236 results on '"Elfarra, Adnan A."'
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2. Myeloperoxidase-Mediated Bioactivation of Olefins
3. Reactive Metabolites of 1,3-Butadiene: DNA and Hemoglobin Adduct Formation and Potential Roles in Carcinogenicity
4. Metabolic Activation and Detoxication of Nephrotoxic Cysteine and Homocysteine S-conjugates
5. Cytotoxicity, genotoxicity, and mutagenicity of 1-chloro-2-hydroxy-3-butene and 1-chloro-3-buten-2-one, two alternative metabolites of 1,3-butadiene
6. Characterization of the chemical reactivity and nephrotoxicity of N-acetyl-S-(1,2-dichlorovinyl)-L-cysteine sulfoxide, a potential reactive metabolite of trichloroethylene
7. Isoform distinct time-, dose-, and castration-dependent alterations in flavin-containing monooxygenase expression in mouse liver after 2,3,7,8-tetrachlorodibenzo-p-dioxin treatment
8. Gender differences in methionine accumulation and metabolism in freshly isolated mouse hepatocytes: Potential roles in toxicity
9. Reduction of L-methionine selenoxide to seleno-L-methionine by endogenous thiols, ascorbic acid, or methimazole
10. Potential roles of flavin-containing monooxygenases in sulfoxidation reactions of l-methionine, N-acetyl- l-methionine and peptides containing l-methionine
11. Human glutathione transferases catalyzing the bioactivation of anticancer thiopurine prodrugs
12. Protection of rats against 3-butene-1,2-diol-induced hepatotoxicity and hypoglycemia by N-acetyl-l-cysteine
13. Methimazole as a protectant against cisplatin-induced nephrotoxicity using the dog as a model
14. Species and Tissue Differences in the Toxicity of 3-Butene-1,2-diol in Male Sprague-Dawley Rats and B6C3F1 Mice
15. Chapter Four - Myeloperoxidase-Mediated Bioactivation of Olefins
16. Renal Toxicity of Perchloroethylene and S-(1,2,2-Trichlorovinyl)glutathione in Rats and Mice: Sex- and Species-Dependent Differences
17. Toxicity mechanism-based prodrugs: glutathione-dependent bioactivation as a strategy for anticancer prodrug design
18. Nephrotoxic Amino Acid and Glutathione S-Conjugates: Formation and Renal Activation
19. Mutagenicity of the cysteine S-conjugate sulfoxides of trichloroethylene and tetrachloroethylene in the Ames test
20. Potential roles of myeloperoxidase and hypochlorous acid in metabolism and toxicity of alkene hydrocarbons and drug molecules containing olefinic moieties
21. Characterization of the Major Purine and Pyrimidine Adducts Formed after Incubations of 1-Chloro-3-buten-2-one with Single-/Double-Stranded DNA and Human Cells
22. Identification of a Fused-Ring 2′-Deoxyadenosine Adduct Formed in Human Cells Incubated with 1-Chloro-3-buten-2-one, a Potential Reactive Metabolite of 1,3-Butadiene
23. Cellular effects of reactive intermediates: Nephrotoxicity of S-conjugates of amino acids
24. Novel adducts from the reaction of 1-chloro-3-buten-2-one with 2′-deoxyguanosine. Structural characterization and potential as tools to investigate 1,3-butadiene carcinogenicity
25. Nephrotoxic Amino Acid and Glutathione S-Conjugates: Formation and Renal Activation
26. Characterization of the Major Purine and Pyrimidine Adducts Formed after Incubations of 1-Chloro-3-buten-2-one with Single-/Double-Stranded DNA and Human Cells.
27. Renal Cytochrome P450s and Flavin-Containing Monooxygenases
28. Formation of Fused-Ring 2′-Deoxycytidine Adducts from 1-Chloro-3-buten-2-one, an in Vitro 1,3-Butadiene Metabolite, under in Vitro Physiological Conditions
29. Identification of a Fused-Ring 2'-Deoxyadenosine Adduct Formed in Human Cells Incubated with 1-Chloro-3-buten-2-one, a Potential Reactive Metabolite of 1,3-Butadiene.
30. Activation of anticancer prodrugs by human glutathione transferases
31. Alcohol Dehydrogenase- and Rat Liver Cytosol-Dependent Bioactivation of 1-Chloro-2-hydroxy-3-butene to 1-Chloro-3-buten-2-one, a Bifunctional Alkylating Agent
32. Role of reactive metabolites in the circulation in extrahepatic toxicity
33. Potential roles of myeloperoxidase and hypochlorous acid in metabolism and toxicity of alkene hydrocarbons and drug molecules containing olefinic moieties
34. N-Biotinyl-S-(1,2-dichlorovinyl)-l-cysteine Sulfoxide as a Potential Model for S-(1,2-Dichlorovinyl)-l-cysteine Sulfoxide: Characterization of Stability and Reactivity with Glutathione and Kidney Proteins in Vitro
35. The biochemical and toxicological significance of hypermethionemia: new insights and clinical relevance
36. Globin Monoadducts and Cross-Links Provide Evidence for the Presence of S-(1,2-Dichlorovinyl)-l-cysteine Sulfoxide, Chlorothioketene, and 2-Chlorothionoacetyl Chloride in the Circulation in Rats Administered S-(1,2-Dichlorovinyl)-l-cysteine
37. Cysteine Conjugate β-Lyase Activity of Rat Erythrocytes and Formation of β-Lyase-Derived Globin Monoadducts and Cross-Links after in Vitro Exposure of Erythrocytes to S-(1,2-Dichlorovinyl)-l-cysteine
38. Mass Spectral Analyses of Hydroxymethylvinyl Ketone-Hemoglobin Adducts Formed after in Vivo Exposure of Sprague−Dawley Rats to 3-Butene-1,2-diol
39. Formation of Mono- and Bis-Michael Adducts by the Reaction of Nucleophilic Amino Acids with Hydroxymethylvinyl Ketone, a Reactive Metabolite of 1,3-Butadiene
40. Differential Localization of Flavin-Containing Monooxygenase (FMO) Isoforms 1, 3, and 4 in Rat Liver and Kidney and Evidence for Expression of FMO4 in Mouse, Rat, and Human Liver and Kidney Microsomes
41. Purification and Characterization of Flavin-Containing Monooxygenase Isoform 3 from Rat Kidney Microsomes
42. l-Methionine-dl-sulfoxide Metabolism and Toxicity in Freshly Isolated Mouse Hepatocytes: Gender Differences and Inhibition with Aminooxyacetic Acid
43. Detection of Multiple Globin Monoadducts and Cross-Links after in Vitro Exposure of Rat Erythrocytes to S-(1,2-Dichlorovinyl)-l-cysteine Sulfoxide and after in Vivo Treatment of Rats with S-(1,2-Dichlorovinyl)-l-cysteine Sulfoxide
44. l-Methionine Toxicity in Freshly Isolated Mouse Hepatocytes Is Gender-Dependent and Mediated in Part by Transamination
45. Formation of Three N-Acetyl-l-cysteine Monoadducts and One Diadduct by the Reaction of S-(1,2-Dichlorovinyl)-l-cysteine Sulfoxide with N-Acetyl-l-cysteine at Physiological Conditions: Chemical Mechanisms and Toxicological Implications
46. S-(1,2,2-Trichlorovinyl)-l-cysteine Sulfoxide, a Reactive Metabolite ofS-(1,2,2-Trichlorovinyl)-l-cysteine Formed in Rat Liver and Kidney Microsomes, Is a Potent Nephrotoxicant
47. Mass spectral analyses of hemoglobin adducts formed after in vitro exposure of erythrocytes to hydroxymethylvinyl ketone
48. Formation of globin mono‐adducts and cross‐links in erythrocytes after exposure to S‐(1,2‐dichlorovinyl)‐L‐cysteine sulfoxide
49. GSH oxidation to GSSG preceded seleno‐L‐methionine cytotoxicity in freshly isolated rat hepatocytes
50. Oxidative Metabolism of Seleno-l-methionine to l-Methionine Selenoxide by Flavin-Containing Monooxygenases
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