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4. The Role of Pro-Inflammatory Chemokines CCL-1, 2, 4, and 5 in the Etiopathogenesis of Type 2 Diabetes Mellitus in Subjects from the Asir Region of Saudi Arabia: Correlation with Different Degrees of Obesity.

Author

Mir, Mohammad Muzaffar, Alfaifi, Jaber, Sohail, Shahzada Khalid, Rizvi, Syeda Fatima, Akhtar, Md Tanwir, Alghamdi, Mushabab Ayed Abdullah, Mir, Rashid, Wani, Javed Iqbal, Sabah, Zia Ul, Alhumaydhi, Fahad A., Alremthi, Fahad, AlQahtani, AbdulElah Al Jarallah, Alharthi, Muffarah Hamid, Adam, Masoud Ishag Elkhalifa, Elfaki, Imadeldin, and Sonpol, Hany M. A.

Subjects
TYPE 2 diabetes, BODY weight, DEVELOPING countries, INSULIN resistance, SEDENTARY behavior
Abstract

Background: Type 2 diabetes mellitus (T2DM) is becoming a major global health concern, especially in developing nations. The high prevalence of obesity and related diabetes cases are attributed to rapid economic progress, physical inactivity, the consumption of high-calorie foods, and changing lifestyles. Objectives: We investigated the roles of pro-inflammatory chemokines CCL1, 2, 4, and 5 in T2DM with varying levels of obesity in the Asir region of Saudi Arabia. Materials and Methods: In total, 170 confirmed T2DM subjects and a normal control group were enrolled. Demographic data, serum levels of CCL-1, 2, 4, and 5, and biochemical indices were assessed in the subjects and control groups by standard procedures. Results: T2DM subjects were divided into four groups: A (normal body weight), B (overweight), C (obese), and D (highly obese). We observed that male and female control subjects had similar mean serum concentrations of pro-inflammatory chemokines CCL-1, 2, 4, and 5. T2DM subjects in all the four groups showed significantly higher levels of all the four chemokines compared to the controls, regardless of gender. In T2DM subjects with obesity and severe obesity, the rise was most significant. There was a progressive rise in the concentrations of CCL-1, 2, and 4 in T2DM subjects with increasing BMI. Serum CCL5 levels increased significantly in all T2DM subject groups. The increase in CCL5 was more predominant in normal-weight people, compared to overweight and obese T2DM subjects. Conclusions: Male and female control subjects had similar serum levels of pro-inflammatory chemokines CCL-1, 2, 4, and 5. The progressive rise in blood concentrations of three pro-inflammatory chemokines CCL-1, 2, and 4 in T2DM subjects with increasing BMI supports the idea that dyslipidemia and obesity contribute to chronic inflammation and insulin resistance. Serum CCL5 levels increased significantly in all T2DM subject groups. The selective and more pronounced increase in CCL5 in the T2DM group with normal BMI, compared to subjects with varying degrees of obesity, was rather surprising. Further research is needed to determine if CCL5 underexpression in overweight and obese T2DM subjects is due to some unexplained counterbalancing processes. [ABSTRACT FROM AUTHOR]

Published
2024
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5. Molecular Dynamics Simulation of Kir6.2 Variants Reveals Potential Association with Diabetes Mellitus.

Author

Elangeeb, Mohamed E., Elfaki, Imadeldin, Eleragi, Ali M. S., Ahmed, Elsadig Mohamed, Mir, Rashid, Alzahrani, Salem M., Bedaiwi, Ruqaiah I., Alharbi, Zeyad M., Mir, Mohammad Muzaffar, Ajmal, Mohammad Rehan, Tayeb, Faris Jamal, and Barnawi, Jameel

Subjects
*POTASSIUM channels, *MOLECULAR dynamics, *MATURITY onset diabetes of the young, *DIABETES, *STRUCTURAL bioinformatics, *GENETIC testing
Abstract

Diabetes mellitus (DM) represents a problem for the healthcare system worldwide. DM has very serious complications such as blindness, kidney failure, and cardiovascular disease. In addition to the very bad socioeconomic impacts, it influences patients and their families and communities. The global costs of DM and its complications are huge and expected to rise by the year 2030. DM is caused by genetic and environmental risk factors. Genetic testing will aid in early diagnosis and identification of susceptible individuals or populations using ATP-sensitive potassium (KATP) channels present in different tissues such as the pancreas, myocardium, myocytes, and nervous tissues. The channels respond to different concentrations of blood sugar, stimulation by hormones, or ischemic conditions. In pancreatic cells, they regulate the secretion of insulin and glucagon. Mutations in the KCNJ11 gene that encodes the Kir6.2 protein (a major constituent of KATP channels) were reported to be associated with Type 2 DM, neonatal diabetes mellitus (NDM), and maturity-onset diabetes of the young (MODY). Kir6.2 harbors binding sites for ATP and phosphatidylinositol 4,5-diphosphate (PIP2). The ATP inhibits the KATP channel, while the (PIP2) activates it. A Kir6.2 mutation at tyrosine330 (Y330) was demonstrated to reduce ATP inhibition and predisposes to NDM. In this study, we examined the effect of mutations on the Kir6.2 structure using bioinformatics tools and molecular dynamic simulations (SIFT, PolyPhen, SNAP2, PANTHER, PhD&SNP, SNP&Go, I-Mutant, MuPro, MutPred, ConSurf, HOPE, and GROMACS). Our results indicated that M199R, R201H, R206H, and Y330H mutations influence Kir6.2 structure and function and therefore may cause DM. We conclude that MD simulations are useful techniques to predict the effects of mutations on protein structure. In addition, the M199R, R201H, R206H, and Y330H variant in the Kir6.2 protein may be associated with DM. These results require further verification in protein–protein interactions, Kir6.2 function, and case-control studies. [ABSTRACT FROM AUTHOR]

Published
2024
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6. Differential Expression of Serum Proinflammatory Cytokine TNF-α and Genetic Determinants of TNF-α, CYP2C19*17, miR-423 Genes and Their Effect on Coronary Artery Disease Predisposition and Progression

Author

Almassabi, Rehab F., primary, Mir, Rashid, additional, Javid, Jamsheed, additional, AbuDuhier, Faisel M., additional, Almotairi, Reema, additional, Alhelali, Marwan H., additional, Algehainy, Naseh, additional, Alsaedi, Basim S. O., additional, Albalawi, Salem Owaid, additional, and Elfaki, Imadeldin, additional

Published
2023
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7. Selective roles of Interleukin-10 Family Members (IL-10, IL-19, IL-22) and Varying Levels of Obesity in the Pathogenesis of Type 2 Diabetes in Patients from Asir Region of Saudi Arabia

Author

Mir, Mohammad Muzaffar, primary, Alfaifi, Jaber, additional, Sohail, Shahzada Khalid, additional, Rizvi, Syeda Fatima, additional, Alghamdi, Mushabab A., additional, Mir, Rashid, additional, Wani, Javed Iqbal, additional, Sabah, Zia UL, additional, Alhumaydhi, Fahad A., additional, Alremthi, Fahad, additional, AlQahtani, AbdulElah Al Jarallah, additional, Alharthi, Muffarah Hamid, additional, Ishag, Masoud, additional, Elfaki, Imadeldin, additional, and Sonpol, Hany M. A., additional

Published
2023
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9. In Silico Investigation of AKT2 Gene and Protein Abnormalities Reveals Potential Association with Insulin Resistance and Type 2 Diabetes

Author

Elangeeb, M. E., primary, Elfaki, Imadeldin, additional, Elkhalifa, M. A., additional, Adam, Khalid M., additional, Alameen, A. O., additional, Elfadl, Ahmed Kamaleldin, additional, Albalawi, Ibrahim Altedlawi, additional, Almasoudi, Kholoud S., additional, Almotairi, Reema, additional, Alsaedi, Basim S. O., additional, Alhelali, Marwan H., additional, Mir, Mohammad Muzaffar, additional, Amle, Dnyanesh, additional, and Mir, Rashid, additional

Published
2023
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10. In Silico Evaluation of the Potential Association of the Pathogenic Mutations of Alpha Synuclein Protein with Induction of Synucleinopathies

Author

Elnageeb, Mohamed E., primary, Elfaki, Imadeldin, additional, Adam, Khalid M., additional, Ahmed, Elsadig Mohamed, additional, Elkhalifa, Elkhalifa M., additional, Abuagla, Hytham A., additional, Ahmed, Abubakr Ali Elamin Mohamed, additional, Ali, Elshazali Widaa, additional, Eltieb, Elmoiz Idris, additional, and Edris, Ali M., additional

Published
2023
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11. Comprehensive Molecular Evaluation of HNF-1 Alpha, miR-27a, and miR-146 Gene Variants and Their Link with Predisposition and Progression in Type 2 Diabetes Patients

Author

Mir, Rashid, primary, Elfaki, Imadeldin, additional, Elangeeb, M. E., additional, Moawadh, Mamdoh S., additional, Tayeb, Faris Jamal, additional, Barnawi, Jameel, additional, Albalawi, Ibrahim Altedlawi, additional, Alharbi, Amnah A., additional, Alhelali, Marwan H., additional, and Alsaedi, Basim S. O., additional

Published
2023
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12. Role of non-coding RNA networks in leukemia progression, metastasis and drug resistance

Author

Bhat, Ajaz A., Younes, Salma N., Raza, Syed Shadab, Zarif, Lubna, Nisar, Sabah, Ahmed, Ikhlak, Mir, Rashid, Kumar, Sachin, Sharawat, Surender K., Hashem, Sheema, Elfaki, Imadeldin, Kulinski, Michal, Kuttikrishnan, Shilpa, Prabhu, Kirti S., Khan, Abdul Q., Yadav, Santosh K., El-Rifai, Wael, Zargar, Mohammad A., Zayed, Hatem, Haris, Mohammad, and Uddin, Shahab

Published
2020
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13. Correction to: Role of non-coding RNA networks in leukemia progression, metastasis and drug resistance

Author

Bhat, Ajaz A., Younes, Salma N., Raza, Syed Shadab, Zarif, Lubna, Nisar, Sabah, Ahmed, Ikhlak, Mir, Rashid, Kumar, Sachin, Sharawat, Surender K., Hashem, Sheema, Elfaki, Imadeldin, Kulinski, Michal, Kuttikrishnan, Shilpa, Prabhu, Kirti S., Khan, Abdul Q., Yadav, Santosh K., El-Rifai, Wael, Zargar, Mohammad A., Zayed, Hatem, Haris, Mohammad, and Uddin, Shahab

Published
2020
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14. Association of Genetic and Allelic Variants of Von Willebrand Factor (VWF), Glutathione S-Transferase and Tumor Necrosis Factor Alpha with Ischemic Stroke Susceptibility and Progression in the Saudi Population

Author

Jalal, Mohammed M., primary, Mir, Rashid, additional, Hamadi, Abdullah, additional, Altayar, Malik A., additional, Elfaki, Imadeldin, additional, Barnawi, Jameel, additional, Alkayyal, Almohanad A., additional, Amr, Mouminah, additional, Hadeel, Jabali, additional, Moawadh, Mamdoh S., additional, Alsaedi, Basim S. O., additional, Alhelali, Marwan H., additional, and Yousif, Aadil, additional

Published
2023
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16. Potential Impact of PI3K-AKT Signaling Pathway Genes, KLF-14, MDM4, miRNAs 27a, miRNA-196a Genetic Alterations in the Predisposition and Progression of Breast Cancer Patients

Author

Alzahrani, Othman R., primary, Mir, Rashid, additional, Alatwi, Hanan E., additional, Hawsawi, Yousef M., additional, Alharbi, Amnah A., additional, Alessa, Abdulrahman H., additional, Albalawi, Elham Saleh, additional, Elfaki, Imadeldin, additional, Alalawi, Yousef, additional, Moharam, Laila, additional, and El-Ghaiesh, Sabah H., additional

Published
2023
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18. Genetic Determinants of Cardiovascular Disease: The Endothelial Nitric Oxide Synthase 3 (eNOS3), Krüppel-Like Factor-14 (KLF-14), Methylenetetrahydrofolate Reductase (MTHFR), MiRNAs27a and Their Association with the Predisposition and Susceptibility to Coronary Artery Disease

Author

Mir, Rashid, primary, Elfaki, Imadeldin, additional, Javid, Jamsheed, additional, Barnawi, Jameel, additional, Altayar, Malik A., additional, Albalawi, Salem Owaid, additional, Jalal, Mohammed M., additional, Tayeb, Faris J., additional, Yousif, Aadil, additional, Ullah, Mohammad Fahad, additional, and AbuDuhier, Faisel M., additional

Published
2022
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19. Identification and Characterization of Novel Mutations in Chronic Kidney Disease (CKD) and Autosomal Dominant Polycystic Kidney Disease (ADPKD) in Saudi Subjects by Whole-Exome Sequencing

Author

Alzahrani, Othman R., primary, Alatwi, Hanan E., additional, Alharbi, Amnah A., additional, Alessa, Abdulrahman H., additional, Al-Amer, Osama M., additional, Alanazi, Abeer F. R., additional, Shams, Anwar M., additional, Alomari, Esra’a, additional, Naser, Abdallah Y., additional, Alzahrani, Faisal a., additional, Hosawi, Salman, additional, Alghamdi, Saeed M., additional, Abdali, Wed A., additional, Elfaki, Imadeldin, additional, and Hawsawi, Yousef M., additional

Published
2022
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20. Protective Effect of Catharanthus roseus Extract on Cadmium-Induced Toxicity in Albino Rats: A Putative Mechanism of Detoxification

Author

Hashim, Mohammad, primary, Arif, Hussain, additional, Tabassum, Baby, additional, Arif, Amin, additional, Rehman, Ahmed A., additional, Rehman, Shahnawaz, additional, Khanam, Rehnuma, additional, Khan, Bushra, additional, Hussain, Arif, additional, Barnawi, Jameel, additional, Tayeb, Faris J., additional, Algehainy, Naseh, additional, Altemani, Faisal H., additional, Mir, Rashid, additional, Almutairi, Fahad M., additional, Ullah, Mohammad Fahad, additional, Elfaki, Imadeldin, additional, and Ajmal, Mohammad Rehan, additional

Published
2022
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24. Targeting cancer signaling pathways by natural products: Exploring promising anti-cancer agents

Author

Hashem, Sheema, primary, Ali, Tayyiba Akbar, additional, Akhtar, Sabah, additional, Nisar, Sabah, additional, Sageena, Geetanjali, additional, Ali, Shahid, additional, Al-Mannai, Sharefa, additional, Therachiyil, Lubna, additional, Mir, Rashid, additional, Elfaki, Imadeldin, additional, Mir, Mohammad Muzaffar, additional, Jamal, Farrukh, additional, Masoodi, Tariq, additional, Uddin, Shahab, additional, Singh, Mayank, additional, Haris, Mohammad, additional, Macha, Muzafar, additional, and Bhat, Ajaz A., additional

Published
2022
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26. Differential impact of the angiotensin‑converting enzyme‑2 (ACE2 rs4343 G>A) and miR‑196a2 rs11614913 C>T gene alterations in COVID‑19 disease severity and mortality

Author

Mir, Mohammad, primary, Mir, Rashid, additional, Alghamdi, Mushabab Ayed, additional, Alsayed, Badr, additional, Elfaki, Imadeldin, additional, Al Bshabshe, Ali, additional, Farooq, Rabia, additional, Alhujaily, Muhanad, additional, Alharthi, Muffarah, additional, Alamri, Mohannad Mohammad, additional, and Al‑Shahrani, Abdullah, additional

Published
2022
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27. Clinical Implications of Glyoxalase1 Gene Polymorphism and Elevated Levels of the Reactive Metabolite Methylglyoxal in the Susceptibility of Type 2 Diabetes Mellitus in the Patients from Asir and Tabuk Regions of Saudi Arabia

Author

Alhujaily, Muhanad, primary, Mir, Mohammad Muzaffar, additional, Mir, Rashid, additional, Alghamdi, Mushabab Ayed Abdullah, additional, Wani, Javed Iqbal, additional, Sabah, Zia ul, additional, Elfaki, Imadeldin, additional, Alnour, Tarig Mohammad Saad, additional, Jeelani, Mohammed, additional, Abomughaid, Mosleh Mohammad, additional, and Alharbi, Amir Abdulkarim, additional

Published
2022
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29. Potential impact of GCK, MIR-196A-2 and MIR-423 gene abnormalities on the development and progression of type 2 diabetes mellitus in Asir and Tabuk regions of Saudi Arabia

Author

Mir, Mohammad, primary, Mir, Rashid, additional, Alghamdi, Mushabab, additional, Wani, Javed, additional, Elfaki, Imadeldin, additional, Sabah, Zia, additional, Alhujaily, Muhanad, additional, Jeelani, Mohammed, additional, Marakala, Vijaya, additional, Alharthi, Muffarah, additional, and Al‑Shahrani, Abdullah, additional

Published
2022
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30. Performance Analysis of a Half Bridge Cell Based Asymmetrical Multilevel Inverter Topology with Minimum Components

Author

Tomei Francesco, Elfaki Imadeldin, Q. Froes Thamires, Ding Yijie, Saeedian Moghadam Ebrahim, Mir Rashid, Amini Mohsen, M. Damato Felice, Tomei Gianfranco, Zhuang Zichong, Javid Jamsheed, Huang Baohua, Sacco Carmina, Ricci Pasquale, Chen Qian, Khullar Naina, Mario di Luca Natale, Kim Chol-Ho, Banu Shaheena, Samin Khan Ghufrana, Chahal S. M. S., Caciari Tiziana, Casale Teodorico, Asif Hanif Muhammad, Wu Hongjie, D. Roy Abeera, Massoni Francesco, Chandrahasan Umayal, S. Castilho Marcelo, Chen Feng, Rashid Umer, G. Patil Asmita, Marchione Stefania, Yun Un-Hui, Ri Kum-Chol, Ricci Lidia, Ke Donghua, Patil Shailendra, Tang Jijun, Kim Chol-Jin, Anzelmo Vincenza, k Jha Chandan, V. Rosati Maria, Ghafary Shahrzad, Zhong Jingpeng, Nardone Nadia, Zhang Jinjin, Massimi Roberto, L. Baldini Regina, Giubilati Roberto, Nadeem Farwa, Li Hyon-Gwang, Ricci Serafino, Lu Yujing, Li Wenbin, Rehman Suriya, Guo Xiaoyi, Vajda Sandor, Zhou Jinlin, K. Mahapatra Debarshi, Muhammad Ikram Mirza, Choe Sunll, Pimpinella Bendetta, and Lorusso Giovanna

Subjects
Computer science, Half bridge, Multilevel inverter, Topology (electrical circuits), Electrical and Electronic Engineering, Topology, Electronic, Optical and Magnetic Materials, Cell based
Abstract

Background: In Multilevel Inverters (MLI) as the number of level increases, there is a proportionate increase in the count of the semiconductor devices that are employed. Methods: This paper deals with an asymmetrical cascaded H-bridge inverter topology with half bridge cells to produce seven level output voltage waveform. Nearest Level Control (NLM) technique is used to produce the switching pulses. The operating principle of the proposed MLI and its performance abilities is verified through MATLAB/Simulink and a prototype is developed to provide the experimental results. Results: Total Harmonic Distortion (THD) is computed for proposed MLI for different types of loads in simulation environment as well as in the developed hardware prototype. Comparison between the proposed MLI and recent topologies demonstrates the advantageous features. Conclusion: The simulation and hardware results confirm the suitability of the proposed seven level MLI as the total component count, and the requirement of DC sources reduces considerably.

Published
2020

31. Biological and Clinical Implications of TNF-α Promoter and CYP1B1 Gene Variations in Coronary Artery Disease Susceptibility

Author

Mir, Rashid, primary, Elfaki, Imadeldin, additional, Jha, Chandan K., additional, Javid, Jamsheed, additional, Babakr, Abdullatif T., additional, Banu, Shaheena, additional, Mir, Mohammad M., additional, Jamwal, Dheeraj, additional, Khullar, Naina, additional, Alzahrani, Khalid J, additional, and Chahal, Sukh M.S., additional

Published
2021
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32. Clinical Implications of MiR128, Angiotensin I Converting Enzyme and Vascular Endothelial Growth Factor Gene Abnormalities and Their Association with T2D

Author

Elfaki, Imadeldin, primary, Mir, Rashid, additional, Duhier, Faisel M. Abu, additional, Alotaibi, Maeidh A., additional, Alalawy, Adel Ibrahim, additional, Barnawi, Jameel, additional, Babakr, Abdullatif Taha, additional, Mir, Mohammad Muzaffar, additional, Altayeb, Faris, additional, Mirghani, Hyder, additional, and Frah, Ehab A. M., additional

Published
2021
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33. Molecular Determination of mirRNA-126 rs4636297, Phosphoinositide-3-Kinase Regulatory Subunit 1-Gene Variability rs7713645, rs706713 (Tyr73Tyr), rs3730089 (Met326Ile) and Their Association with Susceptibility to T2D

Author

Mir, Rashid, primary, Elfaki, Imadeldin, additional, Duhier, Faisel M. Abu, additional, Alotaibi, Maeidh A., additional, AlAlawy, Adel Ibrahim, additional, Barnawi, Jameel, additional, Babakr, Abdullatif Taha, additional, Mir, Mohammad Muzaffar, additional, Mirghani, Hyder, additional, Hamadi, Abdullah, additional, and Dabla, Pradeep Kumar, additional

Published
2021
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36. Role of Selected miRNAs as Diagnostic and Prognostic Biomarkers in Cardiovascular Diseases, Including Coronary Artery Disease, Myocardial Infarction and Atherosclerosis

Author

Mir, Rashid, primary, Elfaki, Imadeldin, additional, Khullar, Naina, additional, Waza, Ajaz Ahmad, additional, Jha, Chandan, additional, Mir, Mohammad Muzaffar, additional, Nisa, Shamsu, additional, Mohammad, Babar, additional, Mir, Tahir Ahmad, additional, Maqbool, Mohsin, additional, Barnawi, Jameel, additional, Albalawi, Salem Owaid, additional, and Abu-Duhier, Faisel M., additional

Published
2021
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43. T and rs2274908 G&gt

Author

Jha, Chandan K, Mir, Rashid, Elfaki, Imadeldin, Javid, Jamsheed, Babakr, Abdullatif Taha, Banu, Shaheena, and Chahal, S. M. S.

Subjects
omentin, intelectin, rs2274907 and rs2274908 SNPs, ARMS-PCR, Coronary Artery Disease, allele specific PCR
Abstract

Coronary artery disease (CAD) is a major cause of death all over the world. CAD is caused by atherosclerosis which is induced by the interaction of genetic factors and environmental factors. Traditional environmental risk factors include hyperlipidemia, diabetes mellitus, lack of exercise, obesity, poor diet and others. Genome-wide association studies have revealed the association of certain gene polymorphisms with susceptibility to CAD. Omentin 1 is an adipokine secreted by the visceral adipose tissues and has been reported to have anti-inflammatory, cardioprotective, and enhances insulin sensitivity. In this study, we examined the role of omentin-1 common single nucleotide polymorphisms (SNPs) (rs2274907 A&gt, T and rs2274908 G&gt, A) in CAD. We genotyped 100 CAD patients and 100 matched healthy controls from the south Indian population using an amplification refractory mutation system (ARMS-PCR) and allele-specific PCR (AS-PCR). Our result indicated the rs2274908 G&gt, A is not associated with CAD. Results showed that there was a significant difference in rs2274907 A&gt, T genotype distribution between controls and CAD cases (P-value &lt, 0.05). Results indicated that the AT genotype of the rs2274907 is associated with CAD with OR = 3.0 (95% confidence interval (CI), 1.64 to 5.49), 1.65 (1.27 to 2.163), P = 0.002. The T allele of the rs2274907 was also associated with CAD with OR = 1.82 (95% CI, 1.193 to 2.80), 1.37 (1.08 to 1.74), P = 0.005. Rs2274907 genotype distribution was also correlated with serum total cholesterol, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), hypertension and diabetes. We conclude that the AT genotype and the T allele of the rs2274907 A&gt, T is associated with Cad in the south Indian population. Further studies on the effect of the rs2274907 A&gt, T on omentin-1 function are recommended, and future well-designed studies with larger sample sizes and in different populations are required to validate our findings.

Published
2019
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50. Molecular Evaluation of MicroRNA-146 Gene Variability (rs2910164 CG) and its Association with Increased Susceptibility to Coronary Artery Disease

Author

Mir, Rashid, Elfaki, Imadeldin, Jha, Chandan, Javid, Jamsheed, Rehman, Suriya, Banu, Shaheena, Mir, Mohammad Muzaffar, Babakr, Abdullatif Taha, and Chahal, Sukh Mohinder Singh

Abstract

Aim: Apart from the modifiable risk factors, genetic factors are believed to influence the outcome of Coronary Artery Diseases (CAD). Under the genetic factors, miRNA polymorphisms, namely Hsa-miR-146a-5p (rs2910164) have become an important tool to study the mechanism that underlies the pathogenesis of this disease. Therefore, we investigated the association of miR-146a gene variations with susceptibility of coronary artery diseases. Methodology: This study was conducted on 100 CAD patients and 117 matched healthy individuals. Genotyping of the Hsa-miR-146a-5p C>G gene variation was performed by using Amplification Refractory Mutation System PCR method (ARMS-PCR). Results: The distribution of Hsa-miR-146a-5p rs2910164 C>G genotypes observed between patients and controls was significantly different (P=0.048). Moreover, the frequency of G allele (fG) was found to be significantly higher among patients than in controls (0.36 vs. 0.25). Our findings showed that the Hsa-miR-146a-5p C>G variant was associated with an increased risk of CAD in codominant inheritance model CC vs. CG genotype (OR = 1.84, 95% CI, 1.02-3.31; p=0.040) and (OR = 3.18, 95% CI, 1.02-9.9; p=0.045) for CC vs. GG genotype in dominant inheritance model. Whereas the G allele significantly increased the risk of coronary artery disease (OR =1,81, 95% CI, 1.18-2.78; p=0.006) compared to C allele. Taken together, these results demonstrated that miR-146a/rs2910164 is associated with susceptibility to coronary artery disease, providing novel insights into the genetic etiology and underlying biology of coronary artery disease. Conclusion: Our findings indicated that Hsa-miR-146a-5p rs2910164 GG genotype and G allele are associated with increased susceptibility to Coronary Artery Disease. A larger sample size can be the key to progress in establishing the genetic co-relation of miRNA gene polymorphisms and cardiovascular diseases.

Published
2020
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