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In multiplexed computational imaging schemes, high-resolution images are reconstructed by fusing the information in multiple low-resolution images detected by a two-dimensional array of low-resolution image sensors. The reconstruction procedure assumes a mathematical model for the imaging process that could have generated the low-resolution observations from an unknown high-resolution image. In practical settings, the parameters of the mathematical imaging model are known only approximately and are typically estimated before the reconstruction procedure takes place. Violations to the assumed model, such as inaccurate knowledge of the field of view of the imagers, erroneous estimation of the model parameters, and/or accidental scene or environmental changes can be detrimental to the reconstruction quality, even if they are small in number. We present an adaptive algorithm for robust reconstruction of high-resolution images in multiplexed computational imaging architectures. Using robust M-estimators and incorporating a similarity measure, the proposed scheme adopts an adaptive estimation strategy that effectively deals with violations to the assumed imaging model. Comparisons with nonadaptive reconstruction techniques demonstrate the superior performance of the proposed algorithm in terms of reconstruction quality and robustness. OCIS codes: 110.1758, 100.2980.