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Vitiligo is a significant dermatological challenge affecting 0.5 to 2% of the global population. Despite the various existing medical approaches, current vitiligo treatments are far from ideal. The present study aimed to prepare and evaluate a film-forming gel of 5 fluorouracil (5FU) using different ratios of hydroxypropyl methylcellulose (HPMC) and Zein for treating vitiligo. The prepared film-forming gels were fully characterized in terms of morphology, Fourier-transform infrared spectroscopy, drug content, pH, drying time, in-vitro drug release, and clinical investigation. A 32-full factorial design was used to study the impact of varying concentrations of HPMC (X1) and Zein (X2) on the percentage of 5FU released (Y1) from the prepared film-forming gels. Scanning electron microscopy (SEM) revealed a cross-linked network structure between polymers. An increase in HPMC concentration (2–4%) correlated with higher 5FU release, whereas increased Zein concentration (1–2%) resulted in reduced 5FU release. Furthermore, patients treated with 5FU film-forming gel after dermabrasion with fractional CO2 (FCO2) laser exhibited a significant decrease in JAK3 gene expression and higher effectiveness than those treated with FCO2 laser alone. Our results suggest that the film-forming gel of 5FU is promising as an effective formulation for treating vitiligo. [ABSTRACT FROM AUTHOR]

Breast cancer is a pressing public health issue globally and in Morocco, with rising cases among women. This study aims to evaluate breast cancer awareness and self-examination practices among female university students, informing future educational interventions. A cross-sectional study surveyed 437 students at Ibn Zohr University, Agadir, using a questionnaire covering demographics, knowledge of breast cancer, risk factors, symptoms, and breast self-examination (BSE). Results showed high awareness of breast cancer (95.3%), with social networks and media being primary information sources. However, only 48.25% had intermediate knowledge levels, and BSE awareness was moderate (60.8%) with low practical skills (28.0%). Reasons for not performing BSE included lack of knowledge and discomfort. Significant associations were found between knowledge levels and age, year of study, study options, and information sources. Despite high awareness, there is a crucial need to enhance knowledge about breast cancer risk factors, symptoms, and BSE practices among young women in Morocco. Educational programs targeting university students are essential for promoting early detection and improving attitudes toward breast health. [ABSTRACT FROM AUTHOR]

Salinity poses a significant challenge to tomato plant development and metabolism. This study explores the use of biostimulants as eco-friendly strategies to enhance tomato plant tolerance to salinity. Conducted in a greenhouse, the research focuses on the Solanum lycopersicum L. behavior under saline conditions. Tomato seeds were treated with arbuscular mycorrhizal fungi (AMF), compost, and their combination under both non-saline and saline conditions (0 and 150 mM NaCl). Plant height, number of flowers and fruits, shoot fresh weight, and root dry weight were negatively impacted by salt stress. The supplementation with compost affected the colonization of AMF, but the application of stress had no effect on this trait. However, the use of compost and AMF separately or in combination showed positive effects on the measured parameters. At the physiological level, compost played a beneficial role in increasing photosynthetic efficiency, whether or not plants were subjected to salinity. In addition, the application of these biostimulants led to an increase in nitrogen content in the plants, irrespective of the stress conditions. AMF and compost, applied alone or in combination, showed positive effects on photosynthetic pigment concentrations and protein content. Under salt stress, characterized by an increase in lipid peroxidation and H2O2 content, the application of these biostimulants succeeded in reducing both these parameters in affected plants through exhibiting an increase in antioxidant enzyme activity. In conclusion, incorporating compost, AMF, or their combined application emerges as a promising approach to alleviate the detrimental impacts of salt stress on both plant performances. These findings indicate optimistic possibilities for advancing sustainable and resilient agricultural practices. [ABSTRACT FROM AUTHOR]

The argan (Argania spinosa L. Skeels) ecosystem is severely degrading in arid and semi-arid lands due to climate change, particularly in terms of density loss and reforestation failure. Thus, it is important to adopt innovative effective sustainable practices to optimize the densification and reforestation success of the argan tree. The purpose of the present research was to investigate the combined effect of subsurface water retention technology (SWRT) and the use of native arbuscular mycorrhizal fungi (AMF) on edaphic, growth, physiological and biochemical parameters of field-grown argan seedlings in the Essaouira region, Morocco. In this experiment, one-year-old argan seedlings were transplanted in the absence and presence of biodegradable plastic and AMF. Our findings revealed that the application of SWRT enhanced soil profile moisture up to 640% at 40 cm depth compared to the control. The combination of this technology with AMF also improved soil fertility. Furthermore, the application of SWRT, with or without AMF, significantly enhanced argan seedling height (208 and 168%, respectively), stomatal conductance (54 and 33%, respectively), and chlorophyll fluorescence (21 and 20%, respectively). Similarly, the combined application of SWRT and AMF significantly improved protein and sugar content (36 and 57%, respectively), as well as antioxidant enzyme activities (peroxidase and polyphenol oxidase) and chlorophyll pigments content compared to the control. However, this treatment reduced malondialdehyde and H2O2 content in the argan leaves. As a summary, SWRT technology combined with AMF may be used as a valuable strategy to promote the success of argan reforestation and to limit soil erosion and desertification in arid and semi-arid climates. [ABSTRACT FROM AUTHOR]