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1,391 results on '"El-Bassel, Nabila"'

2. Identifying Self-Disclosures of Use, Misuse and Addiction in Community-based Social Media Posts

Author

Yang, Chenghao, Chakrabarty, Tuhin, Hochstatter, Karli R, Slavin, Melissa N, El-Bassel, Nabila, and Muresan, Smaranda

Subjects
Computer Science - Computation and Language
Abstract

In the last decade, the United States has lost more than 500,000 people from an overdose involving prescription and illicit opioids making it a national public health emergency (USDHHS, 2017). Medical practitioners require robust and timely tools that can effectively identify at-risk patients. Community-based social media platforms such as Reddit allow self-disclosure for users to discuss otherwise sensitive drug-related behaviors. We present a moderate size corpus of 2500 opioid-related posts from various subreddits labeled with six different phases of opioid use: Medical Use, Misuse, Addiction, Recovery, Relapse, Not Using. For every post, we annotate span-level extractive explanations and crucially study their role both in annotation quality and model development. We evaluate several state-of-the-art models in a supervised, few-shot, or zero-shot setting. Experimental results and error analysis show that identifying the phases of opioid use disorder is highly contextual and challenging. However, we find that using explanations during modeling leads to a significant boost in classification accuracy demonstrating their beneficial role in a high-stakes domain such as studying the opioid use disorder continuum., Comment: NAACL 2024 Findings (Camera-Ready Version). Codes and Data are available at https://github.com/yangalan123/OpioidID

Published
2023

4. Delivering integrated strategies from a mobile unit to address the intertwining epidemics of HIV and addiction in people who inject drugs: the HPTN 094 randomized controlled trial protocol (the INTEGRA Study)

Author

Goodman-Meza, David, Shoptaw, Steven, Hanscom, Brett, Smith, Laramie R, Andrew, Philip, Kuo, Irene, Lake, Jordan E, Metzger, David, Morrison, Ellen AB, Cummings, Melissa, Fogel, Jessica M, Richardson, Paul, Harris, Jayla, Heitner, Jesse, Stansfield, Sarah, and El-Bassel, Nabila

Subjects
Biomedical and Clinical Sciences, Public Health, Health Sciences, Clinical Sciences, Social Determinants of Health, Brain Disorders, Minority Health, Sexually Transmitted Infections, Health Disparities, Comparative Effectiveness Research, Behavioral and Social Science, Infectious Diseases, Clinical Trials and Supportive Activities, Opioid Misuse and Addiction, Substance Misuse, Clinical Research, Prevention, Women's Health, HIV/AIDS, Health Services, Drug Abuse (NIDA only), Opioids, 6.6 Psychological and behavioural, 8.1 Organisation and delivery of services, Infection, Mental health, Good Health and Well Being, Humans, Pharmaceutical Preparations, Substance Abuse, Intravenous, Drug Users, HIV Infections, Sexually Transmitted Diseases, Opioid-Related Disorders, Randomized Controlled Trials as Topic, HPTN 094 Study Team, Cardiorespiratory Medicine and Haematology, Cardiovascular System & Hematology, General & Internal Medicine, Clinical sciences, Epidemiology, Health services and systems
Abstract

BackgroundPersons with opioid use disorders who inject drugs (PWID) in the United States (US) face multiple and intertwining health risks. These include interference with consistent access, linkage, and retention to health care including medication for opioid use disorder (MOUD), HIV prevention using pre-exposure prophylaxis (PrEP), and testing and treatment for sexually transmitted infections (STIs). Most services, when available, including those that address substance misuse, HIV prevention, and STIs, are often provided in multiple locations that may be difficult to access, which further challenges sustained health for PWID. HPTN 094 (INTEGRA) is a study designed to test the efficacy of an integrated, "whole-person" strategy that provides integrated HIV prevention including antiretroviral therapy (ART), PrEP, MOUD, and STI testing and treatment from a mobile health delivery unit ("mobile unit") with peer navigation compared to peer navigation alone to access these services at brick and mortar locations.MethodsHPTN 094 (INTEGRA) is a two-arm, randomized controlled trial in 5 US cities where approximately 400 PWID without HIV are assigned either to an experimental condition that delivers 26 weeks of "one-stop" integrated health services combined with peer navigation and delivered in a mobile unit or to an active control condition using peer navigation only for 26 weeks to the same set of services delivered in community settings. The primary outcomes include being alive and retained in MOUD and PrEP at 26 weeks post-randomization. Secondary outcomes measure the durability of intervention effects at 52 weeks following randomization.DiscussionThis trial responds to a need for evidence on using a "whole-person" strategy for delivering integrated HIV prevention and substance use treatment, while testing the use of a mobile unit that meets out-of-treatment PWID wherever they might be and links them to care systems and/or harm reduction services. Findings will be important in guiding policy for engaging PWID in HIV prevention or care, substance use treatment, and STI testing and treatment by addressing the intertwined epidemics of addiction and HIV among those who have many physical and geographic barriers to access care.Trial registrationClinicalTrials.gov NCT04804072 . Registered on 18 March 2021.

Published
2024

13. Effect of the Communities that HEAL intervention on receipt of behavioral therapies for opioid use disorder: A cluster randomized wait-list controlled trial

Author

Glasgow, LaShawn, Douglas, Christian, Sprunger, Joel G., Campbell, Aimee N.C., Chandler, Redonna, Dasgupta, Anindita, Holloway, JaNae, Marks, Katherine R., Roberts, Sara M., Martinez, Linda Sprague, Thompson, Katherine, Weiss, Roger D., Aldridge, Arnie, Asman, Kat, Barbosa, Carolina, Blevins, Derek, Chassler, Deborah, Cogan, Lindsay, Fanucchi, Laura, Hall, Megan E., Hunt, Timothy, Jadovich, Elizabeth, Levin, Frances R., Lincourt, Patricia, Lofwall, Michelle R., Loukas, Vanessa, McAlearney, Ann Scheck, Nunes, Edward, Oga, Emmanuel, Oller, Devin, Rudorf, Maria, Sullivan, Ann Marie, Talbert, Jeffery, Taylor, Angela, Teater, Julie, Vandergrift, Nathan, Woodlock, Kristin, Zarkin, Gary A., Freisthler, Bridget, Samet, Jeffrey H., Walsh, Sharon L., and El-Bassel, Nabila

Published
2024
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15. Effects of the Communities that Heal (CTH) intervention on perceived opioid-related community stigma in the HEALing Communities Study: results of a multi-site, community-level, cluster-randomized trial

Author

Davis, Alissa, Knudsen, Hannah K., Walker, Daniel M., Chassler, Deborah, Lunze, Karsten, Westgate, Philip M., Oga, Emmanuel, Rodriguez, Sandra, Tan, Sylvia, Holloway, JaNae, Walsh, Sharon L., Oser, Carrie B., Lefebvre, R. Craig, Fanucchi, Laura C., Glasgow, LaShawn, McAlearney, Ann Scheck, Surratt, Hilary L., Konstan, Michael W., Huang, Terry T.-K., LeBaron, Patricia, Nakayima, Julie, Stein, Michael D., Rudorf, Maria, Nouvong, Monica, Kinnard, Elizabeth N., El-Bassel, Nabila, Tilley, Jess, Macoubray, Aaron, Savitzky, Caroline, Farmer, Amy, Beers, Donna, Salsberry, Pamela, and Huerta, Timothy R.

Published
2024
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16. Community-level determinants of stakeholder perceptions of community stigma toward people with opioid use disorders, harm reduction services and treatment in the HEALing Communities Study

Author

Davis, Alissa, Stringer, Kristi Lynn, Drainoni, Mari-Lynn, Oser, Carrie B., Knudsen, Hannah K., Aldrich, Alison, Surratt, Hilary L., Walker, Daniel M., Gilbert, Louisa, Downey, Dget L., Gardner, Sam D., Tan, Sylvia, Lines, Lisa M., Vandergrift, Nathan, Mack, Nicole, Holloway, JaNae, Lunze, Karsten, McAlearney, Ann Scheck, Huerta, Timothy R., Goddard-Eckrich, Dawn A., and El-Bassel, Nabila

Published
2023
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17. Preventing HIV outbreaks among people who inject drugs in the United States: plus ça change, plus ça même chose.

Author

Strathdee, Steffanie A, Kuo, Irene, El-Bassel, Nabila, Hodder, Sally, Smith, Laramie R, and Springer, Sandra A

Subjects
Drug Abuse (NIDA only), Infectious Diseases, Prevention, Behavioral and Social Science, Substance Misuse, HIV/AIDS, 6.1 Pharmaceuticals, Evaluation of treatments and therapeutic interventions, Infection, Good Health and Well Being, Continuity of Patient Care, Disease Outbreaks, HIV Infections, Humans, Pre-Exposure Prophylaxis, Substance Abuse, Intravenous, Substance-Related Disorders, United States, HIV treatment, medications for opioid use disorder, people who inject drugs, preexposure prophylaxis, stimulant use, surveillance, Biological Sciences, Medical and Health Sciences, Psychology and Cognitive Sciences, Virology
Abstract

: This editorial review covers current trends in the epidemiology of HIV among people who inject drugs (PWID) in the United States, including four recent HIV outbreaks. We discuss gaps in the prevention and treatment cascades for HIV and medications for opioid disorder and propose lessons learned to prevent future HIV outbreaks. Over the last decade, North America has been in the throes of a major opioid epidemic, due in part to over-prescribing of prescription opiates, followed by increasing availability of cheap heroin, synthetic opioids (e.g. fentanyl), and stimulants (e.g. methamphetamine). Historically, HIV infection among PWID in the US had predominantly affected communities who were older, urban and Black. More recently, the majority of these infections are among younger, rural or suburban and Caucasian PWID. All four HIV outbreaks were characterized by a high proportion of women who inject drugs and underlying socioeconomic drivers such as homelessness and poverty. We contend that the US response to the HIV epidemic among PWID has been fractured. A crucial lesson is that when evidence-based responses to HIV prevention are undermined or abandoned because of moral objections, untold humanitarian and financial costs on public health will ensue. Restructuring a path forward requires that evidence-based interventions be integrated and brought to scale while simultaneously addressing underlying structural drivers of HIV and related syndemics. Failing to do so will mean that HIV outbreaks among PWID and the communities they live in will continue to occur in a tragic and relentless cycle.

Published
2020

29. Costs and impact on HIV transmission of a switch from a criminalisation to a public health approach to injecting drug use in eastern Europe and central Asia: a modelling analysis

Author

Ward, Zoe, Stone, Jack, Bishop, Chrissy, Ivakin, Viktor, Eritsyan, Ksenia, Deryabina, Anna, Low, Andrea, Cepeda, Javier, Kelly, Sherrie L, Heimer, Robert, Cook, Robert, Altice, Frederick L, Litz, Taylor, Terlikbayeva, Assel, El-Bassel, Nabila, Havarkov, Denis, Fisenka, Alena, Boshnakova, Anelia, Klepikov, Andrey, Saliuk, Tetiana, Deshko, Tetiana, and Vickerman, Peter

Published
2022
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30. Simulating the Simultaneous Impact of Medication for Opioid Use Disorder and Naloxone on Opioid Overdose Death in Eight New York Counties

Author

Cerdá, Magdalena, primary, Hamilton, Ava D., additional, Hyder, Ayaz, additional, Rutherford, Caroline, additional, Bobashev, Georgiy, additional, Epstein, Joshua M., additional, Hatna, Erez, additional, Krawczyk, Noa, additional, El-Bassel, Nabila, additional, Feaster, Daniel J., additional, and Keyes, Katherine M., additional

Published
2024
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39. A cluster-randomized controlled trial of a combination HIV risk reduction and microfinance intervention for female sex workers who use drugs in Kazakhstan

Author

El-Bassel, Nabila, Mccrimmon, Tara, Mergenova, Gaukhar, Chang, Mingway, Terlikbayeva, Assel, Primbetova, Sholpan, Kuskulov, Azamat, Baiserkin, Bauyrzhan, Denebayeva, Alfiya, Kurmetova, Kulpan, and Witte, Susan S.

Subjects
Microfinance -- Evaluation, Prostitutes -- Health aspects, Public health administration -- Economic aspects, HIV infection -- Prevention, Health
Abstract

Introduction: Female sex workers (FSW) who use drugs are a key population at risk of HIV in Kazakhstan, and face multiple structural barriers to HIV prevention. More research is needed on the role of structural interventions such as microfinance (MF) in reducing HIV risk. This paper describes the results of a cluster-randomized controlled trial to test the efficacy of a combination HIVRR + MF intervention in reducing biologically confirmed STIs and HIV risk behaviours. Methods: This study took place from May 2015 to October 2018 in two cities in Kazakhstan. We screened 763 participants for eligibility and enrolled 354 FSW who use drugs. Participants were randomized in cohorts to receive either a four-session HIVRR intervention, or that same intervention plus 30 additional sessions of financial literacy training, vocational training and asset-building through a matched-savings programme. Repeated behavioural and biological assessments were conducted at baseline, 3- 6- and 12-months post-intervention. Biological and behavioural primary outcomes included HIV/STI incidence, sexual risk behaviours and drug use risk behaviours, evaluated over the 12-month period. Results: Over the 12-month follow-up period, few differences in study outcomes were noted between arms. There was only one newly-detected HIV case, and study arms did not significantly differ on any STI incidence. At post-intervention assessments compared to baseline, both HIVRR and HIVRR + MF participants significantly reduced sexual and drug use risk behaviours, and showed improvements in financial outcomes, condom use attitudes and self-efficacy social support, and access to medical care. In addition, HIVRR + MF participants showed a 72% greater reduction in the number of unprotected sex acts with paying partners at the six-month assessment (IRR = IRR = 0.28, 95% CI = 0.08, 0.92), and a 10% greater reduction in the proportion of income from sex work at the three-month assessment (b = -0.10, 95% CI = -0.17, -0.02) than HIVRR participants did. HIVRR + MF participants also showed significantly improved performance on financial self-efficacy compared to HIVRR over the 12-month follow-up period. Conclusions: Compared to a combination HIVRR + MF intervention, a robust HIVRR intervention alone may be sufficient to reduce sexual and drug risk behaviours among FSW who use drugs. There may be structural limitations to the promise of microfinance for HIV risk reduction among this population. Keywords: structural interventions; sex workers; drug use; HIV prevention; clinical trials, 1 | INTRODUCTION Female sex workers (FSW) are a key population at high risk for HIV and other sexually transmitted infections (STIs). In low and middle-income countries, estimates put their [...]

Published
2021
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42. The HEALing (Helping to End Addiction Long-term SM) Communities Study: Protocol for a cluster randomized trial at the community level to reduce opioid overdose deaths through implementation of an integrated set of evidence-based practices

Author

Walsh, Sharon L., El-Bassel, Nabila, Jackson, Rebecca D., Samet, Jeffrey H., Aggarwal, Maneesha, Aldridge, Arnie P., Baker, Trevor, Barbosa, Carolina, Barocas, Joshua A., Battaglia, Tracy A., Beers, Donna, Bernson, Dana, Bowers-Sword, Rachel, Bridden, Carly, Brown, Jennifer L., Bush, Heather M., Bush, Joshua L., Button, Amy, Campbell, Aimee N.C., Cerda, Magdalena, Cheng, Debbie M., Chhatwal, Jag, Clarke, Thomas, Conway, Kevin P., Crable, Erika L., Czajkowski, Andrea, David, James L., Drainoni, Mari-Lynn, Fanucchi, Laura C., Feaster, Daniel J., Fernandez, Soledad, Freedman, Darcy, Freisthler, Bridget, Gilbert, Louisa, Glasgow, LaShawn M., Goddard-Eckrich, Dawn, Gutnick, Damara, Harlow, Kristin, Helme, Donald W., Huang, Terry, Huerta, Timothy R., Hunt, Timothy, Hyder, Ayaz, Kerner, Robin, Keyes, Katherine, Knott, Charles E., Knudsen, Hannah K., Konstan, Michael, Larochelle, Marc R., Craig Lefebvre, R., Levin, Frances, Lewis, Nicky, Linas, Benjamin P., Lofwall, Michelle R., Lounsbury, David, Lyons, Michael S., Mann, Sarah, Marks, Katherine R., McAlearney, Ann, McCollister, Kathryn E., McCrimmon, Tara, Miles, Jennifer, Miller, Cortney C., Nash, Denis, Nunes, Edward, Oga, Emmanuel A., Oser, Carrie B., Plouck, Tracy, Rapkin, Bruce, Freeman, Patricia R., Rodriguez, Sandra, Root, Elisabeth, Rosen-Metsch, Lisa, Sabounchi, Nasim, Saitz, Richard, Salsberry, Pamela, Savitsky, Caroline, Schackman, Bruce R., Seiber, Eric E., Slater, Michael D., Slavova, Svetla, Speer, Drew, Martinez, Linda Sprague, Stambaugh, Leyla F., Staton, Michele, Stein, Michael D., Stevens-Watkins, Danelle J., Surratt, Hilary L., Talbert, Jeffery C., Thompson, Katherine L., Toussant, Kim, Vandergrift, Nathan A., Villani, Jennifer, Walker, Daniel M., Walley, Alexander Y., Walters, Scott T., Westgate, Philip M., Winhusen, Theresa, Wu, Elwin, Young, April M., Young, Greg, Zarkin, Gary A., and Chandler, Redonna K.

Published
2020
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43. Community engagement to implement evidence-based practices in the HEALing communities study

Author

Sprague Martinez, Linda, Rapkin, Bruce D., Young, April, Freisthler, Bridget, Glasgow, LaShawn, Hunt, Tim, Salsberry, Pamela J., Oga, Emmanuel A., Bennet-Fallin, Amanda, Plouck, Tracy J., Drainoni, Mari-Lynn, Freeman, Patricia R., Surratt, Hilary, Gulley, Jennifer, Hamilton, Greer A., Bowman, Paul, Roeber, Carter A., El-Bassel, Nabila, and Battaglia, Tracy

Published
2020
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47. Mental health and cognition in relation to adherence to antiretroviral therapy among people living with HIV in Kazakhstan: a cross‐sectional study.

Author

Mergenova, Gaukhar, Davis, Alissa, Gilbert, Louisa, El‐Bassel, Nabila, Terlikbayeva, Assel, Primbetova, Sholpan, Nugmanova, Zhamilya, Pala, Andrea Norcini, Gustafson, Deborah, Rosenthal, Susan L., Denebayeva, Alfiya Y., and DeHovitz, Jack

Subjects
HIV-positive persons, MENTAL health, POST-traumatic stress disorder, ANTIRETROVIRAL agents, ANXIETY disorders, COGNITION, GENERALIZED anxiety disorder
Abstract

Introduction: There is a research gap in how mental health and cognition are associated with antiretroviral treatment (ART) adherence among people living with HIV (PLWH) in Kazakhstan. Methods: We randomly selected and enrolled 230 PLWH from the Almaty City AIDS Center registry (June−November 2019) into a cross‐sectional study. We examined associations between self‐reported ART adherence for the last 1 and 2 weeks; the Adherence Self‐Efficacy Scale (ASES) and symptoms of depression (Patient Health Questionnaire‐9 [PHQ‐9]), anxiety (Generalized Anxiety Disorder tool [GAD‐7]), post‐traumatic stress disorder (PTSD Checklist [PTSD]); cognitive function (PROMIS v2.0 Adult Cognitive Function 8a short form) and forgetfulness (Forgetfulness Assessment Inventory). We used cut points of ≥5 for at least mild and ≥10 for at least moderate symptom severity for PHQ‐9 and GAD‐7 and of ≥44 for PTSD. Logistic and linear regression analyses were used. Results: Participants' median age was 40.0 (IQR: 34−47) with 40.9% (n = 94) of females in the sample. Those who missed at least one pill for the last 2 weeks had higher odds of reporting at least mild depression (aOR = 3.34, 95% CI: 1.22–9.11, p < 0.05); mild anxiety (aOR = 3.27, 95% CI: 1.20–8.92, p < 0.05); and PTSD (aOR = 4.04, 95% CI: 1.15–14.21, p < 0.05) symptoms. Participants who missed at least one pill for the last week had higher odds of at least mild depression (aOR = 7.74, 95% CI: 1.31–45.7, p < 0.05), moderate anxiety (aOR = 21.33, 95% CI: 3.24–140.33, p < 0.005) and PTSD (aOR = 13.81, 95% CI: 2.36–80.84, p < 0.005) symptoms. Participants with better cognitive function had lower odds of non‐adherence over the last week (aOR = 0.88, 95% CI: 0.81–0.96, p < 0.005) and higher ASES scores (β = 0.26, 95% CI: 0.13–0.40, p < 0.005). Poor memory was associated with higher odds of non‐adherence over the last week (aOR = 4.64, 95% CI: 1.76–12.24, p < 0.005) and lower ASES score (β = −0.31, 95% CI: −0.45 to 0.16, p < 0.005). Those who had at least mild depression (β = −0.21, 95% CI: −0.35 to −0.07, p < 0.005); moderate anxiety (β = −0.21, 95% CI: −0.34 to −0.07, p < 0.005) and PTSD (β = −0.19, 95% CI: −0.33 to −0.05, p < 0.005) symptoms had lower ASES scores. Conclusions: Depression, anxiety and PTSD symptoms, poorer cognition, and forgetfulness were associated with poorer ART adherence and worse adherence self‐efficacy. It is crucial to assess and treat mental illness and provide support for PLWH with worsened cognition to enhance ART adherence. [ABSTRACT FROM AUTHOR]

Published
2024
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48. An Approach to Enhancing Medication Treatment for Opioid Use Disorder in the HEALing Communities Study.

Author

Wai, Jonathan M., Blevins, Derek, Hunt, Tim, Gilbert, Louisa, Campbell, Aimee N. C., Levin, Frances R., El-Bassel, Nabila, and Nunes, Edward

Subjects
OPIOID abuse, OPIOIDS, HEALING, LOCAL delivery services, DRUG overdose
Abstract

The HEALing (Helping to End Addiction Long-term) Communities Study (HCS) aims to test the effectiveness of the Communities That HEAL intervention in decreasing opioid overdose deaths in 67 communities across four U.S. states. This intervention enlists a collaborative team of researchers, academic experts, and community coalitions to select and implement interventions from a menu of evidence-based practices, including medications for opioid use disorder (MOUD). The HCS's New York team developed an integrated network systems (INS) approach with a mapping tool to coach coalitions in the selection of strategies to enhance medication treatment. With the INS approach, community coalitions develop a map of service delivery venues in their local county to better engage people with medication treatment wherever this need arises. The map is structured around core services that can provide maintenance MOUD and satellite services, which include all settings where people with opioid use disorder are encountered and can be identified, possibly given medication, and referred to core programs for ongoing MOUD care. This article describes the rationale for the INS mapping tool, with a discussion framed by the consolidated framework for implementation research, and provides a case example of its application. [ABSTRACT FROM AUTHOR]

Published
2024
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