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4 results on '"Eleonora Penzo"'

1. O2 Serious infection, including severe COVID19, seems not to be a major clinical problem in patients with systemic lupus erythematosus treated with Belimumab, according the data from a large multicenter cohort

Author

Íñigo Rúa-Figueroa, José A Gómez-Puerta, Javier Narváez, Eva Tomero, Clara Moriano, Elvira Díez Álvarez, Consuelo Ramos Giráldez, Maria Angeles Blazquez Cañamero, Maria Galindo Izquierdo, Jaime Calvo Alen, Jose Maria Pego Reigosa, Irene Altabás González, Beatriz Frade-Sosa, Margarida Vasques Rocha, Andrea Hernández-Martín, Paola Vidal-Montal, Eleonora Penzo, Marta de la Rubia Navarro, José Andrés Román Ivorra, Raul Menor Almagro, Tarek Salman Montes, Norman Jiménez Otero, Judit Font Urgelles, Ivette Casafont Sole, María Jesús García Villanueva, Carlos Marras Fernández, María Piqueras García, Julia Martínez Barrio, Marina Sánchez Lucas, Josefina Cortés Hernández, Myriam Gandía Martínez, Carmen Trapero Pérez, and Alejandro Muñoz Jiménez

Subjects
Immunologic diseases. Allergy, RC581-607
Published
2024
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2. P147 Is belimumab dose optimization possible in patients with systemic lupus erythematosus? Analysis of this therapeutic strategy in a large multicenter cohort of patients from Spanish rheumatology departments

Author

Íñigo Rúa-Figueroa, Jose Maria Pego-Reigosa, Javier Narváez, Ivette Casafont-Solé, Eva Tomero, Clara Moriano, Elvira Díez Álvarez, María Jesús García-Villanueva, Consuelo Ramos Giráldez, Sandra Garrote, Maria Galindo Izquierdo, Jaime Calvo Alen, Beatriz Frade-Sosa, Irene Altabás-González, Andrea Hernández-Martín, Paola Vidal-Montal, Eleonora Penzo, Marta de la Rubia Navarro, José Andrés Román Ivorra, Raul Menor Almagro, Tarek Salman Montes, Norman Jimenez, Judit Font Urgelles, Carlos Marras Fernández, María Piqueras García, Julia Martínez Barrio, Marina Sánchez Lucas, Josefina Cortés Hernández, Myriam Gandía Martínez, Carmen Trapero Pérez, Alejandro Muñoz Jiménez, Juan Ramón de Dios, and Jos A Gómez-Puerta

Subjects
Immunologic diseases. Allergy, RC581-607
Published
2024
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3. LP-191 Baseline profile of systemic lupus erythematosus patients on treatment with belimumab of a Spanish multicenter cohort

Author

Íñigo Rúa-Figueroa, Jose Maria Pego-Reigosa, José A Gómez-Puerta, Javier Narváez, Ivette Casafont-Solé, José Andrés Román-Ivorra, Raúl Menor-Almagro, Jaime Calvo-Alén, Eva Tomero, Julia Martínez-Barrio, María Galindo-Izquierdo, Clara Moriano, Josefina Cortés-Hernández, María Jesús García-Villanueva, Elvira Díez-Álvarez, Irene Altabás-González, Coral Mouriño-Rodriguez, Norman Jiménez-Otero, Andrea Hernández-Martín, Judit Font-Urgelles, Marta De La Rubia-Navarro, Tarek Salman-Montes, Paola Vidal-Montal, Sandra Garrote-Corral, María Ángeles Blázquez-Cañamero, Carlos Marras-Fernández, María Piqueras-García, Marina Sánchez-Lucas, Eleonora Penzo, Juan Ramón De Dios Jiménez De Aberásturi, Belén Álvarez-Rodríguez, Margarida Vasques-Rocha, Myriam Gandía-Martínez, Consuelo Ramos-Giráldez, Carmen Trapero-Pérez, and Alejandro Muñoz-Jiménez

Subjects
Immunologic diseases. Allergy, RC581-607
Published
2023
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4. Downregulation of miR-885-5p Promotes NF-κB Pathway Activation and Immune Recruitment in Cutaneous Lupus Erythematosus

Author

Cristina Solé, Sandra Domingo, Eleonora Penzo, Teresa Moliné, Laura Porres, Gloria Aparicio, Berta Ferrer, and Josefina Cortés-Hernández

Subjects
Cell Biology, Dermatology, Molecular Biology, Biochemistry
Abstract

Cutaneous lupus erythematosus (CLE) has a specific microRNA expression profile. MiR-885-5p has been found to be downregulated in the epidermis of CLE lesions; however, its biological role in the disease has not been studied. In this study, we show that miR-885-5p is markedly reduced in CLE keratinocytes (KCs) with IFN-α and UVB being strong miR-885-5p regulators in vitro. Microarray expression profiling of anti‒miR-885-5p‒transfected KCs identified PSMB5 as a direct target. Specific inhibition of miR-885-5p increased epidermal proliferation by modulating keratin 16 gene K16, BIRC5, TP63, and CDK4 proliferative genes and promoted NF-κB signaling pathway in human primary KCs by increasing IκBα degradation. Silencing PSMB5 rescued the effect of miR-885-5p inhibition, indicating that miR-885-5p regulates proliferation and NF-κB activation by targeting PSMB5 in KCs. In addition, inhibition of miR-885-5p increased the ability of KCs to attract leukocytes in a PSMB5-independent manner. We identified TRAF1 as another direct target, and its silencing reduced leukocyte migration. Collectively, our findings suggest that UVB and IFN-ɑ downregulate miR-885-5p in CLE KCs, leading to epidermal inflammation by NF-κB activity enhancement and proliferation through PSMB5 and immune recruitment through TRAF1. Our data indicate that miR-885-5p is a potential therapeutic target in CLE.

Published
2022

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