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The aim of the study is assess the reliability, internal stability and effectiveness of adaptation of individual questions of the QAA-25 questionnaire to assess the potential adherence to treatment of persons aged 12–14 years, in comparison with a similar QAA-25 questionnaire for persons aged 15–17 years. Material and Methods. In a descriptive observational study, including 314 students of general schools in Omsk the level of treatment adherence was determined using the QAA-25 questionnaire, using traditional and alternative formulations of individual questions. Results. For adolescents aged 12–14 years a good diagnostic value was shown higher individual testing quality (absence of blank answers to questions) of the tested version of the questionnaire compared to the alternative one. 96.8% of respondents indicated that the wording of the specialized questionnaire was “more accurate” and “more correct”. The tested version of the questionnaire demonstrated good reliability (Cronbach’s alpha total 0.901, based on standardized items αst 0.914) with high internal consistency (consistent elimination of scale items maintains questionnaire validity in the 0.886–0.909 range), with near perfect expert agreement (Cohen’s kappa 0.908). Conclusion. The questionnaire is characterized by good validity and has a high internal stability, and the content and wording of all questions of the questionnaire are adequately perceived by the audience for which the questionnaire is designed. This makes it advisable to use it to assess the potential adherence to treatment of adolescents aged 12–14 years.

A growth of antibiotic-resistant Pseudomonas aeruginosa from patients with cystic fibrosis decreases a lung function significantly, which requires searching new, up-to-date antibiotics. Goal. An investigation of clinical and microbiological features of respiratory lesion and an assessment of elimination therapy at chronic P. aeruginosa infection in children on the example of the Regional Cystic Fibrosis Center. Materials and methods. A retrospective analysis of case histories of children at the Omsk Cystic Fibrosis Center (n=48) was performed, with evaluation of clinical and functional parameters depending on age and microbiological status of respiratory airways. The comparative evaluation of two drugs inhaled tobramycin Bramitob and Tobramycin-Gobbi efficiency was performed. Results. An association of microorganisms was identified from the majority of bacterial cultures of cystic fibrosis patients’ sputum (66.7%). Staphylococcus aureus (18.9%) and P. aeruginosa (16.6%) with the significant prevalence of non-mucoid forms were in the lead at the group of clinically relevant pathogens. From 2011 to 2016 amount of P. aeruginosa strains, which were sensitive to the all usable antibiotics, decreased, an especially significant decline of sensitivity was registered to amikacin (32.7%) and сiprofloxacin (48.6%). Children infected with P. aeruginosa had a lot more deviations of lung function measured by the computed bronchophonography and spirometry, they more often had changes in chest computed tomography than patients free of P. aeruginosa infection. Change from inhaled tobramycin Bramitob into inhaled tobramycin Tobramycin-Gobbi in the patients’ treatment didn’t lead to the elevation of respiratory syndrome exacerbation rates, didn’t increase requirement in the intravenous antibacterial treatment and didn’t influence to the rank of microbial colonization of sputum. Conclusion. In length of time, the increase of P. aeruginosa resistance to antipseudomonal antibiotics is observed, which makes reasonable the introduction high-concentrated forms of antibiotics. The replacement of inhaled tobramycin from Bramitob to Tobramycin-Gobbi didn’t cause the impairment of patients’ clinical and functional condition and didn’t change the microbiological status.