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231 results on '"El-Gowilly, Sahar M."'

7. Suppression by central adenosine A3 receptors of the cholinergic defense against cardiovascular aberrations of sepsis: role of PI3K/MAPKs/NFκB signaling.

Author

El-Naggar, Amany E., Helmy, Mai M., El-Gowilly, Sahar M., and El-Mas, Mahmoud M.

Subjects
CHOLINERGIC receptors, SEPSIS, ADENOSINES, HEART beat, DRUG monitoring
Abstract

Introduction: Despite the established role of peripheral adenosine receptors in sepsis-induced organ dysfunction, little or no data is available on the interaction of central adenosine receptors with sepsis. The current study tested the hypothesis that central adenosine A3 receptors (A3ARs) modulate the cardiovascular aberrations and neuroinflammation triggered by sepsis and their counteraction by the cholinergic antiinflammatory pathway. Methods: Sepsis was induced by cecal ligation and puncture (CLP) in rats pre-instrumented with femoral and intracisternal (i.c.) catheters for hemodynamic monitoring and central drug administration, respectively. Results: The CLP-induced hypotension, reduction in overall heart rate variability (HRV) and sympathovagal imbalance towards parasympathetic predominance were abolished by i.v. nicotine (100 µg/kg) or i.c. VUF5574 (A3AR antagonist, 2 µg/rat). In addition, the selective A3AR agonist, 3-iodobenzyl-5'-N-methylcarboxamidoadenosine IB-MECA, 4 µg/rat, i.c.) exaggerated the hypotension and cardiac autonomic dysfunction induced by sepsis and opposed the favorable nicotine actions against these septic manifestations. Immunohistochemically, IB-MECA abolished the nicotine-mediated downregulation of NFκB and NOX2 expression in rostral ventrolateral medullary areas (RVLM) of brainstem of septic rats. The inhibitory actions of IB-MECA on nicotine responses disappeared after i.c. administration of PD98059 (MAPK-ERK inhibitor), SP600125 (MAPK-JNK inhibitor) or wortmannin (PI3K inhibitor). Moreover, infliximab (TNFα inhibitor) eliminated the IB-MECA-induced rises in RVLM-NFκB expression and falls in HRV, but not blood pressure. Conclusion: Central PI3K/MAPKs pathway mediates the A3AR counteraction of cholinergic defenses against cardiovascular and neuroinflammatory aberrations in sepsis. [ABSTRACT FROM AUTHOR]

Published
2024
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31. The [α.sub.1]-adrenergic receptor not the D[A.sub.1]-dopaminergic receptor mediates cyclosporine-SKF38393 renovascular interaction

Author

El-Mas, Mahmoud M., El-Din, Mahmoud M. Mohy, El-gowilly, Sahar M., and Sharabi, Fouad M.

Subjects
Dopamine -- Dosage and administration -- Research -- Health aspects, Blood vessels -- Dilatation, Cyclosporine -- Health aspects -- Research -- Dosage and administration, Biological sciences, Research, Dosage and administration, Health aspects
Abstract

Abstract: In this study, we investigated the effect of acute exposure to cyclosporine A (CyA) on renal vasodilations evoked by the D[A.sub.1] dopaminergic agonist SKF38393 and whether dopamine D[A.sub.1] receptors [...]

Published
2005

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