1. Immune cell counts in cerebrospinal fluid predict cognitive function in aging and neurodegenerative disease
- Author
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Snyder, Allison, Grant, Harli, Chou, Austin, Lindbergh, Cutter A, Kramer, Joel H, Miller, Bruce L, and Elahi, Fanny M
- Subjects
Biomedical and Clinical Sciences ,Neurosciences ,Clinical Sciences ,Alzheimer's Disease ,Aging ,Acquired Cognitive Impairment ,Neurodegenerative ,Dementia ,Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD) ,Brain Disorders ,2.1 Biological and endogenous factors ,Neurological ,Humans ,Middle Aged ,Neurodegenerative Diseases ,Alzheimer Disease ,Cognitive Dysfunction ,Cognition ,Cell Count ,Biomarkers ,Amyloid beta-Peptides ,aging ,cerebrospinal fluid ,cognition ,executive function ,inflammation ,neurodegeneration ,Geriatrics ,Clinical sciences ,Biological psychology - Abstract
IntroductionImmune dysfunction is important in aging and neurodegeneration; lacking clinically available tools limits research translation. We tested associations of cerebral spinal fluid (CSF) monocyte-to-lymphocyte ratio (MLR)-innate immune activation surrogate-with cognition in an aging and dementia cohort, hypothesizing that elevated MLR is associated with poorer executive functioning.MethodsCSF MLR was calculated in well-characterized, genotyped participants enrolled in studies of aging and dementia at University of California, San Francisco Memory and Aging Center (n = 199, mean age 57.5 years, SD 11.9). Linear models tested associations with episodic memory and executive function (verbal fluency, speeded set-shifting).ResultsAging was associated with higher CSF monocyte, lower lymphocyte counts, and higher MLRs (p
- Published
- 2023