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3. Evaluation of an MRI-based screening pathway for prostate cancer

Author

Eldred-Evans, David and Ahmed, Hashim U.

Abstract

In recent years there has been a wealth of debate regarding prostate cancer screening, with a concurrent increase in new imaging techniques for prostate cancer diagnosis. Imaging has been the technique of choice in lung and breast cancer screening programmes but has not been explored for prostate cancer screening. Herein, this thesis explores the role of magnetic resonance imaging (MRI) as a new approach to screen for prostate cancer. Following an introduction to the current screening landscape, my thesis focuses on the development and validation of a fast MRI, known as a prostagram, that could serve as a viable image-based screening test. Evaluation of this new technique is performed within a prospective, population-based, blinded, cohort study which was conducted at seven primary care practices and two imaging centres. A diverse array of performance characteristics of fast MRI are compared to PSA. These encompass biopsy rates, cancer detection rates, diagnostic accuracy and patient reported experience measures. The second half of this thesis focuses on further optimising the fast MRI protocol for screening and exploring methods of integrating it into an alternative screening pathway. The outcomes point towards a pathway which combines a low threshold PSA and a fast MRI as yielding a more acceptable balance between benefits and harms. This is followed by the development of a risk tool to address the challenges of equivocal MRI lesions. Overall my thesis provides a balanced evaluation of fast MRI as a new screening test and the final chapter highlights outstanding challenges that must be addressed for fast MRI to progress as a legitimate screening modality. There is a requirement for all new screening tests to be evaluated in robust randomised controlled trials and the thesis concludes by setting out a phased research framework for fast MRI to enable a full evaluation over the next decade.

Published
2021
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5. Predicting the Need for Biopsy to Detect Clinically Significant Prostate Cancer in Patients with a Magnetic Resonance Imaging–detected Prostate Imaging Reporting and Data System/Likert ≥3 Lesion: Development and Multinational External Validation of the Imperial Rapid Access to Prostate Imaging and Diagnosis Risk Score

Author

Peters, Max, Eldred-Evans, David, Kurver, Piet, Falagario, Ugo Giovanni, Connor, Martin J., Shah, Taimur T., Verhoeff, Joost J.C., Taimen, Pekka, Aronen, Hannu J., Knaapila, Juha, Montoya Perez, Ileana, Ettala, Otto, Stabile, Armando, Gandaglia, Giorgio, Fossati, Nicola, Martini, Alberto, Cucchiara, Vito, Briganti, Alberto, Lantz, Anna, Picker, Wolfgang, Haug, Erik Skaaheim, Nordström, Tobias, Tanaka, Mariana Bertoncelli, Reddy, Deepika, Bass, Edward, van Rossum, Peter S.N., Wong, Kathie, Tam, Henry, Winkler, Mathias, Gordon, Stephen, Qazi, Hasan, Boström, Peter J., Jambor, Ivan, and Ahmed, Hashim U.

Published
2022
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8. Cancer Control Outcomes Following Focal Therapy Using High-intensity Focused Ultrasound in 1379 Men with Nonmetastatic Prostate Cancer: A Multi-institute 15-year Experience

Author

Reddy, Deepika, Peters, Max, Shah, Taimur T., van Son, Marieke, Tanaka, Mariana Bertoncelli, Huber, Philipp M., Lomas, Derek, Rakauskas, Arnas, Miah, Saiful, Eldred-Evans, David, Guillaumier, Stephanie, Hosking-Jervis, Feargus, Engle, Ryan, Dudderidge, Tim, Hindley, Richard G., Emara, Amr, Nigam, Raj, McCartan, Neil, Valerio, Massimo, Afzal, Naveed, Lewi, Henry, Orczyk, Clement, Ogden, Chris, Shergill, Iqbal, Persad, Raj, Virdi, Jaspal, Moore, Caroline M., Arya, Manit, Winkler, Mathias, Emberton, Mark, and Ahmed, Hashim U.

Published
2022
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9. Multiparametric ultrasound versus multiparametric MRI to diagnose prostate cancer (CADMUS): a prospective, multicentre, paired-cohort, confirmatory study

Author

Grey, Alistair D R, Scott, Rebecca, Shah, Bina, Acher, Peter, Liyanage, Sidath, Pavlou, Menelaos, Omar, Rumana, Chinegwundoh, Frank, Patki, Prasad, Shah, Taimur T, Hamid, Sami, Ghei, Maneesh, Gilbert, Kayleigh, Campbell, Diane, Brew-Graves, Chris, Arumainayagam, Nimalan, Chapman, Alex, McLeavy, Laura, Karatziou, Angeliki, Alsaadi, Zayneb, Collins, Tom, Freeman, Alex, Eldred-Evans, David, Bertoncelli-Tanaka, Mariana, Tam, Henry, Ramachandran, Navin, Madaan, Sanjeev, Winkler, Mathias, Arya, Manit, Emberton, Mark, and Ahmed, Hashim U

Published
2022
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12. Acceptability of magnetic resonance imaging for prostate cancer diagnosis with patients and GPs: a qualitative interview study.

Author

Merriel, Samuel WD, Archer, Stephanie, Forster, Alice S, Eldred-Evans, David, McGrath, John S, Ahmed, Hashim U, Hamilton, Willie, and Walter, Fiona M

Subjects
CANCER diagnosis, MAGNETIC resonance imaging, PROSTATE cancer patients, PRIMARY health care, THEMATIC analysis
Abstract

Background: Magnetic resonance imaging (MRI) of the prostate is a new, more accurate, non-invasive test for prostate cancer diagnosis. Aim: To understand the acceptability of MRI for patients and GPs for prostate cancer diagnosis. Design and setting: Qualitative study of men who had undergone a prostate MRI for possible prostate cancer, and GPs who had referred at least one man for possible prostate cancer in the previous 12 months in West London and Devon. Method: Semi-structured interviews, conducted in person or via telephone, were audio-recorded and transcribed verbatim. Deductive thematic analysis was undertaken using Sekhon's Theoretical Framework of Acceptability, retrospectively for patients and prospectively for GPs. Results: Twenty-two men (12 from Devon, age range 47–80 years), two patients' partners, and 10 GPs (6 female, age range 36–55 years) were interviewed. Prostate MRI was broadly acceptable for most patient participants, and they reported that it was not a significant undertaking to complete the scan. GPs were more varied in their views on prostate MRI, with a broad spectrum of knowledge and understanding of prostate MRI. Some GPs expressed concerns about additional clinical responsibility and local availability of MRI if direct access to prostate MRI in primary care were to be introduced. Conclusion: Prostate MRI appears to be acceptable to patients. Some differences were found between patients in London and Devon, mainly around burden of testing and opportunity costs. Further exploration of GPs' knowledge and understanding of prostate MRI could inform future initiatives to widen access to diagnostic testing in primary care. [ABSTRACT FROM AUTHOR]

Published
2024

13. A Multicentre Analysis of the Detection of Clinically Significant Prostate Cancer Following Transperineal Image-fusion Targeted and Nontargeted Systematic Prostate Biopsy in Men at Risk

Author

Miah, Saiful, Hosking-Jervis, Feargus, Connor, Martin J., Eldred-Evans, David, Shah, Taimur T., Arya, Manit, Barber, Neil, Bhardwa, Jeetesh, Bott, Simon, Burke, Daniel, Doherty, Alan, Foster, Christopher, Freeman, Alex, Hindley, Richard, Jameson, Charles, Karim, Omer, Laniado, Marc, Montgomery, Bruce, Nigam, Raj, Punwani, Shonit, Sinclair, Andrew, Winkler, Mathias, Allen, Clare, and Ahmed, Hashim U.

Published
2020
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18. Prostagram magnetic resonance imaging in a screening population: Prostate Imaging‐Reporting and Data System or Likert?

Author

Mayor, Nikhil, primary, Eldred‐Evans, David, additional, Tam, Henry, additional, Sokhi, Heminder, additional, Padhani, Anwar R., additional, Connor, Martin J., additional, Price, Derek, additional, Gammon, Martin, additional, Klimowska‐Nassar, Natalia, additional, Burak, Paula, additional, Day, Emily, additional, Winkler, Mathias, additional, Fiorentino, Francesca, additional, Shah, Taimur, additional, and Ahmed, Hashim Uddin, additional

Published
2023
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20. Prostagram magnetic resonance imaging in a screening population: Prostate Imaging‐Reporting and Data System or Likert?

Author

Mayor, Nikhil, Eldred‐Evans, David, Tam, Henry, Sokhi, Heminder, Padhani, Anwar R., Connor, Martin J., Price, Derek, Gammon, Martin, Klimowska‐Nassar, Natalia, Burak, Paula, Day, Emily, Winkler, Mathias, Fiorentino, Francesca, Shah, Taimur, and Ahmed, Hashim Uddin

Subjects
*MEDICAL screening, *MAGNETIC resonance imaging, *LIKERT scale, *PROSTATE, *RECEIVER operating characteristic curves
Abstract

Objective: To compare biopsy recommendation rates and accuracy of the Prostate Imaging‐Reporting and Data System, version 2 (PI‐RADSv2) with the Likert scale for detection of clinically significant and insignificant prostate cancer in men screened within the Imperial Prostate 1 Prostate Cancer Screening Trial Using Imaging (IP1‐PROSTAGRAM). Patients and Methods: Men aged 50–69 years were screened with Prostagram MRI. Scans were prospectively reported using both PI‐RADSv2 (excluding dynamic contrast‐enhanced sequence score) and 5‐point Likert scores by expert uro‐radiologists. Systematic and targeted transperineal biopsy was recommended if the scan was scored ≥ 3, based on either reporting system. The proportion of patients recommended for biopsy and detection rates for Grade Groups (GGs) 1 and ≥ 2 were compared. Receiver operating characteristic (ROC) analysis was performed to compare performance. Results: A total of 406 men underwent Prostagram MRI. The median (interquartile range) age and prostate‐specific antigen level were 57 (53–61) years and 0.91 (0.56–1.74) ng/mL, respectively. At MRI score ≥ 3, more patients were recommended for biopsy based on Likert criteria (94/406; 23%, 95% confidence interval [CI] 19.2%–27.6%) compared to PI‐RADSv2 (72/406; 18%, 95% CI 14.2%–21.9%; P = 0.03). For MRI scores ≥ 4, PI‐RADSv2 and Likert scales led to 43/406 (11%, 95% CI 7.9%–14.1%) and 35/406 (9%, 95% CI 6.2%–11.9%) men recommended for biopsy (P = 0.40). For GG ≥ 2 detection, PIRADSv2 and Likert detected 22% (95% CI 11.4%–30.8%, 14/72) and 16% (95% CI 9.5%–25.3%, 15/94), respectively (P = 0.56). For GG1 cancers detection these were 11% (95% CI 4.3%–19.6%, seven of 72) vs 11% (95% CI 4.7%–17.8%, nine of 94; P = 1.00). The accuracy of PI‐RADSv2 and Likert scale was similar (area under the ROC curve 0.64 vs 0.65, P = 0.95). Conclusions: In reporting non‐contrast‐enhanced Prostagram MRI in a screening population, the PI‐RADSv2 and Likert scoring systems were equally accurate; however, Likert scale use led to more men undergoing biopsy without a subsequent increase in significant cancer detection rates. To improve reporting of Prostagram MRI, either the PI‐RADSv2 or a modified Likert scale or a standalone scoring system should be developed. [ABSTRACT FROM AUTHOR]

Published
2024
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21. MP73-11 MEDIUM TERM OUTCOMES FOLLOWING PRIMARY FOCAL CRYOTHERAPY FOR LOCALISED PROSTATE CANCER IN 323 PATIENTS, A MULTI-INSTITUTIONAL OBSERVATIONAL STUDY OVER 10 YEARS

Author

Reddy, Deepika, primary, Peters, Max, additional, Van Son, Marieke, additional, Tanaka, Mariana Bertoncelli, additional, Huber, Philipp, additional, Lomas, Derek, additional, Rakauskas, Arnas, additional, Miah, Saiful, additional, Eldred-Evans, David, additional, Cullen, Emma, additional, Dudderidge, Tim, additional, McCracken, Stuart, additional, Greene, Damian, additional, Nigam, Raj, additional, McCartan, Neil, additional, Valerio, Massimo, additional, Orczyk, Clement, additional, Virdi, Jaspal, additional, Arya, Manit, additional, Shah, Taimur, additional, and Ahmed, Hashim, additional

Published
2023
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24. Circulating Chromosome Conformation Signatures Significantly Enhance PSA Positive Predicting Value and Overall Accuracy for Prostate Cancer Detection

Author

Pchejetski, Dmitri, primary, Hunter, Ewan, additional, Dezfouli, Mehrnoush, additional, Salter, Matthew, additional, Powell, Ryan, additional, Green, Jayne, additional, Naithani, Tarun, additional, Koutsothanasi, Christina, additional, Alshaker, Heba, additional, Jaipuria, Jiten, additional, Connor, Martin J., additional, Eldred-Evans, David, additional, Fiorentino, Francesca, additional, Ahmed, Hashim, additional, Akoulitchev, Alexandre, additional, and Winkler, Mathias, additional

Published
2023
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26. The rapid assessment for prostate imaging and diagnosis ( RAPID ) prostate cancer diagnostic pathway

Author

Eldred‐Evans, David, primary, Connor, Martin J., additional, Bertoncelli Tanaka, Mariana, additional, Bass, Edward, additional, Reddy, Deepika, additional, Walters, Uma, additional, Stroman, Luke, additional, Espinosa, Easter, additional, Das, Raj, additional, Khosla, Nalin, additional, Tam, Henry, additional, Pegers, Elizabeth, additional, Qazi, Hasan, additional, Gordon, Stephen, additional, Winkler, Mathias, additional, and Ahmed, Hashim U., additional

Published
2022
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28. Experiences of 'traditional' and 'one-stop' MRI-based prostate cancer diagnostic pathways in England: a qualitative study with patients and GPs

Author

Merriel, Samuel William David, Archer, Stephanie, Forster, Alice S, Eldred-Evans, David, McGrath, John, Ahmed, Hashim Uddin, Hamilton, Willie, Walter, Fiona M, Merriel, Samuel William David [0000-0003-2919-9087], Archer, Stephanie [0000-0003-1349-7178], Forster, Alice S [0000-0002-9933-7919], Ahmed, Hashim Uddin [0000-0003-1674-6723], Hamilton, Willie [0000-0003-1611-1373], Walter, Fiona M [0000-0002-7191-6476], Apollo - University of Cambridge Repository, and Walter, Fiona [0000-0002-7191-6476]

Subjects
Adult, Aged, 80 and over, Male, urological tumours, Attitude of Health Personnel, Prostatic Neoplasms, General Medicine, Middle Aged, Prostate-Specific Antigen, Magnetic Resonance Imaging, State Medicine, primary care, England, General Practitioners, Prostatic Neoplasms/diagnostic imaging, Humans, Early Detection of Cancer, Qualitative Research, prostate disease, Aged
Abstract

Funder: Wellcome Trust, OBJECTIVES: This study aimed to understand and explore patient and general practitioner (GP) experiences of 'traditional' and 'one-stop' prostate cancer diagnostic pathways in England. DESIGN: Qualitative study using semi-structured interviews, analysed using inductive thematic analysis SETTING: Patients were recruited from National Health Service (NHS) Trusts in London and in Devon; GPs were recruited via National Institute for Health Research (NIHR) Clinical Research Networks. Interviews were conducted in person or via telephone. PARTICIPANTS: Patients who had undergone a MRI scan of the prostate as part of their diagnostic work-up for possible prostate cancer, and GPs who had referred at least one patient for possible prostate cancer in the preceding 12 months. RESULTS: 22 patients (aged 47-80 years) and 10 GPs (6 female, aged 38-58 years) were interviewed. Patients described three key themes: cancer beliefs in relation to patient's attitudes towards prostate cancer;communication with their GP and specialist having a significant impact on experience of the pathway and pathway experience being influenced by appointment and test burden. GP interview themes included: the challenges of dealing with imperfect information in the current pathway; managing uncertainty in identifying patients with possible prostate cancer and sharing this uncertainty with them, and other social, cultural and personal contextual influences. CONCLUSIONS: Patients and GPs reported a range of experiences and views of the current prostate cancer diagnostic pathways in England. Patients valued 'one-stop' pathways integrating prostate MRI and diagnostic consultations with specialists over the more traditional approach of several hospital appointments. GPs remain uncertain how best to identify patients needing referral for urgent prostate cancer testing due to the lack of accurate triage and risk assessment strategies.

Published
2022

30. Cancer Control Outcomes Following Focal Therapy Using High-intensity Focused Ultrasound in 1379 Men with Nonmetastatic Prostate Cancer: A Multi-institute 15-year Experience

Author

Arts-assistenten Radiotherapie, Onderzoek Radiotherapie, Reddy, Deepika, Peters, Max, Shah, Taimur T, van Son, Marieke, Tanaka, Mariana Bertoncelli, Huber, Philipp M, Lomas, Derek, Rakauskas, Arnas, Miah, Saiful, Eldred-Evans, David, Guillaumier, Stephanie, Hosking-Jervis, Feargus, Engle, Ryan, Dudderidge, Tim, Hindley, Richard G, Emara, Amr, Nigam, Raj, McCartan, Neil, Valerio, Massimo, Afzal, Naveed, Lewi, Henry, Orczyk, Clement, Ogden, Chris, Shergill, Iqbal, Persad, Raj, Virdi, Jaspal, Moore, Caroline M, Arya, Manit, Winkler, Mathias, Emberton, Mark, Ahmed, Hashim U, Arts-assistenten Radiotherapie, Onderzoek Radiotherapie, Reddy, Deepika, Peters, Max, Shah, Taimur T, van Son, Marieke, Tanaka, Mariana Bertoncelli, Huber, Philipp M, Lomas, Derek, Rakauskas, Arnas, Miah, Saiful, Eldred-Evans, David, Guillaumier, Stephanie, Hosking-Jervis, Feargus, Engle, Ryan, Dudderidge, Tim, Hindley, Richard G, Emara, Amr, Nigam, Raj, McCartan, Neil, Valerio, Massimo, Afzal, Naveed, Lewi, Henry, Orczyk, Clement, Ogden, Chris, Shergill, Iqbal, Persad, Raj, Virdi, Jaspal, Moore, Caroline M, Arya, Manit, Winkler, Mathias, Emberton, Mark, and Ahmed, Hashim U

Published
2022

31. Predicting the Need for Biopsy to Detect Clinically Significant Prostate Cancer in Patients with a Magnetic Resonance Imaging-detected Prostate Imaging Reporting and Data System/Likert ≥3 Lesion: Development and Multinational External Validation of the Imperial Rapid Access to Prostate Imaging and Diagnosis Risk Score

Author

Arts-assistenten Radiotherapie, MS Radiotherapie, Cancer, Peters, Max, Eldred-Evans, David, Kurver, Piet, Falagario, Ugo Giovanni, Connor, Martin J, Shah, Taimur T, Verhoeff, Joost J C, Taimen, Pekka, Aronen, Hannu J, Knaapila, Juha, Montoya Perez, Ileana, Ettala, Otto, Stabile, Armando, Gandaglia, Giorgio, Fossati, Nicola, Martini, Alberto, Cucchiara, Vito, Briganti, Alberto, Lantz, Anna, Picker, Wolfgang, Haug, Erik Skaaheim, Nordström, Tobias, Tanaka, Mariana Bertoncelli, Reddy, Deepika, Bass, Edward, van Rossum, Peter S N, Wong, Kathie, Tam, Henry, Winkler, Mathias, Gordon, Stephen, Qazi, Hasan, Boström, Peter J, Jambor, Ivan, Ahmed, Hashim U, Arts-assistenten Radiotherapie, MS Radiotherapie, Cancer, Peters, Max, Eldred-Evans, David, Kurver, Piet, Falagario, Ugo Giovanni, Connor, Martin J, Shah, Taimur T, Verhoeff, Joost J C, Taimen, Pekka, Aronen, Hannu J, Knaapila, Juha, Montoya Perez, Ileana, Ettala, Otto, Stabile, Armando, Gandaglia, Giorgio, Fossati, Nicola, Martini, Alberto, Cucchiara, Vito, Briganti, Alberto, Lantz, Anna, Picker, Wolfgang, Haug, Erik Skaaheim, Nordström, Tobias, Tanaka, Mariana Bertoncelli, Reddy, Deepika, Bass, Edward, van Rossum, Peter S N, Wong, Kathie, Tam, Henry, Winkler, Mathias, Gordon, Stephen, Qazi, Hasan, Boström, Peter J, Jambor, Ivan, and Ahmed, Hashim U

Published
2022

32. The rapid assessment for prostate imaging and diagnosis (RAPID) prostate cancer diagnostic pathway.

Author

Eldred‐Evans, David, Connor, Martin J., Bertoncelli Tanaka, Mariana, Bass, Edward, Reddy, Deepika, Walters, Uma, Stroman, Luke, Espinosa, Easter, Das, Raj, Khosla, Nalin, Tam, Henry, Pegers, Elizabeth, Qazi, Hasan, Gordon, Stephen, Winkler, Mathias, and Ahmed, Hashim U.

Subjects
*PROSTATE cancer, *PATIENT satisfaction, *MAGNETIC resonance imaging, *PROSTATE, *EARLY detection of cancer
Abstract

Objective: To report outcomes within the Rapid Assessment for Prostate Imaging and Diagnosis (RAPID) diagnostic pathway, introduced to reduce patient and healthcare burdens and standardize delivery of pre‐biopsy multiparametric magnetic resonance imaging (MRI) and transperineal biopsy. Patients and Methods: A total of 2130 patients from three centres who completed the RAPID pathway (3 April 2017 to 31 March 2020) were consecutively entered as a prospective registry. These patients were also compared to a pre‐RAPID cohort of 2435 patients. Patients on the RAPID pathway with an MRI score 4 or 5 and those with PSA density ≥0.12 and an MRI score 3 were advised to undergo a biopsy. Primary outcomes were rates of biopsy and cancer detection. Secondary outcomes included comparison of transperineal biopsy techniques, patient acceptability and changes in time to diagnosis before and after the introduction of RAPID. Results: The median patient age and PSA level were 66 years and 6.6 ng/mL, respectively. Biopsy could be omitted in 43% of patients (920/2130). A further 7.9% of patients (168/2130) declined a recommendation for biopsy. The percentage of biopsies avoided among sites varied (45% vs 36% vs 51%; P < 0.001). In all, 30% (221/742) had a local anaesthetic (grid and stepper) transperineal biopsy. Clinically significant cancer detection (any Gleason score ≥3 + 4) was 26% (560/2130) and detection of Gleason score 3 + 3 alone constituted 5.8% (124/2130); detection of Gleason score 3 + 3 did not significantly vary among sites (P = 0.7). Among participants who received a transperineal targeted biopsy, there was no difference in cancer detection rates among local anaesthetic, sedation and general anaesthetic groups. In the 2435 patients from the pre‐RAPID cohor, time to diagnosis was 32.1 days (95% confidence interval [CI] 29.3–34.9) compared to 15.9 days (95% CI 12.9–34.9) in the RAPID group. A total of 141 consecutive patient satisfaction surveys indicated a high satisfaction rate with the pathway; 50% indicated a preference for having all tests on a single day. Conclusions: The RAPID prostate cancer diagnostic pathway allows 43% of men to avoid a biopsy while preserving good detection of clinically significant cancers and low detection of insignificant cancers, although there were some centre‐level variations. [ABSTRACT FROM AUTHOR]

Published
2023
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33. MP55-01 CANCER CONTROL OUTCOMES FOLLOWING FOCAL THERAPY USING HIFU IN 1,379 MEN WITH NON-METASTATIC PROSTATE CANCER: A MULTI-INSTITUTE 15-YEAR EXPERIENCE

Author

Reddy, Deepika, primary, Peters, Max, additional, Shah, Taimur, additional, van Son, Marieke, additional, Bertoncelli, Mariana Tanaka, additional, Huber, Philipp, additional, Lomas, Derek, additional, Rakauskas, Arnas, additional, Miah, Saiful, additional, Eldred-Evans, David, additional, Guillaumier, Stephanie, additional, Hosking-Jervis, Feargus, additional, Engle, Ryan, additional, Dudderidge, Tim, additional, Hindley, Richard, additional, Emara, Amr, additional, Nigam, Raj, additional, McCartan, Neil, additional, Valerio, Massimo, additional, Afzal, Naveed, additional, Lewi, Henry, additional, Orczyk, Clement, additional, Ogden, Chris, additional, Shergill, Iqbal, additional, Persad, Raj, additional, Virdi, Jaspal, additional, Moore, Caroline, additional, Arya, Manit, additional, Winkler, Mathias, additional, Emberton, Mark, additional, and Ahmed, Hashim, additional

Published
2022
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34. PD17-01 DERIVATION AND EXTERNAL VALIDATION OF A RAPID RISK SCORE FOR PREDICTING CLINICALLY SIGNIFICANT PROSTATE CANCER IN MEN WITH AN MRI VISIBLE LESION: A MULTINATIONAL COHORT STUDY

Author

Peters, Max, primary, Eldred-Evans, David, additional, Kurver, Piet, additional, Falagario, Ugo Giovanni, additional, Connor, Martin J., additional, Verhoeff, Joost J.C., additional, Carrieri, Giuseppe, additional, Cormio, Luigi, additional, Taimen, Pekka, additional, Aronen, Hannu J, additional, Knaapila, Juha, additional, Perez, Ileana Montoya, additional, Ettala, Otto, additional, Stabile, Armando, additional, Gandaglia, Giorgio, additional, Fossati, Nicola, additional, Martini, Alberto, additional, Cucchiara, Vito, additional, Briganti, Alberto, additional, Lantz, Anna, additional, Picker, Wolfgang, additional, Haug, Erik, additional, Nordström, Tobias, additional, Tanaka, Mariana Bertoncelli, additional, Hosking-Jervis, Feargus, additional, Reddy, Deepika, additional, Bass, Edward, additional, van Rossum, Peter S.N., additional, Joshi, Suchita, additional, Pegers, Elizabeth, additional, Wong, Kathie, additional, Tam, Henry, additional, Hrouda, David, additional, McCraken, Stuart, additional, Winkler, Mathias, additional, Gordon, Stephen, additional, Qazi, Hasan, additional, Boström, Peter J., additional, Jambor, Ivan, additional, and Ahmed, Hashim U., additional

Published
2022
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35. MP55-06 FOCAL ABLATIVE SALVAGE THERAPY FOR RADIO-RECURRENT PROSTATE CANCER: 6 YEAR ONCOLOGICAL AND SAFETY OUTCOMES

Author

Reddy, Deepika, primary, Peters, Max, additional, Shah, Taimur, additional, van Son, Marieke, additional, Bertoncelli, Mariana Tanaka, additional, Huber, Philipp, additional, Lomas, Derek, additional, Rakauskas, Arnas, additional, Miah, Saiful, additional, Eldred-Evans, David, additional, Guillaumier, Stephanie, additional, Hosking-Jervis, Feargus, additional, Engle, Ryan, additional, Dudderidge, Tim, additional, Hindley, Richard, additional, Emara, Amr, additional, Nigam, Raj, additional, McCartan, Neil, additional, Valerio, Massimo, additional, Afzal, Naveed, additional, Lewi, Henry, additional, Orczyk, Clement, additional, Ogden, Chris, additional, Shergill, Iqbal, additional, Persad, Raj, additional, Virdi, Jaspal, additional, McCracken, Stuart, additional, Greene, Damian, additional, Moore, Caroline, additional, Arya, Manit, additional, Winkler, Mathias, additional, Emberton, Mark, additional, and Ahmed, Hashim, additional

Published
2022
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39. MP05-10 IMPACT OF NON-TARGETED PROSTATE SAMPLING HISTOLOGY ON THE PROBABILITY OF RECEIVING INVASIVE LOCAL TREATMENT IN AN MPMRI-TARGETED PATHWAY—ANALYSIS OF 1,719 MEN

Author

Connor, Martin John, primary, van Son, Marieke, additional, Eldred-Evans, David, additional, Bass, Edward J., additional, Tanaka, Mariana Bertoncelli, additional, Walter, Uma, additional, Sakar, Pallab, additional, Hosking-Jervis, Feargus, additional, Bhola-Stewart, Heather, additional, Pegers, Elizabeth, additional, Leelamany, Deepa, additional, Wong, Kathie, additional, Ahmad, Shahzad, additional, McCracken, Stuart, additional, Hrouda, David, additional, Qazi, Hasan, additional, Gordon, Stephen, additional, Winkler, Mathias, additional, and Ahmed, Hashim U., additional

Published
2021
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40. PD34-12 MRI FINDINGS IN DE NOVO SYNCHRONOUS METASTATIC PROSTATE CANCER AND IMPLICATIONS FOR CYTOREDUCTIVE SURGERY

Author

Connor, Martin John, primary, Edison, Marie, additional, Bass, Edward J., additional, Eldred-Evans, David, additional, Bertoncelli, Mariana Tanaka, additional, Hrouda, David, additional, Khoubehi, Bijan, additional, Hellawell, Giles, additional, Rai, Bhavan, additional, Dudderidge, Tim, additional, Tam, Henry, additional, Winkler, Mathias, additional, and Ahmed, Hashim U., additional

Published
2021
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41. MP01-07 PRESERVATION OF SEXUAL FUNCTION FOLLOWING REZUM® THERAPY FOR LUTS/BPH TOO GOOD TO BE TRUE? REAL WORLD OUTCOMES FROM 181 CASES

Author

Connor, Martin John, primary, Rai, Amar, additional, Khoo, Charlie, additional, Tanaka, Mariana Bertoncelli, additional, Bass, Edward J., additional, Eldred-Evans, David, additional, Agarwal, Sanjiv, additional, Dasgupta, Ranan, additional, Winkler, Mathias, additional, Abboudi, Hamid, additional, El-husseiny, Tamer, additional, and Ahmed, Hashim U., additional

Published
2021
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42. MP11-10 RE-REFERRAL RATES IN THE MEDIUM TERM IN PATIENTS WITH A NON-SUSPICIOUS MPMRI WITHIN THE RAPID PATHWAY

Author

Tanaka, Mariana Bertoncelli, primary, Walter, Uma, additional, Eldred-Evans, David, additional, Bass, Edward J., additional, Connor, Martin J., additional, Sarkar, Pallab, additional, Hoskings-Jervis, Feargus, additional, Bhola-Stewart, Heather, additional, Pegers, Elizabeth, additional, Powell, Laura, additional, Leelamany, Deepa, additional, Wong, Kathie, additional, Ahmad, Shahzad, additional, Tam, Henry, additional, Qazi, Hasan, additional, Gordon, Stephen, additional, Hrouda, David, additional, McCracken, Stuart, additional, Winkler, Mathias, additional, and Ahmed, Hashim U., additional

Published
2021
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45. A Comparison of Prostate Cancer Detection Between Visual-Estimation (Cognitive Registration) and Image-Fusion (Software Registration) Targeted Transperineal Prostate Biopsy

Author

Arts-assistenten Radiotherapie, Onderzoek Radiotherapie, Cancer, Khoo, Christopher C, Eldred-Evans, David, Peters, Max, van Son, Marieke, van Rossum, Peter, Connor, Martin J, Hosking-Jervis, Feargus, Tanaka, Mariana Bertoncelli, Reddy, Deepika, Bass, Edward, Powell, Laura, Ahmad, Shahzad, Pegers, Elizabeth, Joshi, Suchita, Sri, Denosshan, Wong, Kathie, Tam, Henry, Hrouda, David, Qazi, Hasan, Gordon, Stephen, McCracken, Stuart, Winkler, Mathias, Ahmed, Hashim U, Arts-assistenten Radiotherapie, Onderzoek Radiotherapie, Cancer, Khoo, Christopher C, Eldred-Evans, David, Peters, Max, van Son, Marieke, van Rossum, Peter, Connor, Martin J, Hosking-Jervis, Feargus, Tanaka, Mariana Bertoncelli, Reddy, Deepika, Bass, Edward, Powell, Laura, Ahmad, Shahzad, Pegers, Elizabeth, Joshi, Suchita, Sri, Denosshan, Wong, Kathie, Tam, Henry, Hrouda, David, Qazi, Hasan, Gordon, Stephen, McCracken, Stuart, Winkler, Mathias, and Ahmed, Hashim U

Published
2021

48. A Comparison of Prostate Cancer Detection between Visual Estimation (Cognitive Registration) and Image Fusion (Software Registration) Targeted Transperineal Prostate Biopsy

Author

Khoo, Christopher C., primary, Eldred-Evans, David, additional, Peters, Max, additional, van Son, Marieke, additional, van Rossum, Peter S. N., additional, Connor, Martin J., additional, Hosking-Jervis, Feargus, additional, Tanaka, Mariana Bertoncelli, additional, Reddy, Deepika, additional, Bass, Edward, additional, Powell, Laura, additional, Ahmad, Shahzad, additional, Pegers, Elizabeth, additional, Joshi, Suchita, additional, Sri, Denosshan, additional, Wong, Kathie, additional, Tam, Henry, additional, Hrouda, David, additional, Qazi, Hasan, additional, Gordon, Stephen, additional, McCracken, Stuart, additional, Winkler, Mathias, additional, and Ahmed, Hashim U., additional

Published
2021
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49. Re: Antonio C. Westphalen, Charles E. McCulloch, Jordan M. Anaokar, et al. Variability of the Positive Predictive Value of PI-RADS for Prostate MRI across 26 Centers: Experience of the Society of Abdominal Radiology Prostate Cancer Disease-focused Panel. Radiology 2020;296:76–84

Author

Jambor, Ivan, primary, Falagario, Ugo G., additional, Martini, Alberto, additional, Eldred-Evans, David, additional, Ahmed, Hashim U., additional, and Boström, Peter J., additional

Published
2020
Full Text
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