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Laparo-endoscopic single site surgery (LESS) is a relatively new technique that has been described in recent medical literature to be feasible in the management of benign gynaecological conditions. However, the use of this technique in the management of gynaecological cancers is still controversial. In this case report, we describe the first single port laparoscopic pelvic lymphadenectomy performed in Singapore. This involved a patient who was diagnosed with endometrial cancer after a vaginal hysterectomy for uterovaginal prolapse.

Mucinous epithelial ovarian cancer has a poor prognosis in the advanced stages and responds poorly to conventional chemotherapy. We aim to elucidate the clinicopathological factors and incidence of HER2 expression of this cancer in a large Asian retrospective cohort from Singapore. Of a total of 133 cases, the median age at diagnosis was 48.3 years (range, 15.8-89.0 years), comparatively younger than western cohorts. Most were Chinese (71%), followed by Malays (16%), others (9.0%), and Indians (5%). 24% were noted to have a significant family history of malignancy of which breast and gastrointestinal cancers the most prominent. Majority of the patients (80%) had stage I disease at diagnosis. Information on HER2 status was available in 113 cases (85%). Of these, 31 cases (27.4%) were HER2+, higher than 18.8% reported in western population. HER2 positivity appeared to be lower among Chinese and higher among Malays patients (p = 0.052). With the current standard of care, there was no discernible impact of HER2 status on overall survival. (HR = 1.79; 95% CI, 0.66-4.85; p = 0.249). On the other hand, positive family history of cancer, presence of lymphovascular invasion, and ovarian surface involvements were significantly associated with inferior overall survival on univariate and continued to be statistically significant after adjustment for stage. While these clinical factors identify high risk patients, it is promising that the finding of a high incidence of HER2 in our Asian population may allow development of a HER2 targeted therapy to improve the management of mucinous ovarian cancers.

Avaliaram-se os efeitos do fornecimento de volumosos suplementares sobre o consumo, a produção e a composição físico-química do leite de cabras F1 (Boer ×Saanen). Utilizaram-se 18 cabras distribuídas em três baias, recebendo como suplemento, à vontade, silagem de sorgo, silagem de milho ou feno de amoreira com controle diário do consumo de matéria seca. A média diária para produção semanal foi calculada reunindo-se dados leiteiros em três períodos pós-parto: 1 (34 a 40 dias/7 dias); 2 [(64 a 70 dias/7 dias) + (91 a 97 dias)/7 dias)]/2; e 3 (125 a 131 dias/7 dias) e a média pontual diária do período pelas datas de referência dos períodos da média diária para produção semanal, que foi correlacionada à composição de gordura, proteína, lactose e extrato seco total e à contagem de células somáticas. Os dados semanais de acidez e densidade foram agrupados em 37, 81±13, 128 e 151±10 dias pós-parto. Com modelos mistos, o animal foi computado como aleatório e os efeitos fixos foram três suplementos e três períodos (composição, médias diárias as produções semanal e do período) ou quatro (acidez e densidade). O consumo de feno de amoreira (0,657 kg) superou o de silagem de milho (0,604 kg), que foi superior ao de silagem de sorgo (0,305 kg). No período 2, a composição em extrato etéreo foi menor, em razão do decréscimo de gordura e lactose. No período 3, a composição em proteína e a acidez aumentaram e a densidade foi maior nos períodos 1 (1,0270) e 3 (1,0277). A mamite aumentou a CCS no período 2. Para proteína, o tipo de suplemento não foi significativo, mas houve efeito da interação período pós-parto ×suplemento. As demais variáveis não foram influenciadas pelo tipo de suplemento, apenas pelo período pós-parto. O feno de amoreira aumenta o consumo suplementar pelas cabras em relação às silagens de milho e sorgo, mas não melhora as médias de produção e composição do leite. Cabras Boer ×Saanen em pastejo e sob suplementação têm bom potencial leiteiro.The effects were assessed of supplying supplementary roughage on intake, milk yield and milk physical and chemical composition in F1 (Boer ×Saanen) goats. Eighteen females were placed in three stalls, and received as ad libitum supplement sorghum silage, corn silage and mulberry hay (MHT), with daily control of dry matter intake. The average daily production per week was calculated by gathering the milk data in three post-parturition periods: 1 (34-40 days/7 days); 2 [(64-70 days/7 days) + (91-97 days)/7 days)]/2 and 3 (125-131 days/7 days). Daily spot-average of each period (DSAP) was calculated from the reference dates of average daily production per week, that was correlated with the composition of fat, protein, lactose, total solids composition and the somatic cell count. The weekly data for acidity and density were grouped in 37, 81±13, 128 and 151±10 days post-parturition. Using mixed models, the animal was computed as random and the fixed effects were three supplements and three periods (composition, average daily production per week and per period) or four (acidity and density). Mulberry hay intake (0.657 kg) was greater than corn silage (0.604 kg) that was greater than sorghum silage (0.305 kg). In period 2, the ether extract composition was smaller because of the decrease in fat and lactose. In period 3, protein and acidity increased and density was great in periods 1 (1.0270) and 3 (1.0277). Mastitis increased SCC in period 2. The type of supplement was not significant for protein, but there was post partum period ×supplement effect. The other variables were not influenced by the type of supplement, only by the post-partum period. Mulberry hay increased the supplement intake by the goats compared to corn and sorghum silage, but it did not improve milk yield = means and composition. Grazing Boer ×Saanen goats with supplementation have good milk production potential.

O objetivo deste trabalho foi avaliar o desempenho produtivo de vacas de corte, das raças Charolês (C), Nelore (N), mestiças CN e NC, mantidas em pastagem nativa, suplementadas com farelo de arroz e desmamadas aos 42 ou 63 dias pós-parto, ou não suplementadas e desmamadas aos 63 dias. A idade das vacas variou de 3 a 12 anos, sendo agrupadas em quatro classes, primíparas, jovens, adultas e velhas. O ganho de peso médio diário (GMD) do parto aos 63 dias pós-parto foi maior para as vacas suplementadas. Vacas desmamadas aos 42 dias apresentaram maior diferença de peso (61,5 kg), do parto ao diagnóstico de gestação, em relação às não suplementadas (45,7 kg), não diferindo das suplementadas desmamadas aos 63 dias (57,8 kg). Do final do período de acasalamento ao diagnóstico de gestação as mestiças CN apresentaram maior GMD (860 g), em relação às C (552 g) e N (648 g), não diferindo das mestiças NC (670 g). Vacas N foram mais leves em relação aos demais grupos genéticos, em todos os períodos. Vacas primíparas e velhas perderam peso, enquanto as jovens e adultas apresentaram leve ganho de peso do parto ao desmame. Vacas suplementadas desmamadas aos 42 dias apresentaram menor intervalo de partos (IP), em relação as desmamadas aos 63 dias (367 contra 384 dias), no entanto, não diferiram quanto à percentagem de parição, respectivamente, 72,0 e 72,2%. Nas vacas desmamadas aos 63 dias, a suplementação não alterou o IP, mas resultou em aumento significativo na taxa de reprodução (72,2 contra 53,7%). Vacas adultas e velhas que desmamaram aos 42 dias apresentaram IP inferior a um ano, 356 e 353 dias, respectivamente, apresentaram maiores peso e condição corporal, por ocasião do diagnóstico de gestação, e maior taxa de parição, respectivamente, 80,0 e 76,3%, contra 41,4 e 57,5% que o observado nas primíparas e jovens.The objective of this experiment was to evaluate the performance of Charolais (C), Nellore (N), CN and NC crossbred cows, kept on native pasture, supplemented with rice bran and weaned at 42 or 63 days, or not supplemented and weaned of 63 days. Cow age ranged from 3 to 12 years and was classified into four groups, first calf, young, adult and old cows. Average daily weight gain (ADG) from calving to 63 days postpartum was higher for supplemented cows. Cows weaned at 42 days showed higher weight difference (61.5 kg) from calving to pregnancy diagnostic than the not supplemented cows (45.7 kg), and did not differ from the supplement cows weaned at 63 days (57.8 kg). From the end of the mating season to the pregnancy diagnostic the CN crossbred cows showed higher ADG (860 g) than the C (552 g) and N (648 g) and did not differ from the NC (670 g). Nellore cows were lighter than the other genetic groups at all periods evaluated. First calf and old cows lost weight, while young and adult cows showed light weight gain from calving to weaning. Supplemented cows weaned at 42 days showed lower calving interval (CI) than those weaned at 63 days (367 vs 384 days), however, did not differ in calving rate, respectively, 72.0 and 72.2%. For 63 days weaned cows, supplementation did not alter CI, but resulted in significant increase in calving rate (72.2 vs 53.7%). Adult and old cows weaned at 42 days showed shorter CI than one year, 356 and 353 days, respectively, displayed higher weight and body condition at gestation diagnostic and higher calving rate, respectively, 80.0 and 76.3 %, versus 41.4 and 57.5%, observed for first calf and young cows.