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5. Traduction et republication de : « Événements thromboemboliques artériels liés au cancer »

Author

Benhamou, Ygal, Benmaziane, Asmahane, Bertoletti, Laurent, Bichon, Virginie, Bozec, Coralie, Cohen, Ariel, Couturaud, Francis, Debourdeau, Philippe, Dielenseger, Pascale, Douriez, Éric, Élias, Antoine, Espitia, Olivier, Frère, Corinne, Gaboreau, Yoann, Gendron, Pascale, Girard, Philippe, Hanon, Olivier, Idbaih, Ahmed, Laporte, Silvy, Mahé, Isabelle, Mayeur, Didier, Mismetti, Patrick, Moustafa, Farès, Pernod, Gilles, Roy, Pierre-Marie, Rouge Bugat, Marie-Ève, Sanchez, Olivier, Schmidt, Jeannot, Scotté, Florian, and Sevestre, Maie-Antoinette

Published
2024
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7. Pathophysiology, risk, diagnosis, and management of venous thrombosis in space: where are we now?

Author

Harris, Katie M., Arya, Roopen, Elias, Antoine, Weber, Tobias, Green, David A., Greaves, Danielle K., Petersen, Lonnie G., Roberts, Lara, Kamine, Tovy Haber, Mazzolai, Lucia, Bergauer, Andrej, Kim, David S., Olde Engberink, Rik H., zu Eulenberg, Peter, Grassi, Bruno, Zuccarelli, Lucrezia, Baldassarre, Giovanni, Tabury, Kevin, Baatout, Sarah, Jordan, Jens, Blaber, Andrew P., Choukér, Alexander, Russomano, Thais, and Goswami, Nandu

Published
2023
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10. Outpatient management of cancer-associated pulmonary embolism: A post-hoc analysis from the HOME-PE trial

Author

Chaibi, Sérine, Roy, Pierre-Marie, Guénégou, Armelle Arnoux, Tran, Yohann, Hugli, Olivier, Penaloza, Andréa, Couturaud, Francis, Tromeur, Cécile, Szwebel, Tali-Anne, Pernod, Gilles, Elias, Antoine, Ghuysen, Alexandre, Benhamou, Ygal, Falvo, Nicolas, Juchet, Henry, Nijkeuter, Mathilde, Mairuhu, Ronne, Faber, Laura M., Mahé, Isabelle, Montaclair, Karine, Planquette, Benjamin, Jimenez, David, Huisman, Menno V., Klok, Federikus A., and Sanchez, Olivier

Published
2024
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20. Noninvasive diagnostic work-up for suspected acute pulmonary embolism during pregnancy: a systematic review and meta-analysis of individual patient data

Author

Stals, Milou A.M., Moumneh, Thomas, Ainle, Fionnuala Ni, Aujesky, Drahomir, van Bemmel, Thomas, Bertoletti, Laurent, Bistervels, Ingrid M., Chauleur, Céline, Couturaud, Francis, van Dooren, Yordi P.A., Elias, Antoine, Faber, Laura M., Le Gall, Catherine, Hofstee, Herman M.A., van der Hulle, Tom, Kruip, Marieke J.H.A., Maignan, Maxime, Mairuhu, Albert T.A., Middeldorp, Saskia, Le Moigne, Emmanuelle, Nijkeuter, Mathilde, van der Pol, Liselotte M., Robert-Ebadi, Helia, Roy, Pierre-Marie, Sanchez, Olivier, Schmidt, Jeannot, van Smeden, Maarten, Tromeur, Cecile, Wolde, Marije ten, Righini, Marc, Le Gal, Grégoire, Huisman, Menno V., and Klok, Frederikus A.

Published
2023
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22. Risk of neonatal hypothyroidism in newborns from mothers exposed to CTPA during pregnancy: Ancillary data from a prospective outcome study

Author

Righini, Marc, Robert-Ebadi, Helia, Cremonesi, Alessio, Elias, Antoine, Sanchez, Olivier, Le Moigne, Emmanuelle, Schmidt, Jeannot, Le Gall, Catherine, Cornuz, Jacques, Aujesky, Drahomir, Roy, Pierre-Marie, Chauleur, Céline, Rouyer, Frédéric, Poletti, Pierre-Alexandre, Moreau, Caroline, and Le Gal, Grégoire

Published
2022
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23. Rivaroxaban vs Dalteparin in Cancer-Associated Thromboembolism: A Randomized Trial

Author

Meyer, Guy, Mismetti, Patrick, Chatellier, Gilles, Laporte, Silvy, Decousus, Hervé, Mahé, Isabelle, Falvo, Nicolas, Delluc, Aurélien, Bertoletti, Laurent, Laneau, Christine, Dinut, Aurelia, Aegerter, Philippe, Emmerich, Joseph, Girard, Philippe, Messas, Emmanuel, Revel, Marie-Pierre, Charles-Nelson, Anaïs, Acassat, Sandrine, Grange, Claire, Planquette, Benjamin, Sanchez, Olivier, Plaisance, Ludovic, Poénou, Géraldine, Pernod, Gilles, Imbert, Bernard, Zenati, Nora, Couturaud, Francis, Le Moigne, Emmanuelle, Le Mao, Raphael, Hoffmann, Clément, Elias, Antoine, Elias, Marie, Loffroy, Romaric, Jandot, Maud, Sevestre, Marie-Antoinette, Modéliar Rémond, Santhi Samy, Ray, Valérie, Burnod, Alexis, Roy, Pierre-Marie, Moumneh, Thomas, Henni, Samir, Brebion, Nicolas, Timor-David, Miruna, Constans, Joël, Boulon, Carine, Aquilanti, Sandro, Brisot, Dominique, Bura-Rivière, Alessandra, Sevestre, Marie Antoinette, Timar-David, Miruna, and Constans, Joel

Published
2022
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25. Hydroxychloroquine in mild-to-moderate coronavirus disease 2019: a placebo-controlled double blind trial

Author

Brangier, Antoine, Codron, Philippe, Lemée, Jean Michel, Pichon, Virginie, Dhersin, Robin, Urbanski, Geoffrey, Lavigne, Christian, Courtois, Roxane, Danielou, Hélène, Lebreton, Jonathan, Vatan, Rémi, Crochette, Nicolas, Lainé, Jean-Baptiste, Perez, Lucia, Blanchi, Sophie, Hitoto, Hikombo, Bernard, Louis, Maillot, François, Marchand Adam, Sylvain, Talarmin, Jean-Philippe, Gaigneux, Emeline, Motte-Vincent, Pauline, Morrier, Marine, Merrien, Dominique, Bleher, Yves, Flori, Maxime, Ducet-Boiffard, Amélie, Colin, Orane, Février, Ronan, Thill, Pauline, Tetart, Macha, Demaeght, François, Lafond-Desmurs, Barthelemy, Pradier, Maxime, Meybeck, Agnes, Picaud, Marjorie, Prazuck, Thierry, Chapelet, Guillaume, Rouaud, Agnès, Le Turnier, Paul, Sunder, Simon, Lorleac'h, Aurélien, Dollon, Christophe, Jacquet, Antoine, Le Vely, Francois, Gazeau, Pierre, Ansart, Séverine, Roger, Hélène, Laterza, François, Buzelé, Rodolphe, Tahmi, Fella, Lepeule, Raphael, Lacombe, Karine, Lefebvre, Bénédicte, Célarier, Thomas, Gagneux-Brunon, Amandine, Botelho-Nevers, Elisabeth, Bernard, Marc, Garnier, Camille, Mourguet, Morgane, Pugnet, Gregory, Vienne-Noyes, Sara, Martin-Blondel, Guillaume, Delobel, Pierre, Grouteau, Gaspard, Debard, Alexa, Guilleminault, Laurent, Arias, Pauline, Chakvetadze, Catherine, Flateau, Clara, Kopp, Aude, Putot, Alain, Barben, Jeremy, Mouries Martin, Suzanne, Nuss, Valentine, Piroth, Lionel, Claessens, Yann-Erick, Hentgen, Veronique, Martinot, Martin, Bach-Bunner, Maxime, Bonijoly, Thomas, Gravier, Simon, Michel, Jean-Marc, Andreu, Mathilde, Roriz, Mélanie, Baldolli, Aurélie, Brochard, Julia, Grossi, Olivier, Pineau, Samuel, Brisset, Josselin, Desvaux, Edouard, Gondran, Guillaume, Faucher, Jean-François, Quesnel, Paul-Antoine, Bezanahary, Holy, Danthu, Clément, Gutierrez, Blandine, Ly, Kim, Simonneau, Yannick, Cypierre, Anne, Pinet, Pauline, Durox, Hélène, Ducroix-Roubertou, Sophie, Genet, Claire, Beraud, Guillaume, Le Moal, Gwenael, Rammaert, Blandine, Lanoix, Jean-Philippe, Andrejak, Claire, Joseph, Cédric, Soriot-Thomas, Sandrine, Dhote, Robin, Abad, Sébastien, Benainous, Ruben, Boitiaux, Jean-François, Briend, Guillaume, Gonfroy, Celine, Harent, Stanislas, Lagrange, Aurore, Tone, Alina, Wayenberg, Laura, Desoutter, Sophie, Ettahar, Nicolas, Gey, Thomas, Leroy, Vincent, Gaillard, Sacha, Toma, Andrea, Broussier, Amaury, Etienne, Sandrine, Spivac, Yann, Martha, Benoit, Roch, Nathalie, Diaz, Pierre, N’guyen Baranoff, Danièle, Rebaudet, Stanislas, Jourda, François, Zeller, Valérie, Bienvenu, Boris, Boyer, Arnaud, Pellier, Isabelle, Mercat, Alain, Darsonval, Astrid, Blanchet, Odile, Custaud, Marc-Antoine, Lefeuvre, Caroline, Parot-Schinkel, Elsa, Vielle, Bruno, Briet, Marie, Roy, Pierre-Marie, Dubée, Vincent, Guidet, Bertrand, Mismetti, Patrick, Vicaut, Eric, Sanchez, Olivier, Girard, Philippe, Elias, Antoine, Couturaud, Francis, Gable, Béatrice, Lazareff, Sybille, Carballido, Loïc, Hue, Catherine, Chrétien, Jean-Marie, Goraguer, Adrien, Eeckhoutte, Lucie van, Abbara, Chadi, Boucher, Sophie, Devaud, Edouard, Robineau, Olivier, Rispal, Patrick, Guimard, Thomas, d’Anglejean, Emma, and Diamantis, Sylvain

Published
2021
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26. Assessment of prognostic models for patients with acute pulmonary embolism

Author

Elias, Antoine, Clarke, Michael, and Mismetti, Patrick

Subjects
616.2, Prognosis, Pulmonary embolism, Prediction
Abstract

Background: Acute pulmonary embolism (PE) is a life-threatening condition. This thesis presents my research into the role of prognostic models and strategies for assessing the severity of acute PE, how these compare with recommendations in clinical guidelines and the role of physician's clinical judgment for improving patient management. Methods: Methods used in each element in the research were appropriate to the relevant objectives: systematic reviews for assessing prognostic markers and prognostic models; sensitivity analysis using the net benefit decision-analytic measure across a range of threshold values for low-risk PE categories in direct comparisons; survey of clinical practice; development and assessment of a case-ascertainment strategy to detect PE patients in one hospital and to explore selection bias; and development of a study protocol for a future comparative study. Findings: Individual prognostic markers are insufficient on their own to accurately predict outcome. Prognostic models are more successful, with the PE severity index (PESI) and simplified PESI (sPESI) models being the most validated. They provided a low event rate in patients identified as low-risk, which was similar to that obtained with other, less validated, strategies, such as the Hestia hospital checklist. High-risk groups were best identified using PESI or other models at high cut-off levels or by adding clinical vital signs, biomarkers and imaging-based markers of right ventricular dysfunction/ myocardial ischemia. The net benefit analysis confirmed the superiority of PESI and sPESI over original competing models, and the incremental value of adding prognostic markers. The survey showed that emergency physicians still rely mostly on their own clinical judgment when deciding about early discharge or complete outpatient management and the case-ascertainment study showed that if case-ascertainment is incomplete, selection bias may mean that event rates and prognosis will be underestimated, prognostic models will be overoptimistic and the results of different studies cannot be compared, contrasted or combined reliably. Conclusions: Based on current evidence, the PESI models are the most appropriate strategies for deciding on early discharge and outpatient management for patients presenting to hospital with acute PE. Future research, with complete case-ascertainment, needs to compare these models with Hestia and clinical judgement to assess their value for decisions about the management of non-selected PE patients.

Published
2016

27. Integration by Selective Area Growth of Multiple Semi‐Insulating Buried Heterostructure‐Distributed Feedback Lasers with Optimized Performance Over 100 nm in the O‐Band.

Author

Afonso, Gustavo, Cerulo, Giancarlo, Vaissiere, Nicolas, Vakarin, Vladyslav, Elias, Antoine, Fortin, Catherine, Paret, Jean-François, Lanteri, Delphine, Mekhazni, Karim, Pommereau, Frédéric, and Decobert, Jean

Subjects
QUANTUM wells, LASERS, SEMICONDUCTOR lasers, INTEGRATED circuits, HETEROSTRUCTURES, DISTRIBUTED feedback lasers, PHOTOLUMINESCENCE measurement, EPITAXY
Abstract

The introduction of selective area growth (SAG) in a mature semi‐insulating buried heterostructure (SIBH) platform for the realization of photonic integrated circuits on monolithic InP has been demonstrated. A thorough determination of the relations between quantum well thickness, transition energies, and mask geometries is performed on dedicated wafers by means of extensive micro‐X‐Ray diffraction and microphotoluminescence measurements. Based on those results, SAG is used to grow, with a single epitaxy step, AlGaInAs multiple quantum wells heterostructures, to tailor the active regions of Fabry–Pérot and distributed feedback (DFB) lasers emitting in the O‐Band. SIBH DFB lasers are realized, exhibiting threshold currents < 7.2 mA (at 25 °C), and emitting over 100‐nm spectral range in the O‐Band. [ABSTRACT FROM AUTHOR]

Published
2024
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31. Home treatment for patients with cancer-associated venous thrombo-embolism

Author

Sanchez, Olivier, primary, Roy, Pierre-Marie, additional, Gaboreau, Yoann, additional, Schmidt, Jeannot, additional, Moustafa, Farès, additional, Benmaziane, Asmahane, additional, Elias, Antoine, additional, Espitia, Olivier, additional, Sevestre, Marie-Antoinette, additional, Couturaud, Francis, additional, and Mahé, Isabelle, additional

Published
2023
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33. Outpatient management of cancer-related pulmonary embolism: a post-hoc analysis of the HOME-PE trial

Author

Chaibi, Sérine, primary, Roy, Pierre-Marie, additional, Arnoux, Armelle, additional, Penaloza, Andrea, additional, Hugli, Olivier, additional, Elias, Antoine, additional, Couturaud, Francis, additional, Joly, Luc-Marie, additional, Lopez, Raphaëlle, additional, Faber, Laura M., additional, Planquette, Benjamin, additional, Bokobza, Jérôme, additional, Viglino, Damien, additional, Schmidt, Jeannot, additional, Juchet, Henry, additional, Mahé, Isabelle, additional, Mulder, Frits, additional, Falvo, Nicolas, additional, Montaclair, Karine, additional, Steinier, Charlotte, additional, Hendriks, Stephan V., additional, Benhamou, Ygal, additional, Szwebel, Tali-Anne, additional, Pernod, Gilles, additional, Lapebie, François-Xavier, additional, Javaud, Nicolas, additional, Ghuysen, Alexandre, additional, Sebbane, Mustapha, additional, Jimenez, David, additional, Huisman, Menno V., additional, Klok, Frederikus A., additional, and Sanchez, Olivier, additional

Published
2023
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34. Hybrid InP/SiN photonic integrated circuits for RF systems and optical sensing

Author

He, Sailing, Vivien, Laurent, van Dijk, Frédéric, Boust, Sylvain, Duport, François, Ibrahimi, Yasmine, Wilmart, Quentin, Guerber, Sylvain, Paret, Jean-François, Garreau, Alexandre, Mekhazni, Karim, Fortin, Catherine, Charbonnier, Philippe, Blache, Fabrice, Gariah, Harry, Vivien, Laurent, Mailliart, Olivier, Raphoz, Natacha, Larrue, Alexandre, Elias, Antoine, Vaissière, Nicolas, Parillaud, Olivier, and Vidal Pinto, Rodrigo Antonio

Published
2024
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36. Pathophysiology, risk, diagnosis, and management of venous thrombosis in space:where are we now?

Author

Harris, Katie M., Arya, Roopen, Elias, Antoine, Weber, Tobias, Green, David A., Greaves, Danielle K., Petersen, Lonnie G., Roberts, Lara, Kamine, Tovy Haber, Mazzolai, Lucia, Bergauer, Andrej, Kim, David S., Olde Engberink, Rik H., zu Eulenberg, Peter, Grassi, Bruno, Zuccarelli, Lucrezia, Baldassarre, Giovanni, Tabury, Kevin, Baatout, Sarah, Jordan, Jens, Blaber, Andrew P., Choukér, Alexander, Russomano, Thais, Goswami, Nandu, Harris, Katie M., Arya, Roopen, Elias, Antoine, Weber, Tobias, Green, David A., Greaves, Danielle K., Petersen, Lonnie G., Roberts, Lara, Kamine, Tovy Haber, Mazzolai, Lucia, Bergauer, Andrej, Kim, David S., Olde Engberink, Rik H., zu Eulenberg, Peter, Grassi, Bruno, Zuccarelli, Lucrezia, Baldassarre, Giovanni, Tabury, Kevin, Baatout, Sarah, Jordan, Jens, Blaber, Andrew P., Choukér, Alexander, Russomano, Thais, and Goswami, Nandu

Abstract

The recent incidental discovery of an asymptomatic venous thrombosis (VT) in the internal jugular vein of an astronaut on the International Space Station prompted a necessary, immediate response from the space medicine community. The European Space Agency formed a topical team to review the pathophysiology, risk and clinical presentation of venous thrombosis and the evaluation of its prevention, diagnosis, mitigation, and management strategies in spaceflight. In this article, we discuss the findings of the ESA VT Topical Team over its 2-year term, report the key gaps as we see them in the above areas which are hindering understanding VT in space. We provide research recommendations in a stepwise manner that build upon existing resources, and highlight the initial steps required to enable further evaluation of this newly identified pertinent medical risk.

Published
2023

37. Effects of whole-body vibration or resistive-vibration exercise on blood clotting and related biomarkers:a systematic review

Author

Zuccarelli, Lucrezia, Baldassarre, Giovanni, Winnard, Andrew, Harris, Katie M., Weber, Tobias, Green, David A., Petersen, Lonnie G., Kamine, Tovy Haber, Roberts, Lara, Kim, David S., Greaves, Danielle K., Arya, Roopen, Laws, Jonathan M., Elias, Antoine, Rittweger, Jörn, Grassi, Bruno, Goswami, Nandu, Zuccarelli, Lucrezia, Baldassarre, Giovanni, Winnard, Andrew, Harris, Katie M., Weber, Tobias, Green, David A., Petersen, Lonnie G., Kamine, Tovy Haber, Roberts, Lara, Kim, David S., Greaves, Danielle K., Arya, Roopen, Laws, Jonathan M., Elias, Antoine, Rittweger, Jörn, Grassi, Bruno, and Goswami, Nandu

Abstract

Whole-body vibration (WBV) and resistive vibration exercise (RVE) are utilized as countermeasures against bone loss, muscle wasting, and physical deconditioning. The safety of the interventions, in terms of the risk of inducing undesired blood clotting and venous thrombosis, is not clear. We therefore performed the present systematic review of the available scientific literature on the issue. The review was conducted following the guidelines by the Space Biomedicine Systematic Review Group, based on Cochrane review guidelines. The relevant context or environment of the studies was “ground-based environment”; space analogs or diseased conditions were not included. The search retrieved 801 studies; 77 articles were selected for further consideration after an initial screening. Thirty-three studies met the inclusion criteria. The main variables related to blood markers involved angiogenic and endothelial factors, fibrinolysis and coagulation markers, cytokine levels, inflammatory and plasma oxidative stress markers. Functional and hemodynamic markers involved blood pressure measurements, systemic vascular resistance, blood flow and microvascular and endothelial functions. The available evidence suggests neutral or potentially positive effects of short- and long-term interventions with WBV and RVE on variables related to blood coagulation, fibrinolysis, inflammatory status, oxidative stress, cardiovascular, microvascular and endothelial functions. No significant warning signs towards an increased risk of undesired clotting and venous thrombosis were identified. If confirmed by further studies, WBV and RVE could be part of the countermeasures aimed at preventing or attenuating the muscular and cardiovascular deconditioning associated with spaceflights, permanence on planetary habitats and ground-based simulations of microgravity.

Published
2023

39. Pregnancy-Adapted YEARS Algorithm for Diagnosis of Suspected Pulmonary Embolism

Author

van der Pol, Liselotte M., Tromeur, Cecile, Bistervels, Ingrid M., Ni Ainle, Fionnuala, van Bemmel, Thomas, Bertoletti, Laurent, Couturaud, Francis, van Dooren, Yordi P. A., Elias, Antoine, Faber, Laura M., Hofstee, Herman M. A., van der Hulle, Tom, Kruip, Marieke J. H. A., Maignan, Maxime, Mairuhu, Albert T. A., Middeldorp, Saskia, Nijkeuter, Mathilde, Roy, Pierre-Marie, Sanchez, Olivier, Schmidt, Jeannot, ten Wolde, Marije, Klok, Frederikus A., and Huisman, Menno V.

Published
2019
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40. Non-invasive diagnostic work-up for suspected acute pulmonary embolism during pregnancy: a systematic review and meta-analysis of individual patient data

Author

Stals, Milou A.M., primary, Moumneh, Thomas, additional, Ainle, Fionnuala Ni, additional, Aujesky, Drahomir, additional, van Bemmel, Thomas, additional, Bertoletti, Laurent, additional, Bistervels, Ingrid M., additional, Chauleur, Céline, additional, Couturaud, Francis, additional, van Dooren, Yordi P.A., additional, Elias, Antoine, additional, Faber, Laura M., additional, Le Gall, Catherine, additional, Hofstee, Herman M.A., additional, van der Hulle, Tom, additional, Kruip, Marieke J.H.A., additional, Maignan, Maxime, additional, Mairuhu, Albert T.A., additional, Middeldorp, Saskia, additional, Le Moigne, Emmanuelle, additional, Nijkeuter, Mathilde, additional, van der Pol, Liselotte M., additional, Robert-Ebadi, Helia, additional, Roy, Pierre-Marie, additional, Sanchez, Olivier, additional, Schmidt, Jeannot, additional, van Smeden, Maarten, additional, Tromeur, Cecile, additional, ten Wolde, Marije, additional, Righini, Marc, additional, Le Gal, Grégoire, additional, Huisman, Menno V., additional, and Klok, Frederikus A., additional

Published
2022
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41. Intermediate-dose versus low-dose low-molecular-weight heparin in pregnant and post-partum women with a history of venous thromboembolism (Highlow study): an open-label, multicentre, randomised, controlled trial

Author

Bistervels, Ingrid M, primary, Buchmüller, Andrea, additional, Wiegers, Hanke M G, additional, Ní Áinle, Fionnuala, additional, Tardy, Bernard, additional, Donnelly, Jennifer, additional, Verhamme, Peter, additional, Jacobsen, Anne F, additional, Hansen, Anette T, additional, Rodger, Marc A, additional, DeSancho, Maria T, additional, Shmakov, Roman G, additional, van Es, Nick, additional, Prins, Martin H, additional, Chauleur, Céline, additional, Middeldorp, Saskia, additional, van den Akker, Eline S, additional, Bekker, Mireille N, additional, van Bemmel, Thomas, additional, Bertoletti, Laurent, additional, Blanc, Julie, additional, Bleker, Suzanne M, additional, Bourtembourg-Matras, Aude, additional, Bretelle, Florence, additional, Byrne, Bridgette, additional, Couturaud, Francis, additional, Delorme, Pierre, additional, Eerenberg, Elise S, additional, Franssen, Maureen TM, additional, Fuglsang, Jens, additional, Ganzevoort, Wessel, additional, Goffinet, François, additional, de Haan-Jebbink, Jiska M, additional, Heidema, Wieteke, additional, Hertzberg, Monique A, additional, Hovens, Marcel MC, additional, Huisman, Menno V, additional, de Jong-Speksnijder, Leonie, additional, Kamphuisen, Pieter-Willem, additional, O'Keeffe, Denis J, additional, Lacut, Karine, additional, Langenveld, Josje, additional, Lunshof, M Simone, additional, Martens, Caroline P, additional, Merah, Adel, additional, Le Moigne, Emmanuelle, additional, Papatsonis, Dimitri NM, additional, Pernod, Gilles, additional, Perrotin, Franck, additional, Peynaud-Debayle, Edith, additional, Pierre, Fabrice, additional, Plu Bureau, Geneviève, additional, Raia-Barjat, Tiphaine, additional, Rijnders, Robbert JP, additional, Rosario, Roger, additional, Ruivard, Marc, additional, Schmidt, Jeannot, additional, Sueters, Marieke, additional, Vanassche, Thomas, additional, Varlet, Marie-Noëlle, additional, Vivanti, Alexandre J, additional, van der Vlist, Matthieu Y, additional, van der Voet, Lucet F, additional, Vollebregt, Karlijn C, additional, de Vries, Johanna IP, additional, de Weerd, Sabina, additional, Westerweel, Peter E, additional, Wijnberger, Lia DE, additional, ten Wolde, Marije, additional, Ypma, Paula F, additional, Zuily-Lamy, Catherine, additional, Zwart, Joost J, additional, Benachi, Alexandra, additional, Beucher, Gaël, additional, Bezanahary, Holy, additional, de Boer, Karin, additional, de Boer, Marjon A., additional, Bousquet, Frantz, additional, Bremer, Henk A., additional, Bressollette, Luc, additional, Brossard, Aurélie, additional, Chau, Cécile, additional, Cleary, Brian, additional, Comte, Fabienne, additional, Corsini, Thomas, additional, Coustel, Anne, additional, Debaveye, Barbara, additional, Desbrière, Raoul, additional, Duvillard, Cécile, additional, Eckman, Astrid, additional, Eikenboom, Jeroen, additional, Elias, Antoine, additional, Faber, Laura M., additional, Ferrari, Emile, additional, Gallot, Denis, additional, Gauchotte, Emilie, additional, Gaugler, Ingrid, additional, Geerlings, Abby E., additional, O'Gorman, Audrey, additional, Grobost, Vincent, additional, de Groot, Pieter-Kees, additional, van der Ham, David P., additional, Hermsen, Brenda, additional, Kamphorst, Kim, additional, Karovitch, Alan, additional, Kleiverda, Gunilla, additional, Kloster, Aiste, additional, Koops, Annemarieke, additional, Krabbendam, Inneke, additional, Kruip, Marieke J.H.A., additional, Kuipers, Saskia, additional, van Laar, Judith, additional, Laneelle, Damien, additional, Lima, Suzanne, additional, MacMahon, Peter, additional, Mandelbrot, Laurent, additional, van Meir, Claudia A., additional, Menez, Caroline, additional, Morssink, Leonard P., additional, Moulin, Nathalie, additional, Mousty, Eve, additional, Muller, Matthieu, additional, Murphy, Lucy, additional, Peerlinck, Kathelijne, additional, O'Reilly, Alma, additional, de Reus, Maartje, additional, Le Roux, Magali Hilmi, additional, Ryan, Kevin, additional, Samren, Bettina, additional, Schippers, Daniela, additional, Schuitemaker, Nico, additional, Schweizer, Chloé, additional, van der Straaten, Hanneke, additional, Tromeur, Cécile, additional, Vanheule, Kristine, additional, Verhagen, Tamara, additional, Visser, Jantien, additional, Watts, Michael, additional, van Wijngaarden, Wim J., additional, Woiski, Mallory, additional, and Zelis, Maartje, additional

Published
2022
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42. Risk of neonatal hypothyroidism in newborns from mothers exposed to CTPA during pregnancy: Ancillary data from a prospective outcome study

Author

Righini, Marc; https://orcid.org/0000-0003-1211-2969, Robert‐Ebadi, Helia; https://orcid.org/0000-0003-3801-1269, Cremonesi, Alessio; https://orcid.org/0000-0002-1524-4169, Elias, Antoine; https://orcid.org/0000-0002-1337-1826, Sanchez, Olivier; https://orcid.org/0000-0003-1633-8391, Le Moigne, Emmanuelle; https://orcid.org/0000-0001-5103-2406, Schmidt, Jeannot; https://orcid.org/0000-0003-3424-337X, Le Gall, Catherine, Cornuz, Jacques; https://orcid.org/0000-0003-1276-9717, Aujesky, Drahomir; https://orcid.org/0000-0002-3970-2670, Roy, Pierre‐Marie; https://orcid.org/0000-0003-4811-6793, Chauleur, Céline; https://orcid.org/0000-0003-4057-8133, Rouyer, Frédéric; https://orcid.org/0000-0002-5727-0859, Poletti, Pierre‐Alexandre; https://orcid.org/0000-0001-9214-5546, Moreau, Caroline; https://orcid.org/0000-0002-5503-4078, Le Gal, Grégoire; https://orcid.org/0000-0002-9253-248X, Righini, Marc; https://orcid.org/0000-0003-1211-2969, Robert‐Ebadi, Helia; https://orcid.org/0000-0003-3801-1269, Cremonesi, Alessio; https://orcid.org/0000-0002-1524-4169, Elias, Antoine; https://orcid.org/0000-0002-1337-1826, Sanchez, Olivier; https://orcid.org/0000-0003-1633-8391, Le Moigne, Emmanuelle; https://orcid.org/0000-0001-5103-2406, Schmidt, Jeannot; https://orcid.org/0000-0003-3424-337X, Le Gall, Catherine, Cornuz, Jacques; https://orcid.org/0000-0003-1276-9717, Aujesky, Drahomir; https://orcid.org/0000-0002-3970-2670, Roy, Pierre‐Marie; https://orcid.org/0000-0003-4811-6793, Chauleur, Céline; https://orcid.org/0000-0003-4057-8133, Rouyer, Frédéric; https://orcid.org/0000-0002-5727-0859, Poletti, Pierre‐Alexandre; https://orcid.org/0000-0001-9214-5546, Moreau, Caroline; https://orcid.org/0000-0002-5503-4078, and Le Gal, Grégoire; https://orcid.org/0000-0002-9253-248X

Abstract

Background: Neonatal hypothyroidism is often raised as a potential concern for the use of computed tomography pulmonary angiography (CTPA) in pregnant women with suspected pulmonary embolism (PE). Objectives: To assess the incidence of neonatal hypothyroidism among newborns from mothers exposed to CTPA. Patients/methods: Pregnant women with clinically suspected PE were included in a multicenter, multinational prospective diagnostic management outcome study, based on pretest clinical probability assessment, high-sensitivity D-dimer testing, bilateral lower limb venous compression ultrasonography, and CTPA. Results of Guthrie tests were systematically collected for newborns of all women who required CTPA as part of the diagnostic strategy. A thyroid-stimulating hormone (TSH) level above 15 U/ml was used to define hypothyroidism. Results: Out of the 166 women included in the Swiss participating centers, 149 underwent a CTPA including 14 with twin pregnancies. Eight women suffered a pregnancy loss and results of the Guthrie test could not be retrieved for four newborns. All TSH levels were reported as being below 15 U/ml. The incidence of neonatal hypothyroidism was 0/151 (0.0%, 95% confidence interval: 0.0%-2.5%). Conclusions: We did not identify any cases of neonatal hypothyroidism in our cohort of 149 pregnant women investigated for suspected PE using a CTPA. Along with previous literature data, this provides further reassuring data regarding the use of CTPA in this indication. Keywords: Guthrie test; diagnosis; hypothyroidism; pregnancy; pulmonary embolism.

Published
2022

44. Search for Venous Endothelial Biomarkers Heralding Venous Thromboembolism in Space: A Qualitative Systematic Review of Terrestrial Studies

Author

Harris, Katie, primary, Laws, Jonathan Michael, additional, Elias, Antoine, additional, Green, David Andrew, additional, Goswami, Nandu, additional, Jordan, Jens, additional, Kamine, Tovy Haber, additional, Mazzolai, Lucia, additional, Petersen, Lonnie G., additional, Winnard, Andrew James, additional, and Weber, Tobias, additional

Published
2022
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45. Rivaroxaban vs Dalteparin in Cancer-Associated Thromboembolism

Author

Planquette, Benjamin, primary, Bertoletti, Laurent, additional, Charles-Nelson, Anaïs, additional, Laporte, Silvy, additional, Grange, Claire, additional, Mahé, Isabelle, additional, Pernod, Gilles, additional, Elias, Antoine, additional, Couturaud, Francis, additional, Falvo, Nicolas, additional, Sevestre, Marie Antoinette, additional, Ray, Valérie, additional, Burnod, Alexis, additional, Brebion, Nicolas, additional, Roy, Pierre-Marie, additional, Timar-David, Miruna, additional, Aquilanti, Sandro, additional, Constans, Joel, additional, Bura-Rivière, Alessandra, additional, Brisot, Dominique, additional, Chatellier, Gilles, additional, Sanchez, Olivier, additional, Meyer, Guy, additional, Girard, Philippe, additional, Mismetti, Patrick, additional, Decousus, Hervé, additional, Delluc, Aurélien, additional, Laneau, Christine, additional, Dinut, Aurelia, additional, Aegerter, Philippe, additional, Emmerich, Joseph, additional, Messas, Emmanuel, additional, Revel, Marie-Pierre, additional, Acassat, Sandrine, additional, Planquette, Benjamin, additional, Plaisance, Ludovic, additional, Poénou, Géraldine, additional, Imbert, Bernard, additional, Zenati, Nora, additional, Le Moigne, Emmanuelle, additional, Le Mao, Raphael, additional, Hoffmann, Clément, additional, Elias, Marie, additional, Loffroy, Romaric, additional, Jandot, Maud, additional, Sevestre, Marie-Antoinette, additional, Modéliar Rémond, Santhi Samy, additional, Moumneh, Thomas, additional, Henni, Samir, additional, Timor-David, Miruna, additional, Constans, Joël, additional, and Boulon, Carine, additional

Published
2022
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46. Hybrid InP-SiN microring-resonator based tunable laser with high output power and narrow linewidth for high capacity coherent systems

Author

Calò, Cosimo, primary, Benyahya, Kaoutar, additional, Mardoyan, Haik, additional, Charbonnier, Philippe, additional, Sacchetto, Davide, additional, Zervas, Michael, additional, Mekhazni, Karim, additional, Lanteri, Delphine, additional, Gariah, Harry, additional, Fortin, Catherine, additional, Vaissière, Nicolas, additional, Elias, Antoine, additional, Parillaud, Olivier, additional, Mallecot, Franck, additional, Decobert, Jean, additional, Pommereau, Frederic, additional, and Renaudier, Jeremie, additional

Published
2022
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48. Effect of a Retrievable Inferior Vena Cava Filter Plus Anticoagulation vs Anticoagulation Alone on Risk of Recurrent Pulmonary Embolism: A Randomized Clinical Trial

Author

Mismetti, Patrick, Laporte, Silvy, Pellerin, Olivier, Ennezat, Pierre-Vladimir, Couturaud, Francis, Elias, Antoine, Falvo, Nicolas, Meneveau, Nicolas, Quere, Isabelle, Roy, Pierre-Marie, Sanchez, Olivier, Schmidt, Jeannot, Seinturier, Christophe, Sevestre, Marie-Antoinette, Beregi, Jean-Paul, Tardy, Bernard, Lacroix, Philippe, Presles, Emilie, Leizorovicz, Alain, Decousus, Hervé, Barral, Fabrice-Guy, and Meyer, Guy

Published
2015
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49. Hydroxychloroquine in mild-to-moderate coronavirus disease 2019: a placebo-controlled double blind trial

Author

Dubée, Vincent, primary, Roy, Pierre-Marie, additional, Vielle, Bruno, additional, Parot-Schinkel, Elsa, additional, Blanchet, Odile, additional, Darsonval, Astrid, additional, Lefeuvre, Caroline, additional, Abbara, Chadi, additional, Boucher, Sophie, additional, Devaud, Edouard, additional, Robineau, Olivier, additional, Rispal, Patrick, additional, Guimard, Thomas, additional, d’Anglejean, Emma, additional, Diamantis, Sylvain, additional, Custaud, Marc-Antoine, additional, Pellier, Isabelle, additional, Mercat, Alain, additional, Brangier, Antoine, additional, Codron, Philippe, additional, Lemée, Jean Michel, additional, Pichon, Virginie, additional, Dhersin, Robin, additional, Urbanski, Geoffrey, additional, Lavigne, Christian, additional, Courtois, Roxane, additional, Danielou, Hélène, additional, Lebreton, Jonathan, additional, Vatan, Rémi, additional, Crochette, Nicolas, additional, Lainé, Jean-Baptiste, additional, Perez, Lucia, additional, Blanchi, Sophie, additional, Hitoto, Hikombo, additional, Bernard, Louis, additional, Maillot, François, additional, Marchand Adam, Sylvain, additional, Talarmin, Jean-Philippe, additional, Gaigneux, Emeline, additional, Motte-Vincent, Pauline, additional, Morrier, Marine, additional, Merrien, Dominique, additional, Bleher, Yves, additional, Flori, Maxime, additional, Ducet-Boiffard, Amélie, additional, Colin, Orane, additional, Février, Ronan, additional, Thill, Pauline, additional, Tetart, Macha, additional, Demaeght, François, additional, Lafond-Desmurs, Barthelemy, additional, Pradier, Maxime, additional, Meybeck, Agnes, additional, Picaud, Marjorie, additional, Prazuck, Thierry, additional, Chapelet, Guillaume, additional, Rouaud, Agnès, additional, Le Turnier, Paul, additional, Sunder, Simon, additional, Lorleac'h, Aurélien, additional, Dollon, Christophe, additional, Jacquet, Antoine, additional, Le Vely, Francois, additional, Gazeau, Pierre, additional, Ansart, Séverine, additional, Roger, Hélène, additional, Laterza, François, additional, Buzelé, Rodolphe, additional, Tahmi, Fella, additional, Lepeule, Raphael, additional, Lacombe, Karine, additional, Lefebvre, Bénédicte, additional, Célarier, Thomas, additional, Gagneux-Brunon, Amandine, additional, Botelho-Nevers, Elisabeth, additional, Bernard, Marc, additional, Garnier, Camille, additional, Mourguet, Morgane, additional, Pugnet, Gregory, additional, Vienne-Noyes, Sara, additional, Martin-Blondel, Guillaume, additional, Delobel, Pierre, additional, Grouteau, Gaspard, additional, Debard, Alexa, additional, Guilleminault, Laurent, additional, Arias, Pauline, additional, Chakvetadze, Catherine, additional, Flateau, Clara, additional, Kopp, Aude, additional, Putot, Alain, additional, Barben, Jeremy, additional, Mouries Martin, Suzanne, additional, Nuss, Valentine, additional, Piroth, Lionel, additional, Claessens, Yann-Erick, additional, Hentgen, Veronique, additional, Martinot, Martin, additional, Bach-Bunner, Maxime, additional, Bonijoly, Thomas, additional, Gravier, Simon, additional, Michel, Jean-Marc, additional, Andreu, Mathilde, additional, Roriz, Mélanie, additional, Baldolli, Aurélie, additional, Brochard, Julia, additional, Grossi, Olivier, additional, Pineau, Samuel, additional, Brisset, Josselin, additional, Desvaux, Edouard, additional, Gondran, Guillaume, additional, Faucher, Jean-François, additional, Quesnel, Paul-Antoine, additional, Bezanahary, Holy, additional, Danthu, Clément, additional, Gutierrez, Blandine, additional, Ly, Kim, additional, Simonneau, Yannick, additional, Cypierre, Anne, additional, Pinet, Pauline, additional, Durox, Hélène, additional, Ducroix-Roubertou, Sophie, additional, Genet, Claire, additional, Beraud, Guillaume, additional, Le Moal, Gwenael, additional, Rammaert, Blandine, additional, Lanoix, Jean-Philippe, additional, Andrejak, Claire, additional, Joseph, Cédric, additional, Soriot-Thomas, Sandrine, additional, Dhote, Robin, additional, Abad, Sébastien, additional, Benainous, Ruben, additional, Boitiaux, Jean-François, additional, Briend, Guillaume, additional, Gonfroy, Celine, additional, Harent, Stanislas, additional, Lagrange, Aurore, additional, Tone, Alina, additional, Wayenberg, Laura, additional, Desoutter, Sophie, additional, Ettahar, Nicolas, additional, Gey, Thomas, additional, Leroy, Vincent, additional, Gaillard, Sacha, additional, Toma, Andrea, additional, Broussier, Amaury, additional, Etienne, Sandrine, additional, Spivac, Yann, additional, Martha, Benoit, additional, Roch, Nathalie, additional, Diaz, Pierre, additional, N’guyen Baranoff, Danièle, additional, Rebaudet, Stanislas, additional, Jourda, François, additional, Zeller, Valérie, additional, Bienvenu, Boris, additional, Boyer, Arnaud, additional, Briet, Marie, additional, Dubée, Vincent, additional, Guidet, Bertrand, additional, Mismetti, Patrick, additional, Vicaut, Eric, additional, Sanchez, Olivier, additional, Girard, Philippe, additional, Elias, Antoine, additional, Couturaud, Francis, additional, Gable, Béatrice, additional, Lazareff, Sybille, additional, Carballido, Loïc, additional, Hue, Catherine, additional, Chrétien, Jean-Marie, additional, Goraguer, Adrien, additional, and Eeckhoutte, Lucie van, additional

Published
2021
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50. Triaging acute pulmonary embolism for home treatment by Hestia or simplified PESI criteria: the HOME-PE randomized trial

Author

Roy, Pierre Marie, Penaloza, Andrea, Hugli, Olivier, Klok, F.A., Arnoux, Armelle, Elias, Antoine, Couturaud, Francis, Joly, Luc Marie, Lopez, Raphaëlle, Faber, Laura L.M., Daoud-Elias, Marie, Planquette, Benjamin, Bokobza, Jérôme, Viglino, Damien, Schmidt, Jeannot, Juchet, Henry, Mahe, Isabelle, Mulder, Frits, Bartiaux, M., Cren, Rosen, Moumneh, Thomas, Quere, Isabelle, Falvo, Nicolas, Montaclair, Karine, Douillet, Delphine, Steinier, Charlotte, Hendriks, Stephan S.V., Benhamou, Ygal, Szwebel, Tali Anne, Pernod, Gilles, Dublanchet, Nicolas, Lapebie, François Xavier, Javaud, Nicolas, Ghuysen, Alexandre, Sebbane, Mustapha, Chatellier, Gilles, Meyer, Guy, Jimenez, David, Huisman, Menno M.V., Sanchez, Olivier, Roy, Pierre Marie, Penaloza, Andrea, Hugli, Olivier, Klok, F.A., Arnoux, Armelle, Elias, Antoine, Couturaud, Francis, Joly, Luc Marie, Lopez, Raphaëlle, Faber, Laura L.M., Daoud-Elias, Marie, Planquette, Benjamin, Bokobza, Jérôme, Viglino, Damien, Schmidt, Jeannot, Juchet, Henry, Mahe, Isabelle, Mulder, Frits, Bartiaux, M., Cren, Rosen, Moumneh, Thomas, Quere, Isabelle, Falvo, Nicolas, Montaclair, Karine, Douillet, Delphine, Steinier, Charlotte, Hendriks, Stephan S.V., Benhamou, Ygal, Szwebel, Tali Anne, Pernod, Gilles, Dublanchet, Nicolas, Lapebie, François Xavier, Javaud, Nicolas, Ghuysen, Alexandre, Sebbane, Mustapha, Chatellier, Gilles, Meyer, Guy, Jimenez, David, Huisman, Menno M.V., and Sanchez, Olivier

Abstract

AIMS: The aim of this study is to compare the Hestia rule vs. the simplified Pulmonary Embolism Severity Index (sPESI) for triaging patients with acute pulmonary embolism (PE) for home treatment. METHODS AND RESULTS: Normotensive patients with PE of 26 hospitals from France, Belgium, the Netherlands, and Switzerland were randomized to either triaging with Hestia or sPESI. They were designated for home treatment if the triaging tool was negative and if the physician-in-charge, taking into account the patient's opinion, did not consider that hospitalization was required. The main outcomes were the 30-day composite of recurrent venous thrombo-embolism, major bleeding or all-cause death (non-inferiority analysis with 2.5% absolute risk difference as margin), and the rate of patients discharged home within 24 h after randomization (NCT02811237). From January 2017 through July 2019, 1975 patients were included. In the per-protocol population, the primary outcome occurred in 3.82% (34/891) in the Hestia arm and 3.57% (32/896) in the sPESI arm (P = 0.004 for non-inferiority). In the intention-to-treat population, 38.4% of the Hestia patients (378/984) were treated at home vs. 36.6% (361/986) of the sPESI patients (P = 0.41 for superiority), with a 30-day composite outcome rate of 1.33% (5/375) and 1.11% (4/359), respectively. No recurrent or fatal PE occurred in either home treatment arm. CONCLUSIONS: For triaging PE patients, the strategy based on the Hestia rule and the strategy based on sPESI had similar safety and effectiveness. With either tool complemented by the overruling of the physician-in-charge, more than a third of patients were treated at home with a low incidence of complications., SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2021

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