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Insulin-independent actions of glucagon-like peptide-1 ( GLP-1) are not yet clear in ruminants. Four Suffolk mature wethers (60.0 ± 6.7 kg body weight ( BW)) were intravenously infused with insulin (0.5 mU/kg BW/min; from 0 to 90 min) and GLP-1 (0.5 μg/kg BW/min; from 60 to 150 min) with both hormones co-administered from 60 to 90 min, in a repeated-measure design under euglycemic clamp for 150 min, to investigate whether GLP-1 has insulin-independent actions. Jugular blood samples were taken at 15-min intervals for plasma hormones and metabolites analysis. Compared to baseline concentrations (at 0 min), insulin infusion decreased ( P < 0.05) plasma concentrations of glucagon, non-esterified fatty acids ( NEFA), lactate, nonessential amino acids ( NEAA), branched-chain amino acids ( BCAA), total amino acids ( TAA) and urea nitrogen ( UN). Insulin plus GLP-1 infusion induced a greater increase ( P < 0.05) in plasma concentrations of insulin and triglyceride ( TG), but decreased ( P < 0.05) glucagon, total cholesterol ( T- Cho), NEAA and UN plasma concentrations. GLP-1 infusion increased ( P < 0.05) NEFA, β-hydroxybutyrate and TG, but decreased ( P < 0.05) glucagon, T- Cho, NEAA, BCAA and UN plasma concentrations. In conclusion, GLP-1 exerts extrapancreatic roles in ruminants not only insulin-independent but probably, in contrast to non-ruminants, antagonistic to insulin effects. [ABSTRACT FROM AUTHOR]

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