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The purpose of this study is to assess blockchain’s impact on the activities of various structures and bodies of the state administration. The levels of blockchain development and blockchain 3.0 characteristics, which can be used for organizational and managerial decisions when building digital systems of a service nature, are considered. The deficiencies of legal regulation that impede blockchain’s integration into such systems are noted. The international experience, where blockchain is already used at the level of the state administration, as well as state and municipal services, is considered. The authors pay attention to the difficulties of introducing digital technology in the state administration, which not only complicates digitalization but can also create new problems if applying incorrect simplifications of virtual and real systems. The blockchain introduction in state services meets the increased demand of society for openness, accessibility, and absence of bureaucracy and does not interfere with its monopoly on the administrative coercion function.

Today, business travel is one of the most interesting phenomena of the 21st century and occupies a significant segment of the tourism and hospitality market. The globalization of the world economy and, as a result, the intensification of scientific, business, and cultural ties encourages trips with official and business purposes and encourages various levels of business events. There is a demand for corporate events even in the context of a pandemic.The article shows the importance of business travel in the modern tourism industry. The article describes the types of business travel, considers the features and components of business travel, its role in the overall turnover of the tourism business, emphasizes the need to create a modern infrastructure of the business travel market, shows the relationship of the main subjects of business travel, presents statistics on the level of development of business travel in the pre-pandemic period.The impact of the COVID-19 pandemic, which caused significant disruptions to international travel due to travel restrictions, has been analyzed. A model for the development of MICE tourism in the period after the lifting of restrictions has been proposed, which can be used to promote business travel in general. The prospects for the development of business travel after the ease of restrictions caused by the COVID-19 pandemic have been presented.The study concluded that after the ease of restrictions caused by the COVID-19 coronavirus pandemic, business travel should be aimed at expanding the tourist range, creating unique experiences, diversifying the tourist offer, creating conditions for epidemic safety and leisure.

The article is devoted to the elaboration of the conceptual basis of the tourism and hospitality industry’s development. It has been established that the extension of the tourism and hospitality industry into other service sectors has become one of the consequences of diversification of the tourism and hotel service market. It has been proved that various specialized businesses manufacturing diverse components and types of tourism and hotel products have appeared. It has been determined that information technologies result in the formation of a unified information space where every enterprise and every consumer finds a niche of their own and forms their network of ties. It has been found that the tourism and hospitality industry’s transition into a new technological space becomes one of the most important signs of the formation of the innovative paradigm of its development that is based on principles of ecologization, socialization and humanization that will eventually improve its efficiency.

The article is concerned with methodological approaches to development strategies for tourism and hospitality industry enterprises. It has been found that most regions, local tourist destinations, tourism and hospitality industry businesses do not have any clear formalized strategy. It was determined that some tourism and hospitality industry businesses apply only individual elements of strategic management, i.e. do not have an integrated system of strategic management. Methodological tools have been proposed for elaborating development strategies for tourism and hospitality industry enterprises, which show that strategic management, which is methodological by nature, i.e. is characterized by the conceptual approach and panoramic vision, cannot give an exact and clear view of the tourism industry’s future. It was proved that strategic management cannot be limited to a set of universal and routine rules, procedures or schemes. It was defined that strategic management requires great efforts, time and resources to make the activity of tourism and hospitality industry businesses remarkable.

Prenatal diagnostics of anatomic and chromosomal defects at future child is represents high-allowing technology in system of obstetric monitoring behind the course of pregnancy and a condition of a fruit. Carrying out reform of system of prenatal screening in territorial subjects of the Russian Federation within transition to the international standard of diagnostics to early terms of the pregnancy which is carried out with support of the Government, demands regular audit. The analysis of the first results innovative for the country of mass combined PS of 1 trimester is carried out with use of the uniform software, allowing to calculate individual risk of frequent chromosomal aneuploidiya at a fruit on biochemical and ultrasonic markers only on condition of existence of personal competence of the ultrasonographer.

The paper refers with the development of approaches to strategic management and development of the tourism and hospitality industry in the regions. The authors justified the creation of a strategy selection model that would take into account the possible strategic positions in organization of the tourism and hospitality industry, as well as unexpected strategic changes in the external business environment that might occur on its path. The model is based on the system of strategy selection and classification of unexpected strategic changes in the external business environment. It is proved that the application of the strategic management concept in tourism and hospitality industry is possible only taking into account the specifics of the organization’s activities, interests of service consumers, existing competitive conditions, and the sustainable development principles. It is revealed that there is a need in a holistic management system that would meet current and future requirements of the dynamic development of the tourism and hospitality industry, and can be implemented at different levels including regional level.