9 results on '"Elina Boycheva"'
Search Results
2. Spanish version of the Mattis Dementia Rating Scale-2 for early detection of Alzheimer's disease and mild cognitive impairment
- Author
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Bernardino Fernández-Calvo, Francisco Ramos-Campos, Verónica Puertas-Martín, Alberto Villarejo-Galende, Israel Contador, Félix Bermejo-Pareja, and Elina Boycheva
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050103 clinical psychology ,medicine.medical_specialty ,medicine.diagnostic_test ,Psychometrics ,Perseveration ,05 social sciences ,Early detection ,Disease ,Audiology ,medicine.disease ,03 medical and health sciences ,Psychiatry and Mental health ,0302 clinical medicine ,medicine ,Criterion validity ,0501 psychology and cognitive sciences ,Neuropsychological assessment ,Geriatrics and Gerontology ,Alzheimer's disease ,medicine.symptom ,Cognitive impairment ,Psychology ,Psychiatry ,030217 neurology & neurosurgery - Abstract
Objective: We aimed to analyse the clinical utility of the Mattis Dementia Rating Scale (MDRS-2) for early detection of Alzheimer's disease (AD) and amnestic mild cognitive impairment (MCI) in a sample of Spanish older adults. Methods: A total of 125 participants (age = 75.12 ± 6.83, years of education =7.08 ± 3.57) were classified in three diagnostic groups: 45 patients with mild AD, 37 with amnestic MCI—single and multiple domain and 43 cognitively healthy controls (HCs). Reliability, criterion validity and diagnostic accuracy of the MDRS-2 (total and subscales) were analysed. The MDRS-2 scores, adjusted by socio-demographic characteristics, were calculated through hierarchical multiple regression analysis. Results: The global scale had adequate reliability (α = 0.736) and good criterion validity (r = 0.760, p
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- 2017
3. Neurological Disorders in Central Spain, Second Survey: Feasibility Pilot Observational Study
- Author
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Sara Llamas-Velasco, Juan-Francisco Gil-García, Alberto Villarejo-Galende, Esther Cubo, Jesús Hernández-Gallego, Ester Tapias-Merino, Eva Carro, Julián Benito-León, Sara Garcia-Ptacek, José Ignacio Serrano, Jesus L. Cacho, Emiliano Rodríguez-Sánchez, Elina Boycheva, Rosalía García García-Patino, José-María Vizcaino Sánchez-Rodrigo, Saturio Vega, Israel Contador, Félix Bermejo-Pareja, F. Sierra-Hidalgo, Rocío Trincado, Instituto de Salud Carlos III, Centro Investigación Biomédica en Red Enfermedades Neurodegenerativas (España), Hernández-Gallego, Jesús [0000-0002-9410-1720], Llamas-Velasco, Sara [0000-0002-9174-2610], Bermejo-Pareja, Felix [0000-0002-5413-232X], Vega, Saturio [0000-0001-5034-0140], Tapias-Merino, Ester [0000-0002-8720-7375], Rodríguez-Sánchez, Emiliano [0000-0003-3667-7155], Boycheva, Elina [0000-0002-9506-8491], González-Serrano, José Ignacio [0000-0003-0795-3026], Vizcaino Sánchez-Rodrigo, José-María [0000-0001-9464-9393], Contador, Israel [0000-0002-7841-1307], Garcia-Ptacek, Sara [0000-0002-1537-6129], Sierra-Hidalgo, Fernando [0000-0003-4044-8304], Carro, Eva [0000-0002-6504-4579], Villarejo-Galende, Alberto [0000-0002-6834-7620], Benito-León, Julián [0000-0002-1769-4809], Hernández-Gallego, Jesús, Llamas-Velasco, Sara, Bermejo-Pareja, Felix, Vega, Saturio, Tapias-Merino, Ester, Rodríguez-Sánchez, Emiliano, Boycheva, Elina, González-Serrano, José Ignacio, Vizcaino Sánchez-Rodrigo, José-María, Contador, Israel, Garcia-Ptacek, Sara, Sierra-Hidalgo, Fernando, Carro, Eva, Villarejo-Galende, Alberto, and Benito-León, Julián
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Longitudinal study ,medicine.medical_specialty ,020205 medical informatics ,Demographics ,02 engineering and technology ,03 medical and health sciences ,0302 clinical medicine ,mild cognitive impairment ,0202 electrical engineering, electronic engineering, information engineering ,medicine ,Dementia ,030212 general & internal medicine ,NEDICES ,Medical diagnosis ,Original Paper ,business.industry ,pilot study ,Headache ,General Medicine ,medicine.disease ,Biobank ,stroke ,Test (assessment) ,population-based study ,Family medicine ,Parkinson’s disease ,Essential tremor ,Observational study ,observational study ,Lifestyle habits ,business - Abstract
Background The Neurological Disorders in Central Spain, second survey (NEDICES-2) is a population-based, closed-cohort study that will include over 8000 subjects aged ≥55 years. It will also include a biobank. Objective The objective of this study was to evaluate all major aspects of the NEDICES-2 (methods, database, screening instruments, and questionnaires, as well as interexpert rating of the neurological diagnoses) in each one of the planned areas (all of them in central Spain) and to test the possibility of obtaining biological samples from each participant. Methods A selection of patients and participants of the planned NEDICES-2 underwent face-to-face interviews including a comprehensive questionnaire on demographics, current medications, medical conditions, and lifestyle habits. Biological samples (blood, saliva, urine, and hair) were also obtained. Furthermore, every participant was examined by a neurologist. Results In this pilot study, 567 study participants were enrolled (196 from hospitals and 371 from primary care physician lists). Of these 567, 310 completed all study procedures (questionnaires and the neurological evaluation). The study was time-consuming for several primary care physicians. Hence, a few primary care physicians from some areas refused to participate, which led to a reconfiguration of study areas. In addition, the central biobank needed to be supplemented by the biobanks of local Spanish National Health System hospitals. Conclusions Population-based epidemiological surveys, such as the NEDICES-2, require a pilot study to evaluate the feasibility of all aspects of a future field study (population selection, methods and instruments to be used, neurological diagnosis agreement, and data collection)., Our thanks to all collaborators in this feasibility pilot study, the Instituto de Salud Carlos III and the Biomedical Research Networking Center on Neurodegenerative Diseases (CIBERNED), and the two hospital computer experts (Victoria Garcia Baquero and Teresa Garcia Morales), who created the website (http://nedices2.ciberned.com/estudio-de-salud-nedices-2/). We would also like to thank Miss Jennifer Gates for the editing and proofreading of the manuscript.
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- 2019
4. Neurological Disorders in Central Spain, Second Survey: Feasibility Pilot Observational Study (Preprint)
- Author
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Jesús Hernández-Gallego, Sara Llamas-Velasco, Felix Bermejo-Pareja, Saturio Vega, Ester Tapias-Merino, Emiliano Rodríguez-Sánchez, Elina Boycheva, José Ignacio Serrano, Juan-Francisco Gil-García, Rocio Trincado, José-María Vizcaino Sánchez-Rodrigo, Jesús Cacho, Israel Contador, Sara Garcia-Ptacek, Fernando Sierra-Hidalgo, Esther Cubo, Eva Carro, Alberto Villarejo-Galende, Rosalía García García-Patino, and Julián Benito-León
- Abstract
BACKGROUND The Neurological Disorders in Central Spain, second survey (NEDICES-2) is a population-based, closed-cohort study that will include over 8000 subjects aged ≥55 years. It will also include a biobank. OBJECTIVE The objective of this study was to evaluate all major aspects of the NEDICES-2 (methods, database, screening instruments, and questionnaires, as well as interexpert rating of the neurological diagnoses) in each one of the planned areas (all of them in central Spain) and to test the possibility of obtaining biological samples from each participant. METHODS A selection of patients and participants of the planned NEDICES-2 underwent face-to-face interviews including a comprehensive questionnaire on demographics, current medications, medical conditions, and lifestyle habits. Biological samples (blood, saliva, urine, and hair) were also obtained. Furthermore, every participant was examined by a neurologist. RESULTS In this pilot study, 567 study participants were enrolled (196 from hospitals and 371 from primary care physician lists). Of these 567, 310 completed all study procedures (questionnaires and the neurological evaluation). The study was time-consuming for several primary care physicians. Hence, a few primary care physicians from some areas refused to participate, which led to a reconfiguration of study areas. In addition, the central biobank needed to be supplemented by the biobanks of local Spanish National Health System hospitals. CONCLUSIONS Population-based epidemiological surveys, such as the NEDICES-2, require a pilot study to evaluate the feasibility of all aspects of a future field study (population selection, methods and instruments to be used, neurological diagnosis agreement, and data collection).
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- 2018
5. Assessing inhibitory control in early-stage Alzheimer's and Parkinson's disease using the Hayling Sentence Completion Test
- Author
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Anthony Martyr, Elina Boycheva, and Aleksandra Kudlicka
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Male ,medicine.medical_specialty ,Coping (psychology) ,Parkinson's disease ,Cognitive Neuroscience ,Disease ,Audiology ,Neuropsychological Tests ,050105 experimental psychology ,Sentence completion tests ,Developmental psychology ,03 medical and health sciences ,Behavioral Neuroscience ,Executive Function ,0302 clinical medicine ,Alzheimer Disease ,Inhibitory control ,medicine ,Reaction Time ,Dementia ,Humans ,0501 psychology and cognitive sciences ,Aged ,Aged, 80 and over ,Verbal Behavior ,05 social sciences ,Parkinson Disease ,medicine.disease ,Inhibition, Psychological ,Neuropsychology and Physiological Psychology ,Female ,Psychology ,030217 neurology & neurosurgery ,Sentence ,Psychomotor Performance ,Stroop effect - Abstract
The ability to inhibit irrelevant information is essential for coping with the demands of everyday life. Inhibitory deficits are present in all stages of dementia and commonly observed in people with Parkinson's disease (PwPD). Inhibition is frequently tested with the Stroop test, but this may lack ecological validity. This study investigates inhibitory control in people with Alzheimer's disease dementia (PwD) and PwPD using the Hayling Sentence Completion Test (HSCT), which aspires to be a more ecologically valid task. A total of 117 people completed the HSCT, a test where participants have to complete a sentence with an unrelated word. The sample comprised 30 PwD, 33 PwPD, and 54 healthy older controls. We compared response times and the number and type of errors across the three groups. Completion time in Part B (Inhibition) did not distinguish between PwD, PwPD, and controls when controlling for the initiation speed, but a higher proportion of Category A errors (producing a word that fits the sentence when instructed otherwise) was a unique characteristic of inferior performance in PwD and PwPD. While not part of the standard test scoring protocol, controlling for the initiation speed and distinguishing between speed and accuracy in test performance appear to be essential for accurate evaluation of the inhibitory control in HSCT in older people. The findings suggest that the HSCT may be sensitive to verbal suppression deficits and may provide insight into inhibitory control in PwD and PwPD.
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- 2016
6. Semantic Verbal Fluency: Normative Data in Older Spanish Adults From NEDICES Population-Based Cohort
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Verónica Puertas-Martín, Julián Benito-León, Katie Moraes de Almondes, Elina Boycheva, Israel Contador, Félix Bermejo-Pareja, and Bernardino Fernández-Calvo
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Gerontology ,050103 clinical psychology ,education.field_of_study ,05 social sciences ,Population ,General Medicine ,medicine.disease ,Educational attainment ,Developmental psychology ,03 medical and health sciences ,Psychiatry and Mental health ,Clinical Psychology ,0302 clinical medicine ,Neuropsychology and Physiological Psychology ,Percentile rank ,medicine ,Verbal fluency test ,Dementia ,Normative ,0501 psychology and cognitive sciences ,Rural area ,Psychology ,education ,Socioeconomic status ,030217 neurology & neurosurgery - Abstract
OBJECTIVE We aimed to provide the normative data stratified by age, sex and educational attainment for two semantic categories (animal and fruits) in older Spanish adults. METHOD A representative sample of 2,744 non-demented older individuals with different socioeconomic background was selected from the Neurological Disorders in Central Spain (NEDICES), a population-based study. Normative data are presented in percentile ranks and divided into four age-tables with different midpoints, using the overlapping interval procedure. RESULTS Correlation analyses showed that age, education and sex influence significantly the scores in both semantic tasks. Normative data presented here covered two urban (Margaritas & Lista) and one rural areas (Arevalo). CONCLUSION These norms may provide useful data for screening cognitive impairment more accurately in Spanish older adults.
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- 2016
7. Spanish version of the Mattis Dementia Rating Scale-2 for early detection of Alzheimer's disease and mild cognitive impairment
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Elina, Boycheva, Israel, Contador, Bernardino, Fernández-Calvo, Francisco, Ramos-Campos, Verónica, Puertas-Martín, Alberto, Villarejo-Galende, and Félix, Bermejo-Pareja
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Aged, 80 and over ,Male ,Psychometrics ,Reproducibility of Results ,Hispanic or Latino ,Middle Aged ,Mental Status and Dementia Tests ,Sensitivity and Specificity ,Early Diagnosis ,Alzheimer Disease ,Memory ,Humans ,Regression Analysis ,Cognitive Dysfunction ,Female ,Aged - Abstract
We aimed to analyse the clinical utility of the Mattis Dementia Rating Scale (MDRS-2) for early detection of Alzheimer's disease (AD) and amnestic mild cognitive impairment (MCI) in a sample of Spanish older adults.A total of 125 participants (age = 75.12 ± 6.83, years of education =7.08 ± 3.57) were classified in three diagnostic groups: 45 patients with mild AD, 37 with amnestic MCI-single and multiple domain and 43 cognitively healthy controls (HCs). Reliability, criterion validity and diagnostic accuracy of the MDRS-2 (total and subscales) were analysed. The MDRS-2 scores, adjusted by socio-demographic characteristics, were calculated through hierarchical multiple regression analysis.The global scale had adequate reliability (α = 0.736) and good criterion validity (r = 0.760, p .001) with the Mini-Mental State Examination. The optimal cut-off point between AD patients and HCs was 124 (sensitivity [Se] = 97% and specificity [Sp] = 95%), whereas 131 (Se = 89%, Sp = 81%) was the optimal cut-off point between MCI and HCs. An optimal cut-off point of 123 had good Se (0.97), but poor Sp (0.56) to differentiate AD and MCI groups. The Memory and Initiation/Perseveration subscales had the highest discriminative capacity between the groups.The MDRS-2 is a reliable and valid instrument for the assessment of cognitive impairment in Spanish older adults. In particular, optimal capacity emerged for the detection of early AD and MCI. Copyright © 2017 John WileySons, Ltd.
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- 2016
8. Prognostic Significance of Mild Cognitive Impairment Subtypes for Dementia and Mortality: Data from the NEDICES Cohort
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J. Benito-León, Elina Boycheva, Sara Llamas, Alejandro Herrero, David Lora, Rocío Trincado, Jesús Hernández-Gallego, Félix Bermejo-Pareja, Israel Contador, Alex J. Mitchell, Álvaro Sánchez-Ferro, and Alberto Villarejo Galende
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Male ,medicine.medical_specialty ,Neuropsychological Tests ,behavioral disciplines and activities ,Likelihood ratios in diagnostic testing ,Cohort Studies ,03 medical and health sciences ,0302 clinical medicine ,Predictive Value of Tests ,Internal medicine ,mental disorders ,medicine ,Dementia ,Humans ,Cognitive Dysfunction ,Aged ,Proportional Hazards Models ,Aged, 80 and over ,030214 geriatrics ,business.industry ,Proportional hazards model ,General Neuroscience ,Incidence (epidemiology) ,Mortality rate ,General Medicine ,medicine.disease ,Prognosis ,Psychiatry and Mental health ,Clinical Psychology ,Spain ,Predictive value of tests ,Cohort ,Female ,Geriatrics and Gerontology ,business ,Mental Status Schedule ,human activities ,030217 neurology & neurosurgery ,Algorithms ,Cohort study - Abstract
Background The predictive value of diverse subtypes of mild cognitive impairment (MCI) for dementia and death is highly variable. Objective To compare the predictive value of several MCI subtypes in progression to dementia and/or mortality in the NEDICES (Neurological Disorders in Central Spain) elderly cohort. Methods Retrospect algorithmic MCI subgroups were established in a non-dementia baseline NEDICES cohort using Spanish adaptations of the original Mini-Mental State Examination (MMSE-37) and Pfeffer's Functional Activities Questionnaire (Pfeffer-11). The presence of MCI was defined according two cognitive criteria: using two cut-offs points on the total MMSE-37 score. Five cognitive domains were used to establish the MCI subtypes. Functional capacity (Pfeffer-11) was preserved or minimally impaired in all MCI participants. The incident dementia diagnoses were established by specialists and the mortality data obtained from Spanish official registries. Results 3,411 participants without dementia were assessed in 1994-5. The baseline prevalence of MCI varied according to the MCI definition (4.3%-31.8%). The follow-up was a mean of 3.2 years (1997-8). The dementia incidence varied between 14.9 and 71.8 per 1,000/person-years. The dementia conversion rate was increased in almost all MCI subgroups (p > 0.01), and mortality rate was raised only in four MCI subtypes. The amnestic-multi-domain MCI (aMd-MCI) had the best dementia predictive accuracy (highest positive likelihood ratio and highest clinical utility when negative). Conclusions Those with aMd-MCI were at greatest risk of progression to dementia, as in other surveys and might be explored with increased attention in MCI research and in dementia preventive trials.
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- 2016
9. The 37 item Version of the Mini-Mental State Examination: Normative Data in a Population-Based Cohort of Older Spanish Adults (NEDICES)
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E. Tapias, Félix Bermejo-Pareja, Sara Llamas, Julián Benito-León, Elina Boycheva, Israel Contador, and Bernardino Fernández-Calvo
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Gerontology ,Male ,050103 clinical psychology ,Neuropsychological Tests ,Community Health Planning ,Cohort Studies ,03 medical and health sciences ,0302 clinical medicine ,Percentile rank ,Sex Factors ,Reference Values ,medicine ,Humans ,0501 psychology and cognitive sciences ,Socioeconomic status ,Aged ,Aged, 80 and over ,Mini–Mental State Examination ,medicine.diagnostic_test ,05 social sciences ,Multilevel model ,Age Factors ,General Medicine ,Test (assessment) ,Psychiatry and Mental health ,Clinical Psychology ,Neuropsychology and Physiological Psychology ,Cross-Sectional Studies ,Spain ,Test score ,Cohort ,Normative ,Educational Status ,Dementia ,Female ,Psychology ,Cognition Disorders ,Mental Status Schedule ,030217 neurology & neurosurgery - Abstract
The 37-item version of the Mini-Mental State Examination (MMSE-37) is an extended version of the original test for individuals with low education, which was adapted for different cultures. Despite its favorable psychometric properties, there is a lack of normative data for this instrument. We provide normative data for the MMSE-37 stratified by age, sex, and education in a large population-based cohort of older Spanish adults. The sample consisted of 3,777 participants without dementia (age range: 65-97 years) from different socioeconomic areas of central Spain. Normative data are presented in percentile ranks and divided into nine overlapping age tables with different midpoints, using the overlapping cell procedure. A hierarchical regression was performed to evaluate the effects of sociodemographic variables on MMSE-37 performance. Results showed that age, sex, and education affect test score. The norms presented herein are important for the correct interpretation of MMSE-37 scores when assessing older adults in Spain.
- Published
- 2016
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