1. Experimental evidence for long-distance electrodynamic intermolecular forces
- Author
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Lechelon, Mathias, Meriguet, Yoann, Gori, Matteo, Ruffenach, Sandra, Nardecchia, Ilaria, Floriani, Elena, Coquillat, Dominique, Teppe, Frédéric, Mailfert, Sébastien, Marguet, Didier, Ferrier, Pierre, Varani, Luca, Sturgis, James, Torres, Jeremie, Pettini, Marco, Centre de Physique Théorique - UMR 7332 (CPT), Aix Marseille Université (AMU)-Université de Toulon (UTLN)-Centre National de la Recherche Scientifique (CNRS), CPT - E7 Systèmes dynamiques : théories et applications, Aix Marseille Université (AMU)-Université de Toulon (UTLN)-Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU)-Université de Toulon (UTLN)-Centre National de la Recherche Scientifique (CNRS), Centre d'Immunologie de Marseille - Luminy (CIML), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU), Institut d’Electronique et des Systèmes (IES), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Charles Coulomb (L2C), Howard University, Modélisation et Spectroscopie THz (MOST), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'ingénierie des systèmes macromoléculaires (LISM), Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Aix Marseille Université (AMU), Excellence Initiative of Aix-Marseille University, European Commission, ANR, CNRS, Excellence Initiative of Aix-Marseille University - A*MIDEX, a French 'Investissements d'Avenir' programme., Projects SIDERANT and NEBULA financed by the french CNRS, by the Occitanie Region and by Montpellier University through its TOP platform and by the LabEx NUMEV (ANR-10-LABX-0020) within the I-Site MUSE, ANR-10-LABX-0020,NUMEV,Digital and Hardware Solutions and Modeling for the Environement and Life Sciences(2010), ANR-10-INBS-0004,France-BioImaging,Développment d'une infrastructure française distribuée coordonnée(2010), European Project: 765426,TeraApps, European Project: 964203,FET-Open LINkS, Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), Excellence Initiative of Aix-Marseille University - A*MIDEX, a French 'Investissements d'Avenir' programme., Projects SIDERANT and NEBULA financed by the french CNRS, by the Occitanie Region and by Montpellier University through its TOP platform and by the LabEx NUMEV (ANR-10-LABX-0020) within the I-Site MUSE, This project has received funding from the European Union’s Horizon 2020 Research and Innovation Programme under grant agreement no. 964203 (FET-Open LINkS project)., Pettini, Marco, Laboratoires d'excellence - Digital and Hardware Solutions and Modeling for the Environement and Life Sciences - - NUMEV2010 - ANR-10-LABX-0020 - LABX - VALID, and Développment d'une infrastructure française distribuée coordonnée - - France-BioImaging2010 - ANR-10-INBS-0004 - INBS - VALID
- Subjects
Horizon 2020 ,Multidisciplinary ,[PHYS.PHYS.PHYS-BIO-PH] Physics [physics]/Physics [physics]/Biological Physics [physics.bio-ph] ,Electrodynamical-Interactions ,[PHYS.PHYS.PHYS-BIO-PH]Physics [physics]/Physics [physics]/Biological Physics [physics.bio-ph] ,FOS: Physical sciences ,Biophysics (molecular) ,Quantum Biology ,TeraHertz THz ,Condensed Matter - Soft Condensed Matter ,Biological Physics (physics.bio-ph) ,collective molecular oscillations ,Terahertz spectroscopy ,biophysics ,Fluorescence Correlation Spectroscopy ,Soft Condensed Matter (cond-mat.soft) ,Physical sciences — Condensed Matter Physics ,European Union ,Physics - Biological Physics ,Physics - Atomic and Molecular Clusters ,Electrodynamic intermolecular interactions ,Atomic and Molecular Clusters (physics.atm-clus) ,Spectroscopy - Abstract
Both classical and quantum electrodynamics predict the existence of dipole-dipole long-range electrodynamic intermolecular forces; however, these have never been hitherto experimentally observed. The discovery of completely new and unanticipated forces acting between biomolecules could have considerable impact on our understanding of the dynamics and functioning of the molecular machines at work in living organisms. Here, using two independent experiments, on the basis of different physical effects detected by fluorescence correlation spectroscopy and terahertz spectroscopy, respectively, we demonstrate experimentally the activation of resonant electrodynamic intermolecular forces. This is an unprecedented experimental proof of principle of a physical phenomenon that, having been observed for biomacromolecules and with long-range action (up to 1000 Angstroms), could be of importance for biology. In addition to thermal fluctuations that drive molecular motion randomly, these resonant (and thus selective) electrodynamic forces may contribute to molecular encounters in the crowded cellular space., 40 pages, 8 figures, Supplementary material for this article (additional data, theory and 4 movies) is available at https://www.science.org/doi/10.1126/sciadv.abl5855#con1
- Published
- 2022