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Background: Beckwith-Wiedemann syndrome (BWS, OMIM #130,650) is a pediatric overgrowth disorder involving a predisposition to tumor development. Although the clinical management of affected patients is well established, it is less clear how to handle with the cases of siblings of affected patients, since the prevalence of the condition in twins (1:1000) is ten times higher than in singletones (1:10000). Case presentation: We report the case of a premature twin patient who during her follow-up develops a clinical phenotype compatible with BWS, genetically confirmed in blood. However, the methylation alteration characteristic of the condition was also found in the almost phenotypically normal sibling, making it challening her management. Conclusion: Through our case report we highlight how the diagnosis of BWS can be made without any prenatal suspicion and we propose a review of the literature on how to manage siblings of affected patients in twinning situation. [ABSTRACT FROM AUTHOR]

The Italian COVID-19 lockdown, from 11 March to 16 May 2020, led to an economic crisis, social uncertainty and stress. However, our data suggest that effective policies are needed to support the Italian birth rate during the COVID-19 pandemic. The first Italian COVID-19 lockdown reduced births and voluntary terminations by just under a fifth. [Extracted from the article]