Search

Your search keyword '"El Solh, Ali A."' showing total 977 results
Start Over Author "El Solh, Ali A."
977 results on '"El Solh, Ali A."'

2. Low-dose methylprednisolone treatment in critically ill patients with severe community-acquired pneumonia

Author

Meduri, G Umberto, Shih, Mei-Chiung, Bridges, Lisa, Martin, Thomas J, El-Solh, Ali, Seam, Nitin, Davis-Karim, Anne, Umberger, Reba, Anzueto, Antonio, Sriram, Peruvemba, Lan, Charlie, Restrepo, Marcos I, Guardiola, Juan J, Buck, Teresa, Johnson, David P, Suffredini, Anthony, Bell, W Andrew, Lin, Julia, Zhao, Lan, Uyeda, Lauren, Nielsen, Lori, and Huang, Grant D

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Pneumonia, Lung, Clinical Research, Pneumonia & Influenza, Clinical Trials and Supportive Activities, Evaluation of treatments and therapeutic interventions, 6.1 Pharmaceuticals, Respiratory, Good Health and Well Being, Adult, Community-Acquired Infections, Critical Illness, Humans, Methylprednisolone, Respiration, Artificial, Treatment Outcome, ESCAPe Study Group, Community-acquired pneumonia, Glucocorticoids, Intensive care, Randomized clinical trial, Public Health and Health Services, Emergency & Critical Care Medicine, Clinical sciences
Abstract

PurposeSevere community-acquired pneumonia (CAP) requiring intensive care unit admission is associated with significant acute and long-term morbidity and mortality. We hypothesized that downregulation of systemic and pulmonary inflammation with prolonged low-dose methylprednisolone treatment would accelerate pneumonia resolution and improve clinical outcomes.MethodsThis double-blind, randomized, placebo-controlled clinical trial recruited adult patients within 72-96 h of hospital presentation. Patients were randomized in 1:1 ratio; an intravenous 40 mg loading bolus was followed by 40 mg/day through day 7 and progressive tapering during the 20-day treatment course. Randomization was stratified by site and need for mechanical ventilation (MV) at the time of randomization. Outcomes included a primary endpoint of 60-day all-cause mortality and secondary endpoints of morbidity and mortality up to 1 year of follow-up.ResultsBetween January 2012 and April 2016, 586 patients from 42 Veterans Affairs Medical Centers were randomized, short of the 1420 target sample size because of low recruitment. 584 patients were included in the analysis. There was no significant difference in 60-day mortality between the methylprednisolone and placebo arms (16% vs. 18%; adjusted odds ratio 0.90, 95% CI 0.57-1.40). There were no significant differences in secondary outcomes or complications.ConclusionsIn patients with severe CAP, prolonged low-dose methylprednisolone treatment did not significantly reduce 60-day mortality. Treatment was not associated with increased complications.

Published
2022

4. Contributors

Author

Adam, Françoise, primary, Akinnusi, Morohunfolu, additional, Alimoradi, Zainab, additional, Andersson, Gerhard, additional, Aonso-Diego, Gema, additional, Apolinário-Hagen, Jennifer, additional, Arumugham, Shyam Sundar, additional, Arya, Yogesh K., additional, Ayache, Samar S., additional, Baños, Rosa M., additional, Bhattacharya, Saswati, additional, Botella, Cristina, additional, Bottera, Angeline R., additional, Buhagiar, Rachel, additional, Caballo, Vicente E., additional, Cardemil, Esteban V., additional, Chalah, Moussa A., additional, Chan, Sunny Ho-Wan, additional, Comșa, Loana, additional, Danino, Roy, additional, David, Oana, additional, Donker, Tara, additional, Drüge, Marie, additional, El-Solh, Ali A., additional, Evelyna Kambanis, P., additional, Fakfum, Puriwat, additional, Fernández-Buendía, Sara, additional, Foo, Cheryl Yunn Shee, additional, Ghosh, Debasruti, additional, Giusti, Laura, additional, González-Roz, Alba, additional, Goyal, Deepika, additional, Griffiths, Mark D., additional, Grimm, Elise, additional, Halder, Susmita, additional, Hamatani, Sayo, additional, Hartman, Sarah J., additional, Heinrichs, Markus, additional, Hofmann, Stefan G., additional, Hsu, Bo-Cheng, additional, Käll, Anton, additional, Kanzaki, Sho, additional, Kataoka, Chinatsu, additional, Ketiš, Zalika-Klemenc, additional, Khan, Anwar, additional, Kimizuka, Tomomi, additional, Kimura, Yasuhiro, additional, Kondo, Masaki, additional, Lau, Charlie, additional, Le, Huynh-Nhu, additional, Lerttrakarnnon, Peerasak, additional, Lin, Chin-Lon, additional, Lin, Tin-Kwang, additional, MacKillop, James, additional, Mahato, Akash Kumar, additional, Mammarella, Silvia, additional, Mamo, Elena, additional, Mancuso, Christopher J., additional, Matsumoto, Kazuki, additional, Miroševič, Špela, additional, Naeem, Farooq, additional, Nanda, Michelle A., additional, Nanjundaswamy, Madhuri H., additional, Pakpour, Amir H., additional, Patel, Vinood B., additional, Preedy, Victor R., additional, Quero, Soledad, additional, Rabemananjara, Kantoniony M., additional, Raj, Saurabh, additional, Rajendram, Rajkumar, additional, Robert, G. Lamar, additional, Roncone, Rita, additional, Rosario, José R., additional, Salazar, Isabel C., additional, Salza, Anna, additional, Secades-Villa, Roberto, additional, Selvapandiyan, Jaiganesh, additional, Sharma, Lavanya P., additional, Singh, Tushar, additional, Sullivan, Karen A., additional, Tanoue, Hiroki, additional, Tasseit, Siegfried, additional, Tay, Alvin Kuowei, additional, Tazoe, Mami, additional, Terry, Danielle L., additional, Tunsuchart, Kongprai, additional, Verdeli, Helen, additional, Verma, Sunil K., additional, Watzke, Birgit, additional, Weidberg, Sara, additional, Weng, Chia-Ying, additional, Wong, Shu-Shu, additional, and Yoshinaga, Naoki, additional

Published
2023
Full Text
View/download PDF

13. Chronic Cough Due to Stable Chronic Bronchitis: CHEST Expert Panel Report

Author

Adams, Todd M., Altman, Kenneth W., Azoulay, Elie, Barker, Alan F., Birring, Surinder S., Blackhall, Fiona, Bolser, Donald C., Boulet, Louis-Philippe, Braman, Sidney S., Brightling, Christopher, Callahan-Lyon, Priscilla, Chang, Anne B., Davenport, Paul, El Solh, Ali A., Escalante, Patricio, Field, Stephen K., Fisher, Dina, French, Cynthia T., Gibson, Peter, Grant, Cameron, Harding, Susan M., Harnden, Anthony, Hill, Adam T., Irwin, Richard S., Kahrilas, Peter J., Kavanagh, Joanne, Keogh, Karina A., Lai, Kefang, Lane, Andrew P., Lilly, Craig, Lim, Kaiser, Lown, Mark, Madison, J. Mark, Malesker, Mark A., Mazzone, Stuart, McGarvey, Lorcan, Molassoitis, Alex, Murad, M. Hassan, Narasimhan, Mangala, Oppenheimer, John, Rosen, Mark, Rubin, Bruce, Russell, Richard J., Ryu, Jay H., Singh, Sonal, Smith, Maeve P., Tarlo, Susan M., Vertigan, Anne E., and Ireland, Belinda

Published
2020
Full Text
View/download PDF

14. Managing Chronic Cough as a Symptom in Children and Management Algorithms: CHEST Guideline and Expert Panel Report

Author

Adams, Todd M., Altman, Kenneth W., Azoulay, Elie, Blackhall, Fiona, Birring, Surinder S., Bolser, Donald C., Boulet, Louis-Philippe, Braman, Sidney S., Brightling, Christopher, Callahan-Lyon, Priscilla, Chang, Anne B., Cowley, Terrie, Davenport, Paul, El Solh, Ali A., Escalante, Patricio, Field, Stephen K., Fisher, Dina, French, Cynthia T., Grant, Cameron, Harding, Susan M., Harnden, Anthony, Hill, Adam T., Irwin, Richard S., Kahrilas, Peter J., Kavanagh, Joanne, Keogh, Karina A., Lai, Kefang, Lane, Andrew P., Lilly, Craig, Lim, Kaiser, Lown, Mark, Madison, J. Mark, Malesker, Mark A., Mazzone, Stuart, McGarvey, Lorcan, Molasoitis, Alex, Murad, M. Hassan, Narasimhan, Mangala, Oppenheimer, John, Russell, Richard J., Ryu, Jay H., Singh, Sonal, Smith, Maeve P., Tarlo, Susan M., Vertigan, Anne E., and Oppenheimer, John J.

Published
2020
Full Text
View/download PDF

15. Managing Chronic Cough Due to Asthma and NAEB in Adults and Adolescents: CHEST Guideline and Expert Panel Report

Author

Altman, Kenneth W., Azoulay, Elie, Barker, Alan F., Blackhall, Fiona, Bolser, Donald C., Birring, Surinder S., Braman, Sidney S., Brightling, Christopher, Callahan-Lyon, Priscilla, Chang, Anne B., Cowley, Terrie, Davenport, Paul, El Solh, Ali A., Escalante, Patricio, Field, Stephen K., Fisher, Dina, French, Cynthia T., Grant, Cameron, Gibson, Peter, Harding, Susan M., Harnden, Anthony, Hill, Adam T., Irwin, Richard S., Kahrilas, Peter J., Kavanagh, Joanne, Lai, Kefang, Lane, Andrew P., Lilly, Craig, Lown, Mark, Madison, J. Mark, Malesker, Mark A., Mazzone, Stuart, McGarvey, Lorcan, Molasoitis, Alex, Moore, Abigail, Murad, M. Hassan, Narasimhan, Mangala, Oppenheimer, John, Rosen, Mark, Rubin, Bruce, Russell, Richard J., Ryu, Jay H., Singh, Sonal, Smith, Jaclyn, Smith, Maeve P., Tarlo, Susan M., Vertigan, Anne E., Weinberger, Miles, Côté, Andreanne, Boulet, Louis-Philippe, Gibson, Peter G., and Brightling, Christopher E.

Published
2020
Full Text
View/download PDF

16. Acute Cough Due to Acute Bronchitis in Immunocompetent Adult Outpatients: CHEST Expert Panel Report

Author

Adams, Todd M., Altman, Kenneth W., Azoulay, Elie, Barker, Alan F., Blackhall, Fiona, Birring, Surinder S., Bolser, Donald C., Boulet, Louis-Philippe, Braman, Sidney S., Brightling, Christopher, Callahan-Lyon, Priscilla, Chang, Anne B., Cowley, Terrie, Davenport, Paul, El Solh, Ali A., Escalante, Patricio, Field, Stephen K., Fisher, Dina, French, Cynthia T., Grant, Cameron, Harding, Susan M., Harnden, Anthony, Hill, Adam T., Irwin, Richard S., Kahrilas, Peter J., Kavanagh, Joanne, Lai, Kefang, Lilly, Craig, Lown, Mark, Madison, J. Mark, Malesker, Mark A., Mazzone, Stuart, McGarvey, Lorcan, Molasoitis, Alex, Murad, M. Hassan, Narasimhan, Mangala, Newcombe, Peter, Oppenheimer, John, Rosen, Mark, Rubin, Bruce, Russell, Richard J., Ryu, Jay H., Singh, Sonal, Smith, Jaclyn, Smith, Maeve P., Tarlo, Susan M., Vertigan, Anne E., Weinberger, Miles, Ireland, Belinda, and Linder, Jeffrey A.

Published
2020
Full Text
View/download PDF

19. Chronic Cough and Gastroesophageal Reflux in Children: CHEST Guideline and Expert Panel Report

Author

Adams, Todd M., Altman, Kenneth W., Azoulay, Elie, Barker, Alan F., Bolser, Donald C., Birring, Surinder S., Braman, Sidney S., Brightling, Christopher, Callahan-Lyon, Priscilla, Chang, Anne B., Cowley, Terrie, Davenport, Paul, El Solh, Ali A., Escalante, Patricio, Field, Stephen K., Fisher, Dina, French, Cynthia T., Grant, Cameron, Gibson, Peter, Harding, Susan M., Gold, Philip, Harnden, Anthony, Hill, Adam T., Irwin, Richard S., Kahrilas, Peter J., Kavanagh, Joanne, Lai, Kefang, Lim, Kaiser, Madison, J. Mark, Malesker, Mark A., Mazzone, Stuart, McGarvey, Lorcan, Metlay, Joshua P., Molasoitis, Alex, Murad, M. Hassan, Narasimhan, Mangala, Newcombe, Peter, Oppenheimer, John, Rosen, Mark, Rubin, Bruce, Russell, Richard J., Ryu, Jay H., Singh, Sonal, Smith, Jaclyn, Smith, Maeve P., Tarlo, Susan M., Turmel, Julie, Vertigan, Anne E., Weinberger, Miles, Oppenheimer, John J., Kantar, Ahmad, and Rubin, Bruce K.

Published
2019
Full Text
View/download PDF

20. Clinically Diagnosing Pertussis-associated Cough in Adults and Children: CHEST Guideline and Expert Panel Report

Author

Altman, Kenneth W., Azoulay, Elie, Barker, Alan F., Bolser, Donald C., Birring, Surinder S., Blackwell, Fiona, Boulet, Louis-Philippe, Braman, Sidney S., Brightling, Christopher, Callahan-Lyon, Priscilla, Chang, Anne B., Cowley, Terrie, Davenport, Paul, El Solh, Ali A., Escalante, Patricio, Field, Stephen K., Fisher, Dina, French, Cynthia T., Grant, Cameron, Gibson, Peter, Gold, Philip, Harding, Susan M., Harnden, Anthony, Hill, Adam T., Irwin, Richard S., Kahrilas, Peter J., Kavanagh, Joanne, Keogh, Karina A., Lai, Kefang, Lane, Andrew P., Lim, Kaiser, Lown, Mark, Madison, J. Mark, Malesker, Mark A., Mazzone, Stuart, McGarvey, Lorcan, Molasoitis, Alex, Moore, Abigail, Murad, M. Hassan, Narasimhan, Mangala, Newcombe, Peter, Nguyen, Huong Q., Oppenheimer, John, Rosen, Mark, Rubin, Bruce, Russell, Richard J., Ryu, Jay H., Singh, Sonal, Smith, Jaclyn, Smith, Maeve P., Tarlo, Susan M., Vertigan, Anne E., Weinberger, Miles, Grant, Cameron C., and Patel, Sheena

Published
2019
Full Text
View/download PDF

21. Adult Outpatients With Acute Cough Due to Suspected Pneumonia or Influenza: CHEST Guideline and Expert Panel Report

Author

Adams, Todd M., Altman, Kenneth W., Azoulay, Elie, Barker, Alan F., Birring, Surinder S., Blackhall, Fiona, Bolser, Donald C., Boulet, Louis-Philippe, Braman, Sidney S., Brightling, Christopher, Callahan-Lyon, Priscilla, Chang, Anne B., Cowley, Terrie, Davenport, Paul, El Solh, Ali A., Escalante, Patricio, Field, Stephen K., Fisher, Dina, French, Cynthia T., Gibson, Peter, Gold, Philip, Grant, Cameron, Harding, Susan M., Harnden, Anthony, Hill, Adam T., Irwin, Richard S., Kahrilas, Peter J., Kavanagh, Joanne, Keogh, Karina A., Lai, Kefang, Lane, Andrew P., Lim, Kaiser, Madison, J. Mark, Malesker, Mark A., Mazzone, Stuart, McGarvey, Lorcan, Molasoitis, Alex, Moore, Abigail, Murad, M. Hassan, Narasimhan, Mangala, Newcombe, Peter, Nguyen, Huong Q., Oppenheimer, John, Rosen, Mark, Rubin, Bruce, Russell, Richard J., Ryu, Jay H., Singh, Sonal, Smith, Jaclyn, Smith, Maeve P., Tarlo, Susan M., Turmel, Julie, Vertigan, Anne E., Wang, Gang, Weinberger, Miles, Gold, Philip M., Metlay, Joshua P., and Ireland, Belinda

Published
2019
Full Text
View/download PDF

25. Chronic Cough Due to Gastroesophageal Reflux in Adults: CHEST Guideline and Expert Panel Report

Author

Adams, Todd M., Altman, Kenneth W., Azoulay, Elie, Barker, Alan F., Blackhall, Fiona, Bolser, Donald C., Boulet, Louis-Philippe, Brightling, Christopher, Callahan-Lyon, Priscilla, Canning, Brendan J., Chang, Anne B., Cowley, Terrie, Ebihara, Satoru, El Solh, Ali A., Escalante, Patricio, Field, Stephen K., Feinstein, Anthony, Fisher, Dina, French, Cynthia T., Gibson, Peter, Gold, Philip, Gould, Michael K., Grant, Cameron, Harding, Susan M., Harnden, Anthony, Hill, Adam T., Irwin, Richard S., Kahrilas, Peter J., Keogh, Karina A., Lai, Kefang, Lane, Andrew P., Lim, Kaiser, Malesker, Mark A., Mazzone, Stuart, McGarvey, Lorcan, Murad, M. Hassan, Nguyen, Huong Q., Newcombe, Peter, Oppenheimer, John, Rosen, Mark, Rubin, Bruce, Ryu, Jay H., Smith, Jaclyn, Tarlo, Susan M., Vertigan, Anne E., Wang, Gang, Weinberger, Miles, and Weir, Kelly

Published
2016
Full Text
View/download PDF

27. Occupational and Environmental Contributions to Chronic Cough in Adults: Chest Expert Panel Report

Author

Adams, Todd M., Altman, Kenneth W., Azoulay, Elie, Barker, Alan F., Birring, Surinder S., Blackhall, Fiona, Bolser, Donald C., Boulet, Louis-Philippe, Braman, Sidney S., Brightling, Christopher, Callahan-Lyon, Priscilla, Chang, Anne B., Ebihara, Satoru, El Solh, Ali A., Escalante, Patricio, Feinstein, Anthony, Field, Stephen K., Fisher, Dina, French, Cynthia T., Gibson, Peter, Gold, Philip, Gould, Michael K., Grant, Cameron, Harding, Susan M., Harnden, Anthony, Hill, Adam T., Irwin, Richard S., Kahrilas, Peter J., Keogh, Karina A., Lai, Kefang, Lane, Andrew P., Lim, Kaiser, Malesker, Mark A., Mazzone, Stuart, McGarvey, Lorcan, Molasiotis, Alex, Murad, M. Hassan, Oppenheimer, John, Prezant, David, Restrepo, Marcos I., Rosen, Mark, Rubin, Bruce, Ryu, Jay H., Tarlo, Susan M., Vertigan, Anne E., Wang, Gang, Weinberger, Miles, Weir, Kelly, and Vertigan, Anne

Published
2016
Full Text
View/download PDF

28. Management of Adults With Hospital-acquired and Ventilator-associated Pneumonia: 2016 Clinical Practice Guidelines by the Infectious Diseases Society of America and the American Thoracic Society

Author

Kalil, Andre C., Metersky, Mark L., Klompas, Michael, Muscedere, John, Sweeney, Daniel A., Palmer, Lucy B., Napolitano, Lena M., O'Grady, Naomi P., Bartlett, John G., Carratalà, Jordi, El Solh, Ali A., Ewig, Santiago, Fey, Paul D., File, Thomas M., Restrepo, Marcos I., Roberts, Jason A., Waterer, Grant W., Cruse, Peggy, Knight, Shandra L., and Brozek, Jan L.

Published
2016

29. Tools for Assessing Outcomes in Studies of Chronic Cough: CHEST Guideline and Expert Panel Report

Author

Adams, Todd M., Altman, Kenneth W., Barker, Alan F., Birring, Surinder S., Blackhall, Fiona, Bolser, Donald C., Boulet, Louis-Philippe, Braman, Sidney S., Brightling, Christopher, Callahan-Lyon, Priscilla, Chang, Anne Bernadette, Coeytaux, Remy, Cowley, Terrie, Davenport, Paul, Diekemper, Rebecca L., Ebihara, Satoru, El Solh, Ali A., Escalante, Patricio, Feinstein, Anthony, Field, Stephen K., Fisher, Dina, French, Cynthia T., Gibson, Peter, Gold, Philip, Gould, Michael K., Grant, Cameron, Harding, Susan M., Harnden, Anthony, Hill, Adam T., Irwin, Richard S., Kahrilas, Peter J., Keogh, Karina A., Lane, Andrew P., Lewis, Sandra Zelman, Lim, Kaiser, Malesker, Mark A., Mazzone, Stuart, McCrory, Douglas C., McGarvey, Lorcan, Molasiotis, Alex, Murad, M. Hassan, Newcombe, Peter, Nguyen, Huong Q., Oppenheimer, John, Prezant, David, Restrepo, Marcos I., Rosen, Mark, Rubin, Bruce, Ryu, Jay H., Smith, Jaclyn, Tarlo, Susan M., Vertigan, Anne, Wang, Gang, Weinberger, Miles, Weir, Kelly, Coeytaux, Remy R., and Chang, Anne B.

Published
2015
Full Text
View/download PDF

30. Methodologies for the Development of the Management of Cough: CHEST Guideline and Expert Panel Report

Author

Adams, Todd M., Altman, Kenneth W., Barker, Alan F., Birring, Surinder S., Bolser, Donald C., Boulet, Louis-Philippe, Braman, Sidney S., Brightling, Christopher, Callahan-Lyon, Priscilla, Canning, Brendan, Chang, Anne Bernadette, Coeytaux, Remy, Cowley, Terrie, Davenport, Paul, Diekemper, Rebecca L., Ebihara, Satoru, El Solh, Ali A., Escalante, Patricio, Field, Stephen K., Fisher, Dina, French, Cynthia T., Gibson, Peter, Gold, Philip, Gould, Michael K., Harding, Susan M., Harnden, Anthony, Hill, Adam T., Irwin, Richard S., Kahrilas, Peter J., Keogh, Karina A., Lane, Andrew P., Lewis, Sandra Zelman, Lim, Kaiser, Malesker, Mark A., Mazzone, Peter, McCrory, Douglas C., McGarvey, Lorcan, Murad, M. Hassan, Newcombe, Peter, Nguyen, Huong Q., Oppenheimer, John, Prezant, David, Pringsheim, Tamara, Restrepo, Marcos I., Rosen, Mark, Rubin, Bruce, Ryu, Jay H., Smith, Jaclyn, Tarlo, Susan M., Turner, Ronald B., Vertigan, Anne, Weir, Kelly, Wiener, Renda Soylemez, Diekemper, Rebecca L, French, Cynthia T, Gold, Philip M, and Irwin, Richard S

Published
2014
Full Text
View/download PDF

32. The Impact of High Versus Low Sedation Dosing Strategy on Cognitive Dysfunction in Survivors of Intensive Care Units: A Systematic Review and Meta-Analysis

Author

Porhomayon Jahan, Joude Philippe, Adlparvar Ghazaleh, El-Solh Ali َA, and Nader D Nader

Subjects
Posttraumatic Stress Disorder, Depression, Cognitive Function, Sedation, Delirium, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Background: The practice of low vs. high sedation dosing strategy may impact the cognitive and mental health function in the intensive care unit (ICU). We aim to demonstrate that high sedation strategy will result in change of mental health function in ICU patients. Methods: We performed a systemic search and meta-analysis of medical databases in MEDLINE(from 1966 to March 2013) and EMBASE (from 1980 to March 2013), as well as the Cochrane Library using the MESH terms "Intensive Care Unit," and "Mental Health, for assessing the impact of sedation on posttraumatic stress disorder (PTSD) or anxiety/depression and deliriumin the mix ICU setting including cardiac surgery patients. A total of 1216 patients were includedin the final analysis.Results: We included 11 studies in the final analysis and concluded that high dose sedationstrategy resulted in higher incidence of cognitive dysfunction with P value of 0.009. Theresult for subgroup of delirium showed P = 0.11 and PTSD/depression or anxiety of P = 0.001,Heterogeneity I2 was 64%. Overall analysis was statistically significant with a P value of 0.002.Conclusion: High sedation dosing strategy will negatively affect cognitive function in criticallyill patients. Large randomized trials are needed to address cognitive dysfunction in subgroup of patients with delirium.

Published
2015
Full Text
View/download PDF

34. Classification of Cough as a Symptom in Adults and Management Algorithms: CHEST Guideline and Expert Panel Report

Author

Irwin, Richard S., French, Cynthia L., Chang, Anne B., Altman, Kenneth W., Adams, Todd M., Azoulay, Elie, Barker, Alan F., Birring, Surinder S., Blackhall, Fiona, Bolser, Donald C., Boulet, Louis-Philippe, Brightling, Christopher, Callahan-Lyon, Priscilla, Cowley, Terrie, Ebihara, Satoru, El Solh, Ali A., Escalante, Patricio, Field, Stephen K., Fisher, Dina, French, Cynthia T., Gibson, Peter, Gold, Philip, Harding, Susan M., Harnden, Anthony, Hill, Adam T., Kavanagh, Joanne, Keogh, Karina A., Lai, Kefang, Lane, Andrew P., Lim, Kaiser, Madison, Mark J., Malesker, Mark A., Mazzone, Stuart, Molassoitis, Alex, Murad, Hassan M., Narasimhan, Mangala, Nguyen, Huong Q., Newcombe, Peter, Oppenheimer, John, Restrepo, Marcos I., Rosen, Mark, Rubin, Bruce, Ryu, Jay H., Tarlo, Susan M., Turmel, Julie, Vertigan, Anne E., Wang, Gang, and Weinberger, Miles

Published
2018
Full Text
View/download PDF

35. Cough in Ambulatory Immunocompromised Adults: CHEST Expert Panel Report

Author

Rosen, Mark J., Ireland, Belinda, Narasimhan, Mangala, French, Cynthia, Irwin, Richard S., Adams, Todd M., Altman, Kenneth W., Barker, Alan F., Birring, Surinder S., Blackhall, Fiona, Bolser, Donald C., Braman, Sidney S., Brightling, Christopher, Callahan-Lyon, Priscilla, Chang, Anne B., Coté, Andréanne, Cowley, Terrie, Davenport, Paul, Ebihara, Satoru, El Solh, Ali A., Escalante, Patricio, Feinstein, Anthony, Field, Stephen K., Fisher, Dina, French, Cynthia T., Gibson, Peter, Gold, Philip, Harnden, Anthony, Hill, Adam T., Kahrilas, Peter J., Keogh, Karina A., Lai, Kefang, Lim, Kaiser, Madison, Mark J., Malesker, Mark A., Mazzone, Stuart, Molassoitis, Alex, Murad, Hassan M., Nguyen, Huong Q., Newcombe, Peter, Oppenheimer, John J., Restrepo, Marcos I., Rosen, Mark, Rubin, Bruce, Ryu, Jay H., Smith, Jaclyn, Tarlo, Susan M., Turmel, Julie, Vertigan, Anne E., Wang, Gang, Weinberger, Miles, and Weir, Kelly

Published
2017
Full Text
View/download PDF

36. Pharmacologic and Nonpharmacologic Treatment for Acute Cough Associated With the Common Cold: CHEST Expert Panel Report

Author

Malesker, Mark A., Callahan-Lyon, Priscilla, Ireland, Belinda, Irwin, Richard S., Adams, Todd M., Altman, Kenneth W., Azoulay, Elie, Barker, Alan F., Birring, Surinder S., Blackhall, Fiona, Bolser, Donald C., Boulet, Louis-Philippe, Braman, Sidney S., Brightling, Christopher, Chang, Anne B., Coté, Andréanne, Cowley, Terrie, Davenport, Paul, Ebihara, Satoru, El Solh, Ali A., Escalante, Patricio, Field, Stephen K., Fisher, Dina, French, Cynthia T., Grant, Cameron, Gibson, Peter, Gold, Philip, Harding, Susan M., Harnden, Anthony, Hill, Adam T., Irwin, Richard S., Kahrilas, Peter J., Kavanagh, Joanne, Keogh, Karina A., Lai, Kefang, Lane, Andrew P., Lim, Kaiser, Madison, Mark J., Mazzone, Stuart, McGarvey, Lorcan, Molassoitis, Alex, Murad, Hassan M., Narasimhan, Mangala, Newcombe, Peter, Nguyen, Huong Q., Oppenheimer, John, Restrepo, Marcos I., Rosen, Mark, Rubin, Bruce, Ryu, Jay H., Smith, Jaclyn, Tarlo, Susan M., Turmel, Julie, Vertigan, Anne E., Wang, Gang, Weinberger, Miles, and Weir, Kelly

Published
2017
Full Text
View/download PDF

37. Residual sleepiness in veterans with post-traumatic stress disorder and obstructive sleep apnea.

Author

El-Solh, Ali A., Bui, Hoang, Lawson, Yolanda, and Attai, Parveen

Abstract

Purpose: The causes of residual excessive sleepiness (RES) in patients with post-traumatic stress disorder (PTSD) and obstructive sleep apnea (OSA) are multifactorial and modulated by comorbid conditions. The aim of the present study was to elucidate clinical and polysomnographic determinants of RES in continuous positive airway pressure (CPAP)-adherent OSA veterans with PTSD. Methods: The study protocol consisted of a retrospective analysis of consecutive cases of patients with PTSD who presented to the Veterans Affairs sleep clinics with adequately treated OSA between June 1, 2017 and October 15, 2021. Based on the Epworth Sleepiness Scale (ESS), patients were categorized into RES (ESS ≥ 11) and no RES (ESS < 11) groups. Demographic and PSG data were subjected to univariate and multivariate analyses to ascertain predictive factors of RES. Results: Out of 171 veterans with PTSD who were adherent to CPAP, 59 (35%) continued to experience RES. The RES group had a decrease in mean ESS score of 1.2 ± 4.5 after CPAP treatment compared with 4.6 ± 4.9 for the no RES group (< 0.001). A dose–response was observed between CPAP use and RES (p = 0.003). Multivariate regression analysis identified higher baseline ESS (OR 1.30; 95% CI 1.16–1.44), greater percentage of time spent in REM sleep (OR 0.91; 95% CI 0.85–0.96), CPAP use less than 6 h (OR 2.82; 95% CI 1.13–7.01), and a positive screen for depression (OR 1.69; 95% CI 1.03–4.72) as independent predictors of RES in patients with PTSD and OSA. Conclusion: RES is highly prevalent in patients with PTSD and OSA despite adherence to CPAP and is independently associated with percentage time spent in REM, duration of CPAP utilization, and symptoms of depression. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

41. Low-dose methylprednisolone treatment in critically ill patients with severe community-acquired pneumonia

Author

Meduri, G. Umberto, Shih, Mei-Chiung, Bridges, Lisa, Martin, Thomas J., El-Solh, Ali, Seam, Nitin, Davis-Karim, Anne, Umberger, Reba, Anzueto, Antonio, Sriram, Peruvemba, Lan, Charlie, Restrepo, Marcos I., Guardiola, Juan J., Buck, Teresa, Johnson, David P., Suffredini, Anthony, Bell, W. Andrew, Lin, Julia, Zhao, Lan, Uyeda, Lauren, Nielsen, Lori, Huang, Grant D., Meduri, G. Umberto, Shih, Mei-Chiung, Bridges, Lisa, Martin, Thomas J., El-Solh, Ali, Seam, Nitin, Davis-Karim, Anne, Umberger, Reba, Anzueto, Antonio, Sriram, Peruvemba, Lan, Charlie, Restrepo, Marcos I., Guardiola, Juan J., Buck, Teresa, Johnson, David P., Suffredini, Anthony, Bell, W. Andrew, Lin, Julia, Zhao, Lan, Uyeda, Lauren, Nielsen, Lori, and Huang, Grant D.

Abstract

Purpose: Severe community-acquired pneumonia (CAP) requiring intensive care unit admission is associated with significant acute and long-term morbidity and mortality. We hypothesized that downregulation of systemic and pulmonary inflammation with prolonged low-dose methylprednisolone treatment would accelerate pneumonia resolution and improve clinical outcomes. Methods: This double-blind, randomized, placebo-controlled clinical trial recruited adult patients within 72–96 h of hospital presentation. Patients were randomized in 1:1 ratio; an intravenous 40 mg loading bolus was followed by 40 mg/day through day 7 and progressive tapering during the 20-day treatment course. Randomization was stratified by site and need for mechanical ventilation (MV) at the time of randomization. Outcomes included a primary endpoint of 60-day all-cause mortality and secondary endpoints of morbidity and mortality up to 1 year of follow-up. Results: Between January 2012 and April 2016, 586 patients from 42 Veterans Affairs Medical Centers were randomized, short of the 1420 target sample size because of low recruitment. 584 patients were included in the analysis. There was no significant difference in 60-day mortality between the methylprednisolone and placebo arms (16% vs. 18%; adjusted odds ratio 0.90, 95% CI 0.57–1.40). There were no significant differences in secondary outcomes or complications. Conclusions: In patients with severe CAP, prolonged low-dose methylprednisolone treatment did not significantly reduce 60-day mortality. Treatment was not associated with increased complications.

Published
2022

42. Cough in the Athlete: CHEST Guideline and Expert Panel Report

Author

Boulet, Louis-Philippe, Turmel, Julie, Irwin, Richard S., Altman, Kenneth W., Barker, Alan F., Birring, Surinder S., Blackhall, Fiona, Bolser, Donald C., Boulet, Louis-Philippe, Braman, Sidney S., Brightling, Christopher, Callahan-Lyon, Priscilla, Chang, Anne B., Cowley, Terrie, Davenport, Paul, Ebihara, Satoru, El Solh, Ali A., Escalante, Patricio, Feinstein, Anthony, Field, Stephen K., Fisher, Dina, French, Cynthia T., Gibson, Peter, Gold, Philip, Grant, Cameron, Harding, Susan M., Harnden, Anthony, Hill, Adam T., Irwin, Richard S., Kahrilas, Peter J., Keogh, Karina A., Lai, Kefang, Lane, Andrew P., Lim, Kaiser, Malesker, Mark A., Mazzone, Peter, McGarvey, Lorcan, Murad, Hassan M., Newcombe, Peter, Nguyen, Huong Q., Oppenheimer, John, Rosen, Mark, Rubin, Bruce, Ryu, Jay H., Smith, Jaclyn, Tarlo, Susan M., Vertigan, Anne E., Wang, Gang, Weinberger, Miles, and Weir, Kelly

Published
2017
Full Text
View/download PDF

49. Survival Benefit of CPAP Favors Hypercapnic Patients with the Overlap Syndrome

Author

Jaoude, Philippe, Kufel, Thomas, and El-Solh, Ali A.

Subjects
Sleep -- Research -- Health aspects, Chronic obstructive lung disease -- Research -- Risk factors -- Development and progression -- Diagnosis -- Care and treatment, Health
Abstract

Background Patients with the combination of chronic obstructive pulmonary disease (COPD) and obstructive sleep apnea (OSA), known as the 'overlap syndrome,' have a substantially greater risk of morbidity and mortality compared to those with either COPD or OSA alone. The study's objective was to report on the long-term outcome of hypercapnic (PaCO.sub.2 [greater than or equal to] 45 mmHg) and normocapnic patients with the overlap syndrome treated with continuous positive airway pressure (CPAP). Methods A nonconcurrent cohort of consecutive patients with the overlap syndrome was followed for a median duration of 71 months (range 1-100) at a VA sleep center. All patients were managed according to the prevailing recommendations of both diseases. The end point of the study was all-cause mortality. Results Of the 271 patients identified, 104 were hypercapnic (PaCO.sub.2 = 51.6 ± 4.3 mmHg). Both normocapnic and hypercapnic patients had comparable apnea-hypopnea indexes (AHI) (29.2 ± 23.8 and 35.2 ± 29.2/h, respectively; p = 0.07) and similar adherence rates to CPAP (43 and 42 %, respectively, p = 0.9). Survival analysis revealed that hypercapnic patients who were adherent to CPAP had reduced mortality compared to nonadherent hypercapnic patients (p = 0.04). In contrast, the cumulative mortality rate for normocapnic patients was not significantly different between the adherent and the nonadherent group (p = 0.42). In multivariate analysis, the comorbidity index was the only independent predictor of mortality in normocapnic patients with the overlap syndrome [hazard ratio (HR) 1.68; p < 0.001] while CPAP adherence was associated with improved survival (HR 0.65; p = 0.04). Conclusions CPAP mitigates the excess risk of mortality in hypercapnic patients but not in normocapnic patients with the overlap syndrome., Author(s): Philippe Jaoude[sup.1] , Thomas Kufel[sup.1] , Ali A. El-Solh[sup.1] [sup.2] [sup.3] Author Affiliations: (1) VA Western New York Healthcare System, Medical Research, Bldg. 20 (151) VISN02, 3495 Bailey Avenue, [...]

Published
2014
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results