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Hydrazinolysis of 4-amino-6-[2-(4-methoxyphenyl)vinyl]-3-thioxo-3,4-dihydro-2H-[1,2,4] triazin-5-one (1) gave the corresponding hydrazino derivatives (2) Cyclocondensation of (2) with carbon disulfide furnished 8-amino-6-[2-(4-methoxyphenyl)vinyl]-3-thioxo-2,8-dihydro-3H-[1,2,4]triazolo[4,3-b][1,2,4]triazin-7-one (3) which was treated with 2,3,4,6- tetra-O-acetyl-α-D-glucopyranosyl bromide (4) in pyridine to give the corresponding N-glucosyl derivative 5, which deblocked to give 8. Compound 2 was reacted with isatin 9 and/or isatoic anhydride 10 to afford 11 and 12. Treatment of 11 and 12 with (4) in pyridine gave the corresponding mono glucosyl derivatives 13 and 14, which were deblocked by ammonia and afforded 15 and 16. Condensation of 2 with aldoses afforded the corresponding cyclic products 17a-f and with D-fructose furnished 18. Acetylation of 17b, d afforded the corresponding polyacetyl derivatives 19b,d. Compound 2 condensed with some aromatic aldehydes in boiling methanol and gave 20a-f. The newly synthesized compounds were tested as antimicrobial agents. [ABSTRACT FROM AUTHOR]

Abstract: Using the first-principles methods, density-functional theory (DFT) and Hartree–Fock (HF), we have studied the defect fullerene cages by removing C2 units from icosahedral C60, sequentially down to C30. It is found that the band gap of defect fullerenes depends on the size considerably, and is shown for the first time that C40 cage can have very small energy gap. Also, we have investigated forty isomers of C40 cage and have selected ones with low energies and high conductivities. Therefore C40 is proposed to be an interesting unit for nanodevice applications. [Copyright &y& Elsevier]