseases of the musculoskeletal system, Rehabilitation, Conservative management, business.industry, medicine.medical_treatment, Scoliosis, medicine.disease, Meeting Abstracts, lcsh:RD701-811, 03 medical and health sciences, 0302 clinical medicine, Physical medicine and rehabilitation, lcsh:Orthopedic surgery, Orthopedic surgery, medicine, Physical therapy, Orthopedics and Sports Medicine, Joint (building), lcsh:RC925-935, business, 030217 neurology & neurosurgery
Published
2017
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8. A Critical Comparison Between Two Scanning Protocols of High-Resolution Peripheral Quantitative Computed Tomography at the Distal Radius in Adolescents

Author

Ka-Yee Cheuk, Elisa Man-Shan Tam, Ali Ghasem-Zadeh, Xiaofang Wang, Jack C. Y. Cheng, Ling Qin, Fiona Wai Ping Yu, Vivian Wing-Yin Hung, Tracy Y. Zhu, Benjamin Hon Kei Yip, and Tsz Ping Lam

Subjects
0301 basic medicine, Male, Common area, medicine.medical_specialty, Wilcoxon signed-rank test, Bone density, Adolescent, Endocrinology, Diabetes and Metabolism, Osteoporosis, 030209 endocrinology & metabolism, 03 medical and health sciences, 0302 clinical medicine, Forearm, Region of interest, Bone Density, mental disorders, Medicine, Humans, Radiology, Nuclear Medicine and imaging, Orthopedics and Sports Medicine, Quantitative computed tomography, Bone mineral, medicine.diagnostic_test, business.industry, medicine.disease, Healthy Volunteers, Surgery, Radius, 030104 developmental biology, medicine.anatomical_structure, nervous system, Female, Nuclear medicine, business, Tomography, X-Ray Computed
Abstract

High-resolution peripheral quantitative computed tomography (HR-pQCT) is a unique technology for assessing bone mineral density and bone microarchitecture. Currently, no universally accepted protocol for selecting the region of interest (ROI) at the distal radius has been established for growing subjects. This study aimed (1) to investigate the differences in HR-pQCT measurements of 2 different ROI protocols applied to the distal radius of healthy adolescents and (2) to identify the least common area of ROI (the least common ROI) between the protocols. Twenty-six boys and 26 girls aged between 13 and 16 yr old were recruited. Nondominant distal radius was scanned by 2 HR-pQCT protocols, namely, the "5-mm protocol," where the distal end of ROI started at 5 mm proximal to a reference line, and the "4% protocol," where the ROI started at 4% of the ulnar length proximal to another reference line. The least common ROI between the 2 protocols was identified and the slice numbering within the common ROI was determined. Bland-Altman plots were used to check the agreement of the least common ROIs between the 2 protocols. Paired t-test and Wilcoxon signed-rank test were used for analysis. In boys, significant differences between protocols were found in most parameters with the maximum difference observed in the cortical area (25.0%, p

Published
2016

9. Bone quality in severe adolescent idiopathic scoliosis -- quantitative computed tomography of lumbar spine vs high-resolution peripheral quantitative computed tomography of the distal radius: a pilot study

Author

James F. Griffith, Elisa Man Shan Tam, Steve C. N. Hui, Tsz Ping Lam, Lin Shi, Wing Yee Choy, Fiona Wai Ping Yu, Bobby K. W. Ng, Vivian Wing-Yin Hung, Pak Yin Lee, Defeng Wang, Lin Qin, Winnie C.W. Chu, and Jack C. Y. Cheng

Subjects
medicine.medical_specialty, medicine.diagnostic_test, business.industry, High resolution, Idiopathic scoliosis, General Medicine, Radius, Peripheral, Bone quality, medicine, Lumbar spine, Radiology, Quantitative computed tomography, business
Published
2015
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12. Serum 25(OH)vitamin D level and Its correlation with bone mineral density in girls with Adolescent Idiopathic Scoliosis (AIS)

Author

Franco Tsz Fung Cheung, Jack C. Y. Cheng, Echo Ka Ling Tsang, Elisa Man Shan Tam, Tsz Ping Lam, Alec Lik-Hang Hung, Bobby K. W. Ng, and Kwong Man Lee

Subjects
Bone mineral, medicine.medical_specialty, business.industry, Physiology, Idiopathic scoliosis, Correlation, Elevated serum, medicine.anatomical_structure, Orthopedic surgery, medicine, Vitamin D and neurology, Oral Presentation, Orthopedics and Sports Medicine, Bone Alkaline Phosphatase, business, Femoral neck
Abstract

Objectives AIS is associated with both low bone mass and elevated serum bone alkaline phosphatase. It was also reported the prevalence of AIS was positively correlated with the latitude of the geographical region. These specific features were compatible with the presence of either Vit-D insufficiency or abnormal physiology with Vit-D. It is important to evaluate these potentially treatable conditions regarding their roles in the etiopathogenesis of AIS. The objectives of this case-control study were to evaluate Vit-D status and its correlation with areal bone mineral density (aBMD) in AIS subjects and normal controls.

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