59 results on '"Elena Corsi"'
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2. Duropathy as a rare motor neuron disease mimic: from bibrachial amyotrophy to infratentorial superficial siderosis
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Viktoriia Iakovleva, Federico Verde, Claudia Cinnante, Alessandro Sillani, Giorgio Conte, Elena Corsini, Emilio Ciusani, Alessandra Erbetta, Vincenzo Silani, and Nicola Ticozzi
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Superficial siderosis ,Bibrachial amyotrophy ,Duropathy ,Dural leak ,Ventral longitudinal intraspinal fluid collection ,ALS mimics ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
Abstract Background Bibrachial amyotrophy associated with an extradural CSF collection and infratentorial superficial siderosis (SS) are rare conditions that may occasionally mimic ALS. Both disorders are assumed to be due to dural tears. Case presentation A 53-year-old man presented with a 7-year history of slowly progressive asymmetric bibrachial amyotrophy. Initially, a diagnosis of atypical motor neuron disease (MND) was made. At re-evaluation 11 years later, upper limb wasting and weakness had further progressed and were accompanied by sensorineural hearing loss. MRI of the brain and spine demonstrated extensive supra- and infratentorial SS (including the surface of the whole spinal cord) as well as a ventral longitudinal intraspinal fluid collection (VLISFC) extending along almost the entire thoracic spine. Osteodegenerative changes were observed at C5-C7 level, with osteophytes protruding posteriorly. The bony spurs at C6-C7 level were hypothesized to have lesioned the dura, causing a CSF leak and thus a VLISFC. Review of the MRI acquired at first evaluation showed that the VLISFC was already present at that time (actually beginning at C7 level), whereas the SS was not. 19 years after the onset of upper limb weakness, the patient additionally developed parkinsonism. Response to levodopa, brain scintigraphy with 123I-ioflupane and brain MRI with nigrosome 1 evaluation were consistent with idiopathic Parkinson’s disease (PD). On the latest follow-up 21 years after symptom onset, the VLISFC was unchanged, as were upper arm weakness and wasting. Conclusions Based on the long-term follow-up, we could establish that, while the evidence of the VLISFC was concomitant with the clinical presentation of upper limb amyotrophy and weakness, the radiological signs of SS appeared later. This suggests that SS was not per se the cause of the ALS-like clinical picture, but rather a long-term sequela of a dural leak. The latter was instead the causative lesion, giving rise to a VLISFC which compressed the cervical motor roots. Dural tears can actually cause several symptoms, and further studies are needed to elucidate the pathophysiological correlates of “duropathies”. Finally, as iron metabolism has been implicated in PD, the co-occurrence of PD with SS deserves further investigation.
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- 2024
- Full Text
- View/download PDF
3. Caratteri demografici, sociali ed economici di un quartiere mondo
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Elena Corsi and Andrea Di Giovanni
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- 2022
4. Esplorare la periferia metropolitana multiculturale privata milanese
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Andrea Di Giovanni, Elena Corsi, Simonetta Armondi, and Vittoria Paglino
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- 2022
5. Adorno und Cornelius
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Elena Corsi
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Philosophy - Published
- 2021
6. Industrial Wearable Robots: A HUMANufacturing Approach
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Edoardo Rota, Giuseppe Colombina, Elena Corsi, and Gaia Salvadore
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Production line ,Engineering management ,Industry 4.0 ,business.industry ,Computer science ,Sustainability ,Wearable computer ,Robot ,Human factors and ergonomics ,business ,Automation ,Wearable technology - Abstract
In the last decades, exoskeletons have mostly been developed and studied for applications in the medical field, as rehabilitation or assistive devices for patients with movement disabilities. Recently, given the high performance of emerging wearable technologies, new applications have been proposed including the every-day support of able-bodied subjects such as workers. The execution of repetitive operations or actions that require excessive effort are the main causes of musculoskeletal injuries in people working in production lines or construction sites. The Industry 4.0 program is bringing companies to re-think their processes by considering human factors, ergonomics and sustainability issues. This is leading to a new trend in automation, which place the workers at the center of a modern smart factory, allowing them to take advantages of new interconnected tools. This new tendency fully embodied Comau’s vision. The company, in fact, has coined a term for better picturing its vision: HUMANufacturing.
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- 2019
7. Libert, Galit, Fragilit: The Rise of Populism in France (B)
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Elena Corsi, Vincent Pons, Elena Corsi, and Vincent Pons
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- 2019
8. Canibal-Play It Green!
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Elena Corsi, Frank V. Cespedes, Joseph B. Fuller, Tonia Labruyere, Elena Corsi, Frank V. Cespedes, Joseph B. Fuller, and Tonia Labruyere
- Abstract
In 2011, Canibal launched a machine that could sort and compress aluminum cans, plastic bottles, and cups. Users could play a jackpot-style game on the machine's digital display, while disposing of their beverage containers and earning coupons or other rewards. The machine could also display advertising or serve as a communication tool. In 2016, the company's new machine, the i3, had more potential than earlier models, due to enhanced reliability and displays that could allow Canibal to pursue new markets. Benoit Paget, CEO and founder of Canibal, must choose a growth path: which customer segment should he focus on? How should he position his product? What would be the implications of these choices for marketing and sales requirements, pricing, and funding?
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- 2019
9. Ferrari
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Ashok Nimgade, Elena Corsi, Stefan Thomke, Ashok Nimgade, Elena Corsi, and Stefan Thomke
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Ferrari is among the world's most powerful brands but how the company operates has remained mysterious. The case reveals the inner workings of the company - the Ferrari Way - from the way it designs, produces, and markets its cars, to how its leadership team is driving future growth. Central to Ferrari's strategy is its response to disruptive changes in the automotive industry and their impact on the company's products and brand.
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- 2018
10. Lexoo: Building a Long-Lasting Platform
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Chiara Farronato, Elena Corsi, Chiara Farronato, and Elena Corsi
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Lexoo, a UK-based online marketplace for legal services, was facing the strategic choice of how to grow from early start-up to mature platform. Daniel van Binsbergen, Lexoo's CEO, and web developer Chris O'Sullivan, CTO, had set up Lexoo to help Small and Medium-Sized Enterprises (SMEs) to find legal advice at low prices. At the time of the case in 2018, Lexoo had just started attracting larger companies in need of specialized legal advice as new customers. Larger companies had higher value and more frequent needs. Lexoo could become their'go-to'place across a broad range of legal services. Nevertheless, larger companies also required a more personalized approach and were more difficult to acquire than SMEs. Van Binsbergen and O'Sullivan were debating whether Lexoo should diversify to serve both SMEs and larger companies, or whether to pivot their focus toward larger companies altogether.
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- 2018
11. The Rise of Populism and Italy's Electoral 'Tsunami'
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Dante Roscini, Elena Corsi, Rawi Abdelal, Dante Roscini, Elena Corsi, and Rawi Abdelal
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Italy's March 2018 elections led to a populist government which included the right-wing League and the anti-establishment 5 Star Movement. To respect their electoral promises, the two parties came up with a budget plan which provided for a public deficit at 2.4%, a figure higher than what the previous administration had promised the EU Commission. On October 23, 2018, the EU Commission rejected such plan asking Italy to revise downwards the public deficit. The same day, Italian bond yields spoke to 4-year highs, up to 3.7% as investors questioned Italy's capacity to repay its public long-term debt, the second highest in the EU. Would the Italian government be able to implement its plan?
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- 2018
12. CIR Group: Passing Wealth Through the Generations
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Christopher J. Malloy, Elena Corsi, Lauren H. Cohen, Christopher J. Malloy, Elena Corsi, and Lauren H. Cohen
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Three brothers discuss the succession plans of their shares in the publicly listed family business.
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- 2018
13. Orsted Goes Global
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Elena Corsi, Joseph L. Bower, Elena Corsi, and Joseph L. Bower
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The European leader in offshore wind, the Danish Orsted is building a global position and entering markets where offshore wind is nascent.
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- 2018
14. Bitfury: Blockchain for Government
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Elena Corsi, Mitchell B. Weiss, Elena Corsi, and Mitchell B. Weiss
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In the Republic of Georgia, legend had it their land was a precious gift from God he had intended to keep for his mother. But over time, the land had been under intermittent threat from without and within. In 2017, the Bitfury Group, which Valery Vavilov had co-founded, had helped publish 300,000 Georgian land titles onto the blockchain, making them immutable and, many believed, unhackable. What came next, Vavilov's team envisioned, were smart purchase and sale contracts via the blockchain; and from there, a full suite of property-related services and, eventually, blockchain as the foundation for a transformation in government services. Vavilov, who had co-founded Bitfury and expanded it substantially from its bitcoin mining roots, felt a blockchain-driven makeover of this sort would take place not just in Georgia's government, but around the world. It was not a matter of'if?'anymore; although that still left the question of'when?'
- Published
- 2017
15. King Digital Entertainment
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Davide Sola, Elena Corsi, Federica Gabrieli, Jeffrey Rayport, Davide Sola, Elena Corsi, Federica Gabrieli, and Jeffrey Rayport
- Abstract
Riccardo Zacconi was the co-founder and CEO of King Digital Entertainment, the video game company which had quickly established itself as the world's leading maker of casual games for mobile devices after the sensational success of its game'Candy Crush Saga.'Zacconi had only a few days left to decide what to reply to Activision Blizzard, one of the largest video game publishers in the world, which had offered to acquire King for almost $6 billion. King had already managed to successfully adapt to disruptive technological changes in the course of its history, could it continue to go solo? Or would an acquisition by a complementary video game maker like Activision be the best choice for King to continue to thrive? The clock was ticking but Zacconi knew that whatever the final decision, it had to satisfy one condition: Player was King.
- Published
- 2017
16. The challenge of pet therapy in systemic sclerosis: evidence for an impact on pain, anxiety, neuroticism and social interaction
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Ginevra, Fiori, Tessa, Marzi, Francesca, Bartoli, Cosimo, Bruni, Carlo, Ciceroni, Michela, Palomba, Michela, Zolferino, Elena, Corsi, Marcello, Galimberti, Alberto, Moggi Pignone, Maria Pia, Viggiano, Serena, Guiducci, Monica, Calamai, and Marco, Matucci-Cerinic
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Male ,Neuroticism ,Scleroderma, Systemic ,Vasodilator Agents ,Pain ,Anxiety ,Middle Aged ,Combined Modality Therapy ,Dogs ,Mental Health ,Treatment Outcome ,Animal Assisted Therapy ,Animals ,Humans ,Female ,Interpersonal Relations ,Iloprost ,Infusions, Intravenous ,Aged - Abstract
The aim of our study was to evaluate the effect of animal-assisted intervention (AAI), a complementary support to traditional therapies focused on the interaction between animals and human beings, in improving psychological trait, anxiety and pain in a cohort of systemic sclerosis (SSc) patients.42 SSc patients, undergoing iloprost intravenous infusion, were divided in three groups: 1) 14 patients submitted to 20 AAI sessions; 2) 14 patients engaged in alternative social activity (control group 1 - C1); and 3) 14 patients without any alternative activity (control group 2 - C2). All patients underwent Visual Analog Scale (VAS), the State-anxiety (STAI-S) and emotional faces at the beginning (s0) and at the end (s1) of each single session, while General Anxiety State-Trait Anxiety Inventory (STAI-T), Beck Depression Inventory (BDI), Social Interaction Anxiety Scale (SIAS), Eysenck Personality Questionnaire-Revised (EPQ-R), the Social Phobia Scale (SPS), the Toronto Alexythymia Scale (TAS-20), the Thought Control Questionnaire (TCQ) were administered at baseline (t0) and at the end of the project (t1).AAI group showed a significant decrease of the anxiety state level in respect to the two control groups (p0.001). VAS scale resulted lower both in AAI (p0.001) and C1 group (p0.01). Moreover, STAI-T and TAS scores were significantly reduced in AAI group (p0.001). TCQ scale showed that patients treated with AAI, compared to control group C2, had greater capacity to avoid unpleasant and unwanted thoughts (p0.05). In AAI group, the EPQ-R test revealed an enhancement of extroversion trait compared to both control groups (p0.05).Our data show that AAI significantly reduces pain perception, anxiety, neuroticism and ameliorates patients' social interaction, therefore it may be a useful to allow a better compliance to traditional therapies.
- Published
- 2017
17. Managing the European Refugee Crisis
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Daniela Beyersdorfer, Elena Corsi, Gunnar Trumbull, Daniela Beyersdorfer, Elena Corsi, and Gunnar Trumbull
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In 2016, Europe struggles to cope with one of the largest refugee flows it has ever witnessed.
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- 2016
18. APG Group: Managing Pensions for the Future (Abridged)
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Elena Corsi, Luis M. Viceira, Elena Corsi, and Luis M. Viceira
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- 2016
19. Essent: From a State Owned Utility to a Commercial Company
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Ananth Raman, Elena Corsi, Ananth Raman, and Elena Corsi
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A formerly state-owned Dutch energy utility transforms itself to compete in a dergulated environment.
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- 2016
20. Models of Endowment Management: King's College, Cambridge
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David Chambers, Elena Corsi, Elroy Dimson, Luis M. Viceira, David Chambers, Elena Corsi, Elroy Dimson, and Luis M. Viceira
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One of the University of Cambridge's Colleges evaluates different asset management options for its endowment fund. The King's College, one of the constituent colleges of the University of Cambridge in the UK, had most of its endowment invested in equity index funds. Its committee was to discuss whether they should overhaul their investment strategy. The college had three options. One was to invest in a new pooled fund created by the University, in which other colleges were also investing, another was to invest through a private multi-asset investment firm also used by other colleges, Partners Capital, or remain in index funds.
- Published
- 2016
21. Aura Light: From a Light Bulb Manufacturer to an Energy Savings Solutions Provider
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Elena Corsi, Krishna G. Palepu, Elena Corsi, and Krishna G. Palepu
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A Swedish light bulb manufacturer reviews its strategy to better compete against large global multinationals.
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- 2015
22. ABB: 'In China, For China'
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J. Gunnar Trumbull, Elena Corsi, and Elisa Farri
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- 2016
23. A pilot study on the neurometric evaluation of 'effective' and 'ineffective' antismoking public service announcements
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Elena Corsi, Dario Rossi, Fabio Babiloni, Enrica Modica, Isotta Venuti, Giulia Rossi, Anton Giulio Maglione, and Giulia Cartocci
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Adult ,Male ,Public Service Announcements as Topic ,Tobacco use ,media_common.quotation_subject ,medicine.medical_treatment ,Emotions ,Biomedical Engineering ,Sample (statistics) ,Pilot Projects ,Signal Processing ,1707 ,Health Informatics ,02 engineering and technology ,03 medical and health sciences ,Young Adult ,0302 clinical medicine ,Heart Rate ,Perception ,0202 electrical engineering, electronic engineering, information engineering ,medicine ,Humans ,Preventable death ,media_common ,Behavior ,Galvanic Skin Response ,Smoking cessation ,020201 artificial intelligence & image processing ,Public service ,Female ,Smoking Cessation ,Psychology ,Skin conductance ,Social psychology ,030217 neurology & neurosurgery ,Clinical psychology - Abstract
Tobacco use is the leading cause of preventable death and smoking-related illness worldwide. Research has shown that antismoking advertising may help reduce this habit. Nowadays, public service announcements (PSAs) are considered “Effective” or “Ineffective” on the base of official reports concerning behavioral/attitudinal changes toward healthier patterns and health-related savings following the exposure to the PSA. In this pilot study, we described the results of the use of three neurometric indexes for the evaluation of the efficacy of a couple of antismoking PSAs in a reduced sample of voluntary participants. The study applied the gathering of the electroencephalographic (EEG) rhythms variations, as well as the heart rate (HR) and galvanic skin response (GSR). The neurometric indicators here employed were the Approach-Withdrawal (AW), the Effort (EfI) and the Emotional (EI) indexes. Results suggest a significant higher values for AW, Effort and Emotional indexes (p=0,02; p= 0,03 and p= 0,01 respectively) related to the perception of the “Effective” antismoking PSAs against the perception of the “Ineffective” one. Since this is a pilot study, the results obtained need further investigation, in terms of enlarged stimuli sample and number of participants to provide indications concerning the relevant features to be included in the realization of effective anti-smoking PSAs.
- Published
- 2016
24. Evaluation of peri-implant bone resorption around Straumann Bone Level© implants placed in areas reconstructed with autogenous vertical onlay bone grafts
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Marco Zaniboni, P. Casentini, Matteo Chiapasco, and Elena Corsi
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Adult ,Male ,Adolescent ,Platform switching ,Alveolar Bone Loss ,Dentistry ,Mandible ,Bone resorption ,Osseointegration ,stomatognathic system ,medicine ,Humans ,Jaw, Edentulous ,Dental Restoration Failure ,Bone Resorption ,Bone level ,Survival rate ,Aged ,Dental Implants ,Bone Transplantation ,business.industry ,Dental Implantation, Endosseous ,Skull ,Dental prosthesis ,Alveolar Ridge Augmentation ,Recovery of Function ,Middle Aged ,Resorption ,Treatment Outcome ,medicine.anatomical_structure ,Female ,Cortical bone ,Atrophy ,Oral Surgery ,business - Abstract
Aim of the study To evaluate the survival and success rate of Straumann Bone Level implants placed in vertically atrophied edentulous jaws previously reconstructed with autogenous onlay bone grafts taken from the calvarium or the mandibular ramus. Materials and methods From 2007 to 2009, 18 patients presenting with vertical deficits of the edentulous ridges were treated with autogenous cortical bone grafts harvested from the mandibular ramus or the calvarium. Four to seven months afterward, 60 Straumann Bone Level implants were placed in the reconstructed areas. After a further waiting period of 2–3 months, patients were rehabilitated with implant-supported fixed prostheses. Follow-up ranged from 12 to 36 months (mean: 19 months) after the start of prosthetic loading. Graft resorption before implant placement, as well as survival and success rates of implants, were recorded. Results The mean bone resorption prior to implant placement was 0.18 mm for calvarial grafts and 0.42 mm for ramus grafts. Survival rate was 100% either for implants placed in calvarial grafts or implants placed in ramus grafts, while success rate was 90.3% for implants placed in calvarial grafts, and 93.1% for implants placed in ramus grafts. Conclusion Results from this study seem to demonstrate that implants with a platform-switching design may predictably integrate in edentulous areas reconstructed with autogenous bone grafts, with survival rates consistent with those reported in recent literature reviews on the same topic, and also with implants placed in native bone. Conversely, this study was not able to demonstrate that implants with platform-switching design may reduce bone resorption around implants placed in reconstructed areas.
- Published
- 2011
25. The Michelin Restaurant Guide: Charting a New Course
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Elena Corsi, Jerome Lenhardt, Mukti Khaire, Elena Corsi, Jerome Lenhardt, and Mukti Khaire
- Abstract
Created in 1900 by the tire manufacturer Michelin, the Michelin Restaurant Guide was widely considered the international benchmark of food rating, and, by 2013, boasted paper editions in 23 countries, and had recently expanded to the United States and Asia. Paper sales however had dropped, following the emergence of free, online guides, global players, and more broadly, the wider diffusion of the Internet. In 2012, the Guide had launched a new range of services targeting restaurateurs. The Director of the Guide was contemplating developing the Guide even more internationally and on digital formats, but also knew he needed to limit costs.
- Published
- 2014
26. APG Group: Managing Pensions for the Future
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Elena Corsi, Luis M. Viceira, Elena Corsi, and Luis M. Viceira
- Published
- 2014
27. Noma: A Lot on the Plate
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Elena Corsi, Mukti Khaire, Elena Corsi, and Mukti Khaire
- Abstract
In 2014, the restaurant Noma, based in Copenhagen, Denmark, was considered to be amongst the best restaurants in the world, and its co-founder, co-owner and chef, Ren Redzepi, among the most influential chefs. The restaurant was also leading the new Nordic food movement, a movement focused on rediscovering Nordic cuisine and ingredients, which had helped increase the popularity of Danish cuisine. Since 2013 Noma had a new investor, the American Marc Blazer, who joined to help Redzepi increase the restaurant's margins to make it a more sustainable business. But the question was-how? What options really were available?
- Published
- 2014
28. What Makes Decentralisation in Developing Countries Pro-poor?
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Elena Corsi, Ida McDonnell, Celine Kauffmann, Johannes Jütting, Nicolas Pinaud, Holger Osterrieder, and Lucia Wegner
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Sustainable development ,Development studies ,Poverty ,Development anthropology ,Geography, Planning and Development ,Development economics ,Economics ,Gender and development ,Development ,International development ,Decentralization ,Human development (humanity) - Abstract
Decentralisation has been advocated by donors and development agencies as an instrument to ensure broader participation of citizens as well as to improve local governance leading to poverty reduction from the bottom up. On the basis of a comprehensive review of nine case studies documented in the literature, this study questions this assumption. According to our findings, a clear link between decentralisation and a reduction in poverty cannot be established. Two important policy lessons emerge from this study. First, in an environment where the central state barely fulfils basic functions and is not interested in giving power and resources to local tiers of government, decentralisation should not be a priority for donors as it could be rather counter-productive. Second, in countries that fulfil basic prerequisites, decentralisation could be a powerful tool for poverty reduction. La decentralisation a ete mise en avant par les partenaires au developpement comme un instrument permettant d'assurer la partici...
- Published
- 2005
29. Chef Davide Oldani and Ristorante D'O
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Alessandro Di Fiore, Elena Corsi, Elisa Farri, Gary P. Pisano, Alessandro Di Fiore, Elena Corsi, Elisa Farri, and Gary P. Pisano
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This case examines the unique business model of Ristorante D'O, a high end gourmet restaurant located near Milan, Italy. Founded by Chef Davide Oldani, D'O offers meals at approximately one-third the price of other Michelin starred restaurants. Oldani has made this business model profitable by making a conscious set of operating strategy choices (menu, meal design, service process, lay-out, reservation process) that reduce waste and inefficiency, while preserving quality. The case enables students to understand how cost-quality trade-offs can be altered through creative operating strategies, and sufficient data are available to analyze the operating model in depth. A second focal point of the case concerns Oldani's choices for growth. The wait list for D'O is currently 18 months. He can presumably open another D'O at a different location. At the time of the case, however, is considering opening a new restaurant in the same vicinity as D'O that would operate at an even lower price point. Case debate can center around whether this new restaurant format makes sense from a strategic point of view, and, in particular, whether the capabilities and know-how acquired in operating D'O are applicable to the new restaurant. The deeper issue in the case concerns how businesses based on the creative talent of an individual (like Chef Oldani) can grow, without losing what makes them special.
- Published
- 2013
30. Siemens AG: Key Account Management
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Elena Corsi, Michael Ahearne, Thomas Steenburgh, Elena Corsi, Michael Ahearne, and Thomas Steenburgh
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The key account manager of an engineering company has to convince a department to give up important contracts. The German engineering company Siemens had set up a global key account management program since 2010. The key account manager of an emerging account had been asked from his customer to cut the costs of two long-term contracts worth about 300 million that his customer had signed with Siemens. Although legally Siemens could refuse the revision, such an act could jeopardize Siemens'relationship with the customer. At the same time, a change in the contracts would bring about losses for Siemens. How should the key account manager handle this problem? He knew that he would have to be resourceful, given that he had no direct authority in the situation, but this was the nature of his job.
- Published
- 2012
31. Global Diversity and Inclusion at Royal Dutch Shell (A)
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Elena Corsi, Sandra J. Sucher, Elena Corsi, and Sandra J. Sucher
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Royal Dutch Shell has been among the early players to implement diversity and inclusion policies in the 1990s, first in the U.S. and then globally. In May 2009, Peter Voser, CFO and soon-to-be CEO, wants to adjust the company's business, head count, and cost levels to adapt to changing economic conditions after one of the worst economic downturns in decades. His all-male executive committee has raised eyebrows because it is a step back from that of his predecessor, and he must decide whether to continue to promote the firm's emphasis on global diversity and inclusion while it restructures its business and reduces its managerial workforce.
- Published
- 2012
32. DONG Energy: Clean and Reliable Energy
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Elena Corsi, Joseph L. Bower, Elena Corsi, and Joseph L. Bower
- Abstract
The head of Denmark's largest energy group pondered how to use their limited resources to advance the delivery of clean and reliable energy. The Danish State owned DONG Energy had started life as an importer and trader of gas and oil. Under the leadership of the current CEO, Anders Eldrup, the company had become an energy group, present in all steps of the gas and oil value chain and particular, in the EU market leader in offshore wind energy. As a developer and operator of wind farms, it was one of the world's leaders. In 2011, the company faced several strategic questions including whether and where they should continue investing in offshore wind and how to identify the next key growth businesses of the future.
- Published
- 2012
33. Cahiers Du Cinema and The French Film Industry
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Elena Corsi, Emilie Billaud, Mukti Khaire, Elena Corsi, Emilie Billaud, and Mukti Khaire
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The French film magazine Cahiers du Cinema contributed to strengthening the characterization of film as art in France. The note provides background information on the magazine's history, on the French film industry and on French film magazines
- Published
- 2012
34. Virgin Group: Finding New Avenues for Growth
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Elena Corsi, Gary P. Pisano, Elena Corsi, and Gary P. Pisano
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The head of the branded private investment company owner of the Virgin brand reflected on the group's new pillars of growth. Since the 1970s when Richard Branson created the Virgin record retailing company, Virgin had developed from scratch six companies worth more than $1 billion each and changed their focus from record retailing and music production to a broader one based on airlines, health, financial services, mobile and media businesses. In addition, Virgin had been able to apply the Virgin brand to several different products without harming the brand. Their challenge had been finding the capital to finance the new ventures rather than the brand. Since 2005, Branson was dedicating more and more time to a charitable organization, Virgin Unite, and had appointed Stephen Murphy the new CEO of the Group. As Murphy contemplated their growth strategy for the next decade he faced a number of difficult decisions. First, how should he fund new ventures? While growing, the Group had sold stakes in its companies and had signed with them licensing agreements for the use of the Virgin brand name. The Virgin Group was today a loose group of companies some linked to Virgin only by brand licensing agreements. Should they expand by signing new licensing agreements? Second, what kind of opportunities should he seek? Should they keep acting as a venture capital firm, nurturing new ventures as in the past or should they invest in larger and more established companies? What would be the consequences of their choices on the brand and on the Group? Would they always be able to inject the Virgin culture and turn around companies?
- Published
- 2012
35. Germany's Green Energy Revolution
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Elena Corsi, Emer Moloney, Emilie Billaud, Noel Maurer, Elena Corsi, Emer Moloney, Emilie Billaud, and Noel Maurer
- Published
- 2012
36. Automating the Paris Subway (B)
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Elena Corsi, Emilie Billaud, Michel Anteby, Elena Corsi, Emilie Billaud, and Michel Anteby
- Abstract
Supplement for case 413061
- Published
- 2012
37. Automating the Paris Subway (A)
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Elena Corsi, Emilie Billaud, Michel Anteby, Elena Corsi, Emilie Billaud, and Michel Anteby
- Abstract
In 2001, the head of the Paris Subway reflected on how to transform Line 1 into a driverless line without triggering a social conflict. After the shock of the 2000 Notre Dame de Lorette subway accident, in which a train derailed and caused 25 injuries in a Paris subway station, the state-owned Paris subway operator Regie Autonome des Transports Parisiens (RATP) decided to adopt new security measures and considered the opportunity to automate the oldest and the busiest line of the network. The Head of the Paris Subway, Serge Lagrange, believed that automating Line 1 would improve security as well as performance. However, the automation would bring about the downsizing of 219 drivers'positions. Lagrange had to figure out how to get the RATP employees on board, particularly drivers and trade unions. How could he convince them of the necessity to automate Line 1? How could he prevent the potentially major social conflict that might result from downsizing the drivers'positions?
- Published
- 2012
38. The Role of Adhesion Molecules and Extracellular Vesicles in an In Vitro Model of the Blood–Brain Barrier for Metastatic Disease
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Chiara Vasco, Ambra Rizzo, Chiara Cordiglieri, Elena Corsini, Emanuela Maderna, Emilio Ciusani, and Andrea Salmaggi
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brain metastasis ,brain metastasis molecular markers ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Metastatic brain disease (MBD) has seen major advances in clinical management, focal radiation therapy approaches and knowledge of biological factors leading to improved prognosis. Extracellular vesicles (EVs) have been found to play a role in tumor cross-talk with the target organ, contributing to the formation of a premetastatic niche. Human lung and breast cancer cell lines were characterized for adhesion molecule expression and used to evaluate their migration ability in an in vitro model. Conditioned culture media and isolated EVs, characterized by super resolution and electron microscopy, were tested to evaluate their pro-apoptotic properties on human umbilical vein endothelial cells (HUVECs) and human cerebral microvascular endothelial cells (HCMEC/D3) by annexin V binding assay. Our data showed a direct correlation between expression of ICAM1, ICAM2, β3-integrin and α2-integrin and the ability to firmly adhere to the blood–brain barrier (BBB) model, whereas the same molecules were down-regulated at a later step. Extracellular vesicles released by tumor cell lines were shown to be able to induce apoptosis in HUVEC while brain endothelial cells showed to be more resistant.
- Published
- 2023
- Full Text
- View/download PDF
39. Vestas' World of Wind
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Elena Corsi, Thomas Steenburgh, Elena Corsi, and Thomas Steenburgh
- Abstract
The wind turbine manufacturer Vestas launched the industry's first highly localized and customized new product launch campaigns which used also new tools such as web 2.0 platforms. Used to operate in a market where demand exceeded supply, Vestas had lost contact with its customer base and had a limited marketing budget, mainly used to finance global media advertisement campaigns. The world economic downturn which followed the U.S. credit crunch crisis of 2008 and the increased competition in the wind turbine market had brought about a sudden drop in Vestas orders of new turbines. Vestas thus decided to focus more on marketing and developed a new department, Global Marketing and Customer Insights. Morten Albaek was hired to manage and develop the department and to transform Vestas into the undisputed most customer focused company in the industry by 2012 and among the most customer centric B2B brand by 2015. He tested his new approach for the first time with the launch of their new V112 turbine for which he developed 72 customized campaigns targeting its main existing and potential customers and major stakeholders. Yet, had the campaign been effective in bringing Vestas closer to its customer base? Were they using the right tools?
- Published
- 2011
40. Shelley Capital and the Hedge Fund Secondary Market
- Author
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Elena Corsi, Luis M. Viceira, Ruth Dittrich, Elena Corsi, Luis M. Viceira, and Ruth Dittrich
- Abstract
An advisory company has to decide how to sell their client's hedge fund holdings in the secondary market, and thinks about their future. Shelley Capital was a a European advisory company operating in the hedge fund secondary market, a market that boosted in 2008 with the world financial crisis. Shelley had identified four final bidders for the $84.5 million portfolio of illiquid hedge fund holdings that one of their clients had commissioned them to sell and had now to decide to whom they should sell the holdings, if they should split up the portfolio, or if they should postpone the sale. At the same time, they needed to decide about their future business. The financial crisis was behind the exceptional growth of the hedge funds'secondary market, yet another crisis could follow and boost the secondary market again. What direction should Shelley take once the hedge fund industry fully recovered? But what if a second global crisis threw the hedge fund industry into disarray once again?
- Published
- 2011
41. ABICI
- Author
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Elena Corsi, Elisa Farri, Mukti Khaire, Elena Corsi, Elisa Farri, and Mukti Khaire
- Abstract
The co-founder of an Italian, design based bicycle manufacturer evaluates if reducing costs by outsourcing would impact its brand. The company was founded in 2005 in Italy by three friends and in its first five years, it had enjoyed steady growth and built a strong reputation for producing high-quality city bicycles, appreciated for their retro-look and style. Its country of origin had probably helped them exporting their products as their bicycles were 100% made in Italy and the Made in Italy label had a reputation of high quality, craftsmanship and creativity. Yet their profit margins were relatively low as their manufacturing costs were very high. Should they outsource their production? If so, to China or to Eastern Europe? Was there some other way to improve the profitability of the company?
- Published
- 2011
42. On Two Wheels in Paris: The Velib' Bicycle-Sharing Program (Supplement)
- Author
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Elena Corsi, Peter A. Coles, Elena Corsi, and Peter A. Coles
- Abstract
French advertising company JCDecaux and the city of Paris jointly developed V lib', a wildly popular bicycle sharing system. Despite V lib's public appeal, vandalism and theft led to ballooning operating costs-costs borne by JCDecaux alone. The two parties opted to renegotiate their contract, which would impact prices, revenue sharing, cost allocation, and the operation of the system as a whole. Could the parties agree on a common strategy that would meet their objectives, while still delivering a first class bicycle sharing service to the city of Paris?
- Published
- 2011
43. On Two Wheels in Paris: The Velib' Bicycle-Sharing Program
- Author
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Elena Corsi, Peter A. Coles, Vincent Dessain, Elena Corsi, Peter A. Coles, and Vincent Dessain
- Abstract
French advertising company JCDecaux and the city of Paris jointly developed V lib', a wildly popular bicycle sharing system. Despite V lib's public appeal, vandalism and theft led to ballooning operating costs-costs borne by JCDecaux alone. The two parties opted to renegotiate their contract, which would impact prices, revenue sharing, cost allocation, and the operation of the system as a whole. Could the parties agree on a common strategy that would meet their objectives, while still delivering a first class bicycle sharing service to the city of Paris?
- Published
- 2011
44. The Eleganzia Group
- Author
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Bharat Sajnani, Elena Corsi, Elie Ofek, Francesco Tronci, Sorina Casian-Botez, Bharat Sajnani, Elena Corsi, Elie Ofek, Francesco Tronci, and Sorina Casian-Botez
- Abstract
Eleganzia Group management faces tough decisions heading into the summer of 2010. With tourism on the decline due to the global economic recession, General Manager Giannuzzi must decide how to set prices at the Forte Village Resort, the Group's most well-known property. His management team is further divided on whether the pricing model at the resort should change to being all-inclusive (as opposed to one where guests are charged for each additional activity or dining option on a pay-as-you-go basis), and whether to convert a large number of the 4-star rooms into 5-star suites. Recently acquired properties, such as the Castel Monastero in Tuscany and the Maddalena Hotel & Yacht Club in north Sardinia, pose a branding challenge. Can all the properties, including the Forte Village, be successfully brought under one umbrella brand, namely, Eleganzia? Moreover, what should the character of each these new properties be?
- Published
- 2011
45. Santander Consumer Finance
- Author
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Andrew Barron, Elena Corsi, Gunnar Trumbull, Andrew Barron, Elena Corsi, and Gunnar Trumbull
- Abstract
A Spanish company has to decide if they should expand into the fragmented European consumer finance market and has to make important organizational strategy decisions, in the midst of the world economic downturn that followed the 2007 US credit crunch. Since 2002, the consumer finance branch of the Spanish banking Grupo Santander, Santander Consumer Finance (SCF) had grown into one of the largest European consumer finance companies capturing the recent growth in Europe of the consumer finance market. Against a background of growing concern about the sustainability of household debt levels in Europe and the United States, in 2008 the new CEO, Magda Salarich Fern ndez de Valderrama, had to decide if this was the right time to expand or if instead she should focus on consolidation. She was also facing important organizational strategy decisions. Which functions should be left to national affiliates to decide, and which should be centralized at headquarters? What processes should be standardized, and which left to local initiatives?
- Published
- 2010
46. ABB: 'In China, for China'
- Author
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Elena Corsi, Elisa Farri, Gunnar Trumbull, Elena Corsi, Elisa Farri, and Gunnar Trumbull
- Abstract
ABB, a power and automation Swiss engineering company had to decide if they wanted to be even more integrated into the Chinese economy, ABB's biggest market, or if they should instead increase their presence in other emerging markets such as India and Brazil.
- Published
- 2010
47. Décentralisation et réduction de la pauvreté
- Author
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Johannes P. Jütting, Elena Corsi, and Albrecht Stockmayer
- Abstract
La decentralisation occupe depuis ces 20 dernieres annees une place centrale dans les politiques de developpement. Si l’on discute depuis quelque temps deja des avantages et des risques du transfert du pouvoir et des ressources a des echelons locaux de gouvernement, on commence tout juste a s’interesser au rapport entre la decentralisation et la reduction de la pauvrete. Cette edition des Reperes met en evidence les principaux determinants d’un processus de decentralisation favorable aux pauvres et discute des grandes lecons tirees par les bailleurs de fonds.
- Published
- 2005
48. Decentralisation and Poverty Reduction
- Author
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Albrecht Stockmayer, Elena Corsi, and Johannes P. Jütting
- Subjects
Government ,Poverty reduction ,Political science ,Development economics ,Decentralization ,Development policy - Abstract
Decentralisation has become a key issue in development policy in the past two decades. Whereas the advantages and risks of transferring power and resources to local tiers of government have been debated for quite some time, it is only very recently that the linkages between decentralization and poverty reduction have been addressed. This Policy Insight highlights key determinants for a pro-poor decentralisation process and discusses major lessons learnt for donors.
- Published
- 2005
49. Gucci Group: Freedom Within the Framework
- Author
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Elena Corsi, F. Asis Martinez-Jerez, Vincent Dessain, Elena Corsi, F. Asis Martinez-Jerez, and Vincent Dessain
- Abstract
Gucci Group's CEO had to decide if his decentralized management style was the most effective philosophy in an economic downturn. The sharing of customer information across units and its use in the creative process are key initiatives analyzed in the case. CEO Robert Polet joined the high-end fashion Gucci Group in 2004, after 26 years at one of the largest consumer goods companies. Since his arrival, the Group had grown both in revenues and profitability. Part of his secret was his decentralized and empowering management style. In 2008, in the midst of the economic downturn following the credit crunch crisis, Polet learned that after four years of growth the Gucci brand-the Group's largest business-would report a slowdown for the year's first semester. He knew that according to his management philosophy he should leave the primary decisions for the Gucci brand to Gucci's CEO. Yet, given the urgency of the situation, Polet wondered if it would be more effective to become directly involved in the brand's decision-making process. To anchor the discussion on Polet's management style, the case discusses how customer information is used in the creative process and whether it would be beneficial for the group to share customer information across stores, regions, and brands.
- Published
- 2009
50. Tenova: Mining for Growth in Economic Crisis
- Author
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Elena Corsi, Elisa Farri, Gary P. Pisano, Elena Corsi, Elisa Farri, and Gary P. Pisano
- Abstract
In December 2008, Gianluigi Nova, CEO of Tenova SpA, a technology and equipment supplier to the metals and mining industry, had to choose between two options. The first was to continue growing in the company's core business: equipment for the steel production. The second option offered growth in a related, but nearly new business for Tenova: the equipment for mining, mineral processing and extractive metallurgy. They only had a small presence in this market. Yet, Nova had to cope with the worldwide economic crisis whose destructive power hit every area of the metals and mining industry. Nova had to decide which option offered the best opportunity to grow in the worst economic crisis since 1929.
- Published
- 2009
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