150 results on '"Elaine M. Smith"'
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2. Introduction
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Karl E. Westhauser, Margaret Holler Stephens, Elaine M. Smith, Jennifer A. Fremlin, and Janice R Franklin
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- 2005
3. Title Page, Copyright
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Karl E. Westhauser, Margaret Holler Stephens, Elaine M. Smith, Jennifer A. Fremlin, and Janice R Franklin
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- 2005
4. PART TWO Region-Wide
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Karl E. Westhauser, Margaret Holler Stephens, Elaine M. Smith, Jennifer A. Fremlin, and Janice R Franklin
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- 2005
5. PART ONE Alabama Black-White Mix
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Karl E. Westhauser, Margaret Holler Stephens, Elaine M. Smith, Jennifer A. Fremlin, and Janice R Franklin
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- 2005
6. Preface
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Karl E. Westhauser, Margaret Holler Stephens, Elaine M. Smith, Jennifer A. Fremlin, and Janice R Franklin
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- 2005
7. 2 / E Pluribus UnumDiscovering Multiculturalism
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Karl E. Westhauser, Margaret Holler Stephens, Elaine M. Smith, Jennifer A. Fremlin, and Janice R Franklin
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- 2005
8. 3 / Genesis of the National Center forthe Study of Civil Rightsand African-American Culture
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Karl E. Westhauser, Margaret Holler Stephens, Elaine M. Smith, Jennifer A. Fremlin, and Janice R Franklin
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- 2005
9. 1 / You Can Go Home Again
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Karl E. Westhauser, Margaret Holler Stephens, Elaine M. Smith, Jennifer A. Fremlin, and Janice R Franklin
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- 2005
10. 8 / City on a Hill
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Karl E. Westhauser, Margaret Holler Stephens, Elaine M. Smith, Jennifer A. Fremlin, and Janice R Franklin
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- 2005
11. 5 / Living a Womanist Legacy
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Karl E. Westhauser, Margaret Holler Stephens, Elaine M. Smith, Jennifer A. Fremlin, and Janice R Franklin
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- 2005
12. PART THREE Non-SouthernWhat Difference?
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Karl E. Westhauser, Margaret Holler Stephens, Elaine M. Smith, Jennifer A. Fremlin, and Janice R Franklin
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- 2005
13. 4 / I Go to College
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Karl E. Westhauser, Margaret Holler Stephens, Elaine M. Smith, Jennifer A. Fremlin, and Janice R Franklin
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- 2005
14. 6 / I Pledge Allegiance toMy “Black-Eyed Susan' University [Contains Image Plates]
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Karl E. Westhauser, Margaret Holler Stephens, Elaine M. Smith, Jennifer A. Fremlin, and Janice R Franklin
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- 2005
15. 7 / Portrait of the Artist as a Young White Man
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Karl E. Westhauser, Margaret Holler Stephens, Elaine M. Smith, Jennifer A. Fremlin, and Janice R Franklin
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- 2005
16. PART FOUR International All Welcome
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Karl E. Westhauser, Margaret Holler Stephens, Elaine M. Smith, Jennifer A. Fremlin, and Janice R Franklin
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- 2005
17. 9 / Called Home
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Karl E. Westhauser, Margaret Holler Stephens, Elaine M. Smith, Jennifer A. Fremlin, and Janice R Franklin
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- 2005
18. Bibliography
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Karl E. Westhauser, Margaret Holler Stephens, Elaine M. Smith, Jennifer A. Fremlin, and Janice R Franklin
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- 2005
19. 11 / The Color BrownAn Asian’s Perspective
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Karl E. Westhauser, Margaret Holler Stephens, Elaine M. Smith, Jennifer A. Fremlin, and Janice R Franklin
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- 2005
20. Appendix: America’s Historically Black Colleges and Universities
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Karl E. Westhauser, Margaret Holler Stephens, Elaine M. Smith, Jennifer A. Fremlin, and Janice R Franklin
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- 2005
21. 10 / “You’re Not White, You’re Canadian'Where I Belong
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Karl E. Westhauser, Margaret Holler Stephens, Elaine M. Smith, Jennifer A. Fremlin, and Janice R Franklin
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- 2005
22. Afterword
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Karl E. Westhauser, Margaret Holler Stephens, Elaine M. Smith, Jennifer A. Fremlin, and Janice R Franklin
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- 2005
23. Case–Control Study of Vulvar Vestibulitis Risk Associated With Genital Infections
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Elaine M. Smith, Justine M. Ritchie, Rudolph Galask, Erica E. Pugh, Jian Jia, and Joan Ricks-McGillan
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Gynecology and obstetrics ,RG1-991 ,Infectious and parasitic diseases ,RC109-216 - Abstract
Objective: To evaluate the risk of vulvar vestibulitis syndrome (VVS) associated with genital infections in a case–control study.
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- 2002
- Full Text
- View/download PDF
24. Predictors of Chlamydia trachomatis Infection Among Women Attending Rural Midwest Family Planning Clinics
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Tami M. Hilger, Elaine M. Smith, and Kevin Ault
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Gynecology and obstetrics ,RG1-991 ,Infectious and parasitic diseases ,RC109-216 - Abstract
Objective: To determine predictors of Chlamydia trachomatis infection among women 14–24 years of age attending family planning clinics throughout a rural Midwestern state.
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- 2001
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25. Evidence for Vertical Transmission of HPV from Mothers to Infants
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Elaine M. Smith, Michael A. Parker, Linda M. Rubenstein, Thomas H. Haugen, Eva Hamsikova, and Lubomir P. Turek
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Gynecology and obstetrics ,RG1-991 ,Infectious and parasitic diseases ,RC109-216 - Abstract
Few large studies have evaluated concordance based on a broad spectrum of human papillomavirus (HPV) types in oral and genital specimens of mothers and their recently born infants. This information is important in determining whether HPV vaccines administered prior to pregnancy may be useful for preventing vertical transmission. HPV DNA was positive in 30% of mothers and 1.5% of newborns. Maternal/newborn concordance (HPV+/+ or HPV−/−) was 71%. Among HPV DNA+ mothers, only 3% of their infants were DNA+ and only 1 pair had the same HPV type. Among HPV− women, 0.8% of infants were HPV+. HPV DNA detected in hospitalized newborns reflects current infection transmitted to infants during pregnancy or delivery. None of the mother/baby HPV DNA+ concordance pairs detected viral types found in HPV vaccines suggesting that vaccination prior to pregnancy is unlikely to be efficacious in preventing vertical transmission.
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- 2010
- Full Text
- View/download PDF
26. Supplementary Methods, Figures 1-6 from Fundamental Differences in Cell Cycle Deregulation in Human Papillomavirus–Positive and Human Papillomavirus–Negative Head/Neck and Cervical Cancers
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Paul Ahlquist, Lubomir P. Turek, Karl T. Kelsey, Elaine M. Smith, Thomas H. Haugen, Joseph P. Connor, Craig D. Woodworth, Carmen J. Marsit, Srikumar Sengupta, Johan A. den Boon, Paul F. Lambert, Michael A. Newton, and Dohun Pyeon
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Supplementary Methods, Figures 1-6 from Fundamental Differences in Cell Cycle Deregulation in Human Papillomavirus–Positive and Human Papillomavirus–Negative Head/Neck and Cervical Cancers
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- 2023
27. Data from Fundamental Differences in Cell Cycle Deregulation in Human Papillomavirus–Positive and Human Papillomavirus–Negative Head/Neck and Cervical Cancers
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Paul Ahlquist, Lubomir P. Turek, Karl T. Kelsey, Elaine M. Smith, Thomas H. Haugen, Joseph P. Connor, Craig D. Woodworth, Carmen J. Marsit, Srikumar Sengupta, Johan A. den Boon, Paul F. Lambert, Michael A. Newton, and Dohun Pyeon
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Human papillomaviruses (HPV) are associated with nearly all cervical cancers, 20% to 30% of head and neck cancers (HNC), and other cancers. Because HNCs also arise in HPV-negative patients, this type of cancer provides unique opportunities to define similarities and differences of HPV-positive versus HPV-negative cancers arising in the same tissue. Here, we describe genome-wide expression profiling of 84 HNCs, cervical cancers, and site-matched normal epithelial samples in which we used laser capture microdissection to enrich samples for tumor-derived versus normal epithelial cells. This analysis revealed that HPV+ HNCs and cervical cancers differed in their patterns of gene expression yet shared many changes compared with HPV− HNCs. Some of these shared changes were predicted, but many others were not. Notably, HPV+ HNCs and cervical cancers were found to be up-regulated in their expression of a distinct and larger subset of cell cycle genes than that observed in HPV− HNC. Moreover, HPV+ cancers overexpressed testis-specific genes that are normally expressed only in meiotic cells. Many, although not all, of the hallmark differences between HPV+ HNC and HPV− HNC were a direct consequence of HPV and in particular the viral E6 and E7 oncogenes. This included a novel association of HPV oncogenes with testis-specific gene expression. These findings in primary human tumors provide novel biomarkers for early detection of HPV+ and HPV− cancers, and emphasize the potential value of targeting E6 and E7 function, alone or combined with radiation and/or traditional chemotherapy, in the treatment of HPV+ cancers. [Cancer Res 2007;67(10):4605–19]
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- 2023
28. The imaginary friends of my friends: Imagined contact interventions which highlight supportive social norms reduce children’s antirefugee bias
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Elaine M. Smith and Anca Minescu
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Cultural Studies ,Sociology and Political Science ,Arts and Humanities (miscellaneous) ,Social Psychology ,Communication ,Refugee ,Psychological intervention ,School intervention ,Psychology ,Social psychology ,Prejudice (legal term) ,The Imaginary - Abstract
Fostering inclusive attitudes among children in host classrooms is key to integrating refugee children. A field experiment tests the prejudice reduction effects of a teacher-led activity integrating imagined intergroup contact and normative influence. To enhance the effectiveness of imagined contact, scenarios include supportive ingroup norms. In 29 classes, 545 children ( Mage = 10.88, SD = 0.96) were randomly assigned to one of five conditions: standard imagined contact, imagined contact encouraged by family, class peers, or religious ingroups, or a control. Children in all norm-framed imagined contact conditions had significantly less antirefugee bias compared with the control. The class-peer norm frame significantly reduced affective and cognitive facets of bias. The family norm frame reduced affective bias, and the religious norm frame reduced cognitive bias. Standard imagined contact did not differ from the control. Potential mediating pathways are explored. These findings illustrate the utility of incorporating norms into imagined contact interventions to reduce antirefugee bias among schoolchildren.
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- 2021
29. Comparing normative influence from multiple groups: Beyond family, religious ingroup norms predict children’s prejudice towards refugees
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Anca Minescu and Elaine M. Smith
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Sociology and Political Science ,Social Psychology ,media_common.quotation_subject ,Refugee ,05 social sciences ,050109 social psychology ,Ingroups and outgroups ,humanities ,language.human_language ,Normative social influence ,Irish ,Perception ,language ,0501 psychology and cognitive sciences ,Business and International Management ,Psychology ,Social psychology ,Social dominance orientation ,Intergroup anxiety ,Prejudice (legal term) ,050104 developmental & child psychology ,media_common - Abstract
In the wake of the global refugee crisis, children are exposed to negative attitudes from public and private spheres. Previous research has identified family, peer, and school norms as significant predictors of children’s inter-ethnic attitudes. We extend this literature by examining normative influence from wider society, which has received substantially less attention. Among 266 children (Mage = 11.24), this study investigates the relative contributions of norms from five ingroups (family, class-peers, Irish, religious and all-humanity) to predict children’s anti-refugee bias. Perceptions of positive family and religious norms were the strongest unique predictors of contact intentions and warmth towards refugees. Intergroup anxiety and perceived threat mediated these relationships. Social dominance orientation mediated family normative influence only. These findings highlight the importance of broader groups (beyond that of proximal ingroups) for understanding children’s intergroup attitudes.
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- 2021
30. Understanding Change in Social‐Movement Participation: The Roles of Social Norms and Group Efficacy
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Cristián Frigolett, Elaine M. Smith, and Roberto González
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Philosophy ,Clinical Psychology ,Sociology and Political Science ,Social Psychology ,Group efficacy ,Political Science and International Relations ,Social change ,Experimental and Cognitive Psychology ,Psychology ,Collective action ,Social psychology ,Social movement - Published
- 2021
31. A test of the maintenance of the effects of imagined contact framed with supportive social norms as a teacher-led field intervention
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Elaine M. Smith and Anca Minescu
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Schools ,Developmental and Educational Psychology ,Social Norms ,Educational Personnel ,Humans ,Child ,Prejudice ,Education - Abstract
As the arrival of refugees and asylum seekers continues to increase, schools continue to become a vital center for children to develop positive intergroup attitudes. Teacher-led activities can become useful tools in sustainable prejudice reduction. A field intervention incorporated normative in-group influence with imagined intergroup contact to reduce children's anti-refugee bias. Ten primary school classes (N = 269, M
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- 2021
32. Infection with Human Papilloma Virus (HPV) and risk of subsites within the oral cancer
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Michael D. McClean, Dana Hashim, Mia Hashibe, Stephen M. Schwartz, Stefania Boccia, Giulia Collatuzzo, Karl T. Kelsey, Elaine M. Smith, Chu Chen, Rolando Herrero, Silvia Franceschi, Luca Giraldi, Paolo Boffetta, Maura L. Gillison, Yuan Chin Amy Lee, Giraldi L., Collatuzzo G., Hashim D., Franceschi S., Herrero R., Chen C., Schwartz S.M., Smith E., Kelsey K., McClean M., Gillison M., Boccia S., Hashibe M., Amy Lee Y.-C., and Boffetta P.
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Cancer Research ,medicine.medical_specialty ,Epidemiology ,Human papilloma virus ,Alphapapillomavirus ,Human papilloma viru ,Gum ,Tongue ,Risk Factors ,Internal medicine ,medicine ,Humans ,Clinical significance ,Papillomaviridae ,Settore MED/42 - IGIENE GENERALE E APPLICATA ,business.industry ,Palate ,Risk Factor ,Oral cancer ,Head and neck cancer ,Not Otherwise Specified ,Alphapapillomaviru ,Papillomavirus Infections ,Floor of mouth ,HPV infection ,Cancer ,Odds ratio ,medicine.disease ,Mouth Neoplasm ,Oral cavity ,medicine.anatomical_structure ,Oncology ,Case-Control Studies ,Mouth Neoplasms ,business ,Case-Control Studie ,Human - Abstract
Background The aim of this study was to investigate the relationship between high-risk genotypes of Human Papilloma Virus (HPV) and cancer of different subsites of the oral cavity. Material and methods A pooled analysis of five studies included on the International Head and Neck Cancer Epidemiology (INHANCE) Consortium was conducted. HPV 16 and HPV 18 were considered. Adjusted odds ratios (ORs) and corresponding 95 % confidence intervals (CIs) for HPV and each oral cavity subsites were simultaneously estimated using multinomial logistic regression models. Results The analysis included 1157 cases and 3272 controls. This study showed a slightly higher prevalence of HPV infection among oral cancer cases than controls. In particular, an increased risk of other and not otherwise specified (NOS) sites within the oral cavity, oral tongue, palate and floor of mouth cancer was observed for overall HPV16 positivity (OR = 1.66, 95 % CI: 1.01−2.72; OR = 1.97, 95 % CI: 1.36−2.85; OR = 2.48, 95 % CI: 1.50−4.11; OR = 2.71, 95 % CI: 1.06−6.95, respectively). In particular, HPV16E7 was related to cancer of floor of mouth, oral cavity NOS and palate (OR = 2.71, 95 % CI: 1.06−6.95; OR = 3.32, 95 % CI:1.53−7.19; OR = 3.34, 95 % CI:1.38−8.06). Results were inconsistent for HPV18 due to low prevalence of infection. Conclusion Our study suggests that HPV16 infection may increase the risk of developing floor of mouth, gum, tongue, and palate cancers. Clinical relevance Subjects with HPV infection have a higher risk of cancer from all sites of the oral cavity.
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- 2021
33. Chapter 1. 'Closed Doors'
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Elaine M. Smith and Mary McLeod Bethune
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- 2020
34. Risk Prediction Models for Head and Neck Cancer in the US Population From the INHANCE Consortium
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Thomas L. Vaughan, Stimson P. Schantz, Neil D. Gross, Yuan Chin Amy Lee, Philip Lazarus, Joshua E. Muscat, Michael D. McClean, Paolo Boffetta, Jose P. Zevallos, Jaewhan Kim, Guo Pei Yu, Zuo-Feng Zhang, Mia Hashibe, Andrew F. Olshan, Chu Chen, Gypsyamber D'Souza, Mohammed H. Al-Temimi, Stephen M. Schwartz, Maura L. Gillison, Elaine M. Smith, Marcus M. Monroe, Karl T. Kelsey, Erich M. Sturgis, Jian Ying, Deborah M. Winn, Guojun Li, and Hal Morgenstern
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Male ,Practice of Epidemiology ,oropharyngeal cancer ,Epidemiology ,medicine.medical_treatment ,absolute risk ,Medical and Health Sciences ,Mathematical Sciences ,risk prediction ,Substance Misuse ,0302 clinical medicine ,Theoretical ,Models ,030212 general & internal medicine ,Family history ,Cancer ,education.field_of_study ,Absolute risk reduction ,Hypopharyngeal cancer ,Middle Aged ,Head and Neck Neoplasms ,030220 oncology & carcinogenesis ,laryngeal cancer ,Female ,medicine.medical_specialty ,Population ,Risk Assessment ,03 medical and health sciences ,Rare Diseases ,Tobacco ,medicine ,Humans ,Risk factor ,Dental/Oral and Craniofacial Disease ,education ,Aged ,Tobacco Smoke and Health ,business.industry ,Prevention ,Head and neck cancer ,oral cavity cancer ,Models, Theoretical ,medicine.disease ,United States ,Good Health and Well Being ,Case-Control Studies ,Smoking cessation ,head and neck cancer ,business ,hypopharyngeal cancer ,Demography - Abstract
Head and neck cancer (HNC) risk prediction models based on risk factor profiles have not yet been developed. We took advantage of the large database of the International Head and Neck Cancer Epidemiology (INHANCE) Consortium, including 14 US studies from 1981–2010, to develop HNC risk prediction models. Seventy percent of the data were used to develop the risk prediction models; the remaining 30% were used to validate the models. We used competing-risk models to calculate absolute risks. The predictors included age, sex, education, race/ethnicity, alcohol drinking intensity, cigarette smoking duration and intensity, and/or family history of HNC. The 20-year absolute risk of HNC was 7.61% for a 60-year-old woman who smoked more than 20 cigarettes per day for over 20 years, consumed 3 or more alcoholic drinks per day, was a high school graduate, had a family history of HNC, and was non-Hispanic white. The 20-year risk for men with a similar profile was 6.85%. The absolute risks of oropharyngeal and hypopharyngeal cancers were generally lower than those of oral cavity and laryngeal cancers. Statistics for the area under the receiver operating characteristic curve (AUC) were 0.70 or higher, except for oropharyngeal cancer in men. This HNC risk prediction model may be useful in promoting healthier behaviors such as smoking cessation or in aiding persons with a family history of HNC to evaluate their risks.
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- 2020
35. Alcohol drinking and head and neck cancer risk: the joint effect of intensity and duration
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Hal Morgenstern, Tongzhang Zheng, Chu Chen, Silvia Franceschi, Ivana Holcatova, Alexander W. Daudt, Fabio Levi, Diego Serraino, Danièle Luce, Marta Vilensky, Paul Brennan, Mark P. Purdue, Joshua E. Muscat, Lorenzo Richiardi, Shu Chun Chuang, Nicola Torelli, Erich M. Sturgis, Valeria Edefonti, Simone Benhamou, Carlo La Vecchia, Leticia Fernandez, Ariana Znaor, Werner Garavello, Raquel Ajub Moyses, Pagona Lagiou, Rosalina Jorge Koifman, Guojun Li, Elaine M. Smith, Philip Lazarus, Gary J. Macfarlane, Maura L. Gillison, David I. Conway, Keitaro Matsuo, Paolo Boffetta, Jose P. Zevallos, Luigino Dal Maso, Karl T. Kelsey, Ana M. B. Menezes, Maria Paula Curado, Zuo-Feng Zhang, Francesco Pauli, Victor Wünsch-Filho, Stephen M. Schwartz, Kristina Kjærheim, Antonio Agudo, Rolando Herrero, Guo Pei Yu, Cristina Canova, Mia Hashibe, Loredana Radoï, Wolfgang Ahrens, Michael D. McClean, Gioia Di Credico, Andrew F. Olshan, Jerry Polesel, Claire M. Healy, Thomas L. Vaughan, Amy Lee Yuan-Chin, Eva Negri, Peter Thomson, Tatiana Natasha Toporcov, Stimson P. Schantz, Richard B. Hayes, Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Mode de vie, génétique et santé : études intégratives et transgénérationnelles (U1018 (Équipe 9)), Institut Gustave Roussy (IGR)-Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Institute of Genetic Medicine [Newcastle], Newcastle University [Newcastle], Charles University [Prague] (CU), Bremen Institute for Prevention Research and Social Medicine (BIPS), Division of Epidemiological Methods and Etiologic Research, University of Bremen, National and Kapodistrian University of Athens (NKUA), Università degli Studi di Padova = University of Padua (Unipd), Imperial College London, Dublin Dental University Hospital, Trinity College [Dublin, Ireland], Cancer Registry of Norway, University of Glasgow, University of Aberdeen, Institut d'Investigació Biomèdica de Bellvitge [Barcelone] (IDIBELL), Di Credico, G., Polesel, J., Dal Maso, L., Pauli, F., Torelli, N., Luce, D., Radoi, L., Matsuo, K., Serraino, D., Brennan, P., Holcatova, I., Ahrens, W., Lagiou, P., Canova, C., Richiardi, L., Healy, C. M., Kjaerheim, K., Conway, D. I., Macfarlane, G. J., Thomson, P., Agudo, A., Znaor, A., Franceschi, S., Herrero, R., Toporcov, T. N., Moyses, R. A., Muscat, J., Negri, E., Vilensky, M., Fernandez, L., Curado, M. P., Menezes, A., Daudt, A. W., Koifman, R., Wunsch-Filho, V., Olshan, A. F., Zevallos, J. P., Sturgis, E. M., Li, G., Levi, F., Zhang, Z. -F., Morgenstern, H., Smith, E., Lazarus, P., La Vecchia, C., Garavello, W., Chen, C., Schwartz, S. M., Zheng, T., Vaughan, T. L., Kelsey, K., Mcclean, M., Benhamou, S., Hayes, R. B., Purdue, M. P., Gillison, M., Schantz, S., Yu, G. -P., Chuang, S. -C., Boffetta, P., Hashibe, M., Yuan-Chin, A. L., Edefonti, V., Di Credico, G, Polesel, J, Dal Maso, L, Pauli, F, Torelli, N, Luce, D, Radoi, L, Matsuo, K, Serraino, D, Brennan, P, Holcatova, I, Ahrens, W, Lagiou, P, Canova, C, Richiardi, L, Healy, C, Kjaerheim, K, Conway, D, Macfarlane, G, Thomson, P, Agudo, A, Znaor, A, Franceschi, S, Herrero, R, Toporcov, T, Moyses, R, Muscat, J, Negri, E, Vilensky, M, Fernandez, L, Curado, M, Menezes, A, Daudt, A, Koifman, R, Wunsch-Filho, V, Olshan, A, Zevallos, J, Sturgis, E, Li, G, Levi, F, Zhang, Z, Morgenstern, H, Smith, E, Lazarus, P, La Vecchia, C, Garavello, W, Chen, C, Schwartz, S, Zheng, T, Vaughan, T, Kelsey, K, Mcclean, M, Benhamou, S, Hayes, R, Purdue, M, Gillison, M, Schantz, S, Yu, G, Chuang, S, Boffetta, P, Hashibe, M, Yuan-Chin, A, and Edefonti, V
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Male ,Cancer Research ,Bivariate spline model ,Time Factors ,Diseases ,Alcohol use disorder ,Severity of Illness Index ,Alcohol Use and Health ,0302 clinical medicine ,Risk Factors ,Laryngeal cancer ,80 and over ,2.2 Factors relating to the physical environment ,Young adult ,Head and neck cancer ,Cancer ,Aged, 80 and over ,Mouth neoplasm ,Oropharyngeal cancer ,Head and Neck Neoplasm ,Smoking ,Confounding ,Substance Abuse ,Middle Aged ,Oropharyngeal Neoplasms ,Alcoholism ,Oncology ,Head and Neck Neoplasms ,030220 oncology & carcinogenesis ,Public Health and Health Services ,Mouth Neoplasms ,Female ,Case-Control Studie ,Hypopharyngeal cancer ,Human ,Oropharyngeal Neoplasm ,Adult ,medicine.medical_specialty ,Time Factor ,Alcohol Drinking ,Adolescent ,Oncology and Carcinogenesis ,Oral cavity cancer ,Article ,Young Adult ,03 medical and health sciences ,Rare Diseases ,Alcohol intensity ,Internal medicine ,Tobacco ,medicine ,Humans ,Oncology & Carcinogenesis ,Dental/Oral and Craniofacial Disease ,Risk factor ,Bivariate spline models ,Alcohol duration ,Laryngeal Neoplasms ,Aged ,Laryngeal Neoplasm ,Tobacco Smoke and Health ,business.industry ,Risk Factor ,Prevention ,Case-control study ,medicine.disease ,Mouth Neoplasm ,Risk factors ,Case-Control Studies ,[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie ,Digestive Diseases ,business - Abstract
Background Alcohol is a well-established risk factor for head and neck cancer (HNC). This study aims to explore the effect of alcohol intensity and duration, as joint continuous exposures, on HNC risk. Methods Data from 26 case-control studies in the INHANCE Consortium were used, including never and current drinkers who drunk ≤10 drinks/day for ≤54 years (24234 controls, 4085 oral cavity, 3359 oropharyngeal, 983 hypopharyngeal and 3340 laryngeal cancers). The dose-response relationship between the risk and the joint exposure to drinking intensity and duration was investigated through bivariate regression spline models, adjusting for potential confounders, including tobacco smoking. Results For all subsites, cancer risk steeply increased with increasing drinks/day, with no appreciable threshold effect at lower intensities. For each intensity level, the risk of oral cavity, hypopharyngeal and laryngeal cancers did not vary according to years of drinking, suggesting no effect of duration. For oropharyngeal cancer, the risk increased with durations up to 28 years, flattening thereafter. The risk peaked at the higher levels of intensity and duration for all subsites (odds ratio = 7.95 for oral cavity, 12.86 for oropharynx, 24.96 for hypopharynx and 6.60 for larynx). Conclusions Present results further encourage the reduction of alcohol intensity to mitigate HNC risk.
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- 2020
36. Joint effects of intensity and duration of cigarette smoking on the risk of head and neck cancer: A bivariate spline model approach
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Philip Lazarus, Claire M. Healy, Richard B. Hayes, Rolando Herrero, Elaine M. Smith, Stefania Boccia, Leonardo F. Boaventura Rios, Paolo Boffetta, Dana Mates, Jerry Polesel, Marta Vilensky, Jose P. Zevallos, Diego Serraino, Gypsyamber D'Souza, Joshua E. Muscat, Kirsten B. Moysich, Yuan Chin Amy Lee, Mark P. Purdue, Carlo La Vecchia, Heribert Ramroth, Thomas L. Vaughan, Peter Thomson, Karl T. Kelsey, Nicola Torelli, Wolfgang Ahrens, Hermann Brenner, Lorenzo Richiardi, Victor Wünsch-Filho, Kristina Kjærheim, Beata Swiatkowska, Keitaro Matsuo, Fabio Levi, Erich M. Sturgis, Eva Negri, Lorenzo Simonato, Danièle Luce, Guo Pei Yu, Chu Chen, Pagona Lagiou, Silvia Franceschi, Andrew F. Olshan, Alexander W. Daudt, Antonio Agudo, Maria Paula Curado, Peter Rudnai, Tatiana V. Macfarlane, Zuo-Feng Zhang, Mia Hashibe, Paul Brennan, Tatiana Natasha Toporcov, Stimson P. Schantz, Maura L. Gillison, Isabelle Stücker, Tongzhang Zheng, Shu Chun Chuang, Oxana Shangina, Eleonora Fabianova, Hal Morgenstern, David I. Conway, Valeria Edefonti, Cristina Bosetti, Ariana Znaor, Leticia Fernandez, Michael D. McClean, Luigino Dal Maso, Neil D. Gross, Stephen M. Schwartz, Ivana Holcatova, Guojun Li, Ana M. B. Menezes, Francesco Pauli, Gioia Di Credico, Deborah M. Winn, Rosalina Jorge Koifman, Gwenn Menvielle, Gabriella Cadoni, Werner Garavello, Jolanda Lissowska, Università degli Studi di Milano [Milano] (UNIMI), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Centre de recherche en épidémiologie et santé des populations (CESP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris-Sud - Paris 11 (UP11)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Centre International de Recherche contre le Cancer - International Agency for Research on Cancer (CIRC - IARC), Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), University of Glasgow, Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM), TW001500, National Institutes of Health, P30ES010126, National Institute of Environmental Health Sciences, Italian Ministry of Education, Università degli Studi di Milano, Jonsson Comprehensive Cancer Center, International Union Against Cancer, Fondo para la Investigacion Cientifica y Tecnologica Argentina, Institut Hospital del Mar d’Investigacions Mediquès (IMIM), Fundação de Amparo à Pesquisa no Estado de São Paulo, Spanish Government, European Community, Ministry of Science, Research and Arts Baden-Wurttemberg, German Ministry of Education and Research, Scientific Research grant from the Ministry of Education, Science, Sports, Culture and Technology of Japan, Labor and Welfare of Japan, Italian Foundation for Cancer Research, Di Credico G., Edefonti V., Polesel J., Pauli F., Torelli N., Serraino D., Negri E., Luce D., Stucker I., Matsuo K., Brennan P., Vilensky M., Fernandez L., Curado M.P., Menezes A., Daudt A.W., Koifman R., Wunsch-Filho V., Holcatova I., Ahrens W., Lagiou P., Simonato L., Richiardi L., Healy C., Kjaerheim K., Conway D.I., Macfarlane T.V., Thomson P., Agudo A., Znaor A., Boaventura Rios L.F., Toporcov T.N., Franceschi S., Herrero R., Muscat J., Olshan A.F., Zevallos J.P., La Vecchia C., Winn D.M., Sturgis E.M., Li G., Fabianova E., Lissowska J., Mates D., Rudnai P., Shangina O., Swiatkowska B., Moysich K., Zhang Z.-F., Morgenstern H., Levi F., Smith E., Lazarus P., Bosetti C., Garavello W., Kelsey K., McClean M., Ramroth H., Chen C., Schwartz S.M., Vaughan T.L., Zheng T., Menvielle G., Boccia S., Cadoni G., Hayes R.B., Purdue M., Gillison M., Schantz S., Yu G.-P., Brenner H., D'Souza G., Gross N.D., Chuang S.-C., Boffetta P., Hashibe M., Lee Y.-C.A., Dal Maso L., Di Credico, G, Edefonti, V, Polesel, J, Pauli, F, Torelli, N, Serraino, D, Negri, E, Luce, D, Stucker, I, Matsuo, K, Brennan, P, Vilensky, M, Fernandez, L, Curado, M, Menezes, A, Daudt, A, Koifman, R, Wunsch-Filho, V, Holcatova, I, Ahrens, W, Lagiou, P, Simonato, L, Richiardi, L, Healy, C, Kjaerheim, K, Conway, D, Macfarlane, T, Thomson, P, Agudo, A, Znaor, A, Boaventura Rios, L, Toporcov, T, Franceschi, S, Herrero, R, Muscat, J, Olshan, A, Zevallos, J, La Vecchia, C, Winn, D, Sturgis, E, Li, G, Fabianova, E, Lissowska, J, Mates, D, Rudnai, P, Shangina, O, Swiatkowska, B, Moysich, K, Zhang, Z, Morgenstern, H, Levi, F, Smith, E, Lazarus, P, Bosetti, C, Garavello, W, Kelsey, K, Mcclean, M, Ramroth, H, Chen, C, Schwartz, S, Vaughan, T, Zheng, T, Menvielle, G, Boccia, S, Cadoni, G, Hayes, R, Purdue, M, Gillison, M, Schantz, S, Yu, G, Brenner, H, D'Souza, G, Gross, N, Chuang, S, Boffetta, P, Hashibe, M, Lee, Y, Dal Maso, L, Di Credico, Gioia, Edefonti, Valeria, Polesel, Jerry, Pauli, Francesco, Torelli, Nicola, Serraino, Diego, Negri, Eva, Luce, Daniele, Stucker, Isabelle, Matsuo, Keitaro, Brennan, Paul, Vilensky, Marta, Fernandez, Leticia, Curado, Maria Paula, Menezes, Ana, Daudt, Alexander W., Koifman, Rosalina, Wunsch-Filho, Victor, Holcatova, Ivana, Ahrens, Wolfgang, Lagiou, Pagona, Simonato, Lorenzo, Richiardi, Lorenzo, Healy, Claire, Kjaerheim, Kristina, Conway, David I., Macfarlane, Tatiana V., Thomson, Peter, Agudo, Antonio, Znaor, Ariana, Boaventura Rios, Leonardo F., Toporcov, Tatiana N., Franceschi, Silvia, Herrero, Rolando, Muscat, Joshua, Olshan, Andrew F., Zevallos, Jose P., La Vecchia, Carlo, Winn, Deborah M., Sturgis, Erich M., Li, Guojun, Fabianova, Eleonora, Lissowska, Jolanda, Mates, Dana, Rudnai, Peter, Shangina, Oxana, Swiatkowska, Beata, Moysich, Kirsten, Zhang, Zuo-Feng, Morgenstern, Hal, Levi, Fabio, Smith, Elaine, Lazarus, Philip, Bosetti, Cristina, Garavello, Werner, Kelsey, Karl, Mcclean, Michael, Ramroth, Heribert, Chen, Chu, Schwartz, Stephen M., Vaughan, Thomas L., Zheng, Tongzhang, Menvielle, Gwenn, Boccia, Stefania, Cadoni, Gabriella, Hayes, Richard B., Purdue, Mark, Gillison, Maura, Schantz, Stimson, Yu, Guo-Pei, Brenner, Hermann, D'Souza, Gypsyamber, Gross, Neil D., Chuang, Shu-Chun, Boffetta, Paolo, Hashibe, Mia, Lee, Yuan-Chin Amy, Dal Maso, Luigino, Università degli Studi di Milano = University of Milan (UNIMI), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM), and Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)
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Male ,Oral cavity and pharyngeal cancers ,Cancer Research ,Bivariate spline model ,medicine.medical_treatment ,Logistic regression ,Substance Misuse ,0302 clinical medicine ,Risk Factors ,Laryngeal cancer ,80 and over ,2.2 Factors relating to the physical environment ,Aetiology ,030223 otorhinolaryngology ,Head and neck cancer ,Cancer ,Aged, 80 and over ,Confounding ,Middle Aged ,3. Good health ,Oncology ,Head and Neck Neoplasms ,030220 oncology & carcinogenesis ,Bivariate spline models ,Cigarette smoking duration ,Cigarette smoking intensity ,Public Health and Health Services ,Female ,Oral Surgery ,Adult ,INHANCE ,Oncology and Carcinogenesis ,[SDV.CAN]Life Sciences [q-bio]/Cancer ,Bivariate analysis ,Cigarette Smoking ,03 medical and health sciences ,Rare Diseases ,Clinical Research ,Tobacco ,medicine ,Humans ,Oncology & Carcinogenesis ,Dental/Oral and Craniofacial Disease ,Aged ,Settore MED/06 - ONCOLOGIA MEDICA ,Tobacco Smoke and Health ,business.industry ,Prevention ,Case-control study ,Odds ratio ,medicine.disease ,Former Smoker ,Good Health and Well Being ,Case-Control Studies ,Dentistry ,Smoking cessation ,business ,Demography - Abstract
Objectives: \ud This study aimed at re-evaluating the strength and shape of the dose-response relationship between the combined (or joint) effect of intensity and duration of cigarette smoking and the risk of head and neck cancer (HNC). We explored this issue considering bivariate spline models, where smoking intensity and duration were treated as interacting continuous exposures.\ud \ud Materials and Methods: \ud We pooled individual-level data from 33 case-control studies (18,260 HNC cases and 29,844 controls) participating in the International Head and Neck Cancer Epidemiology (INHANCE) consortium. In bivariate regression spline models, exposures to cigarette smoking intensity and duration (compared with never smokers) were modeled as a linear piecewise function within a logistic regression also including potential confounders. We jointly estimated the optimal knot locations and regression parameters within the Bayesian framework.\ud \ud Results: \ud For oral-cavity/pharyngeal (OCP) cancers, an odds ratio (OR) >5 was reached after 30 years in current smokers of ∼20 or more cigarettes/day. Patterns of OCP cancer risk in current smokers differed across strata of alcohol intensity. For laryngeal cancer, ORs >20 were found for current smokers of ≥20 cigarettes/day for ≥30 years. In former smokers who quit ≥10 years ago, the ORs were approximately halved for OCP cancers, and ∼1/3 for laryngeal cancer, as compared to the same levels of intensity and duration in current smokers.\ud \ud Conclusion: \ud Referring to bivariate spline models, this study better quantified the joint effect of intensity and duration of cigarette smoking on HNC risk, further stressing the need of smoking cessation policies.
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- 2019
37. Racial differences in the relationship between tobacco, alcohol, and the risk of head and neck cancer: pooled analysis of US studies in the INHANCE Consortium
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Chu Chen, Deborah M. Winn, Guojun Li, Karl T. Kelsey, Erich M. Sturgis, Andrew F. Olshan, Maura L. Gillison, Zuo-Feng Zhang, Michael D. McClean, Elaine M. Smith, Philip Lazarus, Joshua E. Muscat, Stephen M. Schwartz, Hal Morgenstern, Paolo Boffetta, Jose P. Zevallos, Guo Pei Yu, Mia Hashibe, Yuan Chin Amy Lee, Stimson P. Schantz, Kristin J. Voltzke, Thomas L. Vaughan, and Voltzke, K.J. and Lee, Y.-C.A. and Zhang, Z.-F. and Zevallos, J.P. and Yu, G.-P. and Winn, D.M. and Vaughan, T.L. and Sturgis, E.M. and Smith, E. and Schwartz, S.M. and Schantz, S. and Muscat, J. and Morgenstern, H. and McClean, M. and Li, G. and Lazarus, P. and Kelsey, K. and Gillison, M. and Chen, C. and Boffetta, P. and Hashibe, M. and Olshan, A.F.
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Cancer Research ,cancer incidence ,Epidemiology ,pharynx cancer ,cigarette smoking ,race difference ,cancer risk ,Logistic regression ,Tobacco Use ,Substance Misuse ,Alcohol Use and Health ,0302 clinical medicine ,Cigarette smoking ,Risk Factors ,030212 general & internal medicine ,African American ,Head and neck cancer ,Cancer ,Incidence (epidemiology) ,adult ,hypopharynx cancer ,Alcoholism ,aged ,female ,Oncology ,priority journal ,risk factor ,Head and Neck Neoplasms ,030220 oncology & carcinogenesis ,Public Health and Health Services ,Alcohol ,United State ,medicine.medical_specialty ,Alcohol Drinking ,alcohol consumption ,Oncology and Carcinogenesis ,tobacco use ,Caucasian ,Article ,03 medical and health sciences ,Black person ,Rare Diseases ,male ,Clinical Research ,Tobacco ,medicine ,Humans ,controlled study ,human ,Dental/Oral and Craniofacial Disease ,Tobacco Smoke and Health ,alcohol, adolescent ,business.industry ,Prevention ,Public health ,Racial Groups ,larynx cancer ,Odds ratio ,case control study ,medicine.disease ,mouth cancer ,oropharynx cancer ,major clinical study ,Confidence interval ,United States ,Good Health and Well Being ,Case-Control Studies ,Racial difference ,Racial differences ,business ,Demography - Abstract
There have been few published studies on differences between Blacks and Whites in the estimated effects of alcohol and tobacco use on the incidence of head and neck cancer (HNC) in the United States. Previous studies have been limited by small numbers of Blacks. Using pooled data from 13 US case–control studies of oral, pharyngeal, and laryngeal cancers in the International Head and Neck Cancer Epidemiology Consortium, this study comprised a large number of Black HNC cases (n = 975). Logistic regression was used to estimate adjusted odds ratios (OR) and 95% confidence intervals (CI) for several tobacco and alcohol consumption characteristics. Blacks were found to have consistently stronger associations than Whites for the majority of tobacco consumption variables. For example, compared to never smokers, Blacks who smoked cigarettes for > 30 years had an OR 4.53 (95% CI 3.22–6.39), which was larger than that observed in Whites (OR 3.01, 95% CI 2.73–3.33; pinteraction < 0.0001). The ORs for alcohol use were also larger among Blacks compared to Whites. Exclusion of oropharyngeal cases attenuated the racial differences in tobacco use associations but not alcohol use associations. These findings suggest modest racial differences exist in the association of HNC risk with tobacco and alcohol consumption. © 2018, Springer International Publishing AG, part of Springer Nature.
- Published
- 2018
38. The INHANCE consortium: toward a better understanding of the causes and mechanisms of head and neck cancer
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Neonila Szeszenia-Dabrowska, Dana Mates, Danièle Luce, Lorenzo Simonato, José Eluf-Neto, Michael Pawlita, Elaine M. Smith, Kim De Ruyck, Gwenn Menvielle, Cristina Bosetti, Deborah M. Winn, David Zaridze, Gabriella Cadoni, Keitaro Matsuo, Diego Serraino, Isabelle Stücker, Richard B. Hayes, Mia Hashibe, Andrew F. Olshan, Robert I. Haddad, David I. Conway, Guo-Pei Yu, Tatiana V. Macfarlane, Simone Benhamou, Chu Chen, Brenda Diergaarde, Maura L. Gillison, Paul Brennan, Michael D. McClean, Kristina Kjærheim, Vladimir Bencko, Peter Rudnai, Guojun Li, Eleonora Fabianova, Pagona Lagiou, Thomas L. Vaughan, Witold Zatonski, Silvia Franceschi, Gypsyamber D'Souza, Rayjean J. Hung, Victor Wünsch-Filho, Antonio Agudo, Yuan Chin Amy Lee, Martin Lacko, Erich M. Sturgis, Xavier Castellsagué, Fabio Levi, Luigino Dal Maso, Jolanta Lissowska, Carlo La Vecchia, Franco Merletti, Steve Schwartz, Oxana Shangina, Ariana Znaor, Gregory T. Wolf, Jonathan N. Hofmann, Ivana Holcatova, Wolfgang Ahrens, Rolando Herrero, Alexander W. Daudt, Kirsten B. Moysich, Heribert Ramroth, Karl T. Kelsey, Maria Paula Curado, Zuo-Feng Zhang, Ana M. B. Menezes, Philip Lazarus, Laura S. Rozek, Tongzhang Zheng, Paolo Boffetta, Jose P. Zevallos, Peter Thomson, Claire M. Healy, Stefania Boccia, Wilbert H.M. Peters, Stimson P. Schantz, Marta Vilensky, Joshua E. Muscat, Hermann Brenner, Sergio Koifman, Geoffrey Liu, Manoj B. Mahimkar, Leticia Fernandez, Winn, D.M., Lee, Y.-C., Hashibe, M., Boffetta, P., Agudo, A., Ahrens, W., Bencko, V., Benhamou, S., Boccia, S., Bosetti, C., Brennan, P., Brenner, H., Cadoni, G., Castellsague, X., Chen, C., Conway, D., Curado, M.P., D'Souza, G., Maso, L.D., Daudt, A.W., Ruyck, K.D., Diergaarde, B., Eluf-Neto, J., Fabianova, E., Fernandez, L., Franceschi, S., Gillison, M., Haddad, R.I., Hayes, R., Healy, C., Herrero, R., Hofmann, J., Holcátová, I., Hung, R., Kelsey, K., Kjaerheim, K., Koifman, S., Vecchia, C.L., Lacko, M., Lagiou, P., Lazarus, P., Levi, F., Li, G., Lissowska, J., Liu, G., Luce, D., Macfarlane, T., Mahimkar, M., Mates, D., Matsuo, K., McClean, M., Menezes, A., Menvielle, G., Merletti, F., Moysich, K., Muscat, J., Olshan, A., Pawlita, M., Peters, W.H.M., Ramroth, H., Rozek, L., Rudnai, P., Schantz, S., Schwartz, S., Serraino, D., Shangina, O., Simonato, L., Smith, E., Stucker, I., Sturgis, E.M., Szeszenia-Dabrowska, Neonila and Thomson, P., Vaughan, T., Vilensky, M., Wolf, G., Wünsch-Filho, V., Yu, G., Zaridze, D., Zatonski, W., Zevallos, J.P., Zhang, Z.-F., Zheng, T.-Z., and Znaor, A.
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Larynx ,Data Pooling ,Oncology ,medicine.medical_specialty ,Research groups ,Alcohol Drinking ,Scientific productivity ,Risk Factors ,Internal medicine ,Epidemiology ,Humans ,Medicine ,Cooperative Behavior ,Family history ,Settore MED/42 - IGIENE GENERALE E APPLICATA ,General Dentistry ,business.industry ,Smoking ,Head and neck cancer ,Confounding ,medicine.disease ,Diet ,Surgery ,medicine.anatomical_structure ,Socioeconomic Factors ,Otorhinolaryngology ,Head and Neck Neoplasms ,epidemiology ,head and neck cancer ,Settore MED/31 - OTORINOLARINGOIATRIA ,business - Abstract
The International Head and Neck Cancer Epidemiology (INHANCE) consortium is a collaboration of research groups leading large epidemiology studies to improve the understanding of the causes and mechanisms of head and neck cancer. The consortium includes investigators of 35 studies who have pooled their data on 25 500 patients with head and neck cancer (i.e., cancers of the oral cavity, oropharynx, hypopharynx, and larynx) and 37 100 controls. The INHANCE analyses have confirmed that tobacco use and alcohol intake are key risk factors of these diseases and have provided precise estimates of risk and dose response, the benefit of quitting, and the hazard of smoking even a few cigarettes per day. Other risk factors include short height, lean body mass, low education and income, and a family history of head and neck cancer. Risk factors are generally similar for oral cavity, pharynx, and larynx, although the magnitude of risk may vary. Some major strengths of pooling data across studies include more precise estimates of risk and the ability to control for potentially confounding factors and to examine factors that may interact with each other. The INHANCE consortium provides evidence of the scientific productivity and discoveries that can be obtained from data pooling projects. © 2015 John Wiley & Sons A/S.
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- 2015
39. Hormone factors play a favorable role in female head and neck cancer risk
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Diego Serraino, Gabriella Cadoni, Luigino Dal Maso, Fabio Levi, Hung N. Luu, Elaine M. Smith, Dana Hashim, Stefania Boccia, Mia Hashibe, Carlo La Vecchia, Samantha Sartori, Yuan Chin Amy Lee, Paolo Boffetta, Eva Negri, Hashim, D., Sartori, S., la Vecchia, C., Serraino, D., Maso, L.D., Negri, E., Smith, E., Levi, F., Boccia, S., Cadoni, G., Luu, H.N., Lee, Y.-C.A., Hashibe, M., and Boffetta, P.
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0301 basic medicine ,Alcohol Drinking ,Case-Control Studies ,Female ,Head and Neck Neoplasms/epidemiology ,Head and Neck Neoplasms/etiology ,Hormone Replacement Therapy/adverse effects ,Hormones/adverse effects ,Hormones/metabolism ,Humans ,Menopause ,Menstrual Cycle ,Middle Aged ,Odds Ratio ,Reproductive History ,Risk ,Smoking ,Head and neck neoplasms ,hormone replacement therapy ,mouth neoplasms ,reproductive history ,women ,Cancer Research ,medicine.medical_specialty ,Hormone Replacement Therapy ,media_common.quotation_subject ,hormone ,Lower risk ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,medicine ,Radiology, Nuclear Medicine and imaging ,Menstrual cycle ,media_common ,Original Research ,Gynecology ,Mouth neoplasm ,business.industry ,Incidence (epidemiology) ,Case-control study ,Head and neck cancers, exogenous and endogenous hormonal factors ,Odds ratio ,medicine.disease ,Hormones ,3. Good health ,030104 developmental biology ,Oncology ,Transgender hormone therapy ,030220 oncology & carcinogenesis ,head and neck cancer ,Settore MED/31 - OTORINOLARINGOIATRIA ,business ,Cancer Prevention - Abstract
Due to lower female incidence, estimates of exogenous and endogenous hormonal factors in head and neck cancers (HNCs, comprising cancers of the oral cavity, oropharynx, hypopharynx, and larynx) among women have been inconsistent and unable to account for key HNC risk factors. We pooled data from 11 studies from Europe, North America, and Japan. Analysis included 1572 HNC female cases and 4343 controls. Pooled odds ratios (ORs) estimates and their 95% confidence intervals (CIs) were calculated using multivariate logistic regression models adjusting for tobacco smoking and alcohol drinking. Lower risk was observed in women who used hormone replacement therapy (HRT) (OR = 0.58; 95% CI: 0.34–0.77). Pregnancy (OR = 0.61; 95% CI: 0.42–0.90) and giving birth (OR = 0.59; 95% CI: 0.38–0.90) at
- Published
- 2017
40. Estimating and explaining the effect of education and income on head and neck cancer risk: INHANCE consortium pooled analysis of 31 case-control studies from 27 countries
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Elena Matos, Carlo La Vecchia, Hal Morgenstern, Ariana Znaor, Maura L. Gillison, Maria Paula Curado, Dana Mates, Kristina Kjærheim, Jolanta Lissowska, Zuo-Feng Zhang, Lorna M. D. Macpherson, Ivana Holcatova, Philip Lazarus, Antonio Agudo, Peter Thomson, Mark P. Purdue, Ana Maria Menezes, Darren R. Brenner, Joshua E. Muscat, Tongzhang Zheng, Rolando Herrero, Michael D. McClean, Silvia Franceschi, Thomas L. Vaughan, Isabelle Stücker, Peter Rudnai, Oxana Shangina, Kirsten B. Moysich, Victor Wünsch-Filho, Renato Talamini, Gypsyamber D'Souza, Wolfgang Ahrens, Pagona Lagiou, Lorenzo Simonato, Alex D. McMahon, Heribert Ramroth, Karl T. Kelsey, Luigino Dal Maso, Alexander W. Daudt, Guo Pei Yu, Paolo Boffetta, Heiko Müller, Yuan Chin Amy Lee, Elaine M. Smith, Qingyi Wei, Mia Hashibe, Fabio Levi, Stimson P. Schantz, Hermann Brenner, Otávio Alberto Curioni, Shu Chun Chuang, Lorenzo Richiardi, Erich M. Sturgis, Richard B. Hayes, Xavier Castellsagué, David I. Conway, Danièle Luce, José Francisco de Góis Filho, Neonila Szeszenia-Dabrowska, Vijayvel Jayaprakash, Gwenn Menvielle, Claire M. Healy, Stephen M. Schwartz, Chu Chen, Valeria Edefonti, Marianoosh Ghodrat, Leticia Fernandez, Andrew F. Olshan, Paul Brennan, Tatiana V. Macfarlane, Cristina Bosetti, Sergio Koifman, Franco Merletti, Deborah M. Winn, and Eleonora Fabianova
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Gerontology ,Cancer Research ,medicine.medical_specialty ,business.industry ,Head and neck cancer ,Case-control study ,Cancer ,medicine.disease ,Educational attainment ,Oncology ,Economic inequality ,Epidemiology ,medicine ,Household income ,10. No inequality ,business ,Socioeconomic status ,Demography - Abstract
Low socioeconomic status has been reported to be associated with head and neck cancer risk. However, previous studies have been too small to examine the associations by cancer subsite, age, sex, global region and calendar time and to explain the association in terms of behavioral risk factors. Individual participant data of 23,964 cases with head and neck cancer and 31,954 controls from 31 studies in 27 countries pooled with random effects models. Overall, low education was associated with an increased risk of head and neck cancer (OR = 2.50; 95% CI = 2.02 – 3.09). Overall one-third of the increased risk was not explained by differences in the distribution of cigarette smoking and alcohol behaviors; and it remained elevated among never users of tobacco and nondrinkers (OR = 1.61; 95% CI = 1.13 – 2.31). More of the estimated education effect was not explained by cigarette smoking and alcohol behaviors: in women than in men, in older than younger groups, in the oropharynx than in other sites, in South/Central America than in Europe/North America and was strongest in countries with greater income inequality. Similar findings were observed for the estimated effect of low versus high household income. The lowest levels of income and educational attainment were associated with more than 2-fold increased risk of head and neck cancer, which is not entirely explained by differences in the distributions of behavioral risk factors for these cancers and which varies across cancer sites, sexes, countries and country income inequality levels.
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- 2014
41. Association of Marijuana Smoking with Oropharyngeal and Oral Tongue Cancers: Pooled Analysis from the INHANCE Consortium
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Chu Chen, Maria Paula Curado, Zuo-Feng Zhang, Julien Berthiller, Alexander W. Daudt, Hal Morgenstern, Kurt Straif, Morgan A. Marks, Anil K. Chaturvedi, Michael D. McClean, Elaine M. Smith, Paul Brennan, Stephen M. Schwartz, Karl T. Kelsey, Gypsyamber D'Souza, Qingyi Wei, Erich M. Sturgis, Marshall Posner, Victor Wünsch-Filho, Mia Hashibe, Yuan Chin Amy Lee, Elena Matos, Andrew F. Olshan, Leticia Fernandez, Philip Lazarus, Paolo Boffetta, Thomas L. Vaughan, Ana M. B. Menezes, Annah Wyss, Joshua E. Muscat, Sergio Koifman, Marks, M.A., Chaturvedi, A.K., Kelsey, K., Straif, K., Berthiller, J., Schwartz, S.M., Smith, E., Wyss, A., Brennan, P., Olshan, A.F., Wei, Q., Sturgis, E.M., Zhang, Z.-F., Morgenstern, H., Muscat, J., Lazarus, P., McClean, M., Chen, C., Vaughan, T.L., Wunsch-Filho, V., Curado, M.P., Koifman, S., Matos, E., Menezes, A., Daudt, A.W., Fernandez, L., Posner, M., Boffetta, P., Amy Lee, Y.-C., Hashibe, M., and D'Souza, G.
- Subjects
Male ,Epidemiology ,Medical and Health Sciences ,tobacco ,Substance Misuse ,Tobacco Use ,Risk Factors ,2.1 Biological and endogenous factors ,2.2 Factors relating to the physical environment ,Aetiology ,Tobacco Use Epidemiology ,Cancer ,alcohol ,Incidence ,Incidence (epidemiology) ,Confounding ,HPV infection ,Middle Aged ,Tongue Neoplasms ,Oropharyngeal Neoplasms ,medicine.anatomical_structure ,Oncology ,Head and Neck Neoplasms ,Carcinoma, Squamous Cell ,Female ,Adult ,medicine.medical_specialty ,Alcohol Drinking ,Marijuana Smoking ,Article ,Tongue ,Internal medicine ,Tobacco ,Oropharyngeal, oral tongue cancer ,medicine ,Humans ,Dental/Oral and Craniofacial Disease ,Aged ,Tobacco Smoke and Health ,Squamous Cell Carcinoma of Head and Neck ,business.industry ,Prevention ,Carcinoma ,Case-control study ,medicine.disease ,United States ,Confidence interval ,Surgery ,Good Health and Well Being ,Latin America ,Squamous Cell ,Case-Control Studies ,Digestive Diseases ,business ,marijuana - Abstract
Background: The incidence of oropharyngeal and oral tongue cancers has increased over the last 20 years which parallels increased use of marijuana among individuals born after 1950. Methods: A pooled analysis was conducted comprising individual-level data from nine case–control studies from the United States and Latin America in the INHANCE consortium. Self-reported information on marijuana smoking, demographic, and behavioral factors was obtained from 1,921 oropharyngeal cases, 356 oral tongue cases, and 7,639 controls. Results: Compared with never marijuana smokers, ever marijuana smokers had an elevated risk of oropharyngeal [adjusted OR (aOR), 1.24; 95% confidence interval (CI): 1.06–1.47] and a reduced risk of oral tongue cancer (aOR, 0.47; 95% CI, 0.29, 0.75). The risk of oropharyngeal cancer remained elevated among never tobacco and alcohol users. The risk of oral tongue cancer was reduced among never users of tobacco and alcohol. Sensitivity analysis adjusting for potential confounding by HPV exposure attenuated the association of marijuana use with oropharyngeal cancer (aOR, 0.99; 95% CI, 0.71–1.25), but had no effect on the oral tongue cancer association. Conclusions: These results suggest that the association of marijuana use with head and neck carcinoma may differ by tumor site. Impact: The associations of marijuana use with oropharyngeal and oral tongue cancer are consistent with both possible pro- and anticarcinogenic effects of cannabinoids. Additional work is needed to rule out various sources of bias, including residual confounding by HPV infection and misclassification of marijuana exposure. Cancer Epidemiol Biomarkers Prev; 23(1); 160–71. ©2013 AACR.
- Published
- 2014
42. Smokeless tobacco use and the risk of head and neck cancer: Pooled analysis of US studies in the inhance consortium
- Author
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Qingyi Wei, Andrew F. Olshan, Yuan Chin Amy Lee, Maura L. Gillison, Chu Chen, Stimson P. Schantz, Michael D. McClean, Zuo-Feng Zhang, Shu Chun Chuang, Paolo Boffetta, Joshua E. Muscat, Jose P. Zevallos, Deborah M. Winn, Stephen M. Schwartz, Guojun Li, Annah Wyss, Guo Pei Yu, Karl T. Kelsey, Elaine M. Smith, Hal Morgenstern, Mia Hashibe, and Wyss, A.B. and Hashibe, M. and Lee, Y.-C.A. and Chuang, S.-C. and Muscat, J. and Chen, C. and Schwartz, S.M. and Smith, E. and Zhang, Z.-F. and Morgenstern, H. and Wei, Q. and Li, G. and Kelsey, K.T. and McClean, M. and Winn, D.M. and Schantz, S. and Yu, G.-P. and Gillison, M.L. and Zevallos, J.P. and Boffetta, P. and Olshan, A.F.
- Subjects
Male ,cancer patient ,Epidemiology ,very elderly ,cigarette smoking ,Review ,cancer risk ,tobacco ,Medical and Health Sciences ,Mathematical Sciences ,Smokeless ,tobacco consumption ,Tobacco Use ,Systematic Reviews, Meta- and Pooled Analyses ,0302 clinical medicine ,middle aged ,Prevalence ,030212 general & internal medicine ,Smokele ,Cancer ,Mouth neoplasm ,Head and Neck Neoplasm ,adult ,snuff ,tobacco, adolescent ,Tobacco Products ,smokeless tobacco ,Middle Aged ,Chewing tobacco ,aged ,female ,Smokeless tobacco ,chewing tobacco ,030220 oncology & carcinogenesis ,Mouth Neoplasms ,Female ,epidemiology ,Human ,Adult ,tobacco snuff ,United State ,medicine.medical_specialty ,Tobacco, Smokeless ,Snuff ,Adolescent ,Logistic Model ,smoking ,Cigarette Smoking ,03 medical and health sciences ,Young Adult ,Rare Diseases ,head and neck neoplasms ,analytical hierarchy proce ,Internal medicine ,Tobacco ,medicine ,mouth tumor ,Humans ,cancer ,controlled study ,Dental/Oral and Craniofacial Disease ,Aged ,head and neck tumor ,health risk ,Tobacco Smoke and Health ,meta analysi ,business.industry ,Prevention ,Head and neck cancer ,statistical model ,young adult, United States, Nicotiana tabacum, Adolescent ,Odds ratio ,medicine.disease ,major clinical study ,Mouth Neoplasm ,United States ,Confidence interval ,Logistic Models ,Good Health and Well Being ,confidence interval ,Tobacco, Smokele ,head and neck cancer ,business - Abstract
Previous studies on smokeless tobacco use and head and neck cancer (HNC) have found inconsistent and often imprecise estimates, with limited control for cigarette smoking. Using pooled data from 11 US case-control studies (1981-2006) of oral, pharyngeal, and laryngeal cancers (6,772 cases and 8,375 controls) in the International Head and Neck Cancer Epidemiology (INHANCE) Consortium, we applied hierarchical logistic regression to estimate odds ratios and 95% confidence intervals for ever use, frequency of use, and duration of use of snuff and chewing tobacco separately for never and ever cigarette smokers. Ever use (versus never use) of snuff was strongly associated with HNC among never cigarette smokers (odds ratio (OR) = 1.71, 95% confidence interval (CI): 1.08, 2.70), particularly for oral cavity cancers (OR = 3.01, 95% CI: 1.63, 5.55). Although ever (versus never) tobacco chewing was weakly associated with HNC among never cigarette smokers (OR = 1.20, 95% CI: 0.81, 1.77), analyses restricted to cancers of the oral cavity showed a stronger association (OR = 1.81, 95% CI: 1.04, 3.17). Few or no associations between each type of smokeless tobacco and HNC were observed among ever cigarette smokers, possibly reflecting residual confounding by smoking. Smokeless tobacco use appears to be associated with HNC, especially oral cancers, with snuff being more strongly associated than chewing tobacco. © 2016 The Author.
- Published
- 2016
43. Human Papillomavirus Type 16 (HPV-16) Genomes Integrated in Head and Neck Cancers and in HPV-16-Immortalized Human Keratinocyte Clones Express Chimeric Virus-Cell mRNAs Similar to Those Found in Cervical Cancers
- Author
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Thomas H. Haugen, D. Wang, Michael J. Lace, James R. Anson, Jens Peter Klussmann, L. P. Turek, and Elaine M. Smith
- Subjects
Keratinocytes ,Male ,Sequence analysis ,Papillomavirus E7 Proteins ,Virus Integration ,Immunology ,Uterine Cervical Neoplasms ,Genome, Viral ,Biology ,Microbiology ,Genome ,Transformation and Oncogenesis ,Virus ,Virology ,Gene expression ,medicine ,Humans ,RNA, Messenger ,Gene ,Cells, Cultured ,Recombination, Genetic ,Human papillomavirus 16 ,Cancer ,Oncogene Proteins, Viral ,Cell Transformation, Viral ,medicine.disease ,Clone Cells ,Repressor Proteins ,Head and Neck Neoplasms ,Insect Science ,Cancer research ,RNA, Viral ,Female - Abstract
Many human papillomavirus (HPV)-positive high-grade lesions and cancers of the uterine cervix harbor integrated HPV genomes expressing the E6 and E7 oncogenes from chimeric virus-cell mRNAs, but less is known about HPV integration in head and neck cancer (HNC). Here we compared viral DNA status and E6-E7 mRNA sequences in HPV-16-positive HNC tumors to those in independent human keratinocyte cell clones derived from primary tonsillar or foreskin epithelia immortalized with HPV-16 genomes. Three of nine HNC tumors and epithelial clones containing unintegrated HPV-16 genomes expressed mRNAs spliced from HPV-16 SD880 to SA3358 and terminating at the viral early gene p(A) signal. In contrast, most integrated HPV genomes in six HNCs and a set of 31 keratinocyte clones expressed HPV-16 major early promoter (MEP)-initiated mRNAs spliced from viral SD880 directly to diverse cellular sequences, with a minority spliced to SA3358 followed by a cellular DNA junction. Sequence analysis of chimeric virus-cell mRNAs from HNC tumors and keratinocyte clones identified viral integration sites in a variety of chromosomes, with some located in or near growth control genes, including the c- myc protooncogene and the gene encoding FAP-1 phosphatase. Taken together, these findings support the hypothesis that HPV integration in cancers is a stochastic process resulting in clonal selection of aggressively expanding cells with altered gene expression of integrated HPV genomes and potential perturbations of cellular genes at or near viral integration sites. Furthermore, our results demonstrate that this selection also takes place and can be studied in primary human keratinocytes in culture.
- Published
- 2011
44. Tobacco and alcohol use increases the risk of both HPV-associated and HPV-independent head and neck cancers
- Author
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Thomas H. Haugen, Eva Hamsikova, Elaine M. Smith, Lubomir P. Turek, and Linda M. Rubenstein
- Subjects
Adult ,Male ,Oncology ,Cancer Research ,medicine.medical_specialty ,Pathology ,Alcohol Drinking ,Antibodies, Viral ,Logistic regression ,Young Adult ,Risk Factors ,Internal medicine ,Epidemiology ,Prevalence ,medicine ,Humans ,Young adult ,Aged ,Aged, 80 and over ,Hematology ,business.industry ,Papillomavirus Infections ,Smoking ,Head and neck cancer ,HPV infection ,virus diseases ,Odds ratio ,Middle Aged ,medicine.disease ,female genital diseases and pregnancy complications ,Head and Neck Neoplasms ,Female ,business ,Oncovirus - Abstract
Tobacco, alcohol, and human papillomavirus (HPV) are major risk factors for head and neck cancer (HNC), but it is unclear whether there are two distinct HNC risk groups, one associated with HPV and the other with tobacco/alcohol. Because HPV-positive HNC are clinically distinct from HPV-negative cases in treatment response and with more favorable prognoses, determining whether these differences result from infection alone or in association with other HNC risk factors is important for developing future therapeutic strategies. Incident cases of HNC (n = 201) and age-gender frequency-matched controls (n = 324) were recruited to assess anti-HPV VLP (virus like particles) antibodies 16, 18, 31, and 33. Multivariate logistic regression and stratified analyses were used to calculate adjusted odds ratios (OR). HPV-seronegative and seropositive/heavy tobacco users had similar increased adjusted risks of HNC (HPV-seronegative OR = 2.6, 1.4-5.0; HPV-seropositive OR = 2.3, 1.1-4.8), as did HPV-seronegative (OR = 4.3, 2.1-9.1) versus HPV-seropositive/heavy alcohol users (OR = 3.9, 1.6-9.4). Similar HPV/tobacco/alcohol risk profiles also were seen in oropharyngeal and oral cavity tumor sites. Our finding that tobacco/alcohol use increased the risk of HNC in both HPV-seropositive and HPV-seronegative individuals is consistent with the observation that HPV infection is not a sufficient cause of HNC but requires the accumulation of additional cellular changes.
- Published
- 2010
45. Risk factors and survival by HPV-16 E6 and E7 antibody status in human papillomavirus positive head and neck cancer
- Author
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Lubomir P. Turek, Eva Hamsikova, Michael Pawlita, Elaine M. Smith, Thomas H. Haugen, and Linda M. Rubenstein
- Subjects
Male ,Human Papillomavirus Positive ,Oncology ,Cancer Research ,medicine.medical_specialty ,Papillomavirus E7 Proteins ,Enzyme-Linked Immunosorbent Assay ,Antibodies, Viral ,Risk Factors ,Internal medicine ,Epidemiology ,Biopsy ,medicine ,Humans ,Blood test ,Risk factor ,Papillomaviridae ,biology ,medicine.diagnostic_test ,business.industry ,Head and neck cancer ,Cancer ,Oncogene Proteins, Viral ,Middle Aged ,medicine.disease ,Repressor Proteins ,Survival Rate ,Head and Neck Neoplasms ,Immunology ,biology.protein ,Female ,Antibody ,business - Abstract
High-risk human papillomavirus types (HPV-HR) are associated with head and neck cancer (HNC) risk and better survival. Most patients with HPV-HR DNA-positive tumors develop anti-HPV E6/E7 antibodies; however, it is unclear whether those who mount an immune response have similar risk factors or clinical outcomes as those who do not. HPV-16 DNA tumor-positive HNC cases were evaluated for HPV-16 E6 and E7 antibodies using a GST capture ELISA system. Among 57 HPV-16 DNA tumor-positive HNC cases, 67% were detected with HPV-16 E6 and/or E7 antibodies. Male gender (76% vs. 42%, p = 0.02), younger age (63% vs. 16%, p = 0.001) but not tobacco or alcohol were associated with E6 and/or E7 seropositivity. Seropositivity was associated more often with late stage (76%), poor grade (65%), positive nodes (82%). and in the oropharynx (82%), Median disease-specific and recurrence-free survival were longer in E6 and/or E7 seropositive compared to E6/E7-negative cases (2.2 years vs. 1.4 years, both outcomes), although results were not statistically significant. When examined jointly with p16 expression, E6 and/or E7-positive/p16-positive cases had better disease-specific (2.1 years vs. 1.1 years, p = 0.06) and recurrence-free (2.3 years vs. 1.1 years, p = 0.03) survival compared to E6-/E7-/p16- cases. These findings suggest there are 2 distinct HNC patient groups with HPV DNA-positive tumors, distinguishable by E6 and/or E7 antibody status. Differences in antibody status are associated with distinct risk factors and clinical outcomes. This information can be available as a simple blood test at initial presentation, before the removal of tissue through biopsy or surgery.
- Published
- 2009
46. Demographic and risk factors in patients with head and neck tumors
- Author
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Eliška Rotnáglová, Viera Ludvíková, Eva Hamsikova, Martina Salakova, Jan Klozar, Linda M. Rubenstein, Roman Kodet, Jana Smahelova, Elaine M. Smith, and Ruth Tachezy
- Subjects
Male ,Oncology ,medicine.medical_specialty ,Papillomavirus E7 Proteins ,Sexual Behavior ,Antibodies, Viral ,Risk Assessment ,Sensitivity and Specificity ,law.invention ,Antibody Specificity ,Risk Factors ,law ,Virology ,Internal medicine ,Prevalence ,medicine ,Carcinoma ,Humans ,Risk factor ,Papillomaviridae ,Polymerase chain reaction ,Demography ,Human papillomavirus 16 ,biology ,business.industry ,Papillomavirus Infections ,Head and neck cancer ,Case-control study ,virus diseases ,Cancer ,Oncogene Proteins, Viral ,Middle Aged ,medicine.disease ,biology.organism_classification ,Repressor Proteins ,Oropharyngeal Neoplasms ,Infectious Diseases ,Head and Neck Neoplasms ,Case-Control Studies ,DNA, Viral ,Immunology ,Carcinoma, Squamous Cell ,biology.protein ,Female ,Antibody ,business - Abstract
The association between human papillomavirus (HPV) infection and the development of head and neck cancer has been documented recently. In this study on 86 head and neck cancer patients and 124 controls, data regarding demographics, behavioral risk factors, and risks related to HPV exposure were collected. HPV detection was carried out using polymerase chain reaction in the tumors and in oral exfoliated cells, and HPV typing by a reverse line blot assay specific for 37 HPV types. Sera were tested by an enzyme-linked immunosorbent assay specific for HPV proteins. Head and neck cancer cases report significantly more oral-anal contact (P = 0.02) and tobacco and alcohol use than controls (P = 0.001; P = 0.02, respectively). High-risk HPV DNA was detected in 43% of oral washings of cases and 4% of controls (P < 0.0001). The association between the presence of high-risk HPV DNA in oral exfoliated cells and in tumor tissues was statistically significant (adjusted P < 0.0001). The prevalence of HPV-specific antibodies was significantly higher in cases than in controls (adjusted P < 0.0001). These results provide epidemiological and immunological evidence for HR HPV as a strong risk factor (OR = 44.3, P < 0.0001) for head and neck cancer, even after controlling for age, tobacco and alcohol use. The detection of high-risk HPV DNA in oral exfoliated cells and HPV-specific antibodies in serum can be considered as clinically relevant surrogate markers for the presence of a HPV-associated head and neck cancer, with a high sensitivity (83%) and specificity (88%).
- Published
- 2009
47. Interaction between Tobacco and Alcohol Use and the Risk of Head and Neck Cancer: Pooled Analysis in the International Head and Neck Cancer Epidemiology Consortium
- Author
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Elena Matos, Renato Talamini, Karl T. Kelsey, Qingyi Wei, Shu Chun Chuang, Leticia Fernandez, Erich M. Sturgis, Joshua E. Muscat, Xavier Castellsagué, Alexander W. Daudt, Chu Chen, Paul Brennan, Andrew F. Olshan, Carlo La Vecchia, Fabio Levi, Rolando Herrero, Stephen M. Schwartz, Sergio Koifman, Eleonora Fabianova, Dana Mates, Stefania Boccia, Philip Lazarus, Neonilia Szeszenia-Dabrowska, Maria Paula Curado, Victor Wünsch-Filho, Luigino Dal Maso, Agnieszka Pilarska, Zuo-Feng Zhang, Deborah M. Winn, Gilles Ferro, Richard B. Hayes, Peter Rudnai, Paolo Boffetta, Oxana Shangina, Elaine M. Smith, Silvia Franceschi, Julien Berthiller, Mark P. Purdue, Ana Maria Menezes, Mia Hashibe, Juan Lence, Michael D. McClean, José Eluf-Neto, Hashibe, M., Brennan, P., Chuang, S.-C., Boccia, S., Castellsague, X., Chen, C., Curado, M.P., Maso, L.D., Daudt, A.W., Fabianova, E., Fernandez, L., Wünsch-Filho, V., Franceschi, S., Hayes, R.B., Herrero, R., Kelsey, K., Koifman, S., Vecchia, C.L., Lazarus, P., Levi, F., Lence, J.J., Mates, D., Matos, E., Menezes, A., McClean, M.D., Muscat, J., Eluf-Neto, J., Olshan, A.F., Purdue, M., Rudnai, P., Schwartz, S.M., Smith, E., Sturgis, E.M., Szeszenia-Dabrowska, N., Talamini, R., Wei, Q., Winn, D.M., Shangina, O., Pilarska, A., Zhang, Z.-F., Ferro, G., Berthiller, J., and Boffetta, P.
- Subjects
education.field_of_study ,medicine.medical_specialty ,Adult ,Aged ,Alcohol Drinking ,Alcohol Drinking/adverse effects ,Alcohol Drinking/epidemiology ,Case-Control Studies ,Europe ,Female ,Head and Neck Neoplasms ,Head and Neck Neoplasms/epidemiology ,Head and Neck Neoplasms/etiology ,Humans ,Logistic Models ,Male ,Middle Aged ,North America ,North America/epidemiology ,Risk Factors ,Tobacco Use Disorder ,Tobacco Use Disorder/complications ,Tobacco Use Disorder/epidemiology ,Epidemiology ,business.industry ,Population ,Head and neck cancer ,Case-control study ,tobacco and alcohol use ,Cancer ,medicine.disease ,Confidence interval ,Surgery ,Oncology ,Internal medicine ,medicine ,head and neck cancer ,Risk factor ,Risk assessment ,education ,business - Abstract
Background: The magnitude of risk conferred by the interaction between tobacco and alcohol use on the risk of head and neck cancers is not clear because studies have used various methods to quantify the excess head and neck cancer burden. Methods: We analyzed individual-level pooled data from 17 European and American case-control studies (11,221 cases and 16,168 controls) participating in the International Head and Neck Cancer Epidemiology consortium. We estimated the multiplicative interaction parameter (ψ) and population attributable risks (PAR). Results: A greater than multiplicative joint effect between ever tobacco and alcohol use was observed for head and neck cancer risk (ψ = 2.15; 95% confidence interval, 1.53-3.04). The PAR for tobacco or alcohol was 72% (95% confidence interval, 61-79%) for head and neck cancer, of which 4% was due to alcohol alone, 33% was due to tobacco alone, and 35% was due to tobacco and alcohol combined. The total PAR differed by subsite (64% for oral cavity cancer, 72% for pharyngeal cancer, 89% for laryngeal cancer), by sex (74% for men, 57% for women), by age (33% for cases 60 years), and by region (84% in Europe, 51% in North America, 83% in Latin America). Conclusions: Our results confirm that the joint effect between tobacco and alcohol use is greater than multiplicative on head and neck cancer risk. However, a substantial proportion of head and neck cancers cannot be attributed to tobacco or alcohol use, particularly for oral cavity cancer and for head and neck cancer among women and among young-onset cases. (Cancer Epidemiol Biomarkers Prev 2009;18(2):541–50)
- Published
- 2009
48. Type of Alcoholic Beverage and Risk of Head and Neck Cancer—A Pooled Analysis Within the INHANCE Consortium
- Author
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Neonilia Szeszenia-Dabrowska, José Eluf Neto, Silvia Franceschi, Stephen M. Schwartz, Maria Paula Curado, Fabio Levi, Erich M. Sturgis, Elena Matos, Zuo-Feng Zhang, Debbie Winn, Renato Talamini, Mark P. Purdue, Joshua E. Muscat, Hal Morgenstern, Richard B. Hayes, Peter Rudnai, David Zaridze, Luigino Dal Maso, Agnieszka Pilarska, Carlo La Vecchia, Simone Benhamou, Paul Brennan, Ana M. B. Menezes, Victor Wünsch-Filho, Elaine M. Smith, Andrew F. Olshan, Xavier Castellsagué, Qingyi Wei, Eleonora Fabianova, Philip Lazarus, Rolando Herrero, Alexander W. Daudt, Julien Berthiller, Paolo Boffetta, Ioan Nicolae Mates, Mia Hashibe, Juan Lence, Chu Chen, Sergio Koifman, Gilles Ferro, Purdue, M.P., Hashibe, M., Berthiller, J., La Vecchia, C., Maso, L.D., Herrero, R., Franceschi, S., Castellsague, X., Wei, Q., Sturgis, E.M., Morgenstern, H., Zhang, Z.-F., Levi, F., Talamini, R., Smith, E., Muscat, J., Lazarus, P., Schwartz, S.M., Chen, C., Neto, J.E., Wünsch-Filho, V., Zaridze, D., Koifman, S., Curado, M.P., Benhamou, S., Matos, E., Szeszenia-Dabrowska, N., Olshan, A.F., Lence, J., Menezes, A., Daudt, A.W., Mates, I.N., Pilarska, A., Fabianova, E., Rudnai, P., Winn, D., Ferro, G., Brennan, P., Boffetta, P., and Hayes, R.B.
- Subjects
medicine.medical_specialty ,Alcohol Drinking ,Epidemiology ,education ,PROTEIN ,Wine ,Risk Assessment ,DIET ,03 medical and health sciences ,0302 clinical medicine ,VITAMIN ,Risk Factors ,mental disorders ,Odds Ratio ,medicine ,Humans ,030212 general & internal medicine ,Risk factor ,Meta-and Pooled Analyses ,CALIBRATION ,KIDNEY CANCER ,Ethanol ,business.industry ,Alcoholic Beverages ,Confounding ,Case-control study ,Beer ,food and beverages ,Odds ratio ,3. Good health ,Surgery ,ENERGY-INTAKE ,PHYSICAL-ACTIVITY ,Head and Neck Neoplasms ,Case-Control Studies ,030220 oncology & carcinogenesis ,Meta-analysis ,Relative risk ,RISK-FACTORS ,Risk assessment ,business ,Demography - Abstract
The authors pooled data from 15 case-control studies of head and neck cancer (9,107 cases, 14,219 controls) to investigate the independent associations with consumption of beer, wine, and liquor. In particular, they calculated associations with different measures of beverage consumption separately for subjects who drank beer only (858 cases, 986 controls), for liquor-only drinkers (499 cases, 527 controls), and for wine-only drinkers (1,021 cases, 2,460 controls), with alcohol never drinkers (1,124 cases, 3,487 controls) used as a common reference group. The authors observed similar associations with ethanol-standardized consumption frequency for beer-only drinkers (odds ratios (ORs) = 1.6, 1.9, 2.2, and 5.4 for =5, 6-15, 16-30, and >30 drinks per week, respectively; Ptrend < 0.0001) and liquor-only drinkers (ORs = 1.6, 1.5, 2.3, and 3.6; P < 0.0001). Among wine-only drinkers, the odds ratios for moderate levels of consumption frequency approached the null, whereas those for higher consumption levels were comparable to those of drinkers of other beverage types (ORs = 1.1, 1.2, 1.9, and 6.3; P < 0.0001). Study findings suggest that the relative risks of head and neck cancer for beer and liquor are comparable. The authors observed weaker associations with moderate wine consumption, although they cannot rule out confounding from diet and other lifestyle factors as an explanation for this finding. Given the presence of heterogeneity in study-specific results, their findings should be interpreted with caution.
- Published
- 2008
49. Does Pretreatment Seropositivity to Human Papillomavirus Have Prognostic Significance for Head and Neck Cancers?
- Author
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Lubomir P. Turek, Eva Hamsikova, John H. Lee, Justine M. Ritchie, Linda M. Rubenstein, Elaine M. Smith, and Thomas H. Haugen
- Subjects
Adult ,Male ,Oncology ,medicine.medical_specialty ,Epidemiology ,Papillomavirus E7 Proteins ,Antibodies, Viral ,Polymerase Chain Reaction ,Statistics, Nonparametric ,Article ,Antigen ,Risk Factors ,Internal medicine ,medicine ,Humans ,Risk factor ,Papillomaviridae ,Survival analysis ,Aged ,Proportional Hazards Models ,Aged, 80 and over ,biology ,Proportional hazards model ,business.industry ,Papillomavirus Infections ,Head and neck cancer ,Hazard ratio ,virus diseases ,Cancer ,Oncogene Proteins, Viral ,Middle Aged ,Prognosis ,medicine.disease ,biology.organism_classification ,Survival Analysis ,female genital diseases and pregnancy complications ,Repressor Proteins ,Head and Neck Neoplasms ,Immunology ,Female ,business - Abstract
Background: Human papillomavirus (HPV) is a risk factor for head and neck cancers (HNC), yet HPV-associated tumors have better prognosis than HPV-negative tumors. Methods: We evaluated whether pretreatment presence of antibodies to HPV capsids [virus-like particles (VLP)] or to HPV-16 oncoproteins E6 and E7 was a predictor of HPV-positive HNC and clinical outcomes. Sera from 156 HNC patients were tested for antibodies to HPV-16–derived antigens using ELISA. HPV-16 in tumors was evaluated by PCR and DNA sequencing. Results: HPV-16 antibodies were found in 33% with HPV-16 VLP, 21% with HPV-16 E6, and 21% with E7. HPV-16 was detected in 26% of tumors. There was a strong correlation between detection of HPV-16 tumor DNA and antibodies to HPV-16 E6 or E7 (κ = 0.7) but not to HPV-16 VLP (κ = 0.4). Multivariate analyses showed significantly better disease-specific survival in seropositive HPV-16 VLP [hazard ratio (HR), 0.4; 95% confidence interval (95% CI), 0.1-0.9], HPV-16 E6 (HR, 0.1; 95% CI, 0.02-0.5), and HPV-16 E7 (HR, 0.3; 95% CI, 0.1-0.9) cases. Less disease recurrence occurred among those with antibodies to both E6 and E7 compared with those negative to both (P = 0.003). There was better disease-specific survival in patients who were E6 positive at baseline and remained positive at follow-up compared with individuals who were E6 negative at both time points (P = 0.03; κ = 0.9). Conclusions: The presence of antibodies to HPV-16 E6 and E7 is associated with HPV in tumor cells and with better clinical outcomes. These findings suggest that the presence of E6/E7 antibodies before treatment is predictive of better clinical outcomes and that they may serve as biomarkers for selecting targeted therapeutic modalities developed for HPV-associated tumors. (Cancer Epidemiol Biomarkers Prev 2008;17(8):2087–96)
- Published
- 2008
50. Association between p53 and Human Papillomavirus in Head and Neck Cancer Survival
- Author
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Linda M. Rubenstein, Donghong Wang, Lubomir P. Turek, Thomas H. Haugen, William A. Morris, and Elaine M. Smith
- Subjects
Male ,Oncology ,medicine.medical_specialty ,Pathology ,Multivariate analysis ,Epidemiology ,Risk Factors ,Internal medicine ,Biomarkers, Tumor ,medicine ,Humans ,Proportional Hazards Models ,Human papillomavirus 16 ,business.industry ,Papillomavirus Infections ,Head and neck cancer ,Hazard ratio ,Cancer ,Middle Aged ,Prognosis ,medicine.disease ,Survival Analysis ,Confidence interval ,Logistic Models ,Head and Neck Neoplasms ,Immunohistochemistry ,Biomarker (medicine) ,Female ,Viral disease ,Neoplasm Recurrence, Local ,Tumor Suppressor Protein p53 ,business - Abstract
Background: High-risk human papillomavirus (HPV-HR) is a significant risk factor for head and neck cancer (HNC), abrogating normal p53 function. In addition, HPV and p53 have been associated with prognosis of these tumors but the findings have been inconsistent. We examined p53 expression and HPV-HR individually and jointly for differences in predicting HNC survival. Methods: HNC patients (n = 294) were evaluated for p53 by immunohistochemical staining. HPV was detected by PCR/dot blot hybridization and sequencing. Results: HNC tumors showed 48% with p53 overexpression and 27% with HPV-HR. Multivariate analyses showed that p53 positivity was significantly associated with higher risk of disease-specific [hazard ratio (HR); 2.0; 95% confidence interval (95% CI), 1.1-3.7] and recurrence-free mortality (HR, 2.8; 95% CI, 1.4-5.3). HPV− cases had significantly worse disease-specific survival (HR, 2.8; 95% CI, 1.3-6.3) compared with HPV-HR cases. When analyzed jointly, with p53−/HPV-HR tumors as the reference group, p53+/HPV− patients had the worst disease-specific (HR, 5.3; 58% versus 15%, P = 0.006) and recurrence-free survival rates (HR, 9.5; 17% versus 89%, P = 0.001), in contrast to the p53−/HPV− and p53+/HPV-HR groups, which had less elevated and different risks for disease-specific survival (HR, 2.5 and 1.7, respectively) and recurrence-free survival (HR, 4.2 and 7.2, respectively). Conclusion: Joint assessment of p53/HPV status provides different HRs for each clinical outcome in the four biomarker groups that are distinct from the individual biomarkers. These findings suggest that joint assessment of p53/HPV provides a better indicator of prognosis and potentially different types of treatments. (Cancer Epidemiol Biomarkers Prev 2008;17(2):421–7)
- Published
- 2008
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