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1. Identifying and describing cancer survivors: Implications for cancer survivorship research and clinical care

Author

Doose, Michelle, Mollica, Michelle A, Attai, Deanna J, Nasso, Shelley Fuld, Elena, Joanne W, Jacobsen, Paul B, Tonorezos, Emily S, and Nekhlyudov, Larissa

Subjects
Health Services and Systems, Nursing, Health Sciences, Cancer, Rehabilitation, 7.1 Individual care needs, Management of diseases and conditions, Cancer Survivors, Cross-Sectional Studies, Humans, Neoplasms, Surveys and Questionnaires, Survivors, United States, cancer survivors, cross-sectional studies, health surveys, surveys and questionnaires, Oncology and Carcinogenesis, Public Health and Health Services, Oncology & Carcinogenesis, Oncology and carcinogenesis, Public health
Abstract

BackgroundGathering information directly from cancer survivors has advanced our understanding of the cancer survivorship experience. However, it is unknown whether surveys can distinguish important subgroups of cancer survivors. This study aimed to describe the current landscape of survey questions used to identify and describe cancer survivors in national cross-sectional studies.MethodsUsing publicly available databases, the authors identified national cross-sectional surveys used in the United States within the past 15 years that included a question on self-reported history of cancer. After abstracting questions and response items used to identify cancer survivors, they conducted a descriptive analysis.ResultsThe authors identified 14 national cross-sectional surveys, with half administered to the general population and the other half administered to cancer survivors. The most common question used to identify cancer survivors was "Have you ever been told by a doctor or other health professional that you had cancer?" Most surveys had questions asking participants to identify a single cancer type (n = 11), multiple prior cancer diagnoses or types (n = 11), and the time from diagnosis (n = 12). Treatment questions varied from active treatment status to specific treatments received. Questions addressing cancer stage (n = 2), subtypes (n = 1), metastatic status (n = 3), and recurrence (n = 4) were less frequently included.ConclusionsThere is no standard method for assessing self-reported cancer history, and this limits the ability to distinguish among potentially important subgroups of survivors. Future cross-sectional surveys that capture nuanced data elements, such as cancer types, stages/subtypes, metastatic/recurrent status, and treatments received, can help to fill important gaps in cancer survivorship research and clinical care.

Published
2022

3. Cancer Epidemiology in Hispanic Populations: Needs and Opportunities.

Author

Naoko Ishibe, Elena, Joanne W., Gallicchio, Lisa, Kennedy, Amy E., Akif, Kaitlin E., Hanisch, Rachel, Lai, Gabriel Y., Mahabir, Somdat, Martin, Damali N., Pottinger, Camille A., Yu, Catherine T., Srinivasan, Shobha, and Tram Kim Lam

Abstract

This report provides a summary of the identified evidence gaps and a general discussion of the next steps to advance cancer epidemiology research in Hispanic/Latino (H/L) populations based partly on the workshop, "Cancer Epidemiology in Hispanic Populations," convened by the NCI in September 2021. The cancer burden among H/L populations varies greatly by nativity and country of origin, yet this variation is not often captured due to systemic challenges in how racial/ethnic data have been collected and often reported in aggregate for this heterogeneous population. Developing culturally relevant assessment tools, increasing the representation of H/L participants, and adopting appropriate methodologic approaches are critical to enhancing cancer research. There is a variety of current funding mechanisms that may be used to address these evidence gaps and priorities, including investigator-initiated mechanisms. Cancer epidemiologic research in H/L populations should leverage existing resources where possible. New and ongoing studies should collect information on nativity status, country of origin, and related measures, use culturally specific assessment tools, engage in collaborative science, and maintain strong community engagement to build studies that will meaningfully address the cancer burden experienced by the growing H/L population. [ABSTRACT FROM AUTHOR]

Published
2024
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4. Imputation and subset-based association analysis across different cancer types identifies multiple independent risk loci in the TERT-CLPTM1L region on chromosome 5p15.33

Author

Wang, Zhaoming, Zhu, Bin, Zhang, Mingfeng, Parikh, Hemang, Jia, Jinping, Chung, Charles C, Sampson, Joshua N, Hoskins, Jason W, Hutchinson, Amy, Burdette, Laurie, Ibrahim, Abdisamad, Hautman, Christopher, Raj, Preethi S, Abnet, Christian C, Adjei, Andrew A, Ahlbom, Anders, Albanes, Demetrius, Allen, Naomi E, Ambrosone, Christine B, Aldrich, Melinda, Amiano, Pilar, Amos, Christopher, Andersson, Ulrika, Andriole, Gerald, Andrulis, Irene L, Arici, Cecilia, Arslan, Alan A, Austin, Melissa A, Baris, Dalsu, Barkauskas, Donald A, Bassig, Bryan A, Beane Freeman, Laura E, Berg, Christine D, Berndt, Sonja I, Bertazzi, Pier Alberto, Biritwum, Richard B, Black, Amanda, Blot, William, Boeing, Heiner, Boffetta, Paolo, Bolton, Kelly, Boutron-Ruault, Marie-Christine, Bracci, Paige M, Brennan, Paul, Brinton, Louise A, Brotzman, Michelle, Bueno-de-Mesquita, H Bas, Buring, Julie E, Butler, Mary Ann, Cai, Qiuyin, Cancel-Tassin, Geraldine, Canzian, Federico, Cao, Guangwen, Caporaso, Neil E, Carrato, Alfredo, Carreon, Tania, Carta, Angela, Chang, Gee-Chen, Chang, I-Shou, Chang-Claude, Jenny, Che, Xu, Chen, Chien-Jen, Chen, Chih-Yi, Chen, Chung-Hsing, Chen, Constance, Chen, Kuan-Yu, Chen, Yuh-Min, Chokkalingam, Anand P, Chu, Lisa W, Clavel-Chapelon, Francoise, Colditz, Graham A, Colt, Joanne S, Conti, David, Cook, Michael B, Cortessis, Victoria K, Crawford, E David, Cussenot, Olivier, Davis, Faith G, De Vivo, Immaculata, Deng, Xiang, Ding, Ti, Dinney, Colin P, Di Stefano, Anna Luisa, Diver, W Ryan, Duell, Eric J, Elena, Joanne W, Fan, Jin-Hu, Feigelson, Heather Spencer, Feychting, Maria, Figueroa, Jonine D, Flanagan, Adrienne M, Fraumeni, Joseph F, Freedman, Neal D, Fridley, Brooke L, Fuchs, Charles S, Gago-Dominguez, Manuela, Gallinger, Steven, Gao, Yu-Tang, Gapstur, Susan M, and Garcia-Closas, Montserrat

Subjects
Biological Sciences, Genetics, Human Genome, Cancer, Prevention, 2.1 Biological and endogenous factors, Alleles, Chromosomes, Human, Pair 5, Computational Biology, DNA Methylation, Epigenesis, Genetic, Female, Gene Expression Regulation, Neoplastic, Gene Frequency, Genetic Loci, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Male, Membrane Proteins, Neoplasm Proteins, Neoplasms, Odds Ratio, Polymorphism, Single Nucleotide, Risk, Telomerase, Medical and Health Sciences, Genetics & Heredity
Abstract

Genome-wide association studies (GWAS) have mapped risk alleles for at least 10 distinct cancers to a small region of 63 000 bp on chromosome 5p15.33. This region harbors the TERT and CLPTM1L genes; the former encodes the catalytic subunit of telomerase reverse transcriptase and the latter may play a role in apoptosis. To investigate further the genetic architecture of common susceptibility alleles in this region, we conducted an agnostic subset-based meta-analysis (association analysis based on subsets) across six distinct cancers in 34 248 cases and 45 036 controls. Based on sequential conditional analysis, we identified as many as six independent risk loci marked by common single-nucleotide polymorphisms: five in the TERT gene (Region 1: rs7726159, P = 2.10 × 10(-39); Region 3: rs2853677, P = 3.30 × 10(-36) and PConditional = 2.36 × 10(-8); Region 4: rs2736098, P = 3.87 × 10(-12) and PConditional = 5.19 × 10(-6), Region 5: rs13172201, P = 0.041 and PConditional = 2.04 × 10(-6); and Region 6: rs10069690, P = 7.49 × 10(-15) and PConditional = 5.35 × 10(-7)) and one in the neighboring CLPTM1L gene (Region 2: rs451360; P = 1.90 × 10(-18) and PConditional = 7.06 × 10(-16)). Between three and five cancers mapped to each independent locus with both risk-enhancing and protective effects. Allele-specific effects on DNA methylation were seen for a subset of risk loci, indicating that methylation and subsequent effects on gene expression may contribute to the biology of risk variants on 5p15.33. Our results provide strong support for extensive pleiotropy across this region of 5p15.33, to an extent not previously observed in other cancer susceptibility loci.

Published
2014

5. Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer

Author

Wolpin, Brian M, Rizzato, Cosmeri, Kraft, Peter, Kooperberg, Charles, Petersen, Gloria M, Wang, Zhaoming, Arslan, Alan A, Beane-Freeman, Laura, Bracci, Paige M, Buring, Julie, Canzian, Federico, Duell, Eric J, Gallinger, Steven, Giles, Graham G, Goodman, Gary E, Goodman, Phyllis J, Jacobs, Eric J, Kamineni, Aruna, Klein, Alison P, Kolonel, Laurence N, Kulke, Matthew H, Li, Donghui, Malats, Núria, Olson, Sara H, Risch, Harvey A, Sesso, Howard D, Visvanathan, Kala, White, Emily, Zheng, Wei, Abnet, Christian C, Albanes, Demetrius, Andreotti, Gabriella, Austin, Melissa A, Barfield, Richard, Basso, Daniela, Berndt, Sonja I, Boutron-Ruault, Marie-Christine, Brotzman, Michelle, Büchler, Markus W, Bueno-de-Mesquita, H Bas, Bugert, Peter, Burdette, Laurie, Campa, Daniele, Caporaso, Neil E, Capurso, Gabriele, Chung, Charles, Cotterchio, Michelle, Costello, Eithne, Elena, Joanne, Funel, Niccola, Gaziano, J Michael, Giese, Nathalia A, Giovannucci, Edward L, Goggins, Michael, Gorman, Megan J, Gross, Myron, Haiman, Christopher A, Hassan, Manal, Helzlsouer, Kathy J, Henderson, Brian E, Holly, Elizabeth A, Hu, Nan, Hunter, David J, Innocenti, Federico, Jenab, Mazda, Kaaks, Rudolf, Key, Timothy J, Khaw, Kay-Tee, Klein, Eric A, Kogevinas, Manolis, Krogh, Vittorio, Kupcinskas, Juozas, Kurtz, Robert C, LaCroix, Andrea, Landi, Maria T, Landi, Stefano, Le Marchand, Loic, Mambrini, Andrea, Mannisto, Satu, Milne, Roger L, Nakamura, Yusuke, Oberg, Ann L, Owzar, Kouros, Patel, Alpa V, Peeters, Petra HM, Peters, Ulrike, Pezzilli, Raffaele, Piepoli, Ada, Porta, Miquel, Real, Francisco X, Riboli, Elio, Rothman, Nathaniel, Scarpa, Aldo, Shu, Xiao-Ou, Silverman, Debra T, Soucek, Pavel, Sund, Malin, Talar-Wojnarowska, Renata, Taylor, Philip R, and Theodoropoulos, George E

Subjects
Cancer, Aged, Case-Control Studies, Female, Genetic Loci, Genetic Predisposition to Disease, Genome-Wide Association Study, Genotype, Humans, Male, Middle Aged, Pancreatic Neoplasms, Polymorphism, Single Nucleotide, White People, Biological Sciences, Medical and Health Sciences, Developmental Biology
Abstract

We performed a multistage genome-wide association study including 7,683 individuals with pancreatic cancer and 14,397 controls of European descent. Four new loci reached genome-wide significance: rs6971499 at 7q32.3 (LINC-PINT, per-allele odds ratio (OR) = 0.79, 95% confidence interval (CI) 0.74-0.84, P = 3.0 × 10(-12)), rs7190458 at 16q23.1 (BCAR1/CTRB1/CTRB2, OR = 1.46, 95% CI 1.30-1.65, P = 1.1 × 10(-10)), rs9581943 at 13q12.2 (PDX1, OR = 1.15, 95% CI 1.10-1.20, P = 2.4 × 10(-9)) and rs16986825 at 22q12.1 (ZNRF3, OR = 1.18, 95% CI 1.12-1.25, P = 1.2 × 10(-8)). We identified an independent signal in exon 2 of TERT at the established region 5p15.33 (rs2736098, OR = 0.80, 95% CI 0.76-0.85, P = 9.8 × 10(-14)). We also identified a locus at 8q24.21 (rs1561927, P = 1.3 × 10(-7)) that approached genome-wide significance located 455 kb telomeric of PVT1. Our study identified multiple new susceptibility alleles for pancreatic cancer that are worthy of follow-up studies.

Published
2014

7. Epidemiology

Author

Rowland, Julia H., Mariotto, Angela B., Elena, Joanne W., Feuerstein, Michael, editor, and Nekhlyudov, Larissa, editor

Published
2018
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8. Genome-wide association study of survival in patients with pancreatic adenocarcinoma

Author

Wu, Chen, Kraft, Peter, Stolzenberg-Solomon, Rachael, Steplowski, Emily, Brotzman, Michelle, Xu, Mousheng, Mudgal, Poorva, Amundadottir, Laufey, Arslan, Alan A, Bueno-de-Mesquita, H Bas, Gross, Myron, Helzlsouer, Kathy, Jacobs, Eric J, Kooperberg, Charles, Petersen, Gloria M, Zheng, Wei, Albanes, Demetrius, Boutron-Ruault, Marie-Christine, Buring, Julie E, Canzian, Federico, Cao, Guangwen, Duell, Eric J, Elena, Joanne W, Gaziano, J Michael, Giovannucci, Edward L, Hallmans, Goran, Hutchinson, Amy, Hunter, David J, Jenab, Mazda, Jiang, Guoliang, Khaw, Kay-Tee, LaCroix, Andrea, Li, Zhaoshen, Mendelsohn, Julie B, Panico, Salvatore, Patel, Alpa V, Qian, Zhi Rong, Riboli, Elio, Sesso, Howard, Shen, Hongbing, Shu, Xiao-Ou, Tjonneland, Anne, Tobias, Geoffrey S, Trichopoulos, Dimitrios, Virtamo, Jarmo, Visvanathan, Kala, Wactawski-Wende, Jean, Wang, Chengfeng, Yu, Kai, Zeleniuch-Jacquotte, Anne, Chanock, Stephen, Hoover, Robert, Hartge, Patricia, Fuchs, Charles S, Lin, Dongxin, and Wolpin, Brian M

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Cancer, Digestive Diseases, Prevention, Rare Diseases, Pancreatic Cancer, Genetics, Human Genome, Aetiology, 2.1 Biological and endogenous factors, Adenocarcinoma, Adult, Aged, Aged, 80 and over, Asian People, Biomarkers, Tumor, China, Europe, Female, Follow-Up Studies, Genome-Wide Association Study, Humans, Kaplan-Meier Estimate, Male, Middle Aged, Models, Genetic, Pancreatic Neoplasms, Polymorphism, Single Nucleotide, Principal Component Analysis, Proportional Hazards Models, Protein Tyrosine Phosphatases, Non-Receptor, Survival Rate, White People, Cancer Genetics, Molecular Epidemiology, Clinical Sciences, Paediatrics and Reproductive Medicine, Gastroenterology & Hepatology, Clinical sciences, Nutrition and dietetics
Abstract

Background and objectiveSurvival of patients with pancreatic adenocarcinoma is limited and few prognostic factors are known. We conducted a two-stage genome-wide association study (GWAS) to identify germline variants associated with survival in patients with pancreatic adenocarcinoma.MethodsWe analysed overall survival in relation to single nucleotide polymorphisms (SNPs) among 1005 patients from two large GWAS datasets, PanScan I and ChinaPC. Cox proportional hazards regression was used in an additive genetic model with adjustment for age, sex, clinical stage and the top four principal components of population stratification. The first stage included 642 cases of European ancestry (PanScan), from which the top SNPs (p≤10(-5)) were advanced to a joint analysis with 363 additional patients from China (ChinaPC).ResultsIn the first stage of cases of European descent, the top-ranked loci were at chromosomes 11p15.4, 18p11.21 and 1p36.13, tagged by rs12362504 (p=1.63×10(-7)), rs981621 (p=1.65×10(-7)) and rs16861827 (p=3.75×10(-7)), respectively. 131 SNPs with p≤10(-5) were advanced to a joint analysis with cases from the ChinaPC study. In the joint analysis, the top-ranked SNP was rs10500715 (minor allele frequency, 0.37; p=1.72×10(-7)) on chromosome 11p15.4, which is intronic to the SET binding factor 2 (SBF2) gene. The HR (95% CI) for death was 0.74 (0.66 to 0.84) in PanScan I, 0.79 (0.65 to 0.97) in ChinaPC and 0.76 (0.68 to 0.84) in the joint analysis.ConclusionsGermline genetic variation in the SBF2 locus was associated with overall survival in patients with pancreatic adenocarcinoma of European and Asian ancestry. This association should be investigated in additional large patient cohorts.

Published
2014

9. Polymorphisms in genes related to one-carbon metabolism are not related to pancreatic cancer in PanScan and PanC4

Author

Leenders, Max, Bhattacharjee, Samsiddhi, Vineis, Paolo, Stevens, Victoria, Bueno-de-Mesquita, H Bas, Shu, Xiao-Ou, Amundadottir, Laufey, Gross, Myron, Tobias, Geoffrey S, Wactawski-Wende, Jean, Arslan, Alan A, Duell, Eric J, Fuchs, Charles S, Gallinger, Steven, Hartge, Patricia, Hoover, Robert N, Holly, Elizabeth A, Jacobs, Eric J, Klein, Alison P, Kooperberg, Charles, LaCroix, Andrea, Li, Donghui, Mandelson, Margaret T, Olson, Sara H, Petersen, Gloria, Risch, Harvey A, Yu, Kai, Wolpin, Brian M, Zheng, Wei, Agalliu, Ilir, Albanes, Demetrius, Boutron-Ruault, Marie-Christine, Bracci, Paige M, Buring, Julie E, Canzian, Federico, Chang, Kenneth, Chanock, Stephen J, Cotterchio, Michelle, Gaziano, J Michael, Giovanucci, Edward L, Goggins, Michael, Hallmans, Göran, Hankinson, Susan E, Hoffman-Bolton, Judith A, Hunter, David J, Hutchinson, Amy, Jacobs, Kevin B, Jenab, Mazda, Khaw, Kay-Tee, Kraft, Peter, Krogh, Vittorio, Kurtz, Robert C, McWilliams, Robert R, Mendelsohn, Julie B, Patel, Alpa V, Rabe, Kari G, Riboli, Elio, Tjønneland, Anne, Trichopoulos, Dimitrios, Virtamo, Jarmo, Visvanathan, Kala, Elena, Joanne W, Yu, Herbert, Zeleniuch-Jacquotte, Anne, and Stolzenberg-Solomon, Rachael Z

Subjects
Epidemiology, Biomedical and Clinical Sciences, Health Sciences, Oncology and Carcinogenesis, Cancer, Digestive Diseases, Genetics, Pancreatic Cancer, Prevention, Rare Diseases, Aetiology, 2.1 Biological and endogenous factors, Carbon, Case-Control Studies, Cohort Studies, Germ-Line Mutation, Humans, Pancreatic Neoplasms, Polymorphism, Single Nucleotide, United States, Pancreatic cancer, One-carbon metabolism, Polymorphisms, Biomarkers, Public Health and Health Services, Oncology and carcinogenesis
Abstract

PurposeThe evidence of a relation between folate intake and one-carbon metabolism (OCM) with pancreatic cancer (PanCa) is inconsistent. In this study, the association between genes and single-nucleotide polymorphisms (SNPs) related to OCM and PanCa was assessed.MethodsUsing biochemical knowledge of the OCM pathway, we identified thirty-seven genes and 834 SNPs to examine in association with PanCa. Our study included 1,408 cases and 1,463 controls nested within twelve cohorts (PanScan). The ten SNPs and five genes with lowest p values (

Published
2013

10. Diabetes and risk of pancreatic cancer: a pooled analysis from the pancreatic cancer cohort consortium

Author

Elena, Joanne W, Steplowski, Emily, Yu, Kai, Hartge, Patricia, Tobias, Geoffrey S, Brotzman, Michelle J, Chanock, Stephen J, Stolzenberg-Solomon, Rachael Z, Arslan, Alan A, Bueno-de-Mesquita, H Bas, Helzlsouer, Kathy, Jacobs, Eric J, LaCroix, Andrea, Petersen, Gloria, Zheng, Wei, Albanes, Demetrius, Allen, Naomi E, Amundadottir, Laufey, Bao, Ying, Boeing, Heiner, Boutron-Ruault, Marie-Christine, Buring, Julie E, Gaziano, J Michael, Giovannucci, Edward L, Duell, Eric J, Hallmans, Göran, Howard, Barbara V, Hunter, David J, Hutchinson, Amy, Jacobs, Kevin B, Kooperberg, Charles, Kraft, Peter, Mendelsohn, Julie B, Michaud, Dominique S, Palli, Domenico, Phillips, Lawrence S, Overvad, Kim, Patel, Alpa V, Sansbury, Leah, Shu, Xiao-Ou, Simon, Michael S, Slimani, Nadia, Trichopoulos, Dimitrios, Visvanathan, Kala, Virtamo, Jarmo, Wolpin, Brian M, Zeleniuch-Jacquotte, Anne, Fuchs, Charles S, Hoover, Robert N, and Gross, Myron

Subjects
Biomedical and Clinical Sciences, Epidemiology, Health Services and Systems, Health Sciences, Oncology and Carcinogenesis, Obesity, Rare Diseases, Digestive Diseases, Pancreatic Cancer, Prevention, Cancer, Diabetes, 2.1 Biological and endogenous factors, Good Health and Well Being, Adenocarcinoma, Adult, Aged, Aged, 80 and over, Case-Control Studies, Cohort Studies, Diabetes Complications, Diabetes Mellitus, Female, Humans, Male, Middle Aged, Pancreatic Neoplasms, Risk Factors, Public Health and Health Services, Oncology and carcinogenesis
Abstract

PurposeDiabetes is a suspected risk factor for pancreatic cancer, but questions remain about whether it is a risk factor or a result of the disease. This study prospectively examined the association between diabetes and the risk of pancreatic adenocarcinoma in pooled data from the NCI pancreatic cancer cohort consortium (PanScan).MethodsThe pooled data included 1,621 pancreatic adenocarcinoma cases and 1,719 matched controls from twelve cohorts using a nested case-control study design. Subjects who were diagnosed with diabetes near the time (

Published
2013

12. Supplementary Figure 1 from Pooling Prospective Studies to Investigate the Etiology of Second Cancers

Author

Black, Amanda, primary, Gibson, Todd M., primary, Shiels, Meredith S., primary, Park, Yikyung, primary, Robien, Kim, primary, Albanes, Demetrius, primary, Weinstein, Stephanie J., primary, Freeman, Laura E. Beane, primary, Andreotti, Gabriella, primary, Purdue, Mark P., primary, Fraumeni, Joseph F., primary, Hartge, Patricia, primary, Tucker, Margaret A., primary, Hoover, Robert N., primary, Cerhan, James R., primary, Zeleniuch-Jacquotte, Anne, primary, Curtis, Rochelle E., primary, Elena, Joanne, primary, Sampson, Joshua N., primary, de Gonzalez, Amy Berrington, primary, and Morton, Lindsay M., primary

Published
2023
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14. Data from Pooling Prospective Studies to Investigate the Etiology of Second Cancers

Author

Black, Amanda, primary, Gibson, Todd M., primary, Shiels, Meredith S., primary, Park, Yikyung, primary, Robien, Kim, primary, Albanes, Demetrius, primary, Weinstein, Stephanie J., primary, Freeman, Laura E. Beane, primary, Andreotti, Gabriella, primary, Purdue, Mark P., primary, Fraumeni, Joseph F., primary, Hartge, Patricia, primary, Tucker, Margaret A., primary, Hoover, Robert N., primary, Cerhan, James R., primary, Zeleniuch-Jacquotte, Anne, primary, Curtis, Rochelle E., primary, Elena, Joanne, primary, Sampson, Joshua N., primary, de Gonzalez, Amy Berrington, primary, and Morton, Lindsay M., primary

Published
2023
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15. Supplementary Materials and Methods, Supplementary Table 1, Supplementary Figure 1, and Supplementary Figure 2 from The Cancer Epidemiology Descriptive Cohort Database: A Tool to Support Population-Based Interdisciplinary Research

Author

Kennedy, Amy E., primary, Khoury, Muin J., primary, Ioannidis, John P.A., primary, Brotzman, Michelle, primary, Miller, Amy, primary, Lane, Crystal, primary, Lai, Gabriel Y., primary, Rogers, Scott D., primary, Harvey, Chinonye, primary, Elena, Joanne W., primary, and Seminara, Daniela, primary

Published
2023
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16. Supplementary Tables 1 - 3 from Pooling Prospective Studies to Investigate the Etiology of Second Cancers

Author

Black, Amanda, primary, Gibson, Todd M., primary, Shiels, Meredith S., primary, Park, Yikyung, primary, Robien, Kim, primary, Albanes, Demetrius, primary, Weinstein, Stephanie J., primary, Freeman, Laura E. Beane, primary, Andreotti, Gabriella, primary, Purdue, Mark P., primary, Fraumeni, Joseph F., primary, Hartge, Patricia, primary, Tucker, Margaret A., primary, Hoover, Robert N., primary, Cerhan, James R., primary, Zeleniuch-Jacquotte, Anne, primary, Curtis, Rochelle E., primary, Elena, Joanne, primary, Sampson, Joshua N., primary, de Gonzalez, Amy Berrington, primary, and Morton, Lindsay M., primary

Published
2023
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17. Cancer Epidemiology in Hispanic Populations: An Analysis of Funded Observational Research at the National Cancer Institute

Author

Elena, Joanne W., primary, Gallicchio, Lisa, additional, Pottinger, Camille A., additional, Akif, Kaitlin E., additional, Hanisch, Rachel, additional, Kennedy, Amy E., additional, Lai, Gabriel Y., additional, Mahabir, Somdat, additional, Martin, Damali N., additional, Srinivasan, Shobha, additional, Yu, Catherine T., additional, and Lam, Tram Kim., additional

Published
2023
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24. Evidence Gaps in Cancer Survivorship Care: A Report From the 2019 National Cancer Institute Cancer Survivorship Workshop

Author

Gallicchio, Lisa, primary, Tonorezos, Emily, additional, de Moor, Janet S, additional, Elena, Joanne, additional, Farrell, Margaret, additional, Green, Paige, additional, Mitchell, Sandra A, additional, Mollica, Michelle A, additional, Perna, Frank, additional, Saiontz, Nicole Gottlieb, additional, Zhu, Li, additional, Rowland, Julia, additional, and Mayer, Deborah K, additional

Published
2021
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25. Leveraging Epidemiology and Clinical Studies of Cancer Outcomes: Recommendations and Opportunities for Translational Research

Author

Elena, Joanne W., Travis, Lois B., Simonds, Naoko I., Ambrosone, Christine B., Ballard-Barbash, Rachel, Bhatia, Smita, Cerhan, James R., Hartge, Patricia, Heist, Rebecca S., Kushi, Lawrence H., Lash, Timothy L., Morton, Lindsay M., Onel, Kenan, Pierce, John P., Robison, Leslie L., Rowland, Julia H., Schrag, Deborah, Sellers, Thomas A., Seminara, Daniela, Shu, Xiao Ou, Thomas, Nancy E., Ulrich, Cornelia M., and Freedman, Andrew N.

Published
2013
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26. Utilizing SEER Cancer Registries for Population-Based Cancer Survivor Epidemiologic Studies: A Feasibility Study

Author

Gallicchio, Lisa, primary, Elena, Joanne W., additional, Fagan, Sarah, additional, Carter, Marjorie, additional, Hamilton, Ann S., additional, Hastert, Theresa A., additional, Hunter, Lisa L., additional, Li, Jie, additional, Lynch, Charles F., additional, Milam, Joel, additional, Millar, Morgan M., additional, Modjeski, Denise, additional, Paddock, Lisa E., additional, Reed, Amanda R., additional, Moses, Lisa B., additional, Stroup, Antoinette M., additional, Sweeney, Carol, additional, Trapido, Edward J., additional, West, Michele M., additional, Wu, Xiao-Cheng, additional, and Helzlsouer, Kathy J., additional

Published
2020
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27. Myosteatosis in the Context of Skeletal Muscle Function Deficit: An Interdisciplinary Workshop at the National Institute on Aging

Author

Correa-de-Araujo, Rosaly, primary, Addison, Odessa, additional, Miljkovic, Iva, additional, Goodpaster, Bret H., additional, Bergman, Bryan C., additional, Clark, Richard V., additional, Elena, Joanne W., additional, Esser, Karyn A., additional, Ferrucci, Luigi, additional, Harris-Love, Michael O., additional, Kritchevsky, Steve B., additional, Lorbergs, Amanda, additional, Shepherd, John A., additional, Shulman, Gerald I., additional, and Rosen, Clifford J., additional

Published
2020
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28. Body mass index, weight change, and risk of second primary breast cancer in the <scp>WECARE</scp> study: influence of estrogen receptor status of the first breast cancer

Author

Brooks, Jennifer D., John, Esther M., Mellemkjær, Lene, Lynch, Charles F., Knight, Julia A., Malone, Kathleen E., Reiner, Anne S., Bernstein, Leslie, Liang, Xiaolin, Shore, Roy E., Stovall, Marilyn, Bernstein, Jonine L., Capanu, Marinela, Orlow, Irene, Robson, Mark, Woods, Meghan, Boice, John D., Brooks, Jennifer, Concannon, Patrick, Conti, Dave V., Duggan, David, Elena, Joanne W., Haile, Robert W., Olsen, Jørgen H., Seminara, Daniela, Stram, Daniel O., Tischkowitz, Marc, and Thomas, Duncan C.

Subjects
Adult, Risk, Cancer Research, medicine.medical_specialty, Population, Estrogen receptor, Breast Neoplasms, lcsh:RC254-282, Body Mass Index, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Breast cancer, medicine, Humans, Radiology, Nuclear Medicine and imaging, 030212 general & internal medicine, education, Estrogen Receptor Status, Original Research, Aged, Neoplasm Staging, 2. Zero hunger, Gynecology, education.field_of_study, business.industry, Obstetrics, Body Weight, Weight change, Cancer, Neoplasms, Second Primary, Middle Aged, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, medicine.disease, 3. Good health, Receptors, Estrogen, Oncology, Case-Control Studies, Population Surveillance, 030220 oncology & carcinogenesis, contralateral breast cancer, Female, medicine.symptom, business, Cancer Prevention, Body mass index, Weight gain, estrogen receptor, SEER Program
Abstract

Studies examining the relationship between body mass index (BMI) and risk of contralateral breast cancer (CBC) have reported mixed findings. We previously showed that obese postmenopausal women with estrogen receptor (ER)‐negative breast cancer have a fivefold higher risk of CBC compared with normal weight women. In the current analysis, we reexamined this relationship in the expanded Women's Environmental Cancer and Radiation Epidemiology (WECARE) Study, focusing on the impact of menopausal status and ER status of the first breast cancer. The WECARE Study is a population‐based case–control study of young women with CBC (cases, N = 1386) and with unilateral breast cancer (controls, N = 2045). Rate ratios (RR) and 95% confidence intervals (CI) were calculated to assess the relationship between BMI and risk of CBC stratified by menopausal and ER status. Positive associations with obesity and weight gain were limited to women who became postmenopausal following their first primary breast cancer. Among those with an ER‐negative first breast cancer, obesity (vs. normal weight) at first diagnosis was associated with an increased risk of CBC (RR = 1.9, 95% CI: 1.02, 3.4). Also, weight gain of ≥10 kg after first diagnosis was associated with an almost twofold increased risk of CBC (RR = 1.9, 95% CI: 0.99, 3.8). These results suggest that women with an ER‐negative first primary cancer who are obese at first primary diagnosis or who experience a large weight gain afterward may benefit from heightened surveillance. Future studies are needed to address the impact of weight loss interventions on risk of CBC.

Published
2016
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31. Three new pancreatic cancer susceptibility signals identified on chromosomes 1q32.1, 5p15.33 and 8q24.21

Author

Zhang, Mingfeng, Wang, Zhaoming, Obazee, Ofure, Jia, Jinping, Childs, Erica J., Hoskins, Jason, Figlioli, Gisella, Mocci, Evelina, Collins, Irene, Chung, Charles C., Hautman, Christopher, Arslan, Alan A., Beane-Freeman, Laura, Bracci, Paige M., Buring, Julie, Duell, Eric J., Gallinger, Steven, Giles, Graham G., Goodman, Gary E., Goodman, Phyllis J., Kamineni, Aruna, Kolonel, Laurence N., Kulke, Matthew H., Malats, Nuria, Olson, Sara H., Sesso, Howard D., Visvanathan, Kala, White, Emily, Zheng, Wei, Abnet, Christian C., Albanes, Demetrius, Andreotti, Gabriella, Brais, Lauren, Bueno-de-Mesquita, H. Bas, Basso, Daniela, Berndt, Sonja I., Boutron-Ruault, Marie-Christine, Bijlsma, Maarten F., Brenner, Hermann, Burdette, Laurie, Campa, Daniele, Caporaso, Neil E., Capurso, Gabriele, Cavestro, Giulia Martina, Cotterchio, Michelle, Costello, Eithne, Elena, Joanne, Boggi, Ugo, Gaziano, J. Michael, Gazouli, Maria, Giovannucci, Edward L., Goggins, Michael, Gross, Myron, Haiman, Christopher A., Hassan, Manal, Helzlsouer, Kathy J., Hu, Nan, Hunter, David J., Iskierka-Jazdzewska, Elzbieta, Jenab, Mazda, Kaaks, Rudolf, Key, Timothy J., Khaw, Kay-Tee, Klein, Eric A., Kogevinas, Manolis, Krogh, Vittorio, Kupcinskas, Juozas, Kurtz, Robert C., Landi, Maria T., Landi, Stefano, Le Marchand, Loic, Mambrini, Andrea, Mannisto, Satu, Milne, Roger L., Neale, Rachel E., Oberg, Ann L., Panico, Salvatore, Patel, Alpa V., Peeters, Petra H. M., Peters, Ulrike, Pezzilli, Raffaele, Porta, Miquel, Purdue, Mark, Ramon Quiros, J., Riboli, Elio, Rothman, Nathaniel, Scarpa, Aldo, Scelo, Ghislaine, Shu, Xiao-Ou, Silverman, Debra T., Soucek, Pavel, Strobel, Oliver, Sund, Malin, Malecka-Panas, Ewa, Taylor, Philip R., Tavano, Francesca, Travis, Ruth C., Thornquist, Mark, Tjonneland, Anne, Tobias, Geoffrey S., Trichopoulos, Dimitrios, Vashist, Yogesh, Vodicka, Pavel, Wactawski-Wende, Jean, Wentzensen, Nicolas, Yu, Herbert, Yu, Kai, Zeleniuch-Jacquotte, Anne, Kooperberg, Charles, Risch, Harvey A., Jacobs, Eric J., Li, Donghui, Fuchs, Charles, Hoover, Robert, Hartge, Patricia, Chanock, Stephen J., Petersen, Gloria M., Stolzenberg-Solomon, Rachael S., Wolpin, Brian M., Kraft, Peter, Klein, Alison P., Canzian, Federico, Amundadottir, Laufey T., Zhang, Mingfeng, Wang, Zhaoming, Obazee, Ofure, Jia, Jinping, Childs, Erica J., Hoskins, Jason, Figlioli, Gisella, Mocci, Evelina, Collins, Irene, Chung, Charles C., Hautman, Christopher, Arslan, Alan A., Beane-Freeman, Laura, Bracci, Paige M., Buring, Julie, Duell, Eric J., Gallinger, Steven, Giles, Graham G., Goodman, Gary E., Goodman, Phyllis J., Kamineni, Aruna, Kolonel, Laurence N., Kulke, Matthew H., Malats, Nuria, Olson, Sara H., Sesso, Howard D., Visvanathan, Kala, White, Emily, Zheng, Wei, Abnet, Christian C., Albanes, Demetrius, Andreotti, Gabriella, Brais, Lauren, Bueno-de-Mesquita, H. Bas, Basso, Daniela, Berndt, Sonja I., Boutron-Ruault, Marie-Christine, Bijlsma, Maarten F., Brenner, Hermann, Burdette, Laurie, Campa, Daniele, Caporaso, Neil E., Capurso, Gabriele, Cavestro, Giulia Martina, Cotterchio, Michelle, Costello, Eithne, Elena, Joanne, Boggi, Ugo, Gaziano, J. Michael, Gazouli, Maria, Giovannucci, Edward L., Goggins, Michael, Gross, Myron, Haiman, Christopher A., Hassan, Manal, Helzlsouer, Kathy J., Hu, Nan, Hunter, David J., Iskierka-Jazdzewska, Elzbieta, Jenab, Mazda, Kaaks, Rudolf, Key, Timothy J., Khaw, Kay-Tee, Klein, Eric A., Kogevinas, Manolis, Krogh, Vittorio, Kupcinskas, Juozas, Kurtz, Robert C., Landi, Maria T., Landi, Stefano, Le Marchand, Loic, Mambrini, Andrea, Mannisto, Satu, Milne, Roger L., Neale, Rachel E., Oberg, Ann L., Panico, Salvatore, Patel, Alpa V., Peeters, Petra H. M., Peters, Ulrike, Pezzilli, Raffaele, Porta, Miquel, Purdue, Mark, Ramon Quiros, J., Riboli, Elio, Rothman, Nathaniel, Scarpa, Aldo, Scelo, Ghislaine, Shu, Xiao-Ou, Silverman, Debra T., Soucek, Pavel, Strobel, Oliver, Sund, Malin, Malecka-Panas, Ewa, Taylor, Philip R., Tavano, Francesca, Travis, Ruth C., Thornquist, Mark, Tjonneland, Anne, Tobias, Geoffrey S., Trichopoulos, Dimitrios, Vashist, Yogesh, Vodicka, Pavel, Wactawski-Wende, Jean, Wentzensen, Nicolas, Yu, Herbert, Yu, Kai, Zeleniuch-Jacquotte, Anne, Kooperberg, Charles, Risch, Harvey A., Jacobs, Eric J., Li, Donghui, Fuchs, Charles, Hoover, Robert, Hartge, Patricia, Chanock, Stephen J., Petersen, Gloria M., Stolzenberg-Solomon, Rachael S., Wolpin, Brian M., Kraft, Peter, Klein, Alison P., Canzian, Federico, and Amundadottir, Laufey T.

Abstract

Genome-wide association studies (GWAS) have identified common pancreatic cancer susceptibility variants at 13 chromosomal loci in individuals of European descent. To identify new susceptibility variants, we performed imputation based on 1000 Genomes (1000G) Project data and association analysis using 5,107 case and 8,845 control subjects from 27 cohort and case-control studies that participated in the PanScan I-III GWAS. This analysis, in combination with a two-staged replication in an additional 6,076 case and 7,555 control subjects from the PANcreatic Disease ReseArch (PANDoRA) and Pancreatic Cancer Case-Control (PanC4) Consortia uncovered 3 new pancreatic cancer risk signals marked by single nucleotide polymorphisms (SNPs) rs2816938 at chromosome 1q32.1 (per allele odds ratio (OR) = 1.20, P = 4.88x10(-15)), rs10094872 at 8q24.21 (OR = 1.15, P = 3.22x10(-9)) and rs35226131 at 5p15.33 (OR = 0.71, P = 1.70x10(-8)). These SNPs represent independent risk variants at previously identified pancreatic cancer risk loci on chr1q32.1 (NR5A2), chr8q24.21 (MYC) and chr5p15.33 (CLPTM1L-TERT) as per analyses conditioned on previously reported susceptibility variants. We assessed expression of candidate genes at the three risk loci in histologically normal (n = 10) and tumor (n = 8) derived pancreatic tissue samples and observed a marked reduction of NR5A2 expression (chr1q32.1) in the tumors (fold change -7.6, P = 5.7x10(-8)). This finding was validated in a second set of paired (n = 20) histologically normal and tumor derived pancreatic tissue samples (average fold change for three NR5A2 isoforms -31.3 to -95.7, P = 7.5x10(-4)-2.0x10(-3)). Our study has identified new susceptibility variants independently conferring pancreatic cancer risk that merit functional follow-up to identify target genes and explain the underlying biology.

Published
2016
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32. Three new pancreatic cancer susceptibility signals identified on chromosomes 1q32.1, 5p15.33 and 8q24.21

Author

MS MDL 1, Epi Kanker Team 1, JC onderzoeksprogramma Kanker, Cancer, Zhang, Mingfeng, Wang, Zhaoming, Obazee, Ofure, Jia, Jinping, Childs, Erica J, Hoskins, Jason, Figlioli, Gisella, Mocci, Evelina, Collins, Irene, Chung, Charles C, Hautman, Christopher, Arslan, Alan A, Beane-Freeman, Laura, Bracci, Paige M, Buring, Julie, Duell, Eric J, Gallinger, Steven, Giles, Graham G, Goodman, Gary E, Goodman, Phyllis J, Kamineni, Aruna, Kolonel, Laurence N, Kulke, Matthew H, Malats, Núria, Olson, Sara H, Sesso, Howard D, Visvanathan, Kala, White, Emily, Zheng, Wei, Abnet, Christian C, Albanes, Demetrius, Andreotti, Gabriella, Brais, Lauren, Bueno-de-Mesquita, H Bas, Basso, Daniela, Berndt, Sonja I, Boutron-Ruault, Marie-Christine, Bijlsma, Maarten F, Brenner, Hermann, Burdette, Laurie, Campa, Daniele, Caporaso, Neil E, Capurso, Gabriele, Cavestro, Giulia Martina, Cotterchio, Michelle, Costello, Eithne, Elena, Joanne, Boggi, Ugo, Gaziano, J Michael, Gazouli, Maria, Giovannucci, Edward L, Goggins, Michael, Gross, Myron, Haiman, Christopher A, Hassan, Manal, Helzlsouer, Kathy J, Hu, Nan, Hunter, David J, Iskierka-Jazdzewska, Elzbieta, Jenab, Mazda, Kaaks, Rudolf, Key, Timothy J, Khaw, Kay-Tee, Klein, Eric A, Kogevinas, Manolis, Krogh, Vittorio, Kupcinskas, Juozas, Kurtz, Robert C, Landi, Maria T, Landi, Stefano, Le Marchand, Loic, Mambrini, Andrea, Mannisto, Satu, Milne, Roger L, Neale, Rachel E, Oberg, Ann L, Panico, Salvatore, Patel, Alpa V, Peeters, Petra H M, Peters, Ulrike, Pezzilli, Raffaele, Porta, Miquel, Purdue, Mark, Quiros, J Ramón, Riboli, Elio, Rothman, Nathaniel, Scarpa, Aldo, Scelo, Ghislaine, Shu, Xiao-Ou, Silverman, Debra T, Soucek, Pavel, Strobel, Oliver, Sund, Malin, Małecka-Panas, Ewa, Taylor, Philip R, Tavano, Francesca, Travis, Ruth C, Thornquist, Mark, Tjønneland, Anne, Tobias, Geoffrey S, Trichopoulos, Dimitrios, Vashist, Yogesh, Vodicka, Pavel, Wactawski-Wende, Jean, Wentzensen, Nicolas, Yu, Herbert, Yu, Kai, Zeleniuch-Jacquotte, Anne, Kooperberg, Charles, Risch, Harvey A, Jacobs, Eric J, Li, Donghui, Fuchs, Charles, Hoover, Robert, Hartge, Patricia, Chanock, Stephen J, Petersen, Gloria M, Stolzenberg-Solomon, Rachael S, Wolpin, Brian M, Kraft, Peter, Klein, Alison P, Canzian, Federico, Amundadottir, Laufey T, MS MDL 1, Epi Kanker Team 1, JC onderzoeksprogramma Kanker, Cancer, Zhang, Mingfeng, Wang, Zhaoming, Obazee, Ofure, Jia, Jinping, Childs, Erica J, Hoskins, Jason, Figlioli, Gisella, Mocci, Evelina, Collins, Irene, Chung, Charles C, Hautman, Christopher, Arslan, Alan A, Beane-Freeman, Laura, Bracci, Paige M, Buring, Julie, Duell, Eric J, Gallinger, Steven, Giles, Graham G, Goodman, Gary E, Goodman, Phyllis J, Kamineni, Aruna, Kolonel, Laurence N, Kulke, Matthew H, Malats, Núria, Olson, Sara H, Sesso, Howard D, Visvanathan, Kala, White, Emily, Zheng, Wei, Abnet, Christian C, Albanes, Demetrius, Andreotti, Gabriella, Brais, Lauren, Bueno-de-Mesquita, H Bas, Basso, Daniela, Berndt, Sonja I, Boutron-Ruault, Marie-Christine, Bijlsma, Maarten F, Brenner, Hermann, Burdette, Laurie, Campa, Daniele, Caporaso, Neil E, Capurso, Gabriele, Cavestro, Giulia Martina, Cotterchio, Michelle, Costello, Eithne, Elena, Joanne, Boggi, Ugo, Gaziano, J Michael, Gazouli, Maria, Giovannucci, Edward L, Goggins, Michael, Gross, Myron, Haiman, Christopher A, Hassan, Manal, Helzlsouer, Kathy J, Hu, Nan, Hunter, David J, Iskierka-Jazdzewska, Elzbieta, Jenab, Mazda, Kaaks, Rudolf, Key, Timothy J, Khaw, Kay-Tee, Klein, Eric A, Kogevinas, Manolis, Krogh, Vittorio, Kupcinskas, Juozas, Kurtz, Robert C, Landi, Maria T, Landi, Stefano, Le Marchand, Loic, Mambrini, Andrea, Mannisto, Satu, Milne, Roger L, Neale, Rachel E, Oberg, Ann L, Panico, Salvatore, Patel, Alpa V, Peeters, Petra H M, Peters, Ulrike, Pezzilli, Raffaele, Porta, Miquel, Purdue, Mark, Quiros, J Ramón, Riboli, Elio, Rothman, Nathaniel, Scarpa, Aldo, Scelo, Ghislaine, Shu, Xiao-Ou, Silverman, Debra T, Soucek, Pavel, Strobel, Oliver, Sund, Malin, Małecka-Panas, Ewa, Taylor, Philip R, Tavano, Francesca, Travis, Ruth C, Thornquist, Mark, Tjønneland, Anne, Tobias, Geoffrey S, Trichopoulos, Dimitrios, Vashist, Yogesh, Vodicka, Pavel, Wactawski-Wende, Jean, Wentzensen, Nicolas, Yu, Herbert, Yu, Kai, Zeleniuch-Jacquotte, Anne, Kooperberg, Charles, Risch, Harvey A, Jacobs, Eric J, Li, Donghui, Fuchs, Charles, Hoover, Robert, Hartge, Patricia, Chanock, Stephen J, Petersen, Gloria M, Stolzenberg-Solomon, Rachael S, Wolpin, Brian M, Kraft, Peter, Klein, Alison P, Canzian, Federico, and Amundadottir, Laufey T

Published
2016

34. Three new pancreatic cancer susceptibility signals identified on chromosomes 1q32.1, 5p15.33 and 8q24.21

Author

Zhang, Mingfeng, primary, Wang, Zhaoming, additional, Obazee, Ofure, additional, Jia, Jinping, additional, Childs, Erica J., additional, Hoskins, Jason, additional, Figlioli, Gisella, additional, Mocci, Evelina, additional, Collins, Irene, additional, Chung, Charles C., additional, Hautman, Christopher, additional, Arslan, Alan A., additional, Beane-Freeman, Laura, additional, Bracci, Paige M., additional, Buring, Julie, additional, Duell, Eric J., additional, Gallinger, Steven, additional, Giles, Graham G., additional, Goodman, Gary E., additional, Goodman, Phyllis J., additional, Kamineni, Aruna, additional, Kolonel, Laurence N., additional, Kulke, Matthew H., additional, Malats, Núria, additional, Olson, Sara H., additional, Sesso, Howard D., additional, Visvanathan, Kala, additional, White, Emily, additional, Zheng, Wei, additional, Abnet, Christian C., additional, Albanes, Demetrius, additional, Andreotti, Gabriella, additional, Brais, Lauren, additional, Bueno-de-Mesquita, H. Bas, additional, Basso, Daniela, additional, Berndt, Sonja I., additional, Boutron-Ruault, Marie-Christine, additional, Bijlsma, Maarten F., additional, Brenner, Hermann, additional, Burdette, Laurie, additional, Campa, Daniele, additional, Caporaso, Neil E., additional, Capurso, Gabriele, additional, Cavestro, Giulia Martina, additional, Cotterchio, Michelle, additional, Costello, Eithne, additional, Elena, Joanne, additional, Boggi, Ugo, additional, Gaziano, J. Michael, additional, Gazouli, Maria, additional, Giovannucci, Edward L., additional, Goggins, Michael, additional, Gross, Myron, additional, Haiman, Christopher A., additional, Hassan, Manal, additional, Helzlsouer, Kathy J., additional, Hu, Nan, additional, Hunter, David J., additional, Iskierka-Jazdzewska, Elzbieta, additional, Jenab, Mazda, additional, Kaaks, Rudolf, additional, Key, Timothy J., additional, Khaw, Kay-Tee, additional, Klein, Eric A., additional, Kogevinas, Manolis, additional, Krogh, Vittorio, additional, Kupcinskas, Juozas, additional, Kurtz, Robert C., additional, Landi, Maria T., additional, Landi, Stefano, additional, Le Marchand, Loic, additional, Mambrini, Andrea, additional, Mannisto, Satu, additional, Milne, Roger L., additional, Neale, Rachel E., additional, Oberg, Ann L., additional, Panico, Salvatore, additional, Patel, Alpa V., additional, Peeters, Petra H. M., additional, Peters, Ulrike, additional, Pezzilli, Raffaele, additional, Porta, Miquel, additional, Purdue, Mark, additional, Quiros, J. Ramón, additional, Riboli, Elio, additional, Rothman, Nathaniel, additional, Scarpa, Aldo, additional, Scelo, Ghislaine, additional, Shu, Xiao-Ou, additional, Silverman, Debra T., additional, Soucek, Pavel, additional, Strobel, Oliver, additional, Sund, Malin, additional, Małecka-Panas, Ewa, additional, Taylor, Philip R., additional, Tavano, Francesca, additional, Travis, Ruth C., additional, Thornquist, Mark, additional, Tjønneland, Anne, additional, Tobias, Geoffrey S., additional, Trichopoulos, Dimitrios, additional, Vashist, Yogesh, additional, Vodicka, Pavel, additional, Wactawski-Wende, Jean, additional, Wentzensen, Nicolas, additional, Yu, Herbert, additional, Yu, Kai, additional, Zeleniuch-Jacquotte, Anne, additional, Kooperberg, Charles, additional, Risch, Harvey A., additional, Jacobs, Eric J., additional, Li, Donghui, additional, Fuchs, Charles, additional, Hoover, Robert, additional, Hartge, Patricia, additional, Chanock, Stephen J., additional, Petersen, Gloria M., additional, Stolzenberg-Solomon, Rachael S., additional, Wolpin, Brian M., additional, Kraft, Peter, additional, Klein, Alison P., additional, Canzian, Federico, additional, and Amundadottir, Laufey T., additional

Published
2016
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35. Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer

Author

Wolpin, Brian M. Rizzato, Cosmeri Kraft, Peter Kooperberg, Charles Petersen, Gloria M. Wang, Zhaoming Arslan, Alan A. and Beane-Freeman, Laura Bracci, Paige M. Buring, Julie and Canzian, Federico Duell, Eric J. Gallinger, Steven Giles, Graham G. Goodman, Gary E. Goodman, Phyllis J. Jacobs, Eric J. Kamineni, Aruna Klein, Alison P. Kolonel, Laurence N. and Kulke, Matthew H. Li, Donghui Malats, Nuria Olson, Sara H. and Risch, Harvey A. Sesso, Howard D. Visvanathan, Kala and White, Emily Zheng, Wei Abnet, Christian C. Albanes, Demetrius Andreotti, Gabriella Austin, Melissa A. Barfield, Richard Basso, Daniela Berndt, Sonja I. Boutron-Ruault, Marie-Christine Brotzman, Michelle Buechler, Markus W. and Bueno-de-Mesquita, H. Bas Bugert, Peter Burdette, Laurie and Campa, Daniele Caporaso, Neil E. Capurso, Gabriele Chung, Charles Cotterchio, Michelle Costello, Eithne Elena, Joanne and Funel, Niccola Gaziano, J. Michael Giese, Nathalia A. and Goggins, Michael Gorman, Megan J. Gross, Myron Haiman, Christopher A. Hassan, Manal Helzlsouer, Kathy J. Henderson, Brian E. Holly, Elizabeth A. Hu, Nan Hunter, David J. and Innocenti, Federico Jenab, Mazda Kaaks, Rudolf Key, Timothy J. Khaw, Kay-Tee Klein, Eric A. Kogevinas, Manolis and Krogh, Vittorio Kupcinskas, Juozas Kurtz, Robert C. LaCroix, Andrea Landi, Maria T. Landi, Stefano Le Marchand, Loic and Mambrini, Andrea Mannisto, Satu Milne, Roger L. Nakamura, Yusuke Oberg, Ann L. Owzar, Kouros Patel, Alpa V. and Peeters, Petra H. M. Peters, Ulrike Pezzilli, Raffaele and Piepoli, Ada Porta, Miquel Real, Francisco X. Riboli, Elio and Rothman, Nathaniel Scarpa, Aldo Shu, Xiao-Ou Silverman, Debra T. Soucek, Pavel Sund, Malin Talar-Wojnarowska, Renata and Taylor, Philip R. Theodoropoulos, George E. Thornquist, Mark and Tjonneland, Anne Tobias, Geoffrey S. Trichopoulos, Dimitrios and Vodicka, Pavel Wactawski-Wende, Jean Wentzensen, Nicolas and Wu, Chen Yu, Herbert Yu, Kai Zeleniuch-Jacquotte, Anne and Hoover, Robert Hartge, Patricia Fuchs, Charles Chanock, Stephen J. Stolzenberg-Solomon, Rachael S. Amundadottir, Laufey T.

Abstract

We performed a multistage genome-wide association study including 7,683 individuals with pancreatic cancer and 14,397 controls of European descent. Four new loci reached genome-wide significance: rs6971499 at 7q32.3 (LINC-PINT, per-allele odds ratio (OR) = 0.79, 95% confidence interval (CI) 0.74-0.84, P = 3.0 x 10(-12)), rs7190458 at 16q23.1 (BCAR1/CTRB1/CTRB2, OR = 1.46, 95% CI 1.30-1.65, P = 1.1 x 10(-10)), rs9581943 at 13q12.2 (PDX1, OR = 1.15, 95% CI 1.10-1.20, P = 2.4 x 10(-9)) and rs16986825 at 22q12.1 (ZNRF3, OR = 1.18, 95% CI 1.12-1.25, P = 1.2 x 10(-8)). We identified an independent signal in exon 2 of TERT at the established region 5p15.33 (rs2736098, OR = 0.80, 95% CI 0.76-0.85, P = 9.8 x 10(-14)). We also identified a locus at 8q24.21 (rs1561927, P = 1.3 x 10(-7)) that approached genome-wide significance located 455 kb telomeric of PVT1. Our study identified multiple new susceptibility alleles for pancreatic cancer that are worthy of follow-up studies.

Published
2014

36. Imputation and subset-based association analysis across different cancer types identifies multiple independent risk loci in the TERT-CLPTM1L region on chromosome 5p15.33

Author

Wang, Zhaoming Zhu, Bin Zhang, Mingfeng Parikh, Hemang and Jia, Jinping Chung, Charles C. Sampson, Joshua N. Hoskins, Jason W. Hutchinson, Amy Burdette, Laurie Ibrahim, Abdisamad and Hautman, Christopher Raj, Preethi S. Abnet, Christian C. and Adjei, Andrew A. Ahlbom, Anders Albanes, Demetrius Allen, Naomi E. Ambrosone, Christine B. Aldrich, Melinda Amiano, Pilar Amos, Christopher Andersson, Ulrika Andriole, Jr., Gerald Andrulis, Irene L. Arici, Cecilia Arslan, Alan A. and Austin, Melissa A. Baris, Dalsu Barkauskas, Donald A. and Bassig, Bryan A. Freeman, Laura E. Beane Berg, Christine D. and Berndt, Sonja I. Bertazzi, Pier Alberto Biritwum, Richard B. and Black, Amanda Blot, William Boeing, Heiner Boffetta, Paolo and Bolton, Kelly Boutron-Ruault, Marie-Christine Bracci, Paige M. Brennan, Paul Brinton, Louise A. Brotzman, Michelle and Bueno-de-Mesquita, H. Bas Buring, Julie E. Butler, Mary Ann and Cai, Qiuyin Cancel-Tassin, Geraldine Canzian, Federico Cao, Guangwen Caporaso, Neil E. Carrato, Alfredo Carreon, Tania and Carta, Angela Chang, Gee-Chen Chang, I-Shou and Chang-Claude, Jenny Che, Xu Chen, Chien-Jen Chen, Chih-Yi and Chen, Chung-Hsing Chen, Constance Chen, Kuan-Yu Chen, Yuh-Min Chokkalingam, Anand P. Chu, Lisa W. Clavel-Chapelon, Francoise Colditz, Graham A. Colt, Joanne S. Conti, David and Cook, Michael B. Cortessis, Victoria K. Crawford, E. David and Cussenot, Olivier Davis, Faith G. De Vivo, Immaculata and Deng, Xiang Ding, Ti Dinney, Colin P. Di Stefano, Anna Luisa and Diver, W. Ryan Duell, Eric J. Elena, Joanne W. Fan, Jin-Hu Feigelson, Heather Spencer Feychting, Maria Figueroa, Jonine D. Flanagan, Adrienne M. Fraumeni, Jr., Joseph F. and Freedman, Neal D. Fridley, Brooke L. Fuchs, Charles S. and Gago-Dominguez, Manuela Gallinger, Steven Gao, Yu-Tang and Gapstur, Susan M. Garcia-Closas, Montserrat Garcia-Closas, Reina and Gastier-Foster, Julie M. Gaziano, J. Michael Gerhard, Daniela S. Giffen, Carol A. Giles, Graham G. Gillanders, Elizabeth M. Giovannucci, Edward L. Goggins, Michael Gokgoz, Nalan Goldstein, Alisa M. Gonzalez, Carlos Gorlick, Richard and Greene, Mark H. Gross, Myron Grossman, H. Barton Grubb, III, Robert Gu, Jian Guan, Peng Haiman, Christopher A. and Hallmans, Goran Hankinson, Susan E. Harris, Curtis C. and Hartge, Patricia Hattinger, Claudia Hayes, Richard B. He, Qincheng Helman, Lee Henderson, Brian E. Henriksson, Roger and Hoffman-Bolton, Judith Hohensee, Chancellor Holly, Elizabeth A. Hong, Yun-Chul Hoover, Robert N. Hosgood, H. Dean and Hsiao, Chin-Fu Hsing, Ann W. Hsiung, Chao Agnes Hu, Nan and Hu, Wei Hu, Zhibin Huang, Ming-Shyan Hunter, David J. and Inskip, Peter D. Ito, Hidemi Jacobs, Eric J. Jacobs, Kevin B. Jenab, Mazda Ji, Bu-Tian Johansen, Christoffer and Johansson, Mattias Johnson, Alison Kaaks, Rudolf Kamat, Ashish M. Kamineni, Aruna Karagas, Margaret Khanna, Chand and Khaw, Kay-Tee Kim, Christopher Kim, In-Sam Kim, Jin Hee and Kim, Yeul Hong Kim, Young-Chul Kim, Young Tae Kang, Chang Hyun Jung, Yoo Jin Kitahara, Cari M. Klein, Alison P. and Klein, Robert Kogevinas, Manolis Koh, Woon-Puay Kohno, Takashi Kolonel, Laurence N. Kooperberg, Charles Kratz, Christian P. Krogh, Vittorio Kunitoh, Hideo Kurtz, Robert C. and Kurucu, Nilgun Lan, Qing Lathrop, Mark Lau, Ching C. and Lecanda, Fernando Lee, Kyoung-Mu Lee, Maxwell P. Le Marchand, Loic Lerner, Seth P. Li, Donghui Liao, Linda M. and Lim, Wei-Yen Lin, Dongxin Lin, Jie Lindstrom, Sara and Linet, Martha S. Lissowska, Jolanta Liu, Jianjun Ljungberg, Boerje Lloreta, Josep Lu, Daru Ma, Jing Malats, Nuria and Mannisto, Satu Marina, Neyssa Mastrangelo, Giuseppe and Matsuo, Keitaro McGlynn, Katherine A. McKean-Cowdin, Roberta and McNeill, Lorna H. McWilliams, Robert R. Melin, Beatrice S. and Meltzer, Paul S. Mensah, James E. Miao, Xiaoping Michaud, Dominique S. Mondul, Alison M. Moore, Lee E. Muir, Kenneth and Niwa, Shelley Olson, Sara H. Orr, Nick Panico, Salvatore and Park, Jae Yong Patel, Alpa V. Patino-Garcia, Ana and Pavanello, Sofia Peeters, Petra H. M. Peplonska, Beata and Peters, Ulrike Petersen, Gloria M. Picci, Piero Pike, Malcolm C. Porru, Stefano Prescott, Jennifer Pu, Xia and Purdue, Mark P. Qiao, You-Lin Rajaraman, Preetha Riboli, Elio Risch, Harvey A. Rodabough, Rebecca J. Rothman, Nathaniel Ruder, Avima M. Ryu, Jeong-Seon Sanson, Marc and Schned, Alan Schumacher, Fredrick R. Schwartz, Ann G. and Schwartz, Kendra L. Schwenn, Molly Scotlandi, Katia Seow, Adeline Serra, Consol Serra, Massimo Sesso, Howard D. and Severi, Gianluca Shen, Hongbing Shen, Min Shete, Sanjay and Shiraishi, Kouya Shu, Xiao-Ou Siddiq, Afshan Sierrasesumaga, Luis Sierri, Sabina Sihoe, Alan Dart Loon Silverman, Debra T. Simon, Matthias Southey, Melissa C. Spector, Logan and Spitz, Margaret Stampfer, Meir Stattin, Par Stern, Mariana C. Stevens, Victoria L. Stolzenberg-Solomon, Rachael Z. and Stram, Daniel O. Strom, Sara S. Su, Wu-Chou Sund, Malin and Sung, Sook Whan Swerdlow, Anthony Tan, Wen Tanaka, Hideo and Tang, Wei Tang, Ze-Zhang Tardon, Adonina Tay, Evelyn and Taylor, Philip R. Tettey, Yao Thomas, David M. Tirabosco, Roberto Tjonneland, Anne Tobias, Geoffrey S. Toro, Jorge R. and Travis, Ruth C. Trichopoulos, Dimitrios Troisi, Rebecca and Truelove, Ann Tsai, Ying-Huang Tucker, Margaret A. Tumino, Rosario Van Den Berg, David Van Den Eeden, Stephen K. and Vermeulen, Roel Vineis, Paolo Visvanathan, Kala Vogel, Ulla and Wang, Chaoyu Wang, Chengfeng Wang, Junwen Wang, Sophia S. Weiderpass, Elisabete Weinstein, Stephanie J. Wentzensen, Nicolas Wheeler, William White, Emily Wiencke, John K. and Wolk, Alicja Wolpin, Brian M. Wong, Maria Pik Wrensch, Margaret Wu, Chen Wu, Tangchun Wu, Xifeng Wu, Yi-Long and Wunder, Jay S. Xiang, Yong-Bing Xu, Jun Yang, Hannah P. and Yang, Pan-Chyr Yatabe, Yasushi Ye, Yuanqing Yeboah, Edward D. Yin, Zhihua Ying, Chen Yu, Chong-Jen Yu, Kai and Yuan, Jian-Min Zanetti, Krista A. Zeleniuch-Jacquotte, Anne and Zheng, Wei Zhou, Baosen Mirabello, Lisa Savage, Sharon A. Kraft, Peter Chanock, Stephen J. Yeager, Meredith and Landi, Maria Terese Shi, Jianxin Chatterjee, Nilanjan and Amundadottir, Laufey T.

Abstract

Genome-wide association studies (GWAS) have mapped risk alleles for at least 10 distinct cancers to a small region of 63 000 bp on chromosome 5p15.33. This region harbors the TERT and CLPTM1L genes; the former encodes the catalytic subunit of telomerase reverse transcriptase and the latter may play a role in apoptosis. To investigate further the genetic architecture of common susceptibility alleles in this region, we conducted an agnostic subset-based meta-analysis (association analysis based on subsets) across six distinct cancers in 34 248 cases and 45 036 controls. Based on sequential conditional analysis, we identified as many as six independent risk loci marked by common single-nucleotide polymorphisms: five in the TERT gene (Region 1: rs7726159, P = 2.10 x 10(-39); Region 3: rs2853677, P = 3.30 x 10(-36) and P-Conditional = 2.36 x 10(-8); Region 4: rs2736098, P = 3.87 x 10(-12) and P-Conditional = 5.19 x 10(-6), Region 5: rs13172201, P = 0.041 and P-Conditional = 2.04 x 10(-6); and Region 6: rs10069690, P = 7.49 x 10 215 and P-Conditional = 5.35 x 10(-7)) and one in the neighboring CLPTM1L gene(Region 2: rs451360; P = 1.90 x 10(-18) and P-Conditional = 7.06 x 10(-16)). Between three and five cancers mapped to each independent locus with both risk-enhancing and protective effects. Allele-specific effects on DNA methylation were seen for a subset of risk loci, indicating that methylation and subsequent effects on gene expression may contribute to the biology of risk variants on 5p15.33. Our results provide strong support for extensive pleiotropy across this region of 5p15.33, to an extent not previously observed in other cancer susceptibility loci.

Published
2014

37. Detectable clonal mosaicism and its relationship to aging and cancer

Author

Jacobs, Kevin B. Yeager, Meredith Zhou, Weiyin Wacholder, Sholom Wang, Zhaoming Rodriguez-Santiago, Benjamin and Hutchinson, Amy Deng, Xiang Liu, Chenwei Horner, Marie-Josephe Cullen, Michael Epstein, Caroline G. Burdett, Laurie Dean, Michael C. Chatterjee, Nilanjan Sampson, Joshua and Chung, Charles C. Kovaks, Joseph Gapstur, Susan M. and Stevens, Victoria L. Teras, Lauren T. Gaudet, Mia M. and Albanes, Demetrius Weinstein, Stephanie J. Virtamo, Jarmo and Taylor, Philip R. Freedman, Neal D. Abnet, Christian C. and Goldstein, Alisa M. Hu, Nan Yu, Kai Yuan, Jian-Min Liao, Linda Ding, Ti Qiao, You-Lin Gao, Yu-Tang Koh, Woon-Puay and Xiang, Yong-Bing Tang, Ze-Zhong Fan, Jin-Hu Aldrich, Melinda C. Amos, Christopher Blot, William J. Bock, Cathryn H. Gillanders, Elizabeth M. Harris, Curtis C. Haiman, Christopher A. Henderson, Brian E. Kolonel, Laurence N. Le Marchand, Loic McNeill, Lorna H. Rybicki, Benjamin A. and Schwartz, Ann G. Signorello, Lisa B. Spitz, Margaret R. and Wiencke, John K. Wrensch, Margaret Wu, Xifeng Zanetti, Krista A. Ziegler, Regina G. Figueroa, Jonine D. and Garcia-Closas, Montserrat Malats, Nuria Marenne, Gaelle and Prokunina-Olsson, Ludmila Baris, Dalsu Schwenn, Molly and Johnson, Alison Landi, Maria Teresa Goldin, Lynn Consonni, Dario Bertazzi, Pier Alberto Rotunno, Melissa Rajaraman, Preetha Andersson, Ulrika Freeman, Laura E. Beane Berg, Christine D. Buring, Julie E. Butler, Mary A. Carreon, Tania and Feychting, Maria Ahlbom, Anders Gaziano, J. Michael and Giles, Graham G. Hallmans, Goran Hankinson, Susan E. Hartge, Patricia Henriksson, Roger Inskip, Peter D. Johansen, Christoffer Landgren, Annelie McKean-Cowdin, Roberta and Michaud, Dominique S. Melin, Beatrice S. Peters, Ulrike and Ruder, Avima M. Sesso, Howard D. Severi, Gianluca Shu, Xiao-Ou Visvanathan, Kala White, Emily Wolk, Alicja and Zeleniuch-Jacquotte, Anne Zheng, Wei Silverman, Debra T. and Kogevinas, Manolis Gonzalez, Juan R. Villa, Olaya Li, Donghui Duell, Eric J. Risch, Harvey A. Olson, Sara H. and Kooperberg, Charles Wolpin, Brian M. Jiao, Li Hassan, Manal and Wheeler, William Arslan, Alan A. Bueno-de-Mesquita, H. Bas and Fuchs, Charles S. Gallinger, Steven Gross, Myron D. and Holly, Elizabeth A. Klein, Alison P. LaCroix, Andrea and Mandelson, Margaret T. Petersen, Gloria Boutron-Ruault, Marie-Christine Bracci, Paige M. Canzian, Federico Chang, Kenneth Cotterchio, Michelle Giovannucci, Edward L. Goggins, Michael Bolton, Judith A. Hoffman Jenab, Mazda Khaw, Kay-Tee and Krogh, Vittorio Kurtz, Robert C. McWilliams, Robert R. and Mendelsohn, Julie B. Rabe, Kari G. Riboli, Elio Tjonneland, Anne Tobias, Geoffrey S. Trichopoulos, Dimitrios Elena, Joanne W. Yu, Herbert Amundadottir, Laufey and Stolzenberg-Solomon, Rachael Z. Kraft, Peter Schumacher, Fredrick Stram, Daniel Savage, Sharon A. Mirabello, Lisa and Andrulis, Irene L. Wunder, Jay S. Patino Garcia, Ana and Sierrasesumaga, Luis Barkauskas, Donald A. Gorlick, Richard G. and Purdue, Mark Chow, Wong-Ho Moore, Lee E. Schwartz, Kendra L. Davis, Faith G. Hsing, Ann W. Berndt, Sonja I. and Black, Amanda Wentzensen, Nicolas Brinton, Louise A. and Lissowska, Jolanta Peplonska, Beata McGlynn, Katherine A. and Cook, Michael B. Graubard, Barry I. Kratz, Christian P. and Greene, Mark H. Erickson, Ralph L. Hunter, David J. Thomas, Gilles Hoover, Robert N. Real, Francisco X. Fraumeni, Jr., Joseph F. Caporaso, Neil E. Tucker, Margaret Rothman, Nathaniel Perez-Jurado, Luis A. Chanock, Stephen J.

Abstract

In an analysis of 31,717 cancer cases and 26,136 cancer-free controls from 13 genome-wide association studies, we observed large chromosomal abnormalities in a subset of clones in DNA obtained from blood or buccal samples. We observed mosaic abnormalities, either aneuploidy or copy-neutral loss of heterozygosity, of > 2 Mb in size in autosomes of 517 individuals (0.89%), with abnormal cell proportions of between 7% and 95%. In cancer-free individuals, frequency increased with age, from 0.23% under 50 years to 1.91% between 75 and 79 years (P = 4.8 x 10(-8)). Mosaic abnormalities were more frequent in individuals with solid tumors (0.97% versus 0.74% in cancer-free individuals; odds ratio (OR) = 1.25; P = 0.016), with stronger association with cases who had DNA collected before diagnosis or treatment (OR = 1.45; P = 0.0005). Detectable mosaicism was also more common in individuals for whom DNA was collected at least 1 year before diagnosis with leukemia compared to cancer-free individuals (OR = 35.4; P = 3.8 x 10(-11)). These findings underscore the time-dependent nature of somatic events in the etiology of cancer and potentially other late-onset diseases.

Published
2012

38. NCI Funding Trends and Priorities in Physical Activity and Energy Balance Research Among Cancer Survivors

Author

Alfano, Catherine M., primary, Bluethmann, Shirley M., additional, Tesauro, Gina, additional, Perna, Frank, additional, Agurs-Collins, Tanya, additional, Elena, Joanne W., additional, Ross, Sharon A., additional, O’Connell, Mary, additional, Bowles, Heather R., additional, Greenberg, Deborah, additional, and Nebeling, Linda, additional

Published
2015
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39. Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer

Author

Wolpin, Brian M., Rizzato, Cosmeri, Kraft, Peter, Kooperberg, Charles, Petersen, Gloria M., Wang, Zhaoming, Arslan, Alan A., Beane-Freeman, Laura, Bracci, Paige M., Buring, Julie, Canzian, Federico, Duell, Eric J., Gallinger, Steven, Giles, Graham G., Goodman, Gary E., Goodman, Phyllis J., Jacobs, Eric J., Kamineni, Aruna, Klein, Alison P., Kolonel, Laurence N., Kulke, Matthew H., Li, Donghui, Malats, Nuria, Olson, Sara H., Risch, Harvey A., Sesso, Howard D., Visvanathan, Kala, White, Emily, Zheng, Wei, Abnet, Christian C., Albanes, Demetrius, Andreotti, Gabriella, Austin, Melissa A., Barfield, Richard, Basso, Daniela, Berndt, Sonja I., Boutron-Ruault, Marie-Christine, Brotzman, Michelle, Buechler, Markus W., Bueno-de-Mesquita, H. Bas, Bugert, Peter, Burdette, Laurie, Campa, Daniele, Caporaso, Neil E., Capurso, Gabriele, Chung, Charles, Cotterchio, Michelle, Costello, Eithne, Elena, Joanne, Funel, Niccola, Gaziano, J. Michael, Giese, Nathalia A., Goggins, Michael, Gorman, Megan J., Gross, Myron, Haiman, Christopher A., Hassan, Manal, Helzlsouer, Kathy J., Henderson, Brian E., Holly, Elizabeth A., Hu, Nan, Hunter, David J., Innocenti, Federico, Jenab, Mazda, Kaaks, Rudolf, Key, Timothy J., Khaw, Kay-Tee, Klein, Eric A., Kogevinas, Manolis, Krogh, Vittorio, Kupcinskas, Juozas, Kurtz, Robert C., LaCroix, Andrea, Landi, Maria T., Landi, Stefano, Le Marchand, Loic, Mambrini, Andrea, Mannisto, Satu, Milne, Roger L., Nakamura, Yusuke, Oberg, Ann L., Owzar, Kouros, Patel, Alpa V., Peeters, Petra H. M., Peters, Ulrike, Pezzilli, Raffaele, Piepoli, Ada, Porta, Miquel, Real, Francisco X., Riboli, Elio, Rothman, Nathaniel, Scarpa, Aldo, Shu, Xiao-Ou, Silverman, Debra T., Soucek, Pavel, Sund, Malin, Talar-Wojnarowska, Renata, Taylor, Philip R., Theodoropoulos, George E., Thornquist, Mark, Tjonneland, Anne, Tobias, Geoffrey S., Trichopoulos, Dimitrios, Vodicka, Pavel, Wactawski-Wende, Jean, Wentzensen, Nicolas, Wu, Chen, Yu, Herbert, Yu, Kai, Zeleniuch-Jacquotte, Anne, Hoover, Robert, Hartge, Patricia, Fuchs, Charles, Chanock, Stephen J., Stolzenberg-Solomon, Rachael S., Amundadottir, Laufey T., Wolpin, Brian M., Rizzato, Cosmeri, Kraft, Peter, Kooperberg, Charles, Petersen, Gloria M., Wang, Zhaoming, Arslan, Alan A., Beane-Freeman, Laura, Bracci, Paige M., Buring, Julie, Canzian, Federico, Duell, Eric J., Gallinger, Steven, Giles, Graham G., Goodman, Gary E., Goodman, Phyllis J., Jacobs, Eric J., Kamineni, Aruna, Klein, Alison P., Kolonel, Laurence N., Kulke, Matthew H., Li, Donghui, Malats, Nuria, Olson, Sara H., Risch, Harvey A., Sesso, Howard D., Visvanathan, Kala, White, Emily, Zheng, Wei, Abnet, Christian C., Albanes, Demetrius, Andreotti, Gabriella, Austin, Melissa A., Barfield, Richard, Basso, Daniela, Berndt, Sonja I., Boutron-Ruault, Marie-Christine, Brotzman, Michelle, Buechler, Markus W., Bueno-de-Mesquita, H. Bas, Bugert, Peter, Burdette, Laurie, Campa, Daniele, Caporaso, Neil E., Capurso, Gabriele, Chung, Charles, Cotterchio, Michelle, Costello, Eithne, Elena, Joanne, Funel, Niccola, Gaziano, J. Michael, Giese, Nathalia A., Goggins, Michael, Gorman, Megan J., Gross, Myron, Haiman, Christopher A., Hassan, Manal, Helzlsouer, Kathy J., Henderson, Brian E., Holly, Elizabeth A., Hu, Nan, Hunter, David J., Innocenti, Federico, Jenab, Mazda, Kaaks, Rudolf, Key, Timothy J., Khaw, Kay-Tee, Klein, Eric A., Kogevinas, Manolis, Krogh, Vittorio, Kupcinskas, Juozas, Kurtz, Robert C., LaCroix, Andrea, Landi, Maria T., Landi, Stefano, Le Marchand, Loic, Mambrini, Andrea, Mannisto, Satu, Milne, Roger L., Nakamura, Yusuke, Oberg, Ann L., Owzar, Kouros, Patel, Alpa V., Peeters, Petra H. M., Peters, Ulrike, Pezzilli, Raffaele, Piepoli, Ada, Porta, Miquel, Real, Francisco X., Riboli, Elio, Rothman, Nathaniel, Scarpa, Aldo, Shu, Xiao-Ou, Silverman, Debra T., Soucek, Pavel, Sund, Malin, Talar-Wojnarowska, Renata, Taylor, Philip R., Theodoropoulos, George E., Thornquist, Mark, Tjonneland, Anne, Tobias, Geoffrey S., Trichopoulos, Dimitrios, Vodicka, Pavel, Wactawski-Wende, Jean, Wentzensen, Nicolas, Wu, Chen, Yu, Herbert, Yu, Kai, Zeleniuch-Jacquotte, Anne, Hoover, Robert, Hartge, Patricia, Fuchs, Charles, Chanock, Stephen J., Stolzenberg-Solomon, Rachael S., and Amundadottir, Laufey T.

Abstract

We performed a multistage genome-wide association study including 7,683 individuals with pancreatic cancer and 14,397 controls of European descent. Four new loci reached genome-wide significance: rs6971499 at 7q32.3 (LINC-PINT, per-allele odds ratio (OR) = 0.79, 95% confidence interval (CI) 0.74-0.84, P = 3.0 x 10(-12)), rs7190458 at 16q23.1 (BCAR1/CTRB1/CTRB2, OR = 1.46, 95% CI 1.30-1.65, P = 1.1 x 10(-10)), rs9581943 at 13q12.2 (PDX1, OR = 1.15, 95% CI 1.10-1.20, P = 2.4 x 10(-9)) and rs16986825 at 22q12.1 (ZNRF3, OR = 1.18, 95% CI 1.12-1.25, P = 1.2 x 10(-8)). We identified an independent signal in exon 2 of TERT at the established region 5p15.33 (rs2736098, OR = 0.80, 95% CI 0.76-0.85, P = 9.8 x 10(-14)). We also identified a locus at 8q24.21 (rs1561927, P = 1.3 x 10(-7)) that approached genome-wide significance located 455 kb telomeric of PVT1. Our study identified multiple new susceptibility alleles for pancreatic cancer that are worthy of follow-up studies.

Published
2014
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40. Cigarette Smoking Prior to First Cancer and Risk of Second Smoking-Associated Cancers Among Survivors of Bladder, Kidney, Head and Neck, and Stage I Lung Cancers

Author

Shiels, Meredith S., primary, Gibson, Todd, additional, Sampson, Joshua, additional, Albanes, Demetrius, additional, Andreotti, Gabriella, additional, Beane Freeman, Laura, additional, Berrington de Gonzalez, Amy, additional, Caporaso, Neil, additional, Curtis, Rochelle E., additional, Elena, Joanne, additional, Freedman, Neal D., additional, Robien, Kim, additional, Black, Amanda, additional, and Morton, Lindsay M., additional

Published
2014
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41. Pooling Prospective Studies to Investigate the Etiology of Second Cancers

Author

Black, Amanda, primary, Gibson, Todd M., additional, Shiels, Meredith S., additional, Park, Yikyung, additional, Robien, Kim, additional, Albanes, Demetrius, additional, Weinstein, Stephanie J., additional, Freeman, Laura E. Beane, additional, Andreotti, Gabriella, additional, Purdue, Mark P., additional, Fraumeni, Joseph F., additional, Hartge, Patricia, additional, Tucker, Margaret A., additional, Hoover, Robert N., additional, Cerhan, James R., additional, Zeleniuch-Jacquotte, Anne, additional, Curtis, Rochelle E., additional, Elena, Joanne, additional, Sampson, Joshua N., additional, de Gonzalez, Amy Berrington, additional, and Morton, Lindsay M., additional

Published
2014
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42. An absolute risk model to identify individuals at elevated risk for pancreatic cancer in the general population.

Author

Klein, Alison P., Lindström, Sara, Mendelsohn, Julie B., Steplowski, Emily, Arslan, Alan A., Bueno-de-Mesquita, H. Bas, Fuchs, Charles S., Gallinger, Steven, Gross, Myron, Helzlsouer, Kathy, Holly, Elizabeth A., Jacobs, Eric J., Lacroix, Andrea, Li, Donghui, Mandelson, Margaret T., Olson, Sara H., Petersen, Gloria M., Risch, Harvey A., Stolzenberg-Solomon, Rachael Z., Zheng, Wei, Amundadottir, Laufey, Albanes, Demetrius, Allen, Naomi E., Bamlet, William R., Boutron-Ruault, Marie-Christine, Buring, Julie E., Bracci, Paige M., Canzian, Federico, Clipp, Sandra, Cotterchio, Michelle, Duell, Eric J., Elena, Joanne, Gaziano, J. Michael, Giovannucci, Edward L., Goggins, Michael, Hallmans, Göran, Hassan, Manal, Hutchinson, Amy, Hunter, David J., Kooperberg, Charles, Kurtz, Robert C., Liu, Simin, Overvad, Kim, Palli, Domenico, Patel, Alpa V., Rabe, Kari G., Shu, Xiao-Ou, Slimani, Nadia, Tobias, Geoffrey S., Trichopoulos, Dimitrios, Van Den Eeden, Stephen K., Vineis, Paolo, Virtamo, Jarmo, Wactawski-Wende, Jean, Wolpin, Brian M., Yu, Herbert, Yu, Kai, Zeleniuch-Jacquotte, Anne, Chanock, Stephen J., Hoover, Robert N., Hartge, Patricia, Kraft, Peter, Klein, Alison P., Lindström, Sara, Mendelsohn, Julie B., Steplowski, Emily, Arslan, Alan A., Bueno-de-Mesquita, H. Bas, Fuchs, Charles S., Gallinger, Steven, Gross, Myron, Helzlsouer, Kathy, Holly, Elizabeth A., Jacobs, Eric J., Lacroix, Andrea, Li, Donghui, Mandelson, Margaret T., Olson, Sara H., Petersen, Gloria M., Risch, Harvey A., Stolzenberg-Solomon, Rachael Z., Zheng, Wei, Amundadottir, Laufey, Albanes, Demetrius, Allen, Naomi E., Bamlet, William R., Boutron-Ruault, Marie-Christine, Buring, Julie E., Bracci, Paige M., Canzian, Federico, Clipp, Sandra, Cotterchio, Michelle, Duell, Eric J., Elena, Joanne, Gaziano, J. Michael, Giovannucci, Edward L., Goggins, Michael, Hallmans, Göran, Hassan, Manal, Hutchinson, Amy, Hunter, David J., Kooperberg, Charles, Kurtz, Robert C., Liu, Simin, Overvad, Kim, Palli, Domenico, Patel, Alpa V., Rabe, Kari G., Shu, Xiao-Ou, Slimani, Nadia, Tobias, Geoffrey S., Trichopoulos, Dimitrios, Van Den Eeden, Stephen K., Vineis, Paolo, Virtamo, Jarmo, Wactawski-Wende, Jean, Wolpin, Brian M., Yu, Herbert, Yu, Kai, Zeleniuch-Jacquotte, Anne, Chanock, Stephen J., Hoover, Robert N., Hartge, Patricia, and Kraft, Peter

Abstract

PURPOSE: We developed an absolute risk model to identify individuals in the general population at elevated risk of pancreatic cancer. PATIENTS AND METHODS: Using data on 3,349 cases and 3,654 controls from the PanScan Consortium, we developed a relative risk model for men and women of European ancestry based on non-genetic and genetic risk factors for pancreatic cancer. We estimated absolute risks based on these relative risks and population incidence rates. RESULTS: Our risk model included current smoking (multivariable adjusted odds ratio (OR) and 95% confidence interval: 2.20 [1.84-2.62]), heavy alcohol use (>3 drinks/day) (OR: 1.45 [1.19-1.76]), obesity (body mass index >30 kg/m(2)) (OR: 1.26 [1.09-1.45]), diabetes >3 years (nested case-control OR: 1.57 [1.13-2.18], case-control OR: 1.80 [1.40-2.32]), family history of pancreatic cancer (OR: 1.60 [1.20-2.12]), non-O ABO genotype (AO vs. OO genotype) (OR: 1.23 [1.10-1.37]) to (BB vs. OO genotype) (OR 1.58 [0.97-2.59]), rs3790844(chr1q32.1) (OR: 1.29 [1.19-1.40]), rs401681(5p15.33) (OR: 1.18 [1.10-1.26]) and rs9543325(13q22.1) (OR: 1.27 [1.18-1.36]). The areas under the ROC curve for risk models including only non-genetic factors, only genetic factors, and both non-genetic and genetic factors were 58%, 57% and 61%, respectively. We estimate that fewer than 3/1,000 U.S. non-Hispanic whites have more than a 5% predicted lifetime absolute risk. CONCLUSION: Although absolute risk modeling using established risk factors may help to identify a group of individuals at higher than average risk of pancreatic cancer, the immediate clinical utility of our model is limited. However, a risk model can increase awareness of the various risk factors for pancreatic cancer, including modifiable behaviors.

Published
2013
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43. Polymorphisms in genes related to one-carbon metabolism are not related to pancreatic cancer in PanScan and PanC4

Author

LS IRAS EEPI GRA (Gezh.risico-analyse), Leenders, Max, Bhattacharjee, Samsiddhi, Vineis, Paolo, Stevens, Victoria, Bueno-De-Mesquita, H. Bas, Shu, Xiao Ou, Amundadottir, Laufey, Gross, Myron, Tobias, Geoffrey S., Wactawski-Wende, Jean, Arslan, Alan A., Duell, Eric J., Fuchs, Charles S., Gallinger, Steven, Hartge, Patricia, Hoover, Robert N., Holly, Elizabeth A., Jacobs, Eric J., Klein, Alison P., Kooperberg, Charles, Lacroix, Andrea, Li, Donghui, Mandelson, Margaret T., Olson, Sara H., Petersen, Gloria, Risch, Harvey A., Yu, Kai, Wolpin, Brian M., Zheng, Wei, Agalliu, Ilir, Albanes, Demetrius, Boutron-Ruault, Marie Christine, Bracci, Paige M., Buring, Julie E., Canzian, Federico, Chang, Kenneth, Chanock, Stephen J., Cotterchio, Michelle, Gaziano, J. Michael, Giovanucci, Edward L., Goggins, Michael, Hallmans, Göran, Hankinson, Susan E., Hoffman-Bolton, Judith A., Hunter, David J., Hutchinson, Amy, Jacobs, Kevin B., Jenab, Mazda, Khaw, Kay Tee, Kraft, Peter, Krogh, Vittorio, Kurtz, Robert C., McWilliams, Robert R., Mendelsohn, Julie B., Patel, Alpa V., Rabe, Kari G., Riboli, Elio, Tjønneland, Anne, Trichopoulos, Dimitrios, Virtamo, Jarmo, Visvanathan, Kala, Elena, Joanne W., Yu, Herbert, Zeleniuch-Jacquotte, Anne, Stolzenberg-Solomon, Rachael Z., LS IRAS EEPI GRA (Gezh.risico-analyse), Leenders, Max, Bhattacharjee, Samsiddhi, Vineis, Paolo, Stevens, Victoria, Bueno-De-Mesquita, H. Bas, Shu, Xiao Ou, Amundadottir, Laufey, Gross, Myron, Tobias, Geoffrey S., Wactawski-Wende, Jean, Arslan, Alan A., Duell, Eric J., Fuchs, Charles S., Gallinger, Steven, Hartge, Patricia, Hoover, Robert N., Holly, Elizabeth A., Jacobs, Eric J., Klein, Alison P., Kooperberg, Charles, Lacroix, Andrea, Li, Donghui, Mandelson, Margaret T., Olson, Sara H., Petersen, Gloria, Risch, Harvey A., Yu, Kai, Wolpin, Brian M., Zheng, Wei, Agalliu, Ilir, Albanes, Demetrius, Boutron-Ruault, Marie Christine, Bracci, Paige M., Buring, Julie E., Canzian, Federico, Chang, Kenneth, Chanock, Stephen J., Cotterchio, Michelle, Gaziano, J. Michael, Giovanucci, Edward L., Goggins, Michael, Hallmans, Göran, Hankinson, Susan E., Hoffman-Bolton, Judith A., Hunter, David J., Hutchinson, Amy, Jacobs, Kevin B., Jenab, Mazda, Khaw, Kay Tee, Kraft, Peter, Krogh, Vittorio, Kurtz, Robert C., McWilliams, Robert R., Mendelsohn, Julie B., Patel, Alpa V., Rabe, Kari G., Riboli, Elio, Tjønneland, Anne, Trichopoulos, Dimitrios, Virtamo, Jarmo, Visvanathan, Kala, Elena, Joanne W., Yu, Herbert, Zeleniuch-Jacquotte, Anne, and Stolzenberg-Solomon, Rachael Z.

Published
2013

44. Detectable clonal mosaicism and its relationship to aging and cancer

Author

Jacobs, Kevin B., Yeager, Meredith, Zhou, Weiyin, Wacholder, Sholom, Wang, Zhaoming, Rodriguez-Santiago, Benjamin, Hutchinson, Amy, Deng, Xiang, Liu, Chenwei, Horner, Marie-Josephe, Cullen, Michael, Epstein, Caroline G., Burdett, Laurie, Dean, Michael C., Chatterjee, Nilanjan, Sampson, Joshua, Chung, Charles C., Kovaks, Joseph, Gapstur, Susan M., Stevens, Victoria L., Teras, Lauren T., Gaudet, Mia M., Albanes, Demetrius, Weinstein, Stephanie J., Virtamo, Jarmo, Taylor, Philip R., Freedman, Neal D., Abnet, Christian C., Goldstein, Alisa M., Hu, Nan, Yu, Kai, Yuan, Jian-Min, Liao, Linda, Ding, Ti, Qiao, You-Lin, Gao, Yu-Tang, Koh, Woon-Puay, Xiang, Yong-Bing, Tang, Ze-Zhong, Fan, Jin-Hu, Aldrich, Melinda C., Amos, Christopher, Blot, William J., Bock, Cathryn H., Gillanders, Elizabeth M., Harris, Curtis C., Haiman, Christopher A., Henderson, Brian E., Kolonel, Laurence N., Le Marchand, Loic, McNeill, Lorna H., Rybicki, Benjamin A., Schwartz, Ann G., Signorello, Lisa B., Spitz, Margaret R., Wiencke, John K., Wrensch, Margaret, Wu, Xifeng, Zanetti, Krista A., Ziegler, Regina G., Figueroa, Jonine D., Garcia-Closas, Montserrat, Malats, Nuria, Marenne, Gaelle, Prokunina-Olsson, Ludmila, Baris, Dalsu, Schwenn, Molly, Johnson, Alison, Landi, Maria Teresa, Goldin, Lynn, Consonni, Dario, Bertazzi, Pier Alberto, Rotunno, Melissa, Rajaraman, Preetha, Andersson, Ulrika, Freeman, Laura E. Beane, Berg, Christine D., Buring, Julie E., Butler, Mary A., Carreon, Tania, Feychting, Maria, Ahlbom, Anders, Gaziano, J. Michael, Giles, Graham G., Hallmans, Goran, Hankinson, Susan E., Hartge, Patricia, Henriksson, Roger, Inskip, Peter D., Johansen, Christoffer, Landgren, Annelie, McKean-Cowdin, Roberta, Michaud, Dominique S., Melin, Beatrice S., Peters, Ulrike, Ruder, Avima M., Sesso, Howard D., Severi, Gianluca, Shu, Xiao-Ou, Visvanathan, Kala, White, Emily, Wolk, Alicja, Zeleniuch-Jacquotte, Anne, Zheng, Wei, Silverman, Debra T., Kogevinas, Manolis, Gonzalez, Juan R., Villa, Olaya, Li, Donghui, Duell, Eric J., Risch, Harvey A., Olson, Sara H., Kooperberg, Charles, Wolpin, Brian M., Jiao, Li, Hassan, Manal, Wheeler, William, Arslan, Alan A., Bueno-de-Mesquita, H. Bas, Fuchs, Charles S., Gallinger, Steven, Gross, Myron D., Holly, Elizabeth A., Klein, Alison P., LaCroix, Andrea, Mandelson, Margaret T., Petersen, Gloria, Boutron-Ruault, Marie-Christine, Bracci, Paige M., Canzian, Federico, Chang, Kenneth, Cotterchio, Michelle, Giovannucci, Edward L., Goggins, Michael, Bolton, Judith A. Hoffman, Jenab, Mazda, Khaw, Kay-Tee, Krogh, Vittorio, Kurtz, Robert C., McWilliams, Robert R., Mendelsohn, Julie B., Rabe, Kari G., Riboli, Elio, Tjonneland, Anne, Tobias, Geoffrey S., Trichopoulos, Dimitrios, Elena, Joanne W., Yu, Herbert, Amundadottir, Laufey, Stolzenberg-Solomon, Rachael Z., Kraft, Peter, Schumacher, Fredrick, Stram, Daniel, Savage, Sharon A., Mirabello, Lisa, Andrulis, Irene L., Wunder, Jay S., Patino Garcia, Ana, Sierrasesumaga, Luis, Barkauskas, Donald A., Gorlick, Richard G., Purdue, Mark, Chow, Wong-Ho, Moore, Lee E., Schwartz, Kendra L., Davis, Faith G., Hsing, Ann W., Berndt, Sonja I., Black, Amanda, Wentzensen, Nicolas, Brinton, Louise A., Lissowska, Jolanta, Peplonska, Beata, McGlynn, Katherine A., Cook, Michael B., Graubard, Barry I., Kratz, Christian P., Greene, Mark H., Erickson, Ralph L., Hunter, David J., Thomas, Gilles, Hoover, Robert N., Real, Francisco X., Fraumeni, Joseph F., Jr., Caporaso, Neil E., Tucker, Margaret, Rothman, Nathaniel, Perez-Jurado, Luis A., Chanock, Stephen J., Jacobs, Kevin B., Yeager, Meredith, Zhou, Weiyin, Wacholder, Sholom, Wang, Zhaoming, Rodriguez-Santiago, Benjamin, Hutchinson, Amy, Deng, Xiang, Liu, Chenwei, Horner, Marie-Josephe, Cullen, Michael, Epstein, Caroline G., Burdett, Laurie, Dean, Michael C., Chatterjee, Nilanjan, Sampson, Joshua, Chung, Charles C., Kovaks, Joseph, Gapstur, Susan M., Stevens, Victoria L., Teras, Lauren T., Gaudet, Mia M., Albanes, Demetrius, Weinstein, Stephanie J., Virtamo, Jarmo, Taylor, Philip R., Freedman, Neal D., Abnet, Christian C., Goldstein, Alisa M., Hu, Nan, Yu, Kai, Yuan, Jian-Min, Liao, Linda, Ding, Ti, Qiao, You-Lin, Gao, Yu-Tang, Koh, Woon-Puay, Xiang, Yong-Bing, Tang, Ze-Zhong, Fan, Jin-Hu, Aldrich, Melinda C., Amos, Christopher, Blot, William J., Bock, Cathryn H., Gillanders, Elizabeth M., Harris, Curtis C., Haiman, Christopher A., Henderson, Brian E., Kolonel, Laurence N., Le Marchand, Loic, McNeill, Lorna H., Rybicki, Benjamin A., Schwartz, Ann G., Signorello, Lisa B., Spitz, Margaret R., Wiencke, John K., Wrensch, Margaret, Wu, Xifeng, Zanetti, Krista A., Ziegler, Regina G., Figueroa, Jonine D., Garcia-Closas, Montserrat, Malats, Nuria, Marenne, Gaelle, Prokunina-Olsson, Ludmila, Baris, Dalsu, Schwenn, Molly, Johnson, Alison, Landi, Maria Teresa, Goldin, Lynn, Consonni, Dario, Bertazzi, Pier Alberto, Rotunno, Melissa, Rajaraman, Preetha, Andersson, Ulrika, Freeman, Laura E. Beane, Berg, Christine D., Buring, Julie E., Butler, Mary A., Carreon, Tania, Feychting, Maria, Ahlbom, Anders, Gaziano, J. Michael, Giles, Graham G., Hallmans, Goran, Hankinson, Susan E., Hartge, Patricia, Henriksson, Roger, Inskip, Peter D., Johansen, Christoffer, Landgren, Annelie, McKean-Cowdin, Roberta, Michaud, Dominique S., Melin, Beatrice S., Peters, Ulrike, Ruder, Avima M., Sesso, Howard D., Severi, Gianluca, Shu, Xiao-Ou, Visvanathan, Kala, White, Emily, Wolk, Alicja, Zeleniuch-Jacquotte, Anne, Zheng, Wei, Silverman, Debra T., Kogevinas, Manolis, Gonzalez, Juan R., Villa, Olaya, Li, Donghui, Duell, Eric J., Risch, Harvey A., Olson, Sara H., Kooperberg, Charles, Wolpin, Brian M., Jiao, Li, Hassan, Manal, Wheeler, William, Arslan, Alan A., Bueno-de-Mesquita, H. Bas, Fuchs, Charles S., Gallinger, Steven, Gross, Myron D., Holly, Elizabeth A., Klein, Alison P., LaCroix, Andrea, Mandelson, Margaret T., Petersen, Gloria, Boutron-Ruault, Marie-Christine, Bracci, Paige M., Canzian, Federico, Chang, Kenneth, Cotterchio, Michelle, Giovannucci, Edward L., Goggins, Michael, Bolton, Judith A. Hoffman, Jenab, Mazda, Khaw, Kay-Tee, Krogh, Vittorio, Kurtz, Robert C., McWilliams, Robert R., Mendelsohn, Julie B., Rabe, Kari G., Riboli, Elio, Tjonneland, Anne, Tobias, Geoffrey S., Trichopoulos, Dimitrios, Elena, Joanne W., Yu, Herbert, Amundadottir, Laufey, Stolzenberg-Solomon, Rachael Z., Kraft, Peter, Schumacher, Fredrick, Stram, Daniel, Savage, Sharon A., Mirabello, Lisa, Andrulis, Irene L., Wunder, Jay S., Patino Garcia, Ana, Sierrasesumaga, Luis, Barkauskas, Donald A., Gorlick, Richard G., Purdue, Mark, Chow, Wong-Ho, Moore, Lee E., Schwartz, Kendra L., Davis, Faith G., Hsing, Ann W., Berndt, Sonja I., Black, Amanda, Wentzensen, Nicolas, Brinton, Louise A., Lissowska, Jolanta, Peplonska, Beata, McGlynn, Katherine A., Cook, Michael B., Graubard, Barry I., Kratz, Christian P., Greene, Mark H., Erickson, Ralph L., Hunter, David J., Thomas, Gilles, Hoover, Robert N., Real, Francisco X., Fraumeni, Joseph F., Jr., Caporaso, Neil E., Tucker, Margaret, Rothman, Nathaniel, Perez-Jurado, Luis A., and Chanock, Stephen J.

Abstract

In an analysis of 31,717 cancer cases and 26,136 cancer-free controls from 13 genome-wide association studies, we observed large chromosomal abnormalities in a subset of clones in DNA obtained from blood or buccal samples. We observed mosaic abnormalities, either aneuploidy or copy-neutral loss of heterozygosity, of > 2 Mb in size in autosomes of 517 individuals (0.89%), with abnormal cell proportions of between 7% and 95%. In cancer-free individuals, frequency increased with age, from 0.23% under 50 years to 1.91% between 75 and 79 years (P = 4.8 x 10(-8)). Mosaic abnormalities were more frequent in individuals with solid tumors (0.97% versus 0.74% in cancer-free individuals; odds ratio (OR) = 1.25; P = 0.016), with stronger association with cases who had DNA collected before diagnosis or treatment (OR = 1.45; P = 0.0005). Detectable mosaicism was also more common in individuals for whom DNA was collected at least 1 year before diagnosis with leukemia compared to cancer-free individuals (OR = 35.4; P = 3.8 x 10(-11)). These findings underscore the time-dependent nature of somatic events in the etiology of cancer and potentially other late-onset diseases.

Published
2012
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45. An Absolute Risk Model to Identify Individuals at Elevated Risk for Pancreatic Cancer in the General Population

Author

Klein, Alison P., primary, Lindström, Sara, additional, Mendelsohn, Julie B., additional, Steplowski, Emily, additional, Arslan, Alan A., additional, Bueno-de-Mesquita, H. Bas, additional, Fuchs, Charles S., additional, Gallinger, Steven, additional, Gross, Myron, additional, Helzlsouer, Kathy, additional, Holly, Elizabeth A., additional, Jacobs, Eric J., additional, LaCroix, Andrea, additional, Li, Donghui, additional, Mandelson, Margaret T., additional, Olson, Sara H., additional, Petersen, Gloria M., additional, Risch, Harvey A., additional, Stolzenberg-Solomon, Rachael Z., additional, Zheng, Wei, additional, Amundadottir, Laufey, additional, Albanes, Demetrius, additional, Allen, Naomi E., additional, Bamlet, William R., additional, Boutron-Ruault, Marie-Christine, additional, Buring, Julie E., additional, Bracci, Paige M., additional, Canzian, Federico, additional, Clipp, Sandra, additional, Cotterchio, Michelle, additional, Duell, Eric J., additional, Elena, Joanne, additional, Gaziano, J. Michael, additional, Giovannucci, Edward L., additional, Goggins, Michael, additional, Hallmans, Göran, additional, Hassan, Manal, additional, Hutchinson, Amy, additional, Hunter, David J., additional, Kooperberg, Charles, additional, Kurtz, Robert C., additional, Liu, Simin, additional, Overvad, Kim, additional, Palli, Domenico, additional, Patel, Alpa V., additional, Rabe, Kari G., additional, Shu, Xiao-Ou, additional, Slimani, Nadia, additional, Tobias, Geoffrey S., additional, Trichopoulos, Dimitrios, additional, Van Den Eeden, Stephen K., additional, Vineis, Paolo, additional, Virtamo, Jarmo, additional, Wactawski-Wende, Jean, additional, Wolpin, Brian M., additional, Yu, Herbert, additional, Yu, Kai, additional, Zeleniuch-Jacquotte, Anne, additional, Chanock, Stephen J., additional, Hoover, Robert N., additional, Hartge, Patricia, additional, and Kraft, Peter, additional

Published
2013
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46. Leveraging Epidemiology and Clinical Studies of Cancer Outcomes: Recommendations and Opportunities for Translational Research

Author

Elena, Joanne W., primary, Travis, Lois B., additional, Simonds, Naoko I., additional, Ambrosone, Christine B., additional, Ballard-Barbash, Rachel, additional, Bhatia, Smita, additional, Cerhan, James R., additional, Hartge, Patricia, additional, Heist, Rebecca S., additional, Kushi, Lawrence H., additional, Lash, Timothy L., additional, Morton, Lindsay M., additional, Onel, Kenan, additional, Pierce, John P., additional, Robison, Leslie L., additional, Rowland, Julia H., additional, Schrag, Deborah, additional, Sellers, Thomas A., additional, Seminara, Daniela, additional, Shu, Xiao Ou, additional, Thomas, Nancy E., additional, Ulrich, Cornelia M., additional, and Freedman, Andrew N., additional

Published
2012
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47. Genome-wide association study of survival in patients with pancreatic adenocarcinoma

Author

Wu, Chen, primary, Kraft, Peter, additional, Stolzenberg-Solomon, Rachael, additional, Steplowski, Emily, additional, Brotzman, Michelle, additional, Xu, Mousheng, additional, Mudgal, Poorva, additional, Amundadottir, Laufey, additional, Arslan, Alan A, additional, Bueno-de-Mesquita, H Bas, additional, Gross, Myron, additional, Helzlsouer, Kathy, additional, Jacobs, Eric J, additional, Kooperberg, Charles, additional, Petersen, Gloria M, additional, Zheng, Wei, additional, Albanes, Demetrius, additional, Boutron-Ruault, Marie-Christine, additional, Buring, Julie E, additional, Canzian, Federico, additional, Cao, Guangwen, additional, Duell, Eric J, additional, Elena, Joanne W, additional, Gaziano, J Michael, additional, Giovannucci, Edward L, additional, Hallmans, Goran, additional, Hutchinson, Amy, additional, Hunter, David J, additional, Jenab, Mazda, additional, Jiang, Guoliang, additional, Khaw, Kay-Tee, additional, LaCroix, Andrea, additional, Li, Zhaoshen, additional, Mendelsohn, Julie B, additional, Panico, Salvatore, additional, Patel, Alpa V, additional, Qian, Zhi Rong, additional, Riboli, Elio, additional, Sesso, Howard, additional, Shen, Hongbing, additional, Shu, Xiao-Ou, additional, Tjonneland, Anne, additional, Tobias, Geoffrey S, additional, Trichopoulos, Dimitrios, additional, Virtamo, Jarmo, additional, Visvanathan, Kala, additional, Wactawski-Wende, Jean, additional, Wang, Chengfeng, additional, Yu, Kai, additional, Zeleniuch-Jacquotte, Anne, additional, Chanock, Stephen, additional, Hoover, Robert, additional, Hartge, Patricia, additional, Fuchs, Charles S, additional, Lin, Dongxin, additional, and Wolpin, Brian M, additional

Published
2012
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49. Diabetes and risk of pancreatic cancer: a pooled analysis from the pancreatic cancer cohort consortium

Author

Elena, Joanne W., primary, Steplowski, Emily, additional, Yu, Kai, additional, Hartge, Patricia, additional, Tobias, Geoffrey S., additional, Brotzman, Michelle J., additional, Chanock, Stephen J., additional, Stolzenberg-Solomon, Rachael Z., additional, Arslan, Alan A., additional, Bueno-de-Mesquita, H. Bas, additional, Helzlsouer, Kathy, additional, Jacobs, Eric J., additional, LaCroix, Andrea, additional, Petersen, Gloria, additional, Zheng, Wei, additional, Albanes, Demetrius, additional, Allen, Naomi E., additional, Amundadottir, Laufey, additional, Bao, Ying, additional, Boeing, Heiner, additional, Boutron-Ruault, Marie-Christine, additional, Buring, Julie E., additional, Gaziano, J. Michael, additional, Giovannucci, Edward L., additional, Duell, Eric J., additional, Hallmans, Göran, additional, Howard, Barbara V., additional, Hunter, David J., additional, Hutchinson, Amy, additional, Jacobs, Kevin B., additional, Kooperberg, Charles, additional, Kraft, Peter, additional, Mendelsohn, Julie B., additional, Michaud, Dominique S., additional, Palli, Domenico, additional, Phillips, Lawrence S., additional, Overvad, Kim, additional, Patel, Alpa V., additional, Sansbury, Leah, additional, Shu, Xiao-Ou, additional, Simon, Michael S., additional, Slimani, Nadia, additional, Trichopoulos, Dimitrios, additional, Visvanathan, Kala, additional, Virtamo, Jarmo, additional, Wolpin, Brian M., additional, Zeleniuch-Jacquotte, Anne, additional, Fuchs, Charles S., additional, Hoover, Robert N., additional, and Gross, Myron, additional

Published
2012
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50. Detectable clonal mosaicism and its relationship to aging and cancer

Author

Jacobs, Kevin B, primary, Yeager, Meredith, additional, Zhou, Weiyin, additional, Wacholder, Sholom, additional, Wang, Zhaoming, additional, Rodriguez-Santiago, Benjamin, additional, Hutchinson, Amy, additional, Deng, Xiang, additional, Liu, Chenwei, additional, Horner, Marie-Josephe, additional, Cullen, Michael, additional, Epstein, Caroline G, additional, Burdett, Laurie, additional, Dean, Michael C, additional, Chatterjee, Nilanjan, additional, Sampson, Joshua, additional, Chung, Charles C, additional, Kovaks, Joseph, additional, Gapstur, Susan M, additional, Stevens, Victoria L, additional, Teras, Lauren T, additional, Gaudet, Mia M, additional, Albanes, Demetrius, additional, Weinstein, Stephanie J, additional, Virtamo, Jarmo, additional, Taylor, Philip R, additional, Freedman, Neal D, additional, Abnet, Christian C, additional, Goldstein, Alisa M, additional, Hu, Nan, additional, Yu, Kai, additional, Yuan, Jian-Min, additional, Liao, Linda, additional, Ding, Ti, additional, Qiao, You-Lin, additional, Gao, Yu-Tang, additional, Koh, Woon-Puay, additional, Xiang, Yong-Bing, additional, Tang, Ze-Zhong, additional, Fan, Jin-Hu, additional, Aldrich, Melinda C, additional, Amos, Christopher, additional, Blot, William J, additional, Bock, Cathryn H, additional, Gillanders, Elizabeth M, additional, Harris, Curtis C, additional, Haiman, Christopher A, additional, Henderson, Brian E, additional, Kolonel, Laurence N, additional, Le Marchand, Loic, additional, McNeill, Lorna H, additional, Rybicki, Benjamin A, additional, Schwartz, Ann G, additional, Signorello, Lisa B, additional, Spitz, Margaret R, additional, Wiencke, John K, additional, Wrensch, Margaret, additional, Wu, Xifeng, additional, Zanetti, Krista A, additional, Ziegler, Regina G, additional, Figueroa, Jonine D, additional, Garcia-Closas, Montserrat, additional, Malats, Nuria, additional, Marenne, Gaelle, additional, Prokunina-Olsson, Ludmila, additional, Baris, Dalsu, additional, Schwenn, Molly, additional, Johnson, Alison, additional, Landi, Maria Teresa, additional, Goldin, Lynn, additional, Consonni, Dario, additional, Bertazzi, Pier Alberto, additional, Rotunno, Melissa, additional, Rajaraman, Preetha, additional, Andersson, Ulrika, additional, Freeman, Laura E Beane, additional, Berg, Christine D, additional, Buring, Julie E, additional, Butler, Mary A, additional, Carreon, Tania, additional, Feychting, Maria, additional, Ahlbom, Anders, additional, Gaziano, J Michael, additional, Giles, Graham G, additional, Hallmans, Goran, additional, Hankinson, Susan E, additional, Hartge, Patricia, additional, Henriksson, Roger, additional, Inskip, Peter D, additional, Johansen, Christoffer, additional, Landgren, Annelie, additional, McKean-Cowdin, Roberta, additional, Michaud, Dominique S, additional, Melin, Beatrice S, additional, Peters, Ulrike, additional, Ruder, Avima M, additional, Sesso, Howard D, additional, Severi, Gianluca, additional, Shu, Xiao-Ou, additional, Visvanathan, Kala, additional, White, Emily, additional, Wolk, Alicja, additional, Zeleniuch-Jacquotte, Anne, additional, Zheng, Wei, additional, Silverman, Debra T, additional, Kogevinas, Manolis, additional, Gonzalez, Juan R, additional, Villa, Olaya, additional, Li, Donghui, additional, Duell, Eric J, additional, Risch, Harvey A, additional, Olson, Sara H, additional, Kooperberg, Charles, additional, Wolpin, Brian M, additional, Jiao, Li, additional, Hassan, Manal, additional, Wheeler, William, additional, Arslan, Alan A, additional, Bueno-de-Mesquita, H Bas, additional, Fuchs, Charles S, additional, Gallinger, Steven, additional, Gross, Myron D, additional, Holly, Elizabeth A, additional, Klein, Alison P, additional, LaCroix, Andrea, additional, Mandelson, Margaret T, additional, Petersen, Gloria, additional, Boutron-Ruault, Marie-Christine, additional, Bracci, Paige M, additional, Canzian, Federico, additional, Chang, Kenneth, additional, Cotterchio, Michelle, additional, Giovannucci, Edward L, additional, Goggins, Michael, additional, Bolton, Judith A Hoffman, additional, Jenab, Mazda, additional, Khaw, Kay-Tee, additional, Krogh, Vittorio, additional, Kurtz, Robert C, additional, McWilliams, Robert R, additional, Mendelsohn, Julie B, additional, Rabe, Kari G, additional, Riboli, Elio, additional, Tjønneland, Anne, additional, Tobias, Geoffrey S, additional, Trichopoulos, Dimitrios, additional, Elena, Joanne W, additional, Yu, Herbert, additional, Amundadottir, Laufey, additional, Stolzenberg-Solomon, Rachael Z, additional, Kraft, Peter, additional, Schumacher, Fredrick, additional, Stram, Daniel, additional, Savage, Sharon A, additional, Mirabello, Lisa, additional, Andrulis, Irene L, additional, Wunder, Jay S, additional, García, Ana Patiño, additional, Sierrasesúmaga, Luis, additional, Barkauskas, Donald A, additional, Gorlick, Richard G, additional, Purdue, Mark, additional, Chow, Wong-Ho, additional, Moore, Lee E, additional, Schwartz, Kendra L, additional, Davis, Faith G, additional, Hsing, Ann W, additional, Berndt, Sonja I, additional, Black, Amanda, additional, Wentzensen, Nicolas, additional, Brinton, Louise A, additional, Lissowska, Jolanta, additional, Peplonska, Beata, additional, McGlynn, Katherine A, additional, Cook, Michael B, additional, Graubard, Barry I, additional, Kratz, Christian P, additional, Greene, Mark H, additional, Erickson, Ralph L, additional, Hunter, David J, additional, Thomas, Gilles, additional, Hoover, Robert N, additional, Real, Francisco X, additional, Fraumeni, Joseph F, additional, Caporaso, Neil E, additional, Tucker, Margaret, additional, Rothman, Nathaniel, additional, Pérez-Jurado, Luis A, additional, and Chanock, Stephen J, additional

Published
2012
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