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Background:The ductus, an essential component of foetal circulation, normally closes within the first days of life. 5 However, in preterm infants, closure of the ductus arteriosus is frequently delayed or fails to eventuate. We aimed in this study to determine the frequency of spontaneous closure of PDA among preterm infants at Zagazig University Hospitals. Methods: We performed this prospective study on 57 preterm neonates with patent ductus arteriosus admitted at NICU, Zagazig University Hospital. Routine laboratory investigations were done to all neonates. All PDAs were assessed by Echocardiography before 4th day of life and were followed up by once or twice echocardiography per week, the date of the echocardiogram was used as the ductal closure date when it was closed. Results: Among the total cases (n=57), 19.30% experienced spontaneous PDA closure, while 80.70% had persistent DA.Initially, the mean PDA diameter was 1.84 ± 0.85 millimeters, with a median of 1.60 millimeters and a range from 1 to 5 millimeters. Upon follow-up, the mean PDA diameter decreased to 1.33 ± 1.03 millimeters, with a median of 1.10 millimeters and a range from 0 to 5 millimeters. This represents a closure percentage of 25.07%. There were highly statistically significant results between spontaneous PDA closure with gestational age and albumin. The results showed that duct closure increases with increased gestational age andhigh albumin level (p-value = 0.009, and 0.02 respectively). Persistent PDA was associated with a significant lower gestational age, p-value 0.012. Conclusions:The rate of spontaneous PDA Closure in our study was 19.30%, so we concluded giving a chance for spontaneous closure of the duct. Factors associated with persistence of the duct opened included low gestational age and low albumin levels. [ABSTRACT FROM AUTHOR]