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3. Identification of potential antiviral compounds from Egyptian marine algae against influenza A virus.

Author

M. Hassen, Bassel, Rashedy, Sarah H., Mostafa, Ahmed, Mahrous, Noura, Nafie, Mohamed S., Elebeedy, Dalia, and Abdel Azeiz, A. Z.

Subjects
GAS chromatography/Mass spectrometry (GC-MS), MARINE algae, MOLECULES, RESPIRATORY infections, MOLECULAR docking
Abstract

Influenza is a contagious viral infection of the respiratory tract, affecting nearly 10% of the world's population, each year. The aim of this study was to extract and identify antiviral compounds against the influenza-A virus (H1N1) from different species of Egyptian marine algae. Three samples of marine macroalgae species were extracted and the antiviral activity of the extracts were tested on Madin Darby Canine Kidney cells. The bioactive compounds present in the most active fractions were identified using gas chromatography-mass spectrometry (GC-MS), then the binding potentials of the identified compounds were examined towards neuraminidase (NA) of the influenza-A virus using molecular docking. The methanolic extract of Sargassum aquifolium showed promising in-vitro antiviral activity with a selectivity index (SI) value of 101. The GC-MS analysis showed twelve compounds and the molecular docking analysis found that tetradecanoic acid showed the strongest binding affinities towards the NA enzyme. [ABSTRACT FROM AUTHOR]

Published
2024
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5. Synergistic Differential DNA Demethylation Activity of Danshensu (Salvia miltiorrhiza) Associated with Different Probiotics in Nonalcoholic Fatty Liver Disease

Author

Hassan, Amr, primary, Rijo, Patrícia, additional, Abuamara, Tamer M. M., additional, Ali Lashin, Lashin Saad, additional, Kamar, Sherif A., additional, Bangay, Gabrielle, additional, Al-Sawahli, Majid Mohammed, additional, Fouad, Marina K., additional, Zoair, Mohammad A., additional, Abdalrhman, Tamer I., additional, Elebeedy, Dalia, additional, Ibrahim, Ibrahim A., additional, Mohamed, Aly F., additional, and Abd El Maksoud, Ahmed I., additional

Published
2024
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6. Symbiotic Antidiabetic Effect of Lactobacillus casei and the Bioactive Extract of Cleome droserifolia (Forssk.) Del. on Mice with Type 2 Diabetes Induced by Alloxan

Author

El Maksoud, Ahmed I. Abd, primary, Al‐Karmalawy, Ahmed A., additional, ElEbeedy, Dalia, additional, Ghanem, Aml, additional, Rasheed, Yasmin, additional, Ibrahim, Ibrahim A., additional, Elghaish, Reem A., additional, Belal, Amany, additional, Raslan, Mona A., additional, and Taher, Rehab F., additional

Published
2023
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10. Inhibition ofHerpes simplex virusandVesicular stomatitis virusProliferation byLactiplantibacillus planterumand star anise Extract Is Associated with Induction ofMXgene expression

Author

El-Sayed, Marwa, primary, Sayed Abdelgeliel, Asmaa, additional, Ghanem, Aml, additional, Alrohaimi, Abdulmohsen H, additional, Saeed Alzahrani, Seham, additional, Fayad, Eman, additional, Alghamdi, Mashail A, additional, Badawy, Ingy, additional, Bastawy, Ahmed, additional, and Elebeedy, Dalia, additional

Published
2023
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12. In Vivo and In Silico Investigation of the Anti-Obesity Effects of Lactiplantibacillus plantarum Combined with Chia Seeds, Green Tea, and Chitosan in Alleviating Hyperlipidemia and Inflammation

Author

Elebeedy, Dalia, primary, Ghanem, Aml, additional, Saleh, Asmaa, additional, Ibrahim, Mona H., additional, Kamaly, Omkulthom Al, additional, Abourehab, Mohammed A. S., additional, Ali, Mohamed A., additional, Abd El Maksoud, Ahmed I., additional, El Hassab, Mahmoud A., additional, and Eldehna, Wagdy M., additional

Published
2022
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13. Synergistic Antimicrobial Effect of Lactiplantibacillus plantarum and Lawsonia inermis Against Staphylococcus aureus

Author

Elebeedy,Dalia, Ghanem,Aml, El-Sayed,Marwa, Fayad,Eman, Abu Ali,Ola A, Alyamani,Amal, Sayed Abdelgeliel,Asmaa, Elebeedy,Dalia, Ghanem,Aml, El-Sayed,Marwa, Fayad,Eman, Abu Ali,Ola A, Alyamani,Amal, and Sayed Abdelgeliel,Asmaa

Abstract

Dalia Elebeedy,1 Aml Ghanem,2,3 Marwa El-Sayed,4 Eman Fayad,5 Ola A Abu Ali,6 Amal Alyamani,5 Asmaa Sayed Abdelgeliel7 1College of Biotechnology, Misr University for Science and Technology (MUST), 6th of October City, 12573, Egypt; 2Molecular Biology Department, Genetic Engineering and Biotechnology Research Institute, University of Sadat City, Sadat City, 12573, Egypt; 3School of Biotechnology, Badr University in Cairo, Badr City, Cairo, 11829, Egypt; 4Department of Microbiology and Immunology, Faculty of Medicine, South Valley University, Qena, 83523, Egypt; 5Department of Biotechnology, Faculty of Science, Taif University, Taif, 21944, Saudi Arabia; 6Department of Chemistry, College of Science, Taif University, Taif, 21944, Saudi Arabia; 7Department of Botany & Microbiology, Faculty of Sciences, South Valley University, Qena, 83523, EgyptCorrespondence: Marwa El-Sayed, Department of Microbiology and Immunology, Faculty of Medicine, South Valley University, Qena, 83523, Egypt, Tel +20 1003717916, Fax +20 963216128, Email marwa.elsayed@med.svu.edu.eg; Asmaa Sayed Abdelgeliel, Department of Botany & Microbiology, Faculty of Sciences, South Valley University, Qena, 83523, Egypt, Tel +20 1002973907, Fax +20 963216128, Email asmaa.elgafari@sci.svu.edu.egPurpose: The developed resistance of pathogenic microorganisms towards the currently used antimicrobial agents requires the fast search for newer potent antimicrobials. One of the most important ways to combat the previously mentioned disaster is the use of natural alternatives like medicinal plants. Our study aimed to estimate the anti-inflammatory property, and antibacterial effects of probiotics Lactiplantibacillus plantarum and ethanol extracts of Lawsonia inermis leaves against Staphylococcus aureus when they were used separately or collectively as synergism.Material and Methods: Experimentally induced infected wound model in mice was created and divided into 10 groups then treated for two days by L. planta

Published
2022

19. Anti-SARS-CoV-2 activities of tanshinone IIA, carnosic acid, rosmarinic acid, salvianolic acid, baicalein, and glycyrrhetinic acid between computational and in vitro insights

Author

Elebeedy, Dalia, primary, Elkhatib, Walid F., additional, Kandeil, Ahmed, additional, Ghanem, Aml, additional, Kutkat, Omnia, additional, Alnajjar, Radwan, additional, Saleh, Marwa A., additional, Abd El Maksoud, Ahmed I., additional, Badawy, Ingy, additional, and Al-Karmalawy, Ahmed A., additional

Published
2021
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