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2 results on '"Eleanor, Dunican"'

1. The Use of Targeted Monoclonal Antibodies in the Treatment of ABPA—A Case Series

Author

Aoife O’Reilly and Eleanor Dunican

Subjects
allergic bronchopulmonary aspergillosis (ABPA), asthma, Aspergillus fumigatus, monoclonal antibodies, immunoglobulin E, Medicine (General), R5-920
Abstract

Allergic bronchopulmonary aspergillosis (ABPA) is a pulmonary disorder occurring in response to Aspergillus fumigatus that can complicate the course of asthma and cystic fibrosis. Here we present a case of acute ABPA without central bronchiectasis, a case of chronic active ABPA with central bronchiectasis, and a case of severe relapsing ABPA with central bronchiectasis. All three were initially treated with corticosteroids and antifungal agents but had an incomplete response. These patients were then treated with anti-IgE therapy with omalizumab before being switched to the anti-IL5R agent benralizumab. They responded well to both agents. These case reports highlight the potential role of omalizumab and benralizumab in the treatment of ABPA, but further studies are required to evaluate the effectiveness of these medications. Longer follow-up periods and objective measurements of the impact of treatment are necessary.

Published
2021
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2. Neutrophil cytoplasts induce T

Author

Nandini, Krishnamoorthy, David N, Douda, Thayse R, Brüggemann, Isabell, Ricklefs, Melody G, Duvall, Raja-Elie E, Abdulnour, Kimberly, Martinod, Luciana, Tavares, Xiao, Wang, Manuela, Cernadas, Elliot, Israel, David T, Mauger, Eugene R, Bleecker, Mario, Castro, Serpil C, Erzurum, Benjamin M, Gaston, Nizar N, Jarjour, Sally, Wenzel, Eleanor, Dunican, John V, Fahy, Daniel, Irimia, Denisa D, Wagner, and Bruce D, Levy

Abstract

Severe asthma is a debilitating and treatment refractory disease. As many as half of these patients have complex neutrophil-predominant lung inflammation that is distinct from milder asthma with type 2 eosinophilic inflammation. New insights into severe asthma pathogenesis are needed. Concomitant exposure of mice to an aeroallergen and endotoxin during sensitization resulted in complex neutrophilic immune responses to allergen alone during later airway challenge. Unlike allergen alone, sensitization with allergen and endotoxin led to NETosis. In addition to neutrophil extracellular traps (NETs), enucleated neutrophil cytoplasts were evident in the lungs. Surprisingly, allergen-driven airway neutrophilia was decreased in peptidyl arginine deiminase 4-deficient mice with defective NETosis but not by deoxyribonuclease treatment, implicating the cytoplasts for the non-type 2 immune responses to allergen. Neutrophil cytoplasts were also present in mediastinal lymph nodes, and the cytoplasts activated lung dendritic cells in vitro to trigger antigen-specific interleukin-17 (IL-17) production from naïve CD4

Published
2017

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